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Transcription factor ETV1-induced lncRNA MAFG-AS1 promotes migration, invasion, and epithelial-mesenchymal transition of pancreatic cancer cells by recruiting IGF2BP2 to stabilize ETV1 expression
Growth Factors. 2023 Jul 10:1-13. doi: 10.1080/08977194.2023.2227272. Online ahead of print.ABSTRACTWe investigated the mechanism of ETS-translocation variant 1 (ETV1)/lncRNA-MAFG-AS1 in pancreatic cancer (PC). MAFG-AS1 and ETV1 levels in PC cell lines and HPNE cells were determined using reverse transcription quantitative polymerase chain reaction (RT-qPCR) and Western blotting (WB). After transfection with sh-MAFG-AS1, PC cell invasion, migration, proliferation, and epithelial-mesenchymal transition (EMT)-related proteins were measured by 5-ethynyl-2'-deoxyuridine (EdU), Transwell assay, and WB. The binding between ETV1 ...
Source: Growth Factors - July 10, 2023 Category: Research Authors: Hanqin Weng Weijian Feng Fengling Li Dong Huang Liangyi Lin Zaiguo Wang Source Type: research