Androgen Action on Myogenesis Throughout the Lifespan; Comparison with Neurogenesis
Front Neuroendocrinol. 2023 Sep 3:101101. doi: 10.1016/j.yfrne.2023.101101. Online ahead of print.ABSTRACTAndrogens' pleiotropic actions in promoting sex differences present not only a challenge to providing a comprehensive account of their function, but also an opportunity to gain insights by comparing androgenic actions across organ systems. Although often overlooked by neuroscientists, skeletal muscle is another androgen-responsive organ system which shares with the nervous system properties of electrochemical excitability, behavioral relevance, and remarkable capacity for adaptive plasticity. Here we review androgenic ...
Source: Frontiers in Neuroendocrinology - September 5, 2023 Category: Endocrinology Authors: Sabrina Tzivia Barsky Douglas Ashley Monks Source Type: research
Androgen Action on Myogenesis Throughout the Lifespan; Comparison with Neurogenesis
Front Neuroendocrinol. 2023 Sep 3:101101. doi: 10.1016/j.yfrne.2023.101101. Online ahead of print.ABSTRACTAndrogens' pleiotropic actions in promoting sex differences present not only a challenge to providing a comprehensive account of their function, but also an opportunity to gain insights by comparing androgenic actions across organ systems. Although often overlooked by neuroscientists, skeletal muscle is another androgen-responsive organ system which shares with the nervous system properties of electrochemical excitability, behavioral relevance, and remarkable capacity for adaptive plasticity. Here we review androgenic ...
Source: Frontiers in Neuroendocrinology - September 5, 2023 Category: Endocrinology Authors: Sabrina Tzivia Barsky Douglas Ashley Monks Source Type: research
Insufficient support for retinoic acid receptor control of synaptic plasticity through a non-genomic mechanism
Front Neuroendocrinol. 2023 Aug 28:101099. doi: 10.1016/j.yfrne.2023.101099. Online ahead of print.ABSTRACTIt is well established that retinoic acid receptors (RARs) function as nuclear receptors that control gene expression in response to binding of the ligand retinoic acid (RA). However, some studies have proposed that RAR-alpha (RARa) controls synaptic plasticity via non-genomic effects outside the nucleus, i.e. effects on mRNA translation of GluA1, a sub-unit of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. In order to support this non-genomic mechanism, studies have reported RARa knocko...
Source: Frontiers in Neuroendocrinology - August 30, 2023 Category: Endocrinology Authors: Gregg Duester Source Type: research
Insufficient support for retinoic acid receptor control of synaptic plasticity through a non-genomic mechanism
Front Neuroendocrinol. 2023 Aug 28:101099. doi: 10.1016/j.yfrne.2023.101099. Online ahead of print.ABSTRACTIt is well established that retinoic acid receptors (RARs) function as nuclear receptors that control gene expression in response to binding of the ligand retinoic acid (RA). However, some studies have proposed that RAR-alpha (RARa) controls synaptic plasticity via non-genomic effects outside the nucleus, i.e. effects on mRNA translation of GluA1, a sub-unit of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. In order to support this non-genomic mechanism, studies have reported RARa knocko...
Source: Frontiers in Neuroendocrinology - August 30, 2023 Category: Endocrinology Authors: Gregg Duester Source Type: research
Insufficient support for retinoic acid receptor control of synaptic plasticity through a non-genomic mechanism
Front Neuroendocrinol. 2023 Aug 28:101099. doi: 10.1016/j.yfrne.2023.101099. Online ahead of print.ABSTRACTIt is well established that retinoic acid receptors (RARs) function as nuclear receptors that control gene expression in response to binding of the ligand retinoic acid (RA). However, some studies have proposed that RAR-alpha (RARa) controls synaptic plasticity via non-genomic effects outside the nucleus, i.e. effects on mRNA translation of GluA1, a sub-unit of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. In order to support this non-genomic mechanism, studies have reported RARa knocko...
Source: Frontiers in Neuroendocrinology - August 30, 2023 Category: Endocrinology Authors: Gregg Duester Source Type: research
Insufficient support for retinoic acid receptor control of synaptic plasticity through a non-genomic mechanism
Front Neuroendocrinol. 2023 Aug 28:101099. doi: 10.1016/j.yfrne.2023.101099. Online ahead of print.ABSTRACTIt is well established that retinoic acid receptors (RARs) function as nuclear receptors that control gene expression in response to binding of the ligand retinoic acid (RA). However, some studies have proposed that RAR-alpha (RARa) controls synaptic plasticity via non-genomic effects outside the nucleus, i.e. effects on mRNA translation of GluA1, a sub-unit of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. In order to support this non-genomic mechanism, studies have reported RARa knocko...
Source: Frontiers in Neuroendocrinology - August 30, 2023 Category: Endocrinology Authors: Gregg Duester Source Type: research
Insufficient support for retinoic acid receptor control of synaptic plasticity through a non-genomic mechanism
Front Neuroendocrinol. 2023 Aug 28:101099. doi: 10.1016/j.yfrne.2023.101099. Online ahead of print.ABSTRACTIt is well established that retinoic acid receptors (RARs) function as nuclear receptors that control gene expression in response to binding of the ligand retinoic acid (RA). However, some studies have proposed that RAR-alpha (RARa) controls synaptic plasticity via non-genomic effects outside the nucleus, i.e. effects on mRNA translation of GluA1, a sub-unit of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. In order to support this non-genomic mechanism, studies have reported RARa knocko...
Source: Frontiers in Neuroendocrinology - August 30, 2023 Category: Endocrinology Authors: Gregg Duester Source Type: research
A scoping review of hormonal clinical trials in menstrual cycle-related brain disorders: Studies in premenstrual mood disorder, menstrual migraine, and catamenial epilepsy
CONCLUSIONS: Research in PMD, MM, and CE commonly have overlapping study design and research methods, and similar effects of some interventions suggest the possibility of overlapping mechanisms contributing to their cyclical symptom presentation. Our scoping review is the first to summarize existing clinical trials in these three brain disorders, specifically focusing on hormonal treatment trials. We find that PMD has a stronger body of literature for ovulation-suppressing COC and GnRHa trials; the field of MM consists of extensive estrogen-based studies; and current consensus in CE focuses on progesterone supplementation ...
Source: Frontiers in Neuroendocrinology - August 24, 2023 Category: Endocrinology Authors: Jordan C Barone Mitchell P Butler Ashley Ross Anna Patterson Melissa Wagner-Schuman Tory A Eisenlohr-Moul Source Type: research
A scoping review of hormonal clinical trials in menstrual cycle-related brain disorders: studies in premenstrual mood disorder, menstrual migraine, and catamenial epilepsy
CONCLUSIONS: Research in PMD, MM, and CE commonly have overlapping study design and research methods, and similar effects of some interventions suggest the possibility of overlapping mechanisms contributing to their cyclical symptom presentation. Our scoping review is the first to summarize existing clinical trials in these three brain disorders, specifically focusing on hormonal treatment trials. We find that PMD has a stronger body of literature for ovulation-suppressing COC and GnRHa trials; the field of MM consists of extensive estrogen-based studies; and current consensus in CE focuses on progesterone supplementation ...
Source: Frontiers in Neuroendocrinology - August 24, 2023 Category: Endocrinology Authors: Jordan C Barone Mitchell P Butler Ashley Ross Anna Patterson Melissa Wagner-Schuman Tory A Eisenlohr-Moul Source Type: research
A scoping review of hormonal clinical trials in menstrual cycle-related brain disorders: studies in premenstrual mood disorder, menstrual migraine, and catamenial epilepsy
CONCLUSIONS: Research in PMD, MM, and CE commonly have overlapping study design and research methods, and similar effects of some interventions suggest the possibility of overlapping mechanisms contributing to their cyclical symptom presentation. Our scoping review is the first to summarize existing clinical trials in these three brain disorders, specifically focusing on hormonal treatment trials. We find that PMD has a stronger body of literature for ovulation-suppressing COC and GnRHa trials; the field of MM consists of extensive estrogen-based studies; and current consensus in CE focuses on progesterone supplementation ...
Source: Frontiers in Neuroendocrinology - August 24, 2023 Category: Endocrinology Authors: Jordan C Barone Mitchell P Butler Ashley Ross Anna Patterson Melissa Wagner-Schuman Tory A Eisenlohr-Moul Source Type: research
A scoping review of hormonal clinical trials in menstrual cycle-related brain disorders: studies in premenstrual mood disorder, menstrual migraine, and catamenial epilepsy
CONCLUSIONS: Research in PMD, MM, and CE commonly have overlapping study design and research methods, and similar effects of some interventions suggest the possibility of overlapping mechanisms contributing to their cyclical symptom presentation. Our scoping review is the first to summarize existing clinical trials in these three brain disorders, specifically focusing on hormonal treatment trials. We find that PMD has a stronger body of literature for ovulation-suppressing COC and GnRHa trials; the field of MM consists of extensive estrogen-based studies; and current consensus in CE focuses on progesterone supplementation ...
Source: Frontiers in Neuroendocrinology - August 24, 2023 Category: Endocrinology Authors: Jordan C Barone Mitchell P Butler Ashley Ross Anna Patterson Melissa Wagner-Schuman Tory A Eisenlohr-Moul Source Type: research
A scoping review of hormonal clinical trials in menstrual cycle-related brain disorders: studies in premenstrual mood disorder, menstrual migraine, and catamenial epilepsy
CONCLUSIONS: Research in PMD, MM, and CE commonly have overlapping study design and research methods, and similar effects of some interventions suggest the possibility of overlapping mechanisms contributing to their cyclical symptom presentation. Our scoping review is the first to summarize existing clinical trials in these three brain disorders, specifically focusing on hormonal treatment trials. We find that PMD has a stronger body of literature for ovulation-suppressing COC and GnRHa trials; the field of MM consists of extensive estrogen-based studies; and current consensus in CE focuses on progesterone supplementation ...
Source: Frontiers in Neuroendocrinology - August 24, 2023 Category: Endocrinology Authors: Jordan C Barone Mitchell P Butler Ashley Ross Anna Patterson Melissa Wagner-Schuman Tory A Eisenlohr-Moul Source Type: research
Steroid-dependent plasticity in the song control system: perineuronal nets and HVC neurogenesis
Front Neuroendocrinol. 2023 Aug 21:101097. doi: 10.1016/j.yfrne.2023.101097. Online ahead of print.ABSTRACTThe vocal control nucleus HVC in songbirds has emerged as a widespread model system to study adult brain plasticity in response to changes in the hormonal and social environment. I review here studies completed in my laboratory during the last decade that concern two aspects of this plasticity: changes in aggregations of extracellular matrix components surrounding the soma of inhibitory parvalbumin-positive neurons called perineuronal nets (PNN) and the production/incorporation of new neurons. Both features are modula...
Source: Frontiers in Neuroendocrinology - August 23, 2023 Category: Endocrinology Authors: Jacques Balthazart Source Type: research
Steroid-dependent plasticity in the song control system: perineuronal nets and HVC neurogenesis
Front Neuroendocrinol. 2023 Aug 21:101097. doi: 10.1016/j.yfrne.2023.101097. Online ahead of print.ABSTRACTThe vocal control nucleus HVC in songbirds has emerged as a widespread model system to study adult brain plasticity in response to changes in the hormonal and social environment. I review here studies completed in my laboratory during the last decade that concern two aspects of this plasticity: changes in aggregations of extracellular matrix components surrounding the soma of inhibitory parvalbumin-positive neurons called perineuronal nets (PNN) and the production/incorporation of new neurons. Both features are modula...
Source: Frontiers in Neuroendocrinology - August 23, 2023 Category: Endocrinology Authors: Jacques Balthazart Source Type: research
Focus on Fentanyl in Females: Sex and Gender Differences in the Physiological and Behavioral Effects of Fentanyl
Front Neuroendocrinol. 2023 Aug 17:101096. doi: 10.1016/j.yfrne.2023.101096. Online ahead of print.ABSTRACTThe prevalence of opioid use disorder and overdose continues to harm the U.S. population and is further exacerbated by the use of the synthetic opioid, fentanyl, and its analogs. Gender differences in the effects of fentanyl are not well understood. The present article reviews evidence for gender and sex differences in the physiological and behavioral effects of fentanyl in humans and animals. Biological sex seems to be a foundational driver in addiction vulnerability and affects mechanisms related to opioid use inclu...
Source: Frontiers in Neuroendocrinology - August 19, 2023 Category: Endocrinology Authors: Kaitlyn M Little Therese A Kosten Source Type: research
