High prevalence of pneumocystis pneumonia in interstitial lung disease: a retrospective study
ConclusionILD is a new risk group of PCP with high PCP prevalence. Clinicians should pay close attention to the occurrence of PCP in ILD patients who possess the risk factors of previous glucocorticoid therapy, decreased CD4 + T cell count, increased BG level and absence of traction bronchiectasis on HRCT. mNGS showed the most excellent performance for PCP diagnosis in ILD patients. Peripheral blood CD4 + T cell count and BG level are alternative diagnostic methods for PCP in ILD patients. However, the diagnost ic value of serum LDH level was limited in ILD patients. (Source: Infection)
Source: Infection - December 26, 2023 Category: Infectious Diseases Source Type: research
SARS-CoV-2 nucleocapsid protein, rather than spike protein, triggers a cytokine storm originating from lung epithelial cells in patients with COVID-19
ConclusionOur study revealed that nucleocapsid protein, lung epithelial cells, and IP-10 may be potential targets for the development of new strategies to prevent, or control, severe COVID-19. (Source: Infection)
Source: Infection - December 22, 2023 Category: Infectious Diseases Source Type: research
Fatal pulmonary hemorrhage, pneumothorax and skin necrosis caused by IRIS to an Aspergillus flavus infection in a young patient with metamizole associated agranulocytosis
We report the case of a young female with steroid-dependent ulcerative colitis (UC) who developed a complex systemic infection withAspergillus flavus. This occurred following a UC relapse while vacationing in the Middle East, leading to extended use of metamizole and subsequent agranulocytosis. On her return to Germany, she was hospitalized for neutropenic sepsis and later transferred to our hospital due to persistent cytopenia and suspected Hemophagocytic Lymphohistiocytosis (HLH). Despite initial stabilization with targeted treatment for pulmonaryAspergillus flavus infection, her condition rapidly deteriorated following ...
Source: Infection - December 22, 2023 Category: Infectious Diseases Source Type: research
SARS-CoV-2 nucleocapsid protein, rather than spike protein, triggers a cytokine storm originating from lung epithelial cells in patients with COVID-19
ConclusionOur study revealed that nucleocapsid protein, lung epithelial cells, and IP-10 may be potential targets for the development of new strategies to prevent, or control, severe COVID-19. (Source: Infection)
Source: Infection - December 22, 2023 Category: Infectious Diseases Source Type: research
Clinical evaluation of a multiplex droplet digital PCR for pathogen detection in critically ill COVID-19 patients with bloodstream infections
ConclusionThe multiplex ddPCR assay had a significantly higher pathogen detection positivity than the blood culture, which could be an effective diagnostic tool for BSIs in COVID-19 patients and to improve patient outcomes and reduce the burden of sepsis on the healthcare system, though there is room for optimization of the panels used.- Adjusting the targets to includeE. faecalis andE. faecium as well asCandida albicans andCandida glabrata could improve the ddPCR' s effectiveness. However, further research is needed to explore the potential of ddPCR in predicting bacterial resistance through AMR gene detection. (Source: Infection)
Source: Infection - December 21, 2023 Category: Infectious Diseases Source Type: research
Evaluation and clinical practice of pathogens and antimicrobial resistance genes of BioFire FilmArray Pneumonia panel in lower respiratory tract infections
ConclusionThe bacterial pathogens and AMR identified by the PN panel were in good agreement with conventional cultivation, and the clinical benefit of the PN panel increased by 25.97% compared with traditional detection. Therefore, the PN panel is recommended for patients with CAP or HAP who require prompt pathogen diagnosis and resistance identification. (Source: Infection)
Source: Infection - December 20, 2023 Category: Infectious Diseases Source Type: research
Clinical correlates of circulating small dense low-density lipoproteins in acute infective endocarditis
ConclusionsLow circulating sdLDL levels in the acute phase of IE were significantly correlated with unfavorable clinical outcomes. These results suggest that the sdLDL level may serve as an important marker of disease severity in IE and may represent a link between vascular damage, embolic complications, and disease progression. (Source: Infection)
Source: Infection - December 19, 2023 Category: Infectious Diseases Source Type: research
A variant of KSHV-associated inflammatory cytokine syndrome in elderly men of Mediterranean descent
We report here a KICS-like illness occurring in two elderly Greek men without HIV infection or other recognizable cause of immunosuppression. (Source: Infection)
Source: Infection - December 19, 2023 Category: Infectious Diseases Source Type: research
Is antiviral treatment at the acute phase of COVID-19 effective for decreasing the risk of long-COVID? A systematic review
ConclusionAvailable evidence about the effect of medication treatment with antivirals during acute COVID-19 and reduced risk of developing long-COVID is conflicting. Heterogeneous evidence suggests that Remdesivir or Nirmaltrevir/Ritonavir could have a potential protective effect for long-COVID. A limited number of studies demonstrated a potential benefit of other medications such as Dexamethasone or Metformin, but more studies are needed. (Source: Infection)
Source: Infection - December 19, 2023 Category: Infectious Diseases Source Type: research
Postpartum cryptococcosis in an HIV-negative patient
ConclusionWe would like to raise awareness about rare infections such as cryptococcosis in pregnancy and the postpartum period. In addition, we were able to document a successful desensitisation to liposomal amphotericin B. (Source: Infection)
Source: Infection - December 19, 2023 Category: Infectious Diseases Source Type: research
Clinical correlates of circulating small dense low-density lipoproteins in acute infective endocarditis
ConclusionsLow circulating sdLDL levels in the acute phase of IE were significantly correlated with unfavorable clinical outcomes. These results suggest that the sdLDL level may serve as an important marker of disease severity in IE and may represent a link between vascular damage, embolic complications, and disease progression. (Source: Infection)
Source: Infection - December 19, 2023 Category: Infectious Diseases Source Type: research
