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Successful multidisciplinary treatment with complete response to atezolizumab plus bevacizumab in a 90-year-old patient with hepatocellular carcinoma recurrence
AbstractAtezolizumab plus bevacizumab is the first-line regimen in Japan for hepatocellular carcinoma following the results of the IMbrave 150 trial. However, the safety and efficiency of atezolizumab plus bevacizumab in older patients, especially in the oldest-old patients aged over 80  years, have not been thoroughly studied and is still controversial. Eighteen months ago, a 90-year-old woman underwent a laparoscopic hepatectomy (S6) for her primary hepatocellular carcinoma (S6, 2 cm). Nine months after the first surgery, she received transcatheter arterial chemoembolization tr eatment for solitary hepatocellular carci...
Source: International Cancer Conference Journal - June 23, 2023 Category: Cancer & Oncology Source Type: research

Successful management of a rare case of gallbladder neuroendocrine carcinoma with tumor thrombi
AbstractA gallbladder neuroendocrine neoplasm (GB ‑NEN) is a bizarre heterogeneous neoplasm arising from neuroendocrine cells, which are present in minimal amounts on the GB mucosa either due to conversion of undifferentiated stem cells, chronic inflammation and resulting in pathological metaplasia or switching of GB adenocarcinoma to neuroendocr ine one. Among all the GB malignancies, GB-NEN accounts for approximately 2.1%. A 41-year-old lady presented with right upper abdomen pain and distension for 2 weeks. Contrast CT showed heterogeneously enhancing wall thickening involving fundus-body of the GB with large exophyt...
Source: International Cancer Conference Journal - May 31, 2023 Category: Cancer & Oncology Source Type: research

Who benefits from the abscopal effect?
(Source: International Cancer Conference Journal)
Source: International Cancer Conference Journal - May 23, 2023 Category: Cancer & Oncology Source Type: research

A case series title: femoral nerve injury with an episode of motor neuropathy caused by gynecological surgery: a case series
ConclusionPostoperative femoral nerve injury can be diagnosed based on gait disturbances and difficulties climbing stairs. It is difficult to identify risk factors for femoral nerve injury as they may involve a combination of features, such as intraoperative compression with self-retaining retractors, the lithotomy position, and the use of energy devices. The surgeon should be familiar with the nature of energy devices, make every effort to understand the necessary anatomy, and make every effort to avoid femoral nerve injury. Iatrogenic femoral nerve injury caused by gynecological surgery should be further investigated reg...
Source: International Cancer Conference Journal - May 17, 2023 Category: Cancer & Oncology Source Type: research

A case of testicular seminoma with testicular abscess caused by Salmonella saintpaul
AbstractTesticular abscesses are rarer than epididymitis and orchitis. Here, we report a case of testicular seminoma with testicular abscess caused bySalmonella saintpaul. A 41-year-old male was referred for painful enlargement of the right scrotal content and fever for 1  week. With the diagnosis of epididymitis, he was administered levofloxacin (LVFX) but the fever and painful enlargement persisted. Because of the poor response to antimicrobial agents and the undeniable complications of testicular malignancy, radical orchiectomy was performed. The testis was enlar ged to 7 cm, weighed approximately 100 g, and was fill...
Source: International Cancer Conference Journal - May 17, 2023 Category: Cancer & Oncology Source Type: research

Gastric neuroendocrine carcinoma presenting complete durable response by nivolumab treatment for multiple metastases and radiotherapy to oligoprogressive metastasis
AbstractGastric neuroendocrine carcinomas (NEC) are highly aggressive cancer with dismal prognosis. Platinum-based chemotherapy is used as the first-line treatment for this entity. However, there are no established therapeutic guidelines for platinum-resistant gastric NEC. We herein report a patient with metastatic gastric NEC who achieved durable and complete response to nivolumab with radiotherapy for oligoprogressive metastasis. A 70-year-old male patient had recurrences of resected gastric NEC, involving the liver and lymph nodes. His disease became refractory to cisplatin and etoposide combination therapy, after which...
Source: International Cancer Conference Journal - May 12, 2023 Category: Cancer & Oncology Source Type: research

Multidisciplinary management for primary uterine osteosarcoma, including gene panel testing: case report and literature review
AbstractPrimary osteosarcoma of the uterus (uOS) is rare, and its standard treatment has not yet been established. Herein, we present the case of a 50-year-old woman with uOS who demonstrated an improved prognosis after multiple surgeries to the metastatic sites. After the initial diagnosis of uOS, the patient showed recurrence and distant metastasis and hence expected to exhibit a poor prognosis. The patient underwent multiple surgical resections of the metastatic as well as primary tumors, which enabled the patient to survive for 24  months after the initial surgery. Considering that the median survival time of patients...
Source: International Cancer Conference Journal - May 9, 2023 Category: Cancer & Oncology Source Type: research

Myxoid liposarcoma in an 11-year-old patient
AbstractMyxoid liposarcoma is a mesenchymal malignancy that most commonly presents in young adults, with peak incidence between the ages of 30 –50 years. The clinical behavior of myxoid liposarcoma has been well characterized in adults. However, little is known about the clinical features and treatment outcomes of myxoid liposarcoma in child, owing to its rarity. This case report describes an 11-year-old previously healthy female who pr esented with a painless mass in her right thigh. Ultrasonography, computed tomography, and magnetic resonance imaging demonstrated a soft tissue mass with clear margins in the subfascial...
Source: International Cancer Conference Journal - May 9, 2023 Category: Cancer & Oncology Source Type: research

Characteristic imaging findings in a patient with chronic expanding hematoma on the floor of the mouth
We report a case of CEH on the floor of the mouth, which required differentiation fro m malignant tumor. A 42-year-old woman was referred to our hospital for a submucosal mass on the right floor of the mouth, with a diagnosis of class 3 on aspiration cytology. Computed tomography revealed a submucosal mass with peripheral calcification on the floor of the mouth, which exhibited a hyp ointense rim on T2-weighted imaging and gradual nodular-like enhancement in the periphery on contrast-enhanced magnetic resonance imaging. Enucleation was performed to reach a definitive diagnosis, and CEH was confirmed pathologically. Well-de...
Source: International Cancer Conference Journal - May 4, 2023 Category: Cancer & Oncology Source Type: research

A surgical resection of hepatic granuloma mimicking intrahepatic cholangiocarcinoma: a case report
AbstractHepatic granuloma is relatively rare, and benign tumor of the liver. Herein, we report an unusual case of hepatic granuloma mimicking intrahepatic cholangiocarcinoma (ICC). An 82-year-old woman with a history of viral hepatitis B was admitted for investigation of liver mass in the left lobe. Dynamic computed tomography revealed a mostly hypo-enhancing main tumor with a peripheral ring enhancement, and positron emission tomography demonstrated localized an abnormal accumulation of fludeoxyglucose. Considering the possibility of malignant disease, extended left hepatectomy was performed. The resected tumor was macros...
Source: International Cancer Conference Journal - April 26, 2023 Category: Cancer & Oncology Source Type: research

An unusual case of a tibial metastasis as the first clinical presentation of a serous papillary carcinoma of the ovarian epithelial type of the testis
We describe the case of an 82-year-old man, presented with complaints of right leg pain and difficulty walking, who was found to have a large right tibial metastasis of unknown primary origin. Whole body CT scan did not reveal any cranial, thoracic or abdominal tumor masses, but it showed abnormal para-aortic lymph nodes and right spermatic cord swelling. An extemporary ultrasound examination found a right testicular mass. The patient underwent radical orchiectomy, and the diagnosis of a serous papillary carcinoma of the ovarian epithelial type of the testis was made. To the best of our knowledge, this is the first case in...
Source: International Cancer Conference Journal - April 13, 2023 Category: Cancer & Oncology Source Type: research

A long-term survival case of bladder cancer with distant metastases: abscopal effect of brain metastases after stereotactic radiotherapy with immune checkpoint blockade therapy to lung metastases
We report a case of abscopal effect in a single brain metastasis from bladder cancer in a patient treated with focal stereotactic radiotherapy (total dose  = 52 Gy, administered in eight fractions) with immune checkpoint blockade therapy for lung metastases, who achieved long-term disease-free survival (>  4 years). To our knowledge, although there have been some reports on abscopal effects in bladder cancer, there are no previous reports on patients with brain metastases. To date, the brain metastasis, which showed an “abscopal effect,” continues to maintain complete regression. (Source: International Cance...
Source: International Cancer Conference Journal - April 3, 2023 Category: Cancer & Oncology Source Type: research

Abscopal effect of radiation in metastatic esophageal carcinoma: fourth reported case
We describe a case of abscopal regression of distant mediastinal and upper abdominal lymph nodes in a 65-year-old gentleman whose primary esophageal tumor was irradiated with hypo-fractionated radiotherapy in an attempt to achieve local palliation. Our case study emphasizes the systemic benefit of local radiotherapy and the need for future research to investigate its utility as this clinical event poses widespread response in an otherwise dismal Stage-IV cancer with minimal treatment-related side effects. (Source: International Cancer Conference Journal)
Source: International Cancer Conference Journal - April 1, 2023 Category: Cancer & Oncology Source Type: research

Peritoneal and pulmonary tuberculosis following intravesical administration of Bacillus Calmette –Guérin for bladder cancer
We report a rare case of peritoneal and pulmonary tuberculosis after intravesical instillation of Bacillus Calmette –Guérin (BCG). A 76-year-old man diagnosed as high-grade urothelial carcinoma (UC) with carcinoma in situ (CIS) was treated with intravesical BCG instillation and transurethral resection of bladder tumor (TUR-BT). Three months later, TUR-BT for recurrent tumors and multiple site biopsy of bladder mucosa were performed. During TUR-BT, near perforation in the posterior wall was observed, and was disappeared after observation with urethral catheterization for 1 week. Two weeks later, he was admitted with a co...
Source: International Cancer Conference Journal - April 1, 2023 Category: Cancer & Oncology Source Type: research

Symptom palliation with QUAD Shot radiation therapy to penile metastasis derived from descending colon cancer: a case report
AbstractA 54-year-old man was diagnosed with descending colon cancer with metastases in the liver, para-aortic lymph nodes, and penis, and chemotherapy was introduced after construction of a colostomy. The patient reported only mild penile pain at the time of diagnosis; however, the pain gradually worsened and interfered with his daily life. Opioids did not provide sufficient analgesia, and the patient developed dysuria and priapism. Through construction of a cystostomy, palliative radiotherapy with QUAD Shot regimen (14  Gy in 4 fractions twice-daily on 2 days repeated every 4 weeks) to the penile metastasis was starte...
Source: International Cancer Conference Journal - March 30, 2023 Category: Cancer & Oncology Source Type: research