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Transcription factors TP63 facilitates malignant progression of thyroid cancer by upregulating KRT17 expression and inducing epithelial-mesenchymal transition
Growth Factors. 2023 Mar 15:1-11. doi: 10.1080/08977194.2023.2184656. Online ahead of print.ABSTRACTThyroid cancer (TC) is a relatively prevalent endocrine tumor among women, the incidence of which is rapidly rising. In this present study, we aimed to provide new therapeutic targets from the aspect of transcription factor-target gene interaction. TP63 and KRT17 were both highly expressed in TC tissues and cells. The results of ChIP and dual-luciferase assays confirmed TP63 to bind the KRT17 promoter. Cell function assays revealed that knockdown of TP63 could repress TC cell progression. Furthermore, the rescue assay verifi...
Source: Growth Factors - March 15, 2023 Category: Research Authors: Fanbo Meng Liting Dai Source Type: research