The interaction of genetic sex and prenatal alcohol exposure on health across the lifespan
Front Neuroendocrinol. 2023 Oct 4;71:101103. doi: 10.1016/j.yfrne.2023.101103. Online ahead of print.ABSTRACTPrenatal alcohol exposure (PAE) can reprogram the development of cells and tissues, resulting in a spectrum of physical and neurobehavioral teratology. PAE immediately impacts fetal growth, but its effects carry forward post-parturition, into adolescence and adulthood, and can result in a cluster of disabilities, collectively termed Fetal Alcohol Spectrum Disorders. Emerging preclinical and clinical research investigating neurological and behavioral outcomes in exposed offspring point to genetic sex as an important ...
Source: Frontiers in Neuroendocrinology - October 6, 2023 Category: Endocrinology Authors: Shameena Bake Siara K Rouzer Shruti Mavuri Rajesh C Miranda Amanda H Mahnke Source Type: research
The interaction of genetic sex and prenatal alcohol exposure on health across the lifespan
Front Neuroendocrinol. 2023 Oct 4;71:101103. doi: 10.1016/j.yfrne.2023.101103. Online ahead of print.ABSTRACTPrenatal alcohol exposure (PAE) can reprogram the development of cells and tissues, resulting in a spectrum of physical and neurobehavioral teratology. PAE immediately impacts fetal growth, but its effects carry forward post-parturition, into adolescence and adulthood, and can result in a cluster of disabilities, collectively termed Fetal Alcohol Spectrum Disorders. Emerging preclinical and clinical research investigating neurological and behavioral outcomes in exposed offspring point to genetic sex as an important ...
Source: Frontiers in Neuroendocrinology - October 6, 2023 Category: Endocrinology Authors: Shameena Bake Siara K Rouzer Shruti Mavuri Rajesh C Miranda Amanda H Mahnke Source Type: research
The interaction of genetic sex and prenatal alcohol exposure on health across the lifespan
Front Neuroendocrinol. 2023 Oct 4:101103. doi: 10.1016/j.yfrne.2023.101103. Online ahead of print.ABSTRACTPrenatal alcohol exposure (PAE) can reprogram the development of cells and tissues, resulting in a spectrum of physical and neurobehavioral teratology. PAE immediately impacts fetal growth, but its effects carry forward post-parturition, into adolescence and adulthood, and can result in a cluster of disabilities, collectively termed Fetal Alcohol Spectrum Disorders. Emerging preclinical and clinical research investigating neurological and behavioral outcomes in exposed offspring point to genetic sex as an important mod...
Source: Frontiers in Neuroendocrinology - October 6, 2023 Category: Endocrinology Authors: Shameena Bake Siara K Rouzer Shruti Mavuri Rajesh C Miranda Amanda H Mahnke Source Type: research
The interaction of genetic sex and prenatal alcohol exposure on health across the lifespan
Front Neuroendocrinol. 2023 Oct 4:101103. doi: 10.1016/j.yfrne.2023.101103. Online ahead of print.ABSTRACTPrenatal alcohol exposure (PAE) can reprogram the development of cells and tissues, resulting in a spectrum of physical and neurobehavioral teratology. PAE immediately impacts fetal growth, but its effects carry forward post-parturition, into adolescence and adulthood, and can result in a cluster of disabilities, collectively termed Fetal Alcohol Spectrum Disorders. Emerging preclinical and clinical research investigating neurological and behavioral outcomes in exposed offspring point to genetic sex as an important mod...
Source: Frontiers in Neuroendocrinology - October 6, 2023 Category: Endocrinology Authors: Shameena Bake Siara K Rouzer Shruti Mavuri Rajesh C Miranda Amanda H Mahnke Source Type: research
The interaction of genetic sex and prenatal alcohol exposure on health across the lifespan
Front Neuroendocrinol. 2023 Oct 4:101103. doi: 10.1016/j.yfrne.2023.101103. Online ahead of print.ABSTRACTPrenatal alcohol exposure (PAE) can reprogram the development of cells and tissues, resulting in a spectrum of physical and neurobehavioral teratology. PAE immediately impacts fetal growth, but its effects carry forward post-parturition, into adolescence and adulthood, and can result in a cluster of disabilities, collectively termed Fetal Alcohol Spectrum Disorders. Emerging preclinical and clinical research investigating neurological and behavioral outcomes in exposed offspring point to genetic sex as an important mod...
Source: Frontiers in Neuroendocrinology - October 6, 2023 Category: Endocrinology Authors: Shameena Bake Siara K Rouzer Shruti Mavuri Rajesh C Miranda Amanda H Mahnke Source Type: research
The interaction of genetic sex and prenatal alcohol exposure on health across the lifespan
Front Neuroendocrinol. 2023 Oct 4:101103. doi: 10.1016/j.yfrne.2023.101103. Online ahead of print.ABSTRACTPrenatal alcohol exposure (PAE) can reprogram the development of cells and tissues, resulting in a spectrum of physical and neurobehavioral teratology. PAE immediately impacts fetal growth, but its effects carry forward post-parturition, into adolescence and adulthood, and can result in a cluster of disabilities, collectively termed Fetal Alcohol Spectrum Disorders. Emerging preclinical and clinical research investigating neurological and behavioral outcomes in exposed offspring point to genetic sex as an important mod...
Source: Frontiers in Neuroendocrinology - October 6, 2023 Category: Endocrinology Authors: Shameena Bake Siara K Rouzer Shruti Mavuri Rajesh C Miranda Amanda H Mahnke Source Type: research
The interaction of genetic sex and prenatal alcohol exposure on health across the lifespan
Front Neuroendocrinol. 2023 Oct 4:101103. doi: 10.1016/j.yfrne.2023.101103. Online ahead of print.ABSTRACTPrenatal alcohol exposure (PAE) can reprogram the development of cells and tissues, resulting in a spectrum of physical and neurobehavioral teratology. PAE immediately impacts fetal growth, but its effects carry forward post-parturition, into adolescence and adulthood, and can result in a cluster of disabilities, collectively termed Fetal Alcohol Spectrum Disorders. Emerging preclinical and clinical research investigating neurological and behavioral outcomes in exposed offspring point to genetic sex as an important mod...
Source: Frontiers in Neuroendocrinology - October 6, 2023 Category: Endocrinology Authors: Shameena Bake Siara K Rouzer Shruti Mavuri Rajesh C Miranda Amanda H Mahnke Source Type: research
The interaction of genetic sex and prenatal alcohol exposure on health across the lifespan
Front Neuroendocrinol. 2023 Oct 4:101103. doi: 10.1016/j.yfrne.2023.101103. Online ahead of print.ABSTRACTPrenatal alcohol exposure (PAE) can reprogram the development of cells and tissues, resulting in a spectrum of physical and neurobehavioral teratology. PAE immediately impacts fetal growth, but its effects carry forward post-parturition, into adolescence and adulthood, and can result in a cluster of disabilities, collectively termed Fetal Alcohol Spectrum Disorders. Emerging preclinical and clinical research investigating neurological and behavioral outcomes in exposed offspring point to genetic sex as an important mod...
Source: Frontiers in Neuroendocrinology - October 6, 2023 Category: Endocrinology Authors: Shameena Bake Siara K Rouzer Shruti Mavuri Rajesh C Miranda Amanda H Mahnke Source Type: research
The interaction of genetic sex and prenatal alcohol exposure on health across the lifespan
Front Neuroendocrinol. 2023 Oct 4:101103. doi: 10.1016/j.yfrne.2023.101103. Online ahead of print.ABSTRACTPrenatal alcohol exposure (PAE) can reprogram the development of cells and tissues, resulting in a spectrum of physical and neurobehavioral teratology. PAE immediately impacts fetal growth, but its effects carry forward post-parturition, into adolescence and adulthood, and can result in a cluster of disabilities, collectively termed Fetal Alcohol Spectrum Disorders. Emerging preclinical and clinical research investigating neurological and behavioral outcomes in exposed offspring point to genetic sex as an important mod...
Source: Frontiers in Neuroendocrinology - October 6, 2023 Category: Endocrinology Authors: Shameena Bake Siara K Rouzer Shruti Mavuri Rajesh C Miranda Amanda H Mahnke Source Type: research
Neuroestradiol and neuronal development: Not an exclusive male tale anymore
Front Neuroendocrinol. 2023 Sep 7;71:101102. doi: 10.1016/j.yfrne.2023.101102. Online ahead of print.ABSTRACTThe brain synthesizes a variety of neurosteroids, including neuroestradiol. Inhibition of neuroestradiol synthesis results in alterations in basic neurodevelopmental processes, such as neurogenesis, neuroblast migration, neuritogenesis and synaptogenesis. Although the neurodevelopmental actions of neuroestradiol are exerted in both sexes, some of them are sex-specific, such as the well characterized effects of neuroestradiol derived from the metabolism of testicular testosterone during critical periods of male brain...
Source: Frontiers in Neuroendocrinology - September 9, 2023 Category: Endocrinology Authors: Luis M Garcia-Segura Pablo M éndez M Angeles Arevalo I ñigo Azcoitia Source Type: research
Neuroestradiol and neuronal development: Not an exclusive male tale anymore
Front Neuroendocrinol. 2023 Sep 7;71:101102. doi: 10.1016/j.yfrne.2023.101102. Online ahead of print.ABSTRACTThe brain synthesizes a variety of neurosteroids, including neuroestradiol. Inhibition of neuroestradiol synthesis results in alterations in basic neurodevelopmental processes, such as neurogenesis, neuroblast migration, neuritogenesis and synaptogenesis. Although the neurodevelopmental actions of neuroestradiol are exerted in both sexes, some of them are sex-specific, such as the well characterized effects of neuroestradiol derived from the metabolism of testicular testosterone during critical periods of male brain...
Source: Frontiers in Neuroendocrinology - September 9, 2023 Category: Endocrinology Authors: Luis M Garcia-Segura Pablo M éndez M Angeles Arevalo I ñigo Azcoitia Source Type: research
Neuroestradiol and neuronal development: Not an exclusive male tale anymore
Front Neuroendocrinol. 2023 Sep 7;71:101102. doi: 10.1016/j.yfrne.2023.101102. Online ahead of print.ABSTRACTThe brain synthesizes a variety of neurosteroids, including neuroestradiol. Inhibition of neuroestradiol synthesis results in alterations in basic neurodevelopmental processes, such as neurogenesis, neuroblast migration, neuritogenesis and synaptogenesis. Although the neurodevelopmental actions of neuroestradiol are exerted in both sexes, some of them are sex-specific, such as the well characterized effects of neuroestradiol derived from the metabolism of testicular testosterone during critical periods of male brain...
Source: Frontiers in Neuroendocrinology - September 9, 2023 Category: Endocrinology Authors: Luis M Garcia-Segura Pablo M éndez M Angeles Arevalo I ñigo Azcoitia Source Type: research
Neuroestradiol and neuronal development: Not an exclusive male tale anymore
Front Neuroendocrinol. 2023 Sep 7;71:101102. doi: 10.1016/j.yfrne.2023.101102. Online ahead of print.ABSTRACTThe brain synthesizes a variety of neurosteroids, including neuroestradiol. Inhibition of neuroestradiol synthesis results in alterations in basic neurodevelopmental processes, such as neurogenesis, neuroblast migration, neuritogenesis and synaptogenesis. Although the neurodevelopmental actions of neuroestradiol are exerted in both sexes, some of them are sex-specific, such as the well characterized effects of neuroestradiol derived from the metabolism of testicular testosterone during critical periods of male brain...
Source: Frontiers in Neuroendocrinology - September 9, 2023 Category: Endocrinology Authors: Luis M Garcia-Segura Pablo M éndez M Angeles Arevalo I ñigo Azcoitia Source Type: research
Neuroestradiol and neuronal development: Not an exclusive male tale anymore
Front Neuroendocrinol. 2023 Sep 7;71:101102. doi: 10.1016/j.yfrne.2023.101102. Online ahead of print.ABSTRACTThe brain synthesizes a variety of neurosteroids, including neuroestradiol. Inhibition of neuroestradiol synthesis results in alterations in basic neurodevelopmental processes, such as neurogenesis, neuroblast migration, neuritogenesis and synaptogenesis. Although the neurodevelopmental actions of neuroestradiol are exerted in both sexes, some of them are sex-specific, such as the well characterized effects of neuroestradiol derived from the metabolism of testicular testosterone during critical periods of male brain...
Source: Frontiers in Neuroendocrinology - September 9, 2023 Category: Endocrinology Authors: Luis M Garcia-Segura Pablo M éndez M Angeles Arevalo I ñigo Azcoitia Source Type: research
Neuroestradiol and neuronal development: Not an exclusive male tale anymore
Front Neuroendocrinol. 2023 Sep 7;71:101102. doi: 10.1016/j.yfrne.2023.101102. Online ahead of print.ABSTRACTThe brain synthesizes a variety of neurosteroids, including neuroestradiol. Inhibition of neuroestradiol synthesis results in alterations in basic neurodevelopmental processes, such as neurogenesis, neuroblast migration, neuritogenesis and synaptogenesis. Although the neurodevelopmental actions of neuroestradiol are exerted in both sexes, some of them are sex-specific, such as the well characterized effects of neuroestradiol derived from the metabolism of testicular testosterone during critical periods of male brain...
Source: Frontiers in Neuroendocrinology - September 9, 2023 Category: Endocrinology Authors: Luis M Garcia-Segura Pablo M éndez M Angeles Arevalo I ñigo Azcoitia Source Type: research
