Advances in steroid research from the pioneering neurosteroid concept to metabolomics: New insights into pregnenolone function
Front Neuroendocrinol. 2023 Nov 21;72:101113. doi: 10.1016/j.yfrne.2023.101113. Online ahead of print.ABSTRACTAdvances in neuroendocrinology have led to major discoveries since the 19th century, identifying adaptive loops for maintaining homeostasis. One of the most remarkable discoveries was the concept of neurosteroids, according to which the brain is not only a target but also a source of steroid production. The identification of new membrane steroid targets now underpins the neuromodulatory effects of neurosteroids such as pregnenolone, which is involved in functions mediated by the GPCR CB1 receptor. Structural analys...
Source: Frontiers in Neuroendocrinology - November 22, 2023 Category: Endocrinology Authors: Monique Vall ée Source Type: research
Sex differences in bipolar disorder: The dorsolateral prefrontal cortex as an etiopathogenic region
Front Neuroendocrinol. 2023 Nov 21;72:101115. doi: 10.1016/j.yfrne.2023.101115. Online ahead of print.ABSTRACTBipolar disorder (BD) is worldwide a prevalent mental illness and a leading risk factor for suicide. Over the past three decades, it has been discovered that sex differences exist throughout the entire panorama of BD, but the etiologic regions and mechanisms that generate such differences remain poorly characterized. Available evidence indicates that the dorsolateral prefrontal cortex (DLPFC), a critical region that controls higher-order cognitive processing and mood, exhibits biological disparities between male an...
Source: Frontiers in Neuroendocrinology - November 22, 2023 Category: Endocrinology Authors: Lin Zhang Dick F Swaab Source Type: research
Post-Finasteride Syndrome And Post-Ssri Sexual Dysfunction: Two Clinical Conditions Apparently Distant, But Very Close
Front Neuroendocrinol. 2023 Nov 21;72:101114. doi: 10.1016/j.yfrne.2023.101114. Online ahead of print.ABSTRACTPost-finasteride syndrome and post-SSRI sexual dysfunction, are two poorly explored clinical conditions in which men treated for androgenetic alopecia with finasteride or for depression with SSRI antidepressants show persistent side effects despite drug suspension (e.g., sexual dysfunction, psychological complaints, sleep disorders). Because of some similarities in the symptoms, common pathological mechanisms are proposed here. Indeed, as discussed, clinical studies and preclinical data obtained so far suggest an i...
Source: Frontiers in Neuroendocrinology - November 22, 2023 Category: Endocrinology Authors: Silvia Giatti Silvia Diviccaro Lucia Cioffi Roberto Cosimo Melcangi Source Type: research
Advances in steroid research from the pioneering neurosteroid concept to metabolomics: New insights into pregnenolone function
Front Neuroendocrinol. 2023 Nov 21;72:101113. doi: 10.1016/j.yfrne.2023.101113. Online ahead of print.ABSTRACTAdvances in neuroendocrinology have led to major discoveries since the 19th century, identifying adaptive loops for maintaining homeostasis. One of the most remarkable discoveries was the concept of neurosteroids, according to which the brain is not only a target but also a source of steroid production. The identification of new membrane steroid targets now underpins the neuromodulatory effects of neurosteroids such as pregnenolone, which is involved in functions mediated by the GPCR CB1 receptor. Structural analys...
Source: Frontiers in Neuroendocrinology - November 22, 2023 Category: Endocrinology Authors: Monique Vall ée Source Type: research
Sex differences in bipolar disorder: The dorsolateral prefrontal cortex as an etiopathogenic region
Front Neuroendocrinol. 2023 Nov 21;72:101115. doi: 10.1016/j.yfrne.2023.101115. Online ahead of print.ABSTRACTBipolar disorder (BD) is worldwide a prevalent mental illness and a leading risk factor for suicide. Over the past three decades, it has been discovered that sex differences exist throughout the entire panorama of BD, but the etiologic regions and mechanisms that generate such differences remain poorly characterized. Available evidence indicates that the dorsolateral prefrontal cortex (DLPFC), a critical region that controls higher-order cognitive processing and mood, exhibits biological disparities between male an...
Source: Frontiers in Neuroendocrinology - November 22, 2023 Category: Endocrinology Authors: Lin Zhang Dick F Swaab Source Type: research
Post-Finasteride Syndrome And Post-Ssri Sexual Dysfunction: Two Clinical Conditions Apparently Distant, But Very Close
Front Neuroendocrinol. 2023 Nov 21;72:101114. doi: 10.1016/j.yfrne.2023.101114. Online ahead of print.ABSTRACTPost-finasteride syndrome and post-SSRI sexual dysfunction, are two poorly explored clinical conditions in which men treated for androgenetic alopecia with finasteride or for depression with SSRI antidepressants show persistent side effects despite drug suspension (e.g., sexual dysfunction, psychological complaints, sleep disorders). Because of some similarities in the symptoms, common pathological mechanisms are proposed here. Indeed, as discussed, clinical studies and preclinical data obtained so far suggest an i...
Source: Frontiers in Neuroendocrinology - November 22, 2023 Category: Endocrinology Authors: Silvia Giatti Silvia Diviccaro Lucia Cioffi Roberto Cosimo Melcangi Source Type: research
Advances in steroid research from the pioneering neurosteroid concept to metabolomics: New insights into pregnenolone function
Front Neuroendocrinol. 2023 Nov 21;72:101113. doi: 10.1016/j.yfrne.2023.101113. Online ahead of print.ABSTRACTAdvances in neuroendocrinology have led to major discoveries since the 19th century, identifying adaptive loops for maintaining homeostasis. One of the most remarkable discoveries was the concept of neurosteroids, according to which the brain is not only a target but also a source of steroid production. The identification of new membrane steroid targets now underpins the neuromodulatory effects of neurosteroids such as pregnenolone, which is involved in functions mediated by the GPCR CB1 receptor. Structural analys...
Source: Frontiers in Neuroendocrinology - November 22, 2023 Category: Endocrinology Authors: Monique Vall ée Source Type: research
Sex differences in bipolar disorder: The dorsolateral prefrontal cortex as an etiopathogenic region
Front Neuroendocrinol. 2023 Nov 21;72:101115. doi: 10.1016/j.yfrne.2023.101115. Online ahead of print.ABSTRACTBipolar disorder (BD) is worldwide a prevalent mental illness and a leading risk factor for suicide. Over the past three decades, it has been discovered that sex differences exist throughout the entire panorama of BD, but the etiologic regions and mechanisms that generate such differences remain poorly characterized. Available evidence indicates that the dorsolateral prefrontal cortex (DLPFC), a critical region that controls higher-order cognitive processing and mood, exhibits biological disparities between male an...
Source: Frontiers in Neuroendocrinology - November 22, 2023 Category: Endocrinology Authors: Lin Zhang Dick F Swaab Source Type: research
Post-Finasteride Syndrome And Post-Ssri Sexual Dysfunction: Two Clinical Conditions Apparently Distant, But Very Close
Front Neuroendocrinol. 2023 Nov 21;72:101114. doi: 10.1016/j.yfrne.2023.101114. Online ahead of print.ABSTRACTPost-finasteride syndrome and post-SSRI sexual dysfunction, are two poorly explored clinical conditions in which men treated for androgenetic alopecia with finasteride or for depression with SSRI antidepressants show persistent side effects despite drug suspension (e.g., sexual dysfunction, psychological complaints, sleep disorders). Because of some similarities in the symptoms, common pathological mechanisms are proposed here. Indeed, as discussed, clinical studies and preclinical data obtained so far suggest an i...
Source: Frontiers in Neuroendocrinology - November 22, 2023 Category: Endocrinology Authors: Silvia Giatti Silvia Diviccaro Lucia Cioffi Roberto Cosimo Melcangi Source Type: research
Advances in steroid research from the pioneering neurosteroid concept to metabolomics: New insights into pregnenolone function
Front Neuroendocrinol. 2023 Nov 21;72:101113. doi: 10.1016/j.yfrne.2023.101113. Online ahead of print.ABSTRACTAdvances in neuroendocrinology have led to major discoveries since the 19th century, identifying adaptive loops for maintaining homeostasis. One of the most remarkable discoveries was the concept of neurosteroids, according to which the brain is not only a target but also a source of steroid production. The identification of new membrane steroid targets now underpins the neuromodulatory effects of neurosteroids such as pregnenolone, which is involved in functions mediated by the GPCR CB1 receptor. Structural analys...
Source: Frontiers in Neuroendocrinology - November 22, 2023 Category: Endocrinology Authors: Monique Vall ée Source Type: research
Sex differences in bipolar disorder: The dorsolateral prefrontal cortex as an etiopathogenic region
Front Neuroendocrinol. 2023 Nov 21;72:101115. doi: 10.1016/j.yfrne.2023.101115. Online ahead of print.ABSTRACTBipolar disorder (BD) is worldwide a prevalent mental illness and a leading risk factor for suicide. Over the past three decades, it has been discovered that sex differences exist throughout the entire panorama of BD, but the etiologic regions and mechanisms that generate such differences remain poorly characterized. Available evidence indicates that the dorsolateral prefrontal cortex (DLPFC), a critical region that controls higher-order cognitive processing and mood, exhibits biological disparities between male an...
Source: Frontiers in Neuroendocrinology - November 22, 2023 Category: Endocrinology Authors: Lin Zhang Dick F Swaab Source Type: research
Post-Finasteride Syndrome And Post-Ssri Sexual Dysfunction: Two Clinical Conditions Apparently Distant, But Very Close
Front Neuroendocrinol. 2023 Nov 21;72:101114. doi: 10.1016/j.yfrne.2023.101114. Online ahead of print.ABSTRACTPost-finasteride syndrome and post-SSRI sexual dysfunction, are two poorly explored clinical conditions in which men treated for androgenetic alopecia with finasteride or for depression with SSRI antidepressants show persistent side effects despite drug suspension (e.g., sexual dysfunction, psychological complaints, sleep disorders). Because of some similarities in the symptoms, common pathological mechanisms are proposed here. Indeed, as discussed, clinical studies and preclinical data obtained so far suggest an i...
Source: Frontiers in Neuroendocrinology - November 22, 2023 Category: Endocrinology Authors: Silvia Giatti Silvia Diviccaro Lucia Cioffi Roberto Cosimo Melcangi Source Type: research
Advances in steroid research from the pioneering neurosteroid concept to metabolomics: New insights into pregnenolone function
Front Neuroendocrinol. 2023 Nov 21;72:101113. doi: 10.1016/j.yfrne.2023.101113. Online ahead of print.ABSTRACTAdvances in neuroendocrinology have led to major discoveries since the 19th century, identifying adaptive loops for maintaining homeostasis. One of the most remarkable discoveries was the concept of neurosteroids, according to which the brain is not only a target but also a source of steroid production. The identification of new membrane steroid targets now underpins the neuromodulatory effects of neurosteroids such as pregnenolone, which is involved in functions mediated by the GPCR CB1 receptor. Structural analys...
Source: Frontiers in Neuroendocrinology - November 22, 2023 Category: Endocrinology Authors: Monique Vall ée Source Type: research
Sex differences in bipolar disorder: The dorsolateral prefrontal cortex as an etiopathogenic region
Front Neuroendocrinol. 2023 Nov 21;72:101115. doi: 10.1016/j.yfrne.2023.101115. Online ahead of print.ABSTRACTBipolar disorder (BD) is worldwide a prevalent mental illness and a leading risk factor for suicide. Over the past three decades, it has been discovered that sex differences exist throughout the entire panorama of BD, but the etiologic regions and mechanisms that generate such differences remain poorly characterized. Available evidence indicates that the dorsolateral prefrontal cortex (DLPFC), a critical region that controls higher-order cognitive processing and mood, exhibits biological disparities between male an...
Source: Frontiers in Neuroendocrinology - November 22, 2023 Category: Endocrinology Authors: Lin Zhang Dick F Swaab Source Type: research
Post-Finasteride Syndrome And Post-Ssri Sexual Dysfunction: Two Clinical Conditions Apparently Distant, But Very Close
Front Neuroendocrinol. 2023 Nov 21;72:101114. doi: 10.1016/j.yfrne.2023.101114. Online ahead of print.ABSTRACTPost-finasteride syndrome and post-SSRI sexual dysfunction, are two poorly explored clinical conditions in which men treated for androgenetic alopecia with finasteride or for depression with SSRI antidepressants show persistent side effects despite drug suspension (e.g., sexual dysfunction, psychological complaints, sleep disorders). Because of some similarities in the symptoms, common pathological mechanisms are proposed here. Indeed, as discussed, clinical studies and preclinical data obtained so far suggest an i...
Source: Frontiers in Neuroendocrinology - November 22, 2023 Category: Endocrinology Authors: Silvia Giatti Silvia Diviccaro Lucia Cioffi Roberto Cosimo Melcangi Source Type: research
