PLA2G2D fosters angiogenesis in non-small cell lung cancer through aerobic glycolysis
This study analyzed the expression and enriched pathways of PLA2G2D in NSCLC tissues through bioinformatics analysis, and measured the expression of PLA2G2D in NSCLC cells using qRT-PCR and western blot (WB). Subsequently, the viability and angiogenic potential of NSCLC cells were assessed employing CCK-8 and angiogenesis assays, respectively. The expression profile of angiogenic factors was analyzed through WB. Finally, the expression of glycolysis pathway-related genes, extracellular acidification rate and oxygen consumption rate, and the levels of pyruvate, lactate, citrate, and malate were analyzed in NSCLC cells using...
Source: Growth Factors - January 2, 2024 Category: Research Authors: Huaizhong Zhang Keng Chen Yongqing Zhou Zhuo Cao Cunlai Xu Lin Zhou Gongzhi Wu Congxiong Peng Songqing Lai Xuhui Wu Source Type: research
