Focus on Fentanyl in Females: Sex and Gender Differences in the Physiological and Behavioral Effects of Fentanyl
Front Neuroendocrinol. 2023 Aug 17:101096. doi: 10.1016/j.yfrne.2023.101096. Online ahead of print.ABSTRACTThe prevalence of opioid use disorder and overdose continues to harm the U.S. population and is further exacerbated by the use of the synthetic opioid, fentanyl, and its analogs. Gender differences in the effects of fentanyl are not well understood. The present article reviews evidence for gender and sex differences in the physiological and behavioral effects of fentanyl in humans and animals. Biological sex seems to be a foundational driver in addiction vulnerability and affects mechanisms related to opioid use inclu...
Source: Frontiers in Neuroendocrinology - August 19, 2023 Category: Endocrinology Authors: Kaitlyn M Little Therese A Kosten Source Type: research
Focus on Fentanyl in Females: Sex and Gender Differences in the Physiological and Behavioral Effects of Fentanyl
Front Neuroendocrinol. 2023 Aug 17:101096. doi: 10.1016/j.yfrne.2023.101096. Online ahead of print.ABSTRACTThe prevalence of opioid use disorder and overdose continues to harm the U.S. population and is further exacerbated by the use of the synthetic opioid, fentanyl, and its analogs. Gender differences in the effects of fentanyl are not well understood. The present article reviews evidence for gender and sex differences in the physiological and behavioral effects of fentanyl in humans and animals. Biological sex seems to be a foundational driver in addiction vulnerability and affects mechanisms related to opioid use inclu...
Source: Frontiers in Neuroendocrinology - August 19, 2023 Category: Endocrinology Authors: Kaitlyn M Little Therese A Kosten Source Type: research
Stress and Gonadal Steroid Influences on Alcohol Drinking and Withdrawal, with Focus on Animal Models in Females
Front Neuroendocrinol. 2023 Aug 7:101094. doi: 10.1016/j.yfrne.2023.101094. Online ahead of print.ABSTRACTSexually dimorphic effects of alcohol, following binge drinking, chronic intoxication, and withdrawal, are documented at the level of the transcriptome and in behavioral and physiological responses. The purpose of the current review is to update and to expand upon contributions of the endocrine system to alcohol drinking and withdrawal in females, with a focus on animal models. Steroids important in the hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes, the reciprocal interactions between these axe...
Source: Frontiers in Neuroendocrinology - August 9, 2023 Category: Endocrinology Authors: Deborah A Finn Source Type: research
Aversion-associated drug and alcohol seeking in females
Front Neuroendocrinol. 2023 Aug 7;71:101095. doi: 10.1016/j.yfrne.2023.101095. Online ahead of print.ABSTRACTCompulsive drug intake is characterized by the continuation of use regardless of negative consequences. This is modeled preclinically using procedures where a negative stimulus is delivered contingently with consumption of the reinforcer. In humans, women and men exhibit different drug taking behavior as it pertains to overall use, withdrawal symptoms, and rate of dependence. In substance use research, females have often been excluded from many studies due to concerns that circulating sex hormones may affect drug se...
Source: Frontiers in Neuroendocrinology - August 9, 2023 Category: Endocrinology Authors: Miranda E Arnold Jesse R Schank Source Type: research
Stress and Gonadal Steroid Influences on Alcohol Drinking and Withdrawal, with Focus on Animal Models in Females
Front Neuroendocrinol. 2023 Aug 7:101094. doi: 10.1016/j.yfrne.2023.101094. Online ahead of print.ABSTRACTSexually dimorphic effects of alcohol, following binge drinking, chronic intoxication, and withdrawal, are documented at the level of the transcriptome and in behavioral and physiological responses. The purpose of the current review is to update and to expand upon contributions of the endocrine system to alcohol drinking and withdrawal in females, with a focus on animal models. Steroids important in the hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes, the reciprocal interactions between these axe...
Source: Frontiers in Neuroendocrinology - August 9, 2023 Category: Endocrinology Authors: Deborah A Finn Source Type: research
Aversion-associated drug and alcohol seeking in females
Front Neuroendocrinol. 2023 Aug 7;71:101095. doi: 10.1016/j.yfrne.2023.101095. Online ahead of print.ABSTRACTCompulsive drug intake is characterized by the continuation of use regardless of negative consequences. This is modeled preclinically using procedures where a negative stimulus is delivered contingently with consumption of the reinforcer. In humans, women and men exhibit different drug taking behavior as it pertains to overall use, withdrawal symptoms, and rate of dependence. In substance use research, females have often been excluded from many studies due to concerns that circulating sex hormones may affect drug se...
Source: Frontiers in Neuroendocrinology - August 9, 2023 Category: Endocrinology Authors: Miranda E Arnold Jesse R Schank Source Type: research
Stress and Gonadal Steroid Influences on Alcohol Drinking and Withdrawal, with Focus on Animal Models in Females
Front Neuroendocrinol. 2023 Aug 7:101094. doi: 10.1016/j.yfrne.2023.101094. Online ahead of print.ABSTRACTSexually dimorphic effects of alcohol, following binge drinking, chronic intoxication, and withdrawal, are documented at the level of the transcriptome and in behavioral and physiological responses. The purpose of the current review is to update and to expand upon contributions of the endocrine system to alcohol drinking and withdrawal in females, with a focus on animal models. Steroids important in the hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes, the reciprocal interactions between these axe...
Source: Frontiers in Neuroendocrinology - August 9, 2023 Category: Endocrinology Authors: Deborah A Finn Source Type: research
Aversion-associated drug and alcohol seeking in females
Front Neuroendocrinol. 2023 Aug 7;71:101095. doi: 10.1016/j.yfrne.2023.101095. Online ahead of print.ABSTRACTCompulsive drug intake is characterized by the continuation of use regardless of negative consequences. This is modeled preclinically using procedures where a negative stimulus is delivered contingently with consumption of the reinforcer. In humans, women and men exhibit different drug taking behavior as it pertains to overall use, withdrawal symptoms, and rate of dependence. In substance use research, females have often been excluded from many studies due to concerns that circulating sex hormones may affect drug se...
Source: Frontiers in Neuroendocrinology - August 9, 2023 Category: Endocrinology Authors: Miranda E Arnold Jesse R Schank Source Type: research
Stress and Gonadal Steroid Influences on Alcohol Drinking and Withdrawal, with Focus on Animal Models in Females
Front Neuroendocrinol. 2023 Aug 7:101094. doi: 10.1016/j.yfrne.2023.101094. Online ahead of print.ABSTRACTSexually dimorphic effects of alcohol, following binge drinking, chronic intoxication, and withdrawal, are documented at the level of the transcriptome and in behavioral and physiological responses. The purpose of the current review is to update and to expand upon contributions of the endocrine system to alcohol drinking and withdrawal in females, with a focus on animal models. Steroids important in the hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes, the reciprocal interactions between these axe...
Source: Frontiers in Neuroendocrinology - August 9, 2023 Category: Endocrinology Authors: Deborah A Finn Source Type: research
Aversion-Associated Drug and Alcohol Seeking in Females
Front Neuroendocrinol. 2023 Aug 7:101095. doi: 10.1016/j.yfrne.2023.101095. Online ahead of print.ABSTRACTCompulsive drug intake is characterized by the continuation of use regardless of negative consequences. This is modeled preclinically using procedures where a negative stimulus is delivered contingently with consumption of the reinforcer. In humans, women and men exhibit different drug taking behavior as it pertains to overall use, withdrawal symptoms, and rate of dependence. In substance use research, females have often been excluded from many studies due to concerns that circulating sex hormones may affect drug seeki...
Source: Frontiers in Neuroendocrinology - August 9, 2023 Category: Endocrinology Authors: Miranda E Arnold Jesse R Schank Source Type: research
Stress and Gonadal Steroid Influences on Alcohol Drinking and Withdrawal, with Focus on Animal Models in Females
Front Neuroendocrinol. 2023 Aug 7:101094. doi: 10.1016/j.yfrne.2023.101094. Online ahead of print.ABSTRACTSexually dimorphic effects of alcohol, following binge drinking, chronic intoxication, and withdrawal, are documented at the level of the transcriptome and in behavioral and physiological responses. The purpose of the current review is to update and to expand upon contributions of the endocrine system to alcohol drinking and withdrawal in females, with a focus on animal models. Steroids important in the hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes, the reciprocal interactions between these axe...
Source: Frontiers in Neuroendocrinology - August 9, 2023 Category: Endocrinology Authors: Deborah A Finn Source Type: research
Aversion-Associated Drug and Alcohol Seeking in Females
Front Neuroendocrinol. 2023 Aug 7:101095. doi: 10.1016/j.yfrne.2023.101095. Online ahead of print.ABSTRACTCompulsive drug intake is characterized by the continuation of use regardless of negative consequences. This is modeled preclinically using procedures where a negative stimulus is delivered contingently with consumption of the reinforcer. In humans, women and men exhibit different drug taking behavior as it pertains to overall use, withdrawal symptoms, and rate of dependence. In substance use research, females have often been excluded from many studies due to concerns that circulating sex hormones may affect drug seeki...
Source: Frontiers in Neuroendocrinology - August 9, 2023 Category: Endocrinology Authors: Miranda E Arnold Jesse R Schank Source Type: research
Stress and Gonadal Steroid Influences on Alcohol Drinking and Withdrawal, with Focus on Animal Models in Females
Front Neuroendocrinol. 2023 Aug 7:101094. doi: 10.1016/j.yfrne.2023.101094. Online ahead of print.ABSTRACTSexually dimorphic effects of alcohol, following binge drinking, chronic intoxication, and withdrawal, are documented at the level of the transcriptome and in behavioral and physiological responses. The purpose of the current review is to update and to expand upon contributions of the endocrine system to alcohol drinking and withdrawal in females, with a focus on animal models. Steroids important in the hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes, the reciprocal interactions between these axe...
Source: Frontiers in Neuroendocrinology - August 9, 2023 Category: Endocrinology Authors: Deborah A Finn Source Type: research
Aversion-Associated Drug and Alcohol Seeking in Females
Front Neuroendocrinol. 2023 Aug 7:101095. doi: 10.1016/j.yfrne.2023.101095. Online ahead of print.ABSTRACTCompulsive drug intake is characterized by the continuation of use regardless of negative consequences. This is modeled preclinically using procedures where a negative stimulus is delivered contingently with consumption of the reinforcer. In humans, women and men exhibit different drug taking behavior as it pertains to overall use, withdrawal symptoms, and rate of dependence. In substance use research, females have often been excluded from many studies due to concerns that circulating sex hormones may affect drug seeki...
Source: Frontiers in Neuroendocrinology - August 9, 2023 Category: Endocrinology Authors: Miranda E Arnold Jesse R Schank Source Type: research
Stress and Gonadal Steroid Influences on Alcohol Drinking and Withdrawal, with Focus on Animal Models in Females
Front Neuroendocrinol. 2023 Aug 7:101094. doi: 10.1016/j.yfrne.2023.101094. Online ahead of print.ABSTRACTSexually dimorphic effects of alcohol, following binge drinking, chronic intoxication, and withdrawal, are documented at the level of the transcriptome and in behavioral and physiological responses. The purpose of the current review is to update and to expand upon contributions of the endocrine system to alcohol drinking and withdrawal in females, with a focus on animal models. Steroids important in the hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes, the reciprocal interactions between these axe...
Source: Frontiers in Neuroendocrinology - August 9, 2023 Category: Endocrinology Authors: Deborah A Finn Source Type: research
