ATM mutation in aggressive uterine adenosarcoma in which systemic chemotherapies had remarkable effects

This study presents a case of uterine adenosarcoma without sarcomatous overgrowth but withTP53 mutation that exhibited clinically aggressive behaviors. The patient had anATM mutation, which is a gene associated with homologous recombination deficiency, and exhibited a good response against platinum-based chemotherapy and possible therapeutic target by poly(ADP-ribose) polymerase inhibitors.
Source: International Cancer Conference Journal - Category: Cancer & Oncology Source Type: research