Novel ADAMTS13 mutations in a patient with congenital thrombotic thrombocytopenic purpura
Hematology. 2023 Dec;28(1):2269513. doi: 10.1080/16078454.2023.2269513. Epub 2023 Oct 18.ABSTRACTCongenital thrombotic thrombocytopenic purpura (TTP) is a rare autosomal recessive genetic disorder caused by mutations in the ADAMTS13 gene. Approximately 200 mutations of the ADAMTS-13 gene have been identified, although only a few have been characterized through in vitro expression studies. We conducted an investigation on a male congenital TTP patient with reduced plasma levels of ADAMTS13 activity. DNA sequence analysis revealed two mutations on chromosome 9 (1.9q34.2) in the patient's ADAMTS13 gene. One mutation was a non...
Source: Hematology - October 18, 2023 Category: Hematology Authors: Zhitao Wang Xinhui Zhang Xueqin Lu Peng Peng Huiru Wang Shanglong Feng Li Zhou Source Type: research
Autologous followed by allogeneic versus tandem-autologous transplantation in high-risk, newly diagnosed multiple myeloma: a systematic review and meta-analysis
CONCLUSION: Auto-allo-SCT seemed to be associated with improvements in PFS and CR when compared to tandem-auto-SCT in patients with HRMM, but it did not lead to a significant improvement in OS. Furthermore, patients in the auto-allo-SCT group were at a higher risk of developing TRM and NRM. Auto-allo-SCT transplantation should not be routinely incorporated into HRMM therapy but rather should be considered investigational.PMID:37850613 | DOI:10.1080/16078454.2023.2269509 (Source: Hematology)
Source: Hematology - October 18, 2023 Category: Hematology Authors: Min Wei Chunhong Xie Jinxiong Huang Qin Liu Yongrong Lai Source Type: research
Novel ADAMTS13 mutations in a patient with congenital thrombotic thrombocytopenic purpura
Hematology. 2023 Dec;28(1):2269513. doi: 10.1080/16078454.2023.2269513. Epub 2023 Oct 18.ABSTRACTCongenital thrombotic thrombocytopenic purpura (TTP) is a rare autosomal recessive genetic disorder caused by mutations in the ADAMTS13 gene. Approximately 200 mutations of the ADAMTS-13 gene have been identified, although only a few have been characterized through in vitro expression studies. We conducted an investigation on a male congenital TTP patient with reduced plasma levels of ADAMTS13 activity. DNA sequence analysis revealed two mutations on chromosome 9 (1.9q34.2) in the patient's ADAMTS13 gene. One mutation was a non...
Source: Hematology - October 18, 2023 Category: Hematology Authors: Zhitao Wang Xinhui Zhang Xueqin Lu Peng Peng Huiru Wang Shanglong Feng Li Zhou Source Type: research
Autologous followed by allogeneic versus tandem-autologous transplantation in high-risk, newly diagnosed multiple myeloma: a systematic review and meta-analysis
CONCLUSION: Auto-allo-SCT seemed to be associated with improvements in PFS and CR when compared to tandem-auto-SCT in patients with HRMM, but it did not lead to a significant improvement in OS. Furthermore, patients in the auto-allo-SCT group were at a higher risk of developing TRM and NRM. Auto-allo-SCT transplantation should not be routinely incorporated into HRMM therapy but rather should be considered investigational.PMID:37850613 | DOI:10.1080/16078454.2023.2269509 (Source: Hematology)
Source: Hematology - October 18, 2023 Category: Hematology Authors: Min Wei Chunhong Xie Jinxiong Huang Qin Liu Yongrong Lai Source Type: research
Novel ADAMTS13 mutations in a patient with congenital thrombotic thrombocytopenic purpura
Hematology. 2023 Dec;28(1):2269513. doi: 10.1080/16078454.2023.2269513. Epub 2023 Oct 18.ABSTRACTCongenital thrombotic thrombocytopenic purpura (TTP) is a rare autosomal recessive genetic disorder caused by mutations in the ADAMTS13 gene. Approximately 200 mutations of the ADAMTS-13 gene have been identified, although only a few have been characterized through in vitro expression studies. We conducted an investigation on a male congenital TTP patient with reduced plasma levels of ADAMTS13 activity. DNA sequence analysis revealed two mutations on chromosome 9 (1.9q34.2) in the patient's ADAMTS13 gene. One mutation was a non...
Source: Hematology - October 18, 2023 Category: Hematology Authors: Zhitao Wang Xinhui Zhang Xueqin Lu Peng Peng Huiru Wang Shanglong Feng Li Zhou Source Type: research
Autologous followed by allogeneic versus tandem-autologous transplantation in high-risk, newly diagnosed multiple myeloma: a systematic review and meta-analysis
CONCLUSION: Auto-allo-SCT seemed to be associated with improvements in PFS and CR when compared to tandem-auto-SCT in patients with HRMM, but it did not lead to a significant improvement in OS. Furthermore, patients in the auto-allo-SCT group were at a higher risk of developing TRM and NRM. Auto-allo-SCT transplantation should not be routinely incorporated into HRMM therapy but rather should be considered investigational.PMID:37850613 | DOI:10.1080/16078454.2023.2269509 (Source: Hematology)
Source: Hematology - October 18, 2023 Category: Hematology Authors: Min Wei Chunhong Xie Jinxiong Huang Qin Liu Yongrong Lai Source Type: research
Novel ADAMTS13 mutations in a patient with congenital thrombotic thrombocytopenic purpura
Hematology. 2023 Dec;28(1):2269513. doi: 10.1080/16078454.2023.2269513. Epub 2023 Oct 18.ABSTRACTCongenital thrombotic thrombocytopenic purpura (TTP) is a rare autosomal recessive genetic disorder caused by mutations in the ADAMTS13 gene. Approximately 200 mutations of the ADAMTS-13 gene have been identified, although only a few have been characterized through in vitro expression studies. We conducted an investigation on a male congenital TTP patient with reduced plasma levels of ADAMTS13 activity. DNA sequence analysis revealed two mutations on chromosome 9 (1.9q34.2) in the patient's ADAMTS13 gene. One mutation was a non...
Source: Hematology - October 18, 2023 Category: Hematology Authors: Zhitao Wang Xinhui Zhang Xueqin Lu Peng Peng Huiru Wang Shanglong Feng Li Zhou Source Type: research
Autologous followed by allogeneic versus tandem-autologous transplantation in high-risk, newly diagnosed multiple myeloma: a systematic review and meta-analysis
CONCLUSION: Auto-allo-SCT seemed to be associated with improvements in PFS and CR when compared to tandem-auto-SCT in patients with HRMM, but it did not lead to a significant improvement in OS. Furthermore, patients in the auto-allo-SCT group were at a higher risk of developing TRM and NRM. Auto-allo-SCT transplantation should not be routinely incorporated into HRMM therapy but rather should be considered investigational.PMID:37850613 | DOI:10.1080/16078454.2023.2269509 (Source: Hematology)
Source: Hematology - October 18, 2023 Category: Hematology Authors: Min Wei Chunhong Xie Jinxiong Huang Qin Liu Yongrong Lai Source Type: research
Novel ADAMTS13 mutations in a patient with congenital thrombotic thrombocytopenic purpura
Hematology. 2023 Dec;28(1):2269513. doi: 10.1080/16078454.2023.2269513. Epub 2023 Oct 18.ABSTRACTCongenital thrombotic thrombocytopenic purpura (TTP) is a rare autosomal recessive genetic disorder caused by mutations in the ADAMTS13 gene. Approximately 200 mutations of the ADAMTS-13 gene have been identified, although only a few have been characterized through in vitro expression studies. We conducted an investigation on a male congenital TTP patient with reduced plasma levels of ADAMTS13 activity. DNA sequence analysis revealed two mutations on chromosome 9 (1.9q34.2) in the patient's ADAMTS13 gene. One mutation was a non...
Source: Hematology - October 18, 2023 Category: Hematology Authors: Zhitao Wang Xinhui Zhang Xueqin Lu Peng Peng Huiru Wang Shanglong Feng Li Zhou Source Type: research
Autologous followed by allogeneic versus tandem-autologous transplantation in high-risk, newly diagnosed multiple myeloma: a systematic review and meta-analysis
CONCLUSION: Auto-allo-SCT seemed to be associated with improvements in PFS and CR when compared to tandem-auto-SCT in patients with HRMM, but it did not lead to a significant improvement in OS. Furthermore, patients in the auto-allo-SCT group were at a higher risk of developing TRM and NRM. Auto-allo-SCT transplantation should not be routinely incorporated into HRMM therapy but rather should be considered investigational.PMID:37850613 | DOI:10.1080/16078454.2023.2269509 (Source: Hematology)
Source: Hematology - October 18, 2023 Category: Hematology Authors: Min Wei Chunhong Xie Jinxiong Huang Qin Liu Yongrong Lai Source Type: research
Novel ADAMTS13 mutations in a patient with congenital thrombotic thrombocytopenic purpura
Hematology. 2023 Dec;28(1):2269513. doi: 10.1080/16078454.2023.2269513. Epub 2023 Oct 18.ABSTRACTCongenital thrombotic thrombocytopenic purpura (TTP) is a rare autosomal recessive genetic disorder caused by mutations in the ADAMTS13 gene. Approximately 200 mutations of the ADAMTS-13 gene have been identified, although only a few have been characterized through in vitro expression studies. We conducted an investigation on a male congenital TTP patient with reduced plasma levels of ADAMTS13 activity. DNA sequence analysis revealed two mutations on chromosome 9 (1.9q34.2) in the patient's ADAMTS13 gene. One mutation was a non...
Source: Hematology - October 18, 2023 Category: Hematology Authors: Zhitao Wang Xinhui Zhang Xueqin Lu Peng Peng Huiru Wang Shanglong Feng Li Zhou Source Type: research
Autologous followed by allogeneic versus tandem-autologous transplantation in high-risk, newly diagnosed multiple myeloma: a systematic review and meta-analysis
CONCLUSION: Auto-allo-SCT seemed to be associated with improvements in PFS and CR when compared to tandem-auto-SCT in patients with HRMM, but it did not lead to a significant improvement in OS. Furthermore, patients in the auto-allo-SCT group were at a higher risk of developing TRM and NRM. Auto-allo-SCT transplantation should not be routinely incorporated into HRMM therapy but rather should be considered investigational.PMID:37850613 | DOI:10.1080/16078454.2023.2269509 (Source: Hematology)
Source: Hematology - October 18, 2023 Category: Hematology Authors: Min Wei Chunhong Xie Jinxiong Huang Qin Liu Yongrong Lai Source Type: research
Novel ADAMTS13 mutations in a patient with congenital thrombotic thrombocytopenic purpura
Hematology. 2023 Dec;28(1):2269513. doi: 10.1080/16078454.2023.2269513. Epub 2023 Oct 18.ABSTRACTCongenital thrombotic thrombocytopenic purpura (TTP) is a rare autosomal recessive genetic disorder caused by mutations in the ADAMTS13 gene. Approximately 200 mutations of the ADAMTS-13 gene have been identified, although only a few have been characterized through in vitro expression studies. We conducted an investigation on a male congenital TTP patient with reduced plasma levels of ADAMTS13 activity. DNA sequence analysis revealed two mutations on chromosome 9 (1.9q34.2) in the patient's ADAMTS13 gene. One mutation was a non...
Source: Hematology - October 18, 2023 Category: Hematology Authors: Zhitao Wang Xinhui Zhang Xueqin Lu Peng Peng Huiru Wang Shanglong Feng Li Zhou Source Type: research
Autologous followed by allogeneic versus tandem-autologous transplantation in high-risk, newly diagnosed multiple myeloma: a systematic review and meta-analysis
CONCLUSION: Auto-allo-SCT seemed to be associated with improvements in PFS and CR when compared to tandem-auto-SCT in patients with HRMM, but it did not lead to a significant improvement in OS. Furthermore, patients in the auto-allo-SCT group were at a higher risk of developing TRM and NRM. Auto-allo-SCT transplantation should not be routinely incorporated into HRMM therapy but rather should be considered investigational.PMID:37850613 | DOI:10.1080/16078454.2023.2269509 (Source: Hematology)
Source: Hematology - October 18, 2023 Category: Hematology Authors: Min Wei Chunhong Xie Jinxiong Huang Qin Liu Yongrong Lai Source Type: research
Novel ADAMTS13 mutations in a patient with congenital thrombotic thrombocytopenic purpura
Hematology. 2023 Dec;28(1):2269513. doi: 10.1080/16078454.2023.2269513. Epub 2023 Oct 18.ABSTRACTCongenital thrombotic thrombocytopenic purpura (TTP) is a rare autosomal recessive genetic disorder caused by mutations in the ADAMTS13 gene. Approximately 200 mutations of the ADAMTS-13 gene have been identified, although only a few have been characterized through in vitro expression studies. We conducted an investigation on a male congenital TTP patient with reduced plasma levels of ADAMTS13 activity. DNA sequence analysis revealed two mutations on chromosome 9 (1.9q34.2) in the patient's ADAMTS13 gene. One mutation was a non...
Source: Hematology - October 18, 2023 Category: Hematology Authors: Zhitao Wang Xinhui Zhang Xueqin Lu Peng Peng Huiru Wang Shanglong Feng Li Zhou Source Type: research
