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Role of transforming growth factor- β in airway remodelling in bronchiolitis obliterans
Growth Factors. 2023 Jul 24:1-18. doi: 10.1080/08977194.2023.2239356. Online ahead of print.ABSTRACTAirway remodelling is the main pathological mechanism of bronchiolitis obliterans (BO). Several studies have found that transforming growth factor-β (TGF-β) expression is increased in BO during airway remodelling, where it plays an important role in various biological processes by binding to its receptor complex to activate multiple signalling proteins and pathways. This review examines the role of TGF-β in airway remodelling in BO and its potential as a therapeutic target, highlighting the mechanisms of TGF-β activation...
Source: Growth Factors - July 24, 2023 Category: Research Authors: Ziwei Wang Source Type: research