Persistent immune abnormalities discriminate post-COVID syndrome from convalescence
ConclusionThese results define immunological parameters associated with PCS and might help find biomarkers and disease-relevant therapeutic strategies. (Source: Infection)
Source: Infection - February 7, 2024 Category: Infectious Diseases Source Type: research
In-label, off-label prescription, efficacy and tolerability of dalbavancin: report from a National Registry
ConclusionIn conclusion, by virtue of its PK/PD properties, dalbavancin represents a valuable option to daily in-hospital intravenous or outpatient antimicrobial regimens also for off-label indications requiring a long-term treatment of Gram-positive infections. (Source: Infection)
Source: Infection - February 7, 2024 Category: Infectious Diseases Source Type: research
Endothelial dysfunction and cardiovascular risk in post-COVID-19 patients after 6- and 12-months SARS-CoV-2 infection
ConclusionsThese findings highlight the presence of vascular sequela that last up to 6- and 12-months post-infection and point out the need for preventive measures and patient follow-up. (Source: Infection)
Source: Infection - February 7, 2024 Category: Infectious Diseases Source Type: research
The role of gut barrier dysfunction in postoperative complications in liver transplantation: pathophysiological and therapeutic considerations
ConclusionA pathophysiology-based approach to prophylactic or therapeutic interventions may lead to enhancement of gut barrier function eliminating its detrimental consequences and leading to better outcomes for LT patients. (Source: Infection)
Source: Infection - February 7, 2024 Category: Infectious Diseases Source Type: research
Protective role of SARS-CoV-2 anti-S IgG against breakthrough infections among European healthcare workers during pre and post-Omicron surge —ORCHESTRA project
ConclusionVaccine effectiveness wanes significantly after new variants surge, making anti-S titer unsuitable to predict optimal timing for further booster dose administration. Studies on other immunological indicators, such as cellular immunity, are therefore needed to better understand the mechanisms and duration of protection against breakthrough infection risk. (Source: Infection)
Source: Infection - February 7, 2024 Category: Infectious Diseases Source Type: research
Persistent immune abnormalities discriminate post-COVID syndrome from convalescence
ConclusionThese results define immunological parameters associated with PCS and might help find biomarkers and disease-relevant therapeutic strategies. (Source: Infection)
Source: Infection - February 7, 2024 Category: Infectious Diseases Source Type: research
In-label, off-label prescription, efficacy and tolerability of dalbavancin: report from a National Registry
ConclusionIn conclusion, by virtue of its PK/PD properties, dalbavancin represents a valuable option to daily in-hospital intravenous or outpatient antimicrobial regimens also for off-label indications requiring a long-term treatment of Gram-positive infections. (Source: Infection)
Source: Infection - February 7, 2024 Category: Infectious Diseases Source Type: research
Endothelial dysfunction and cardiovascular risk in post-COVID-19 patients after 6- and 12-months SARS-CoV-2 infection
ConclusionsThese findings highlight the presence of vascular sequela that last up to 6- and 12-months post-infection and point out the need for preventive measures and patient follow-up. (Source: Infection)
Source: Infection - February 7, 2024 Category: Infectious Diseases Source Type: research
The role of gut barrier dysfunction in postoperative complications in liver transplantation: pathophysiological and therapeutic considerations
ConclusionA pathophysiology-based approach to prophylactic or therapeutic interventions may lead to enhancement of gut barrier function eliminating its detrimental consequences and leading to better outcomes for LT patients. (Source: Infection)
Source: Infection - February 7, 2024 Category: Infectious Diseases Source Type: research
Protective efficacy and safety of radiation-attenuated and chemo-attenuated Plasmodium Falciparum sporozoite vaccines against controlled and natural malaria infection: a systematic review and meta-analysis of randomized controlled trials
ConclusionPfSPZ and PfSPZ-CVacs showed comparable efficacy. Therefore, they can introduce a promising strategy for malaria prophylaxis, but more large-scale field trials are required to sustain efficacy and yield clinically applicable findings. (Source: Infection)
Source: Infection - February 6, 2024 Category: Infectious Diseases Source Type: research
Clinical presentation, management, and outcome of suspected central nervous system infections in Indonesia: a prospective cohort study
ConclusionCNS infections in Indonesia are characterized by late presentation, severe disease, frequent HIV coinfection, low microbiological confirmation and high mortality. These findings highlight the need for earlier disease recognition, faster and more accurate diagnosis, and optimized treatment, coupled with wider efforts to improve the uptake of HIV services. (Source: Infection)
Source: Infection - February 5, 2024 Category: Infectious Diseases Source Type: research
Ceftazidime-related neurotoxicity in a patient with renal impairment: a case report and literature review
ConclusionCeftazidime-related neurotoxicity is a known issue, especially in patients with severe renal impairment. Yet no concrete toxicity threshold has been reported so far. We propose the first toxicity threshold for ceftazidime of 78 mg/L. Future prospective studies are needed to validate and optimize the neurotoxicity threshold as upper limit for ceftazidime therapeutic drug monitoring. (Source: Infection)
Source: Infection - February 2, 2024 Category: Infectious Diseases Source Type: research
Clinical and immunological outcomes of SARS-CoV-2-infected vaccine responders, vaccine non-responders, and unvaccinated patients evaluated for neutralizing monoclonal antibody treatment at a single German tertiary care center: a retrospective cohort study with prospective follow-up
ConclusionVNR, particularly B-cell-depleted VNR, remained at risk of hospitalization due to COVID-19. In the VR group, however, no clinical complications or severe disease were observed, despite not receiving nMAbs. Tailoring the administration of nMABs according to patient vaccination and immunological status may be advisable. (Source: Infection)
Source: Infection - February 2, 2024 Category: Infectious Diseases Source Type: research
