Sex differences in bipolar disorder: the dorsolateral prefrontal cortex as an etiopathogenic region
Front Neuroendocrinol. 2023 Nov 20:101115. doi: 10.1016/j.yfrne.2023.101115. Online ahead of print.ABSTRACTBipolar disorder (BD) is worldwide a prevalent mental illness and a leading risk factor for suicide. Over the past three decades, it has been discovered that sex differences exist throughout the entire panorama of BD, but the etiologic regions and mechanisms that generate such differences remain poorly characterized. Available evidence indicates that the dorsolateral prefrontal cortex (DLPFC), a critical region that controls higher-order cognitive processing and mood, exhibits biological disparities between male and f...
Source: Frontiers in Neuroendocrinology - November 22, 2023 Category: Endocrinology Authors: Lin Zhang Dick F Swaab Source Type: research
Post-finasteride syndrome and post-ssri sexual dysfunction: two clinical conditions apparently distant, but very close
Front Neuroendocrinol. 2023 Nov 20:101114. doi: 10.1016/j.yfrne.2023.101114. Online ahead of print.ABSTRACTPost-finasteride syndrome and post-SSRI sexual dysfunction, are two poorly explored clinical conditions in which men treated for androgenetic alopecia with finasteride or for depression with SSRI antidepressants show persistent side effects despite drug suspension (e.g., sexual dysfunction, psychological complaints, sleep disorders). Because of some similarities in the symptoms, common pathological mechanisms are proposed here. Indeed, as discussed, clinical studies and preclinical data obtained so far suggest an impo...
Source: Frontiers in Neuroendocrinology - November 22, 2023 Category: Endocrinology Authors: Silvia Giatti Silvia Diviccaro Lucia Cioffi Roberto Cosimo Melcangi Source Type: research
Advances in steroid research from the pioneering neurosteroid concept to metabolomics: New insights into pregnenolone function
Front Neuroendocrinol. 2023 Nov 20:101113. doi: 10.1016/j.yfrne.2023.101113. Online ahead of print.ABSTRACTAdvances in neuroendocrinology have led to major discoveries since the 19th century, identifying adaptive loops for maintaining homeostasis. One of the most remarkable discoveries was the concept of neurosteroids, according to which the brain is not only a target but also a source of steroid production. The identification of new membrane steroid targets now underpins the neuromodulatory effects of neurosteroids such as pregnenolone, which is involved in functions mediated by the GPCR CB1 receptor. Structural analysis ...
Source: Frontiers in Neuroendocrinology - November 22, 2023 Category: Endocrinology Authors: Monique Vall ée Source Type: research
Testosterone's Role in Modulating Human Behaviors Relevant to Mating and Parenting
We examined whether the available evidence supports trade-off interpretations of T's adaptive function whereby high T levels correspond to greater mating/reproductive effort and competition and low T levels to greater parenting effort and nurturance. We found mixed support for trade-off hypotheses, suggesting that T's function in modulating human mating and parenting might be more nuanced and highly dependent on context and individual trait differences. Results were largely similar for men and women, although studies with women were scarcer than those with men for most behaviors we reviewed.PMID:37972861 | DOI:10.1016/j.yf...
Source: Frontiers in Neuroendocrinology - November 16, 2023 Category: Endocrinology Authors: Francesca R Luberti Justin M Carr é Source Type: research
Testosterone's Role in Modulating Human Behaviors Relevant to Mating and Parenting
We examined whether the available evidence supports trade-off interpretations of T's adaptive function whereby high T levels correspond to greater mating/reproductive effort and competition and low T levels to greater parenting effort and nurturance. We found mixed support for trade-off hypotheses, suggesting that T's function in modulating human mating and parenting might be more nuanced and highly dependent on context and individual trait differences. Results were largely similar for men and women, although studies with women were scarcer than those with men for most behaviors we reviewed.PMID:37972861 | DOI:10.1016/j.yf...
Source: Frontiers in Neuroendocrinology - November 16, 2023 Category: Endocrinology Authors: Francesca R Luberti Justin M Carr é Source Type: research
Testosterone's Role in Modulating Human Behaviors Relevant to Mating and Parenting
We examined whether the available evidence supports trade-off interpretations of T's adaptive function whereby high T levels correspond to greater mating/reproductive effort and competition and low T levels to greater parenting effort and nurturance. We found mixed support for trade-off hypotheses, suggesting that T's function in modulating human mating and parenting might be more nuanced and highly dependent on context and individual trait differences. Results were largely similar for men and women, although studies with women were scarcer than those with men for most behaviors we reviewed.PMID:37972861 | DOI:10.1016/j.yf...
Source: Frontiers in Neuroendocrinology - November 16, 2023 Category: Endocrinology Authors: Francesca R Luberti Justin M Carr é Source Type: research
Testosterone's Role in Modulating Human Behaviors Relevant to Mating and Parenting
We examined whether the available evidence supports trade-off interpretations of T's adaptive function whereby high T levels correspond to greater mating/reproductive effort and competition and low T levels to greater parenting effort and nurturance. We found mixed support for trade-off hypotheses, suggesting that T's function in modulating human mating and parenting might be more nuanced and highly dependent on context and individual trait differences. Results were largely similar for men and women, although studies with women were scarcer than those with men for most behaviors we reviewed.PMID:37972861 | DOI:10.1016/j.yf...
Source: Frontiers in Neuroendocrinology - November 16, 2023 Category: Endocrinology Authors: Francesca R Luberti Justin M Carr é Source Type: research
Testosterone's Role in Modulating Human Behaviors Relevant to Mating and Parenting
We examined whether the available evidence supports trade-off interpretations of T's adaptive function whereby high T levels correspond to greater mating/reproductive effort and competition and low T levels to greater parenting effort and nurturance. We found mixed support for trade-off hypotheses, suggesting that T's function in modulating human mating and parenting might be more nuanced and highly dependent on context and individual trait differences. Results were largely similar for men and women, although studies with women were scarcer than those with men for most behaviors we reviewed.PMID:37972861 | DOI:10.1016/j.yf...
Source: Frontiers in Neuroendocrinology - November 16, 2023 Category: Endocrinology Authors: Francesca R Luberti Justin M Carr é Source Type: research
Symptoms of mental disorders and oral contraception use: A systematic review and meta-analysis
Front Neuroendocrinol. 2023 Nov 13:101111. doi: 10.1016/j.yfrne.2023.101111. Online ahead of print.ABSTRACTWorldwide, over 150 million adolescent and adult women use oral contraceptives (OC). An association between OC-use and the emergence of symptoms of mental disorders has been suggested. This systematic review and meta-analysis provide an overview of published research regarding symptoms of mental disorders in association with OC-use, factoring the influence of OC types, age of first-use, duration of OC-intake, and previous diagnoses of mental disorders. A systematic literature search was conducted between June-July 202...
Source: Frontiers in Neuroendocrinology - November 15, 2023 Category: Endocrinology Authors: Mathilda Z Kraft Philine Rojczyk Thomas Weiss Birgit Derntl Zora Kikinis Ilona Croy Carina Heller Source Type: research
Symptoms of mental disorders and oral contraception use: A systematic review and meta-analysis
Front Neuroendocrinol. 2023 Nov 13:101111. doi: 10.1016/j.yfrne.2023.101111. Online ahead of print.ABSTRACTWorldwide, over 150 million adolescent and adult women use oral contraceptives (OC). An association between OC-use and the emergence of symptoms of mental disorders has been suggested. This systematic review and meta-analysis provide an overview of published research regarding symptoms of mental disorders in association with OC-use, factoring the influence of OC types, age of first-use, duration of OC-intake, and previous diagnoses of mental disorders. A systematic literature search was conducted between June-July 202...
Source: Frontiers in Neuroendocrinology - November 15, 2023 Category: Endocrinology Authors: Mathilda Z Kraft Philine Rojczyk Thomas Weiss Birgit Derntl Zora Kikinis Ilona Croy Carina Heller Source Type: research
The interaction of genetic sex and prenatal alcohol exposure on health across the lifespan
Front Neuroendocrinol. 2023 Oct 4;71:101103. doi: 10.1016/j.yfrne.2023.101103. Online ahead of print.ABSTRACTPrenatal alcohol exposure (PAE) can reprogram the development of cells and tissues, resulting in a spectrum of physical and neurobehavioral teratology. PAE immediately impacts fetal growth, but its effects carry forward post-parturition, into adolescence and adulthood, and can result in a cluster of disabilities, collectively termed Fetal Alcohol Spectrum Disorders. Emerging preclinical and clinical research investigating neurological and behavioral outcomes in exposed offspring point to genetic sex as an important ...
Source: Frontiers in Neuroendocrinology - October 6, 2023 Category: Endocrinology Authors: Shameena Bake Siara K Rouzer Shruti Mavuri Rajesh C Miranda Amanda H Mahnke Source Type: research
The interaction of genetic sex and prenatal alcohol exposure on health across the lifespan
Front Neuroendocrinol. 2023 Oct 4;71:101103. doi: 10.1016/j.yfrne.2023.101103. Online ahead of print.ABSTRACTPrenatal alcohol exposure (PAE) can reprogram the development of cells and tissues, resulting in a spectrum of physical and neurobehavioral teratology. PAE immediately impacts fetal growth, but its effects carry forward post-parturition, into adolescence and adulthood, and can result in a cluster of disabilities, collectively termed Fetal Alcohol Spectrum Disorders. Emerging preclinical and clinical research investigating neurological and behavioral outcomes in exposed offspring point to genetic sex as an important ...
Source: Frontiers in Neuroendocrinology - October 6, 2023 Category: Endocrinology Authors: Shameena Bake Siara K Rouzer Shruti Mavuri Rajesh C Miranda Amanda H Mahnke Source Type: research
The interaction of genetic sex and prenatal alcohol exposure on health across the lifespan
Front Neuroendocrinol. 2023 Oct 4;71:101103. doi: 10.1016/j.yfrne.2023.101103. Online ahead of print.ABSTRACTPrenatal alcohol exposure (PAE) can reprogram the development of cells and tissues, resulting in a spectrum of physical and neurobehavioral teratology. PAE immediately impacts fetal growth, but its effects carry forward post-parturition, into adolescence and adulthood, and can result in a cluster of disabilities, collectively termed Fetal Alcohol Spectrum Disorders. Emerging preclinical and clinical research investigating neurological and behavioral outcomes in exposed offspring point to genetic sex as an important ...
Source: Frontiers in Neuroendocrinology - October 6, 2023 Category: Endocrinology Authors: Shameena Bake Siara K Rouzer Shruti Mavuri Rajesh C Miranda Amanda H Mahnke Source Type: research
The interaction of genetic sex and prenatal alcohol exposure on health across the lifespan
Front Neuroendocrinol. 2023 Oct 4;71:101103. doi: 10.1016/j.yfrne.2023.101103. Online ahead of print.ABSTRACTPrenatal alcohol exposure (PAE) can reprogram the development of cells and tissues, resulting in a spectrum of physical and neurobehavioral teratology. PAE immediately impacts fetal growth, but its effects carry forward post-parturition, into adolescence and adulthood, and can result in a cluster of disabilities, collectively termed Fetal Alcohol Spectrum Disorders. Emerging preclinical and clinical research investigating neurological and behavioral outcomes in exposed offspring point to genetic sex as an important ...
Source: Frontiers in Neuroendocrinology - October 6, 2023 Category: Endocrinology Authors: Shameena Bake Siara K Rouzer Shruti Mavuri Rajesh C Miranda Amanda H Mahnke Source Type: research
The interaction of genetic sex and prenatal alcohol exposure on health across the lifespan
Front Neuroendocrinol. 2023 Oct 4;71:101103. doi: 10.1016/j.yfrne.2023.101103. Online ahead of print.ABSTRACTPrenatal alcohol exposure (PAE) can reprogram the development of cells and tissues, resulting in a spectrum of physical and neurobehavioral teratology. PAE immediately impacts fetal growth, but its effects carry forward post-parturition, into adolescence and adulthood, and can result in a cluster of disabilities, collectively termed Fetal Alcohol Spectrum Disorders. Emerging preclinical and clinical research investigating neurological and behavioral outcomes in exposed offspring point to genetic sex as an important ...
Source: Frontiers in Neuroendocrinology - October 6, 2023 Category: Endocrinology Authors: Shameena Bake Siara K Rouzer Shruti Mavuri Rajesh C Miranda Amanda H Mahnke Source Type: research
