Aversion-Associated Drug and Alcohol Seeking in Females
Front Neuroendocrinol. 2023 Aug 7:101095. doi: 10.1016/j.yfrne.2023.101095. Online ahead of print.ABSTRACTCompulsive drug intake is characterized by the continuation of use regardless of negative consequences. This is modeled preclinically using procedures where a negative stimulus is delivered contingently with consumption of the reinforcer. In humans, women and men exhibit different drug taking behavior as it pertains to overall use, withdrawal symptoms, and rate of dependence. In substance use research, females have often been excluded from many studies due to concerns that circulating sex hormones may affect drug seeki...
Source: Frontiers in Neuroendocrinology - August 9, 2023 Category: Endocrinology Authors: Miranda E Arnold Jesse R Schank Source Type: research
Stress and Gonadal Steroid Influences on Alcohol Drinking and Withdrawal, with Focus on Animal Models in Females
Front Neuroendocrinol. 2023 Aug 7:101094. doi: 10.1016/j.yfrne.2023.101094. Online ahead of print.ABSTRACTSexually dimorphic effects of alcohol, following binge drinking, chronic intoxication, and withdrawal, are documented at the level of the transcriptome and in behavioral and physiological responses. The purpose of the current review is to update and to expand upon contributions of the endocrine system to alcohol drinking and withdrawal in females, with a focus on animal models. Steroids important in the hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes, the reciprocal interactions between these axe...
Source: Frontiers in Neuroendocrinology - August 9, 2023 Category: Endocrinology Authors: Deborah A Finn Source Type: research
Aversion-Associated Drug and Alcohol Seeking in Females
Front Neuroendocrinol. 2023 Aug 7:101095. doi: 10.1016/j.yfrne.2023.101095. Online ahead of print.ABSTRACTCompulsive drug intake is characterized by the continuation of use regardless of negative consequences. This is modeled preclinically using procedures where a negative stimulus is delivered contingently with consumption of the reinforcer. In humans, women and men exhibit different drug taking behavior as it pertains to overall use, withdrawal symptoms, and rate of dependence. In substance use research, females have often been excluded from many studies due to concerns that circulating sex hormones may affect drug seeki...
Source: Frontiers in Neuroendocrinology - August 9, 2023 Category: Endocrinology Authors: Miranda E Arnold Jesse R Schank Source Type: research
Interaction of gonadal hormones, dopaminergic system, and epigenetic regulation in the generation of sex differences in substance use disorders: a systematic review
Front Neuroendocrinol. 2023 Aug 3:101085. doi: 10.1016/j.yfrne.2023.101085. Online ahead of print.ABSTRACTSubstance use disorder (SUD) is a chronic condition characterized by pathological drug-taking and seeking behaviors. remarkably different between males and females, suggesting that drug addiction is a sexually differentiated disorder. The neurobiological bases of sex differences in SUD include sex-specific reward system activation, influenced by interactions between gonadal hormone level changes, dopaminergic reward circuits, and epigenetic modifications of key reward system genes. This systematic review, adhering to P...
Source: Frontiers in Neuroendocrinology - August 5, 2023 Category: Endocrinology Authors: Raquel Santos-Toscano Maria Angeles Arevalo Luis Miguel Garcia-Segura Daniela Grassi Natalia Lagunas Source Type: research
Interaction of gonadal hormones, dopaminergic system, and epigenetic regulation in the generation of sex differences in substance use disorders: a systematic review
Front Neuroendocrinol. 2023 Aug 3:101085. doi: 10.1016/j.yfrne.2023.101085. Online ahead of print.ABSTRACTSubstance use disorder (SUD) is a chronic condition characterized by pathological drug-taking and seeking behaviors. remarkably different between males and females, suggesting that drug addiction is a sexually differentiated disorder. The neurobiological bases of sex differences in SUD include sex-specific reward system activation, influenced by interactions between gonadal hormone level changes, dopaminergic reward circuits, and epigenetic modifications of key reward system genes. This systematic review, adhering to P...
Source: Frontiers in Neuroendocrinology - August 5, 2023 Category: Endocrinology Authors: Raquel Santos-Toscano Maria Angeles Arevalo Luis Miguel Garcia-Segura Daniela Grassi Natalia Lagunas Source Type: research
Interaction of gonadal hormones, dopaminergic system, and epigenetic regulation in the generation of sex differences in substance use disorders: a systematic review
Front Neuroendocrinol. 2023 Aug 3:101085. doi: 10.1016/j.yfrne.2023.101085. Online ahead of print.ABSTRACTSubstance use disorder (SUD) is a chronic condition characterized by pathological drug-taking and seeking behaviors. remarkably different between males and females, suggesting that drug addiction is a sexually differentiated disorder. The neurobiological bases of sex differences in SUD include sex-specific reward system activation, influenced by interactions between gonadal hormone level changes, dopaminergic reward circuits, and epigenetic modifications of key reward system genes. This systematic review, adhering to P...
Source: Frontiers in Neuroendocrinology - August 5, 2023 Category: Endocrinology Authors: Raquel Santos-Toscano Maria Angeles Arevalo Luis Miguel Garcia-Segura Daniela Grassi Natalia Lagunas Source Type: research
Interaction of gonadal hormones, dopaminergic system, and epigenetic regulation in the generation of sex differences in substance use disorders: a systematic review
Front Neuroendocrinol. 2023 Aug 3:101085. doi: 10.1016/j.yfrne.2023.101085. Online ahead of print.ABSTRACTSubstance use disorder (SUD) is a chronic condition characterized by pathological drug-taking and seeking behaviors. remarkably different between males and females, suggesting that drug addiction is a sexually differentiated disorder. The neurobiological bases of sex differences in SUD include sex-specific reward system activation, influenced by interactions between gonadal hormone level changes, dopaminergic reward circuits, and epigenetic modifications of key reward system genes. This systematic review, adhering to P...
Source: Frontiers in Neuroendocrinology - August 5, 2023 Category: Endocrinology Authors: Raquel Santos-Toscano Maria Angeles Arevalo Luis Miguel Garcia-Segura Daniela Grassi Natalia Lagunas Source Type: research
Mechanisms linking neurological disorders with reproductive endocrine dysfunction: Insights from epilepsy research
Front Neuroendocrinol. 2023 Jul 27;71:101084. doi: 10.1016/j.yfrne.2023.101084. Online ahead of print.ABSTRACTGonadal hormone actions in the brain can both worsen and alleviate symptoms of neurological disorders. Although neurological conditions and reproductive endocrine function are seemingly disparate, compelling evidence indicates that reciprocal interactions exist between certain disorders and hypothalamic-pituitary-gonadal (HPG) axis irregularities. Epilepsy is a neurological disorder that shows significant reproductive endocrine dysfunction (RED) in clinical populations. Seizures, particularly those arising from tem...
Source: Frontiers in Neuroendocrinology - July 28, 2023 Category: Endocrinology Authors: Cathryn A Cutia Catherine A Christian-Hinman Source Type: research
Mechanisms linking neurological disorders with reproductive endocrine dysfunction: Insights from epilepsy research
Front Neuroendocrinol. 2023 Jul 27;71:101084. doi: 10.1016/j.yfrne.2023.101084. Online ahead of print.ABSTRACTGonadal hormone actions in the brain can both worsen and alleviate symptoms of neurological disorders. Although neurological conditions and reproductive endocrine function are seemingly disparate, compelling evidence indicates that reciprocal interactions exist between certain disorders and hypothalamic-pituitary-gonadal (HPG) axis irregularities. Epilepsy is a neurological disorder that shows significant reproductive endocrine dysfunction (RED) in clinical populations. Seizures, particularly those arising from tem...
Source: Frontiers in Neuroendocrinology - July 28, 2023 Category: Endocrinology Authors: Cathryn A Cutia Catherine A Christian-Hinman Source Type: research
Mechanisms linking neurological disorders with reproductive endocrine dysfunction: Insights from epilepsy research
Front Neuroendocrinol. 2023 Jul 27;71:101084. doi: 10.1016/j.yfrne.2023.101084. Online ahead of print.ABSTRACTGonadal hormone actions in the brain can both worsen and alleviate symptoms of neurological disorders. Although neurological conditions and reproductive endocrine function are seemingly disparate, compelling evidence indicates that reciprocal interactions exist between certain disorders and hypothalamic-pituitary-gonadal (HPG) axis irregularities. Epilepsy is a neurological disorder that shows significant reproductive endocrine dysfunction (RED) in clinical populations. Seizures, particularly those arising from tem...
Source: Frontiers in Neuroendocrinology - July 28, 2023 Category: Endocrinology Authors: Cathryn A Cutia Catherine A Christian-Hinman Source Type: research
Mechanisms linking neurological disorders with reproductive endocrine dysfunction: insights from epilepsy research
Front Neuroendocrinol. 2023 Jul 26:101084. doi: 10.1016/j.yfrne.2023.101084. Online ahead of print.ABSTRACTGonadal hormone actions in the brain can both worsen and alleviate symptoms of neurological disorders. Although neurological conditions and reproductive endocrine function are seemingly disparate, compelling evidence indicates that reciprocal interactions exist between certain disorders and hypothalamic-pituitary-gonadal (HPG) axis irregularities. Epilepsy is a neurological disorder that shows significant reproductive endocrine dysfunction (RED) in clinical populations. Seizures, particularly those arising from tempor...
Source: Frontiers in Neuroendocrinology - July 28, 2023 Category: Endocrinology Authors: Cathryn A Cutia Catherine A Christian-Hinman Source Type: research
Mechanisms linking neurological disorders with reproductive endocrine dysfunction: insights from epilepsy research
Front Neuroendocrinol. 2023 Jul 26:101084. doi: 10.1016/j.yfrne.2023.101084. Online ahead of print.ABSTRACTGonadal hormone actions in the brain can both worsen and alleviate symptoms of neurological disorders. Although neurological conditions and reproductive endocrine function are seemingly disparate, compelling evidence indicates that reciprocal interactions exist between certain disorders and hypothalamic-pituitary-gonadal (HPG) axis irregularities. Epilepsy is a neurological disorder that shows significant reproductive endocrine dysfunction (RED) in clinical populations. Seizures, particularly those arising from tempor...
Source: Frontiers in Neuroendocrinology - July 28, 2023 Category: Endocrinology Authors: Cathryn A Cutia Catherine A Christian-Hinman Source Type: research
Mechanisms linking neurological disorders with reproductive endocrine dysfunction: insights from epilepsy research
Front Neuroendocrinol. 2023 Jul 26:101084. doi: 10.1016/j.yfrne.2023.101084. Online ahead of print.ABSTRACTGonadal hormone actions in the brain can both worsen and alleviate symptoms of neurological disorders. Although neurological conditions and reproductive endocrine function are seemingly disparate, compelling evidence indicates that reciprocal interactions exist between certain disorders and hypothalamic-pituitary-gonadal (HPG) axis irregularities. Epilepsy is a neurological disorder that shows significant reproductive endocrine dysfunction (RED) in clinical populations. Seizures, particularly those arising from tempor...
Source: Frontiers in Neuroendocrinology - July 28, 2023 Category: Endocrinology Authors: Cathryn A Cutia Catherine A Christian-Hinman Source Type: research
Mechanisms linking neurological disorders with reproductive endocrine dysfunction: insights from epilepsy research
Front Neuroendocrinol. 2023 Jul 26:101084. doi: 10.1016/j.yfrne.2023.101084. Online ahead of print.ABSTRACTGonadal hormone actions in the brain can both worsen and alleviate symptoms of neurological disorders. Although neurological conditions and reproductive endocrine function are seemingly disparate, compelling evidence indicates that reciprocal interactions exist between certain disorders and hypothalamic-pituitary-gonadal (HPG) axis irregularities. Epilepsy is a neurological disorder that shows significant reproductive endocrine dysfunction (RED) in clinical populations. Seizures, particularly those arising from tempor...
Source: Frontiers in Neuroendocrinology - July 28, 2023 Category: Endocrinology Authors: Cathryn A Cutia Catherine A Christian-Hinman Source Type: research
Salivary secretory immunoglobulin A as a potential biomarker of psychosocial stress response during the first stages of life: A systematic review
Front Neuroendocrinol. 2023 Jul 19;71:101083. doi: 10.1016/j.yfrne.2023.101083. Online ahead of print.ABSTRACTMucosal secretory immunoglobulin A (s-IgA) has been recognized as a key component of human first line defense against infection. However, its reactivity to psychosocial stressors is poorly understood. This systematic review aimed to explore whether s-IgA levels changed after psychosocial stress in subjects under the age of 18. Fifteen articles were included. s-IgA basal levels are increased in children older than 9 years old exposed to stress. Furthermore, s-IgA seems to follow a circadian rhythm, which is altered ...
Source: Frontiers in Neuroendocrinology - July 21, 2023 Category: Endocrinology Authors: Águeda Castro-Quintas Helena Palma-Gudiel Nerea San Mart ín-González Javier R Caso Juan C Leza Lourdes Fa ñanás Source Type: research
