The prognostic significance of POD24 in peripheral T-cell lymphoma
CONCLUSION: POD24 is a prognostic factor associated with unfavorable outcomes in patients with PTCL and can be used to identify high-risk patients and guide treatment decisions.PMID:38251872 | DOI:10.1080/16078454.2024.2304483 (Source: Hematology)
Source: Hematology - January 22, 2024 Category: Hematology Authors: Huimin Chen Ruixue Ma Qianqian Zhang Fengyi Lu Yuhan Ma Jingxin Zhou Jiang Cao Kunming Qi Zhiling Yan Wei Sang Feng Zhu Haiying Sun Depeng Li Zhenyu Li Hai Cheng Kailin Xu Wei Chen Source Type: research
Serum indicators in functional high-risk multiple myeloma patients undertaking proteasome inhibitors therapy: a retrospective study
CONCLUSION: Therefore, in the PIs era, transplantations are still effective therapies for transplant-eligible MM patients.PMID:38205814 | DOI:10.1080/16078454.2023.2293579 (Source: Hematology)
Source: Hematology - January 11, 2024 Category: Hematology Authors: Linquan Zhan Dai Yuan Xueling Ge Mei Ding Jianhong Wang Xiangxiang Zhou Xin Wang Source Type: research
Insights into the role of JAK2-I724T variant in myeloproliferative neoplasms from a unique cohort of New Zealand patients
CONCLUSION: Several non-canonical JAK2 variants with high REVEL scores have been reported in MPN, highlighting the need to further understand their relationship with disease. The JAK2-I724T variant does not drive MPN, but additional investigations are required to exclude any potential modulatory effect on the MPN phenotype.PMID:38197452 | DOI:10.1080/16078454.2023.2297597 (Source: Hematology)
Source: Hematology - January 10, 2024 Category: Hematology Authors: Christopher Puli'uvea Tracey Immanuel Taryn N Green Peter Tsai Peter R Shepherd Maggie L Kalev-Zylinska Source Type: research
Quality assessment of the preparation and storage of leukocyte-depleted pooled platelet concentrates
CONCLUSION: The quality of leukocyte-depleted pooled platelet concentrates prepared by the buffy coat method using disposable platelet storage bags containing a leukocyte filter was comparable to that of leukocyte-depleted apheresis platelets, and could be used clinically.PMID:38193467 | DOI:10.1080/16078454.2023.2293492 (Source: Hematology)
Source: Hematology - January 9, 2024 Category: Hematology Authors: Feng Chen Xiaoqing Dai Azhong Li Yinhong Zheng Wei Hu Source Type: research
A combined immune and exosome-related risk signature as prognostic biomakers in acute myeloid leukemia
CONCLUSIONS: An immune-ERG-based risk model was developed to effectively predict prognostic outcomes for AML patients. There is potential for immune therapy in AML targeting the five hub genes.PMID:38186215 | DOI:10.1080/16078454.2023.2300855 (Source: Hematology)
Source: Hematology - January 8, 2024 Category: Hematology Authors: Zenghui Fang Jiali Fu Xin Chen Source Type: research
Understanding thrombosis: the critical role of oxidative stress
Hematology. 2024 Dec;29(1):2301633. doi: 10.1080/16078454.2023.2301633. Epub 2024 Jan 7.ABSTRACTThrombosis, a leading contributor to global health burden, is a complex process involving the interplay of various cell types, including vascular endothelial cells, platelets, and red blood cells. Oxidative stress, characterized by an overproduction of reactive oxygen species (ROS), can significantly impair the function of these cells, thus instigating a cascade of events leading to thrombus formation. In this review, we comprehensively explore the role of oxidative stress within these cells, and its mechanistic contribution to ...
Source: Hematology - January 8, 2024 Category: Hematology Authors: Peiming Li Xueru Ma Guofei Huang Source Type: research
A combined immune and exosome-related risk signature as prognostic biomakers in acute myeloid leukemia
CONCLUSIONS: An immune-ERG-based risk model was developed to effectively predict prognostic outcomes for AML patients. There is potential for immune therapy in AML targeting the five hub genes.PMID:38186215 | DOI:10.1080/16078454.2023.2300855 (Source: Hematology)
Source: Hematology - January 8, 2024 Category: Hematology Authors: Zenghui Fang Jiali Fu Xin Chen Source Type: research
Understanding thrombosis: the critical role of oxidative stress
Hematology. 2024 Dec;29(1):2301633. doi: 10.1080/16078454.2023.2301633. Epub 2024 Jan 7.ABSTRACTThrombosis, a leading contributor to global health burden, is a complex process involving the interplay of various cell types, including vascular endothelial cells, platelets, and red blood cells. Oxidative stress, characterized by an overproduction of reactive oxygen species (ROS), can significantly impair the function of these cells, thus instigating a cascade of events leading to thrombus formation. In this review, we comprehensively explore the role of oxidative stress within these cells, and its mechanistic contribution to ...
Source: Hematology - January 8, 2024 Category: Hematology Authors: Peiming Li Xueru Ma Guofei Huang Source Type: research
High- vs regular-dose recombinant human thrombopoietin plus cyclosporine A in patients with newly diagnosed non-severe aplastic anemia: a retrospective cohort study
CONCLUSIONS: Adding a higher dose of rhTPO can further accelerate platelet recovery and platelet transfusion independence in patients with newly diagnosed NSAA.PMID:38156735 | DOI:10.1080/16078454.2023.2298523 (Source: Hematology)
Source: Hematology - December 29, 2023 Category: Hematology Authors: Yuan Yang Qinglin Hu Chen Yang Miao Chen Bing Han Source Type: research
Prognosis influence of additional chromosome abnormalities in newly diagnosed acute promyelocytic leukemia with t(15;17)(q24;q21)
CONCLUSIONS: Our results suggested that OS and DFS were unaffected by ACAs. Nonetheless, in the subgroup of patients older than 60, the existence of ACAs or trisomy 8 appeared to impact OS and DFS negatively. Individuals with t(15;17) alone had a higher DFS and were more susceptible to ATRA + ATO/RIF + CH than individuals with t(15;17) ACAs.PMID:38149662 | DOI:10.1080/16078454.2023.2293513 (Source: Hematology)
Source: Hematology - December 27, 2023 Category: Hematology Authors: Lin Liu Jinghan Wang Huan Xu Shuqi Zhao Lu Wang Jiansong Huang Huanping Wang Hongyan Tong Jie Jin Source Type: research
