Production of a biosimilar version of aflibercept to improve VEGF blocker cytotoxicity on endothelial cells
Growth Factors. 2023 Jun 28:1-12. doi: 10.1080/08977194.2023.2227271. Online ahead of print.ABSTRACTThis project aimed to produce a biosimilar version of aflibercept (AFL) and evaluate the effect of the co-treatment of AFL with other vascular endothelial growth factor (VEGF) blocker drugs. For this purpose, the optimized gene was inserted into the pCHO1.0 plasmid and transfected into the CHO-S cell line. The final concentration of biosimilar-AFL for the selected clone was 782 mg/L. Results revealed that the inhibition potential of the biosimilar-AFL on HUVEC cells was significant at 10 and 100 nM concentrations and in a do...
Source: Growth Factors - June 28, 2023 Category: Research Authors: Amin Ramezani Mohammadrasul Zareinejad Elham Mahmoudi Maymand Elina Kaviani Abbas Ghaderi Source Type: research
Comparative evaluation of autologous platelet-rich plasma and platelet lysate in patients with knee osteoarthritis
Growth Factors. 2023 Jun 23:1-13. doi: 10.1080/08977194.2023.2227273. Online ahead of print.ABSTRACTAutologous platelet-rich plasma (PRP) and platelet lysate (PL) are nowadays promising candidates in the treatment of articular cartilage lesions. We aimed to compare PRP and PL injection effectiveness in patients with knee osteoarthritis (KOA). A total of fifty women with KOA were included in the study. Patients were treated with intra-articular injections of PRP and PL. Clinical outcomes were evaluated using the comparison of VAS, WOMAC, and ROM scores. The concentration levels of growth factors and cytokines were measured ...
Source: Growth Factors - June 23, 2023 Category: Research Authors: Sareh Hosseini Mohammad Sadegh Soltani-Zangbar Majid Zamani Yoda Yaghoubi Reza Rikhtegar Ghiasi Roza Motavalli Ali Ghassabi Rahim Iranzad Amir Mehdizadeh Seyed Kazem Shakouri Alireza Pishgahi Mehdi Yousefi Source Type: research
Technological advances define shifting pathway signaling from normal to primary and metastatic colorectal cancer
Growth Factors. 2023 Jun 23:1-13. doi: 10.1080/08977194.2023.2227274. Online ahead of print.ABSTRACTAdoption of organoid/tumoroid propagation of normal and malignant intestinal epithelia has provided unparalleled opportunities to compare cell growth factor and signaling dependencies. These 3D structures recapitulate tumours in terms of gene expression regarding the tumor cells but also allow deeper insights into the contribution of the tumour microenvironment (TME). Elements of the TME can be manipulated or added back in the form of infiltrating cytotoxic lymphocytes and/or cancer associated fibroblasts. The effectiveness ...
Source: Growth Factors - June 23, 2023 Category: Research Authors: Robert G Ramsay Vicki Whitehall Michael P Flood Source Type: research
Comparative evaluation of autologous platelet-rich plasma and platelet lysate in patients with knee osteoarthritis
Growth Factors. 2023 Jun 23:1-13. doi: 10.1080/08977194.2023.2227273. Online ahead of print.ABSTRACTAutologous platelet-rich plasma (PRP) and platelet lysate (PL) are nowadays promising candidates in the treatment of articular cartilage lesions. We aimed to compare PRP and PL injection effectiveness in patients with knee osteoarthritis (KOA). A total of fifty women with KOA were included in the study. Patients were treated with intra-articular injections of PRP and PL. Clinical outcomes were evaluated using the comparison of VAS, WOMAC, and ROM scores. The concentration levels of growth factors and cytokines were measured ...
Source: Growth Factors - June 23, 2023 Category: Research Authors: Sareh Hosseini Mohammad Sadegh Soltani-Zangbar Majid Zamani Yoda Yaghoubi Reza Rikhtegar Ghiasi Roza Motavalli Ali Ghassabi Rahim Iranzad Amir Mehdizadeh Seyed Kazem Shakouri Alireza Pishgahi Mehdi Yousefi Source Type: research
Technological advances define shifting pathway signaling from normal to primary and metastatic colorectal cancer
Growth Factors. 2023 Jun 23:1-13. doi: 10.1080/08977194.2023.2227274. Online ahead of print.ABSTRACTAdoption of organoid/tumoroid propagation of normal and malignant intestinal epithelia has provided unparalleled opportunities to compare cell growth factor and signaling dependencies. These 3D structures recapitulate tumours in terms of gene expression regarding the tumor cells but also allow deeper insights into the contribution of the tumour microenvironment (TME). Elements of the TME can be manipulated or added back in the form of infiltrating cytotoxic lymphocytes and/or cancer associated fibroblasts. The effectiveness ...
Source: Growth Factors - June 23, 2023 Category: Research Authors: Robert G Ramsay Vicki Whitehall Michael P Flood Source Type: research
Comparative evaluation of autologous platelet-rich plasma and platelet lysate in patients with knee osteoarthritis
Growth Factors. 2023 Jun 23:1-13. doi: 10.1080/08977194.2023.2227273. Online ahead of print.ABSTRACTAutologous platelet-rich plasma (PRP) and platelet lysate (PL) are nowadays promising candidates in the treatment of articular cartilage lesions. We aimed to compare PRP and PL injection effectiveness in patients with knee osteoarthritis (KOA). A total of fifty women with KOA were included in the study. Patients were treated with intra-articular injections of PRP and PL. Clinical outcomes were evaluated using the comparison of VAS, WOMAC, and ROM scores. The concentration levels of growth factors and cytokines were measured ...
Source: Growth Factors - June 23, 2023 Category: Research Authors: Sareh Hosseini Mohammad Sadegh Soltani-Zangbar Majid Zamani Yoda Yaghoubi Reza Rikhtegar Ghiasi Roza Motavalli Ali Ghassabi Rahim Iranzad Amir Mehdizadeh Seyed Kazem Shakouri Alireza Pishgahi Mehdi Yousefi Source Type: research
Technological advances define shifting pathway signaling from normal to primary and metastatic colorectal cancer
Growth Factors. 2023 Jun 23:1-13. doi: 10.1080/08977194.2023.2227274. Online ahead of print.ABSTRACTAdoption of organoid/tumoroid propagation of normal and malignant intestinal epithelia has provided unparalleled opportunities to compare cell growth factor and signaling dependencies. These 3D structures recapitulate tumours in terms of gene expression regarding the tumor cells but also allow deeper insights into the contribution of the tumour microenvironment (TME). Elements of the TME can be manipulated or added back in the form of infiltrating cytotoxic lymphocytes and/or cancer associated fibroblasts. The effectiveness ...
Source: Growth Factors - June 23, 2023 Category: Research Authors: Robert G Ramsay Vicki Whitehall Michael P Flood Source Type: research
Comparative evaluation of autologous platelet-rich plasma and platelet lysate in patients with knee osteoarthritis
Growth Factors. 2023 Jun 23:1-13. doi: 10.1080/08977194.2023.2227273. Online ahead of print.ABSTRACTAutologous platelet-rich plasma (PRP) and platelet lysate (PL) are nowadays promising candidates in the treatment of articular cartilage lesions. We aimed to compare PRP and PL injection effectiveness in patients with knee osteoarthritis (KOA). A total of fifty women with KOA were included in the study. Patients were treated with intra-articular injections of PRP and PL. Clinical outcomes were evaluated using the comparison of VAS, WOMAC, and ROM scores. The concentration levels of growth factors and cytokines were measured ...
Source: Growth Factors - June 23, 2023 Category: Research Authors: Sareh Hosseini Mohammad Sadegh Soltani-Zangbar Majid Zamani Yoda Yaghoubi Reza Rikhtegar Ghiasi Roza Motavalli Ali Ghassabi Rahim Iranzad Amir Mehdizadeh Seyed Kazem Shakouri Alireza Pishgahi Mehdi Yousefi Source Type: research
Technological advances define shifting pathway signaling from normal to primary and metastatic colorectal cancer
Growth Factors. 2023 Jun 23:1-13. doi: 10.1080/08977194.2023.2227274. Online ahead of print.ABSTRACTAdoption of organoid/tumoroid propagation of normal and malignant intestinal epithelia has provided unparalleled opportunities to compare cell growth factor and signaling dependencies. These 3D structures recapitulate tumours in terms of gene expression regarding the tumor cells but also allow deeper insights into the contribution of the tumour microenvironment (TME). Elements of the TME can be manipulated or added back in the form of infiltrating cytotoxic lymphocytes and/or cancer associated fibroblasts. The effectiveness ...
Source: Growth Factors - June 23, 2023 Category: Research Authors: Robert G Ramsay Vicki Whitehall Michael P Flood Source Type: research
Comparative evaluation of autologous platelet-rich plasma and platelet lysate in patients with knee osteoarthritis
Growth Factors. 2023 Jun 23:1-13. doi: 10.1080/08977194.2023.2227273. Online ahead of print.ABSTRACTAutologous platelet-rich plasma (PRP) and platelet lysate (PL) are nowadays promising candidates in the treatment of articular cartilage lesions. We aimed to compare PRP and PL injection effectiveness in patients with knee osteoarthritis (KOA). A total of fifty women with KOA were included in the study. Patients were treated with intra-articular injections of PRP and PL. Clinical outcomes were evaluated using the comparison of VAS, WOMAC, and ROM scores. The concentration levels of growth factors and cytokines were measured ...
Source: Growth Factors - June 23, 2023 Category: Research Authors: Sareh Hosseini Mohammad Sadegh Soltani-Zangbar Majid Zamani Yoda Yaghoubi Reza Rikhtegar Ghiasi Roza Motavalli Ali Ghassabi Rahim Iranzad Amir Mehdizadeh Seyed Kazem Shakouri Alireza Pishgahi Mehdi Yousefi Source Type: research
Technological advances define shifting pathway signaling from normal to primary and metastatic colorectal cancer
Growth Factors. 2023 Jun 23:1-13. doi: 10.1080/08977194.2023.2227274. Online ahead of print.ABSTRACTAdoption of organoid/tumoroid propagation of normal and malignant intestinal epithelia has provided unparalleled opportunities to compare cell growth factor and signaling dependencies. These 3D structures recapitulate tumours in terms of gene expression regarding the tumor cells but also allow deeper insights into the contribution of the tumour microenvironment (TME). Elements of the TME can be manipulated or added back in the form of infiltrating cytotoxic lymphocytes and/or cancer associated fibroblasts. The effectiveness ...
Source: Growth Factors - June 23, 2023 Category: Research Authors: Robert G Ramsay Vicki Whitehall Michael P Flood Source Type: research
A review about the role of additives in nerve tissue engineering: growth factors, vitamins, and drugs
This study tried to provide a concise review of all these additives that facilitates nerve regeneration. An attempt was first made to provide information on the main principle of nerve tissue engineering, and then to shed light on the effectiveness of these additives on nerve tissue engineering. Our research has shown that growth factors accelerate cell proliferation and survival, while vitamins play an effective role in cell signalling, differentiation, and tissue growth. They can also act as hormones, antioxidants, and mediators. Drugs also have an excellent and necessary effect on this process by reducing inflammation a...
Source: Growth Factors - June 21, 2023 Category: Research Authors: Mehrsa Nasiri Javad Esmaeili Amir Tebyani Hojat Basati Source Type: research
