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Dynamics of transforming growth factor β signaling and therapeutic efficacy
Growth Factors. 2023 May 25:1-19. doi: 10.1080/08977194.2023.2215335. Online ahead of print.ABSTRACTTransforming growth factor β (TGFβ) is a multifunctional cytokine, and its signalling responses are exerted via integrated intracellular pathways and complex regulatory mechanisms. Due to its high potency, TGFβ signalling is tightly controlled under normal circumstances, while its dysregulation in cancer favours metastasis. The recognised potential of TGFβ as a therapeutic target led to emerging development of anti-TGFβ reagents with preclinical success, yet these therapeutics failed to recapitulate their efficacy in ex...
Source: Growth Factors - May 25, 2023 Category: Research Authors: Siqi Wu Rodney Brian Luwor Hong-Jian Zhu Source Type: research