Reversibility of disturbed pituitary function in pediatric conditions with psychological stressors: implications for clinical practice
Hormones (Athens). 2024 Feb 29. doi: 10.1007/s42000-024-00536-z. Online ahead of print.ABSTRACTThe complex communication network between the central nervous system and the hypothalamic-pituitary axis forms the basis of endocrine functional plasticity, which facilitates adaptation to changing internal and external conditions, but also makes it vulnerable to the negative effects of stressful psychological factors. Herein, clinical conditions such as functional hypothalamic amenorrhea, eating disorders, growth faltering, post-traumatic stress disorder, and pubertal disorders that may emerge during childhood or adolescence, th...
Source: Hormones - February 29, 2024 Category: Endocrinology Authors: Aristeidis Giannakopoulos Dionisios Chrysis Source Type: research
Mitigating bisphenol A-induced apoptosis in KGN cells: the therapeutic role of 1,25-dihydroxyvitamin D < sub > 3 < /sub > through upregulation of PGC-1 α expression and inhibition of the mitochondrial cytochrome c pathway
CONCLUSIONS: 1,25(OH)2VD3 mitigated BPA-induced damage and apoptosis in KGN cells by upregulating the expression of PGC-1α and impeding the mitochondrial cytochrome c (Cyt c) apoptotic pathway. This study established a novel theoretical foundation for utilizing vitamin D in the treatment of PCOS patients.PMID:38421590 | DOI:10.1007/s42000-024-00539-w (Source: Hormones)
Source: Hormones - February 29, 2024 Category: Endocrinology Authors: Liting Tang Ke Du Kaiming Luo Long Wang Fei Hua Source Type: research
Challenges and pitfalls in the management of endocrine toxicities from immune checkpoint inhibitors: a case presentation of synchronous thyrotoxicosis and primary adrenal insufficiency in a melanoma patient
CONCLUSIONS: The simultaneous occurrence of adrenal and thyroid autoimmune diseases, resembling autoimmune polyendocrine syndrome type 2, may occur as a rare but serious side effect of ICI treatment. It often presents with abrupt onset and rapid evolution towards polyglandular insufficiency. Physicians should be aware of the potential association of two or more endocrine disorders and careful monitoring of endocrine function is needed during ICI therapy.PMID:38421588 | DOI:10.1007/s42000-024-00535-0 (Source: Hormones)
Source: Hormones - February 29, 2024 Category: Endocrinology Authors: Calogera Claudia Spagnolo Irene Campo Alfredo Campenn ì Davide Cardile Salvatore Cannav ò Nicola Silvestris Mariacarmela Santarpia Rosaria Maddalena Ruggeri Source Type: research
Reversibility of disturbed pituitary function in pediatric conditions with psychological stressors: implications for clinical practice
Hormones (Athens). 2024 Feb 29. doi: 10.1007/s42000-024-00536-z. Online ahead of print.ABSTRACTThe complex communication network between the central nervous system and the hypothalamic-pituitary axis forms the basis of endocrine functional plasticity, which facilitates adaptation to changing internal and external conditions, but also makes it vulnerable to the negative effects of stressful psychological factors. Herein, clinical conditions such as functional hypothalamic amenorrhea, eating disorders, growth faltering, post-traumatic stress disorder, and pubertal disorders that may emerge during childhood or adolescence, th...
Source: Hormones - February 29, 2024 Category: Endocrinology Authors: Aristeidis Giannakopoulos Dionisios Chrysis Source Type: research
Mitigating bisphenol A-induced apoptosis in KGN cells: the therapeutic role of 1,25-dihydroxyvitamin D < sub > 3 < /sub > through upregulation of PGC-1 α expression and inhibition of the mitochondrial cytochrome c pathway
CONCLUSIONS: 1,25(OH)2VD3 mitigated BPA-induced damage and apoptosis in KGN cells by upregulating the expression of PGC-1α and impeding the mitochondrial cytochrome c (Cyt c) apoptotic pathway. This study established a novel theoretical foundation for utilizing vitamin D in the treatment of PCOS patients.PMID:38421590 | DOI:10.1007/s42000-024-00539-w (Source: Hormones)
Source: Hormones - February 29, 2024 Category: Endocrinology Authors: Liting Tang Ke Du Kaiming Luo Long Wang Fei Hua Source Type: research
Challenges and pitfalls in the management of endocrine toxicities from immune checkpoint inhibitors: a case presentation of synchronous thyrotoxicosis and primary adrenal insufficiency in a melanoma patient
CONCLUSIONS: The simultaneous occurrence of adrenal and thyroid autoimmune diseases, resembling autoimmune polyendocrine syndrome type 2, may occur as a rare but serious side effect of ICI treatment. It often presents with abrupt onset and rapid evolution towards polyglandular insufficiency. Physicians should be aware of the potential association of two or more endocrine disorders and careful monitoring of endocrine function is needed during ICI therapy.PMID:38421588 | DOI:10.1007/s42000-024-00535-0 (Source: Hormones)
Source: Hormones - February 29, 2024 Category: Endocrinology Authors: Calogera Claudia Spagnolo Irene Campo Alfredo Campenn ì Davide Cardile Salvatore Cannav ò Nicola Silvestris Mariacarmela Santarpia Rosaria Maddalena Ruggeri Source Type: research
Reversibility of disturbed pituitary function in pediatric conditions with psychological stressors: implications for clinical practice
Hormones (Athens). 2024 Feb 29. doi: 10.1007/s42000-024-00536-z. Online ahead of print.ABSTRACTThe complex communication network between the central nervous system and the hypothalamic-pituitary axis forms the basis of endocrine functional plasticity, which facilitates adaptation to changing internal and external conditions, but also makes it vulnerable to the negative effects of stressful psychological factors. Herein, clinical conditions such as functional hypothalamic amenorrhea, eating disorders, growth faltering, post-traumatic stress disorder, and pubertal disorders that may emerge during childhood or adolescence, th...
Source: Hormones - February 29, 2024 Category: Endocrinology Authors: Aristeidis Giannakopoulos Dionisios Chrysis Source Type: research
Mitigating bisphenol A-induced apoptosis in KGN cells: the therapeutic role of 1,25-dihydroxyvitamin D < sub > 3 < /sub > through upregulation of PGC-1 α expression and inhibition of the mitochondrial cytochrome c pathway
CONCLUSIONS: 1,25(OH)2VD3 mitigated BPA-induced damage and apoptosis in KGN cells by upregulating the expression of PGC-1α and impeding the mitochondrial cytochrome c (Cyt c) apoptotic pathway. This study established a novel theoretical foundation for utilizing vitamin D in the treatment of PCOS patients.PMID:38421590 | DOI:10.1007/s42000-024-00539-w (Source: Hormones)
Source: Hormones - February 29, 2024 Category: Endocrinology Authors: Liting Tang Ke Du Kaiming Luo Long Wang Fei Hua Source Type: research
Challenges and pitfalls in the management of endocrine toxicities from immune checkpoint inhibitors: a case presentation of synchronous thyrotoxicosis and primary adrenal insufficiency in a melanoma patient
CONCLUSIONS: The simultaneous occurrence of adrenal and thyroid autoimmune diseases, resembling autoimmune polyendocrine syndrome type 2, may occur as a rare but serious side effect of ICI treatment. It often presents with abrupt onset and rapid evolution towards polyglandular insufficiency. Physicians should be aware of the potential association of two or more endocrine disorders and careful monitoring of endocrine function is needed during ICI therapy.PMID:38421588 | DOI:10.1007/s42000-024-00535-0 (Source: Hormones)
Source: Hormones - February 29, 2024 Category: Endocrinology Authors: Calogera Claudia Spagnolo Irene Campo Alfredo Campenn ì Davide Cardile Salvatore Cannav ò Nicola Silvestris Mariacarmela Santarpia Rosaria Maddalena Ruggeri Source Type: research
Reversibility of disturbed pituitary function in pediatric conditions with psychological stressors: implications for clinical practice
Hormones (Athens). 2024 Feb 29. doi: 10.1007/s42000-024-00536-z. Online ahead of print.ABSTRACTThe complex communication network between the central nervous system and the hypothalamic-pituitary axis forms the basis of endocrine functional plasticity, which facilitates adaptation to changing internal and external conditions, but also makes it vulnerable to the negative effects of stressful psychological factors. Herein, clinical conditions such as functional hypothalamic amenorrhea, eating disorders, growth faltering, post-traumatic stress disorder, and pubertal disorders that may emerge during childhood or adolescence, th...
Source: Hormones - February 29, 2024 Category: Endocrinology Authors: Aristeidis Giannakopoulos Dionisios Chrysis Source Type: research
Mitigating bisphenol A-induced apoptosis in KGN cells: the therapeutic role of 1,25-dihydroxyvitamin D < sub > 3 < /sub > through upregulation of PGC-1 α expression and inhibition of the mitochondrial cytochrome c pathway
CONCLUSIONS: 1,25(OH)2VD3 mitigated BPA-induced damage and apoptosis in KGN cells by upregulating the expression of PGC-1α and impeding the mitochondrial cytochrome c (Cyt c) apoptotic pathway. This study established a novel theoretical foundation for utilizing vitamin D in the treatment of PCOS patients.PMID:38421590 | DOI:10.1007/s42000-024-00539-w (Source: Hormones)
Source: Hormones - February 29, 2024 Category: Endocrinology Authors: Liting Tang Ke Du Kaiming Luo Long Wang Fei Hua Source Type: research
Relationship between body adiposity parameters and insulin resistance: a preliminary study of surrogate markers in Japan
CONCLUSION: Application of this finding should be useful in the early screening of obesity in men with non-obesity, such as during regular health check-up with the TG/HDL ratio in addition to the usually used WC, to assess insulin resistance and prevent lifestyle-related diseases that can lead to cardiovascular events.PMID:38396110 | DOI:10.1007/s42000-024-00537-y (Source: Hormones)
Source: Hormones - February 23, 2024 Category: Endocrinology Authors: Nanae Tanemura Tetsuya Kubota Naoto Kubota Tsuyoshi Chiba Source Type: research
