Pediatric Dermatologist UC Davis School of Medicine Department of Dermatology.
Abstract The University of California, Davis, School of Medicine, Department of Dermatology, is recruiting for a PediatricDermatologist in the Clinical X series or Health Sciences Clinical Professor (HSCP) series at the Assistant/Associate/FullProfessor level based on experience and qualifications. The appointment may be made up to 100%.Basic Qualifications: Candidates must possess an MD or MD/PhD, can be board eligible, but must be board-certified in dermatology at the time ofstarting employment and must be eligible for medical licensure in the State of California. Candidates must also be board eligible in ...
Source: Dermatol Online J - October 15, 2019 Category: Dermatology Authors: Department Of Dermatology UDSOM Tags: Dermatol Online J Source Type: research

Review of onychocryptosis: epidemiology, pathogenesis, risk factors, diagnosis and treatment.
Abstract Ingrown toenail, or onychocryptosis, is a highly prevalent nail condition that occurs when the nail edge grows into the periungual dermis. It most frequently affects the hallux and has a biphasic presentation, being most common in the second and fifth decades. It is often painful and may be debilitating in severe cases. Risk factors include trauma, weight changes, poor nail-cutting technique, and hyperhidrosis. Both conservative and surgical treatments have been described, and choice of therapy is dependent on patient co-morbidities, severity, and associated symptoms. This review covers the epidemiology, ...
Source: Dermatol Online J - September 15, 2019 Category: Dermatology Authors: Geizhals S, Lipner SR Tags: Dermatol Online J Source Type: research

Omphaloliths: a case series and review of 29 cases in literature.
We present three cases of omphaloliths from our department and review all 26 cases previously reported in the English literature with regard to modes of presentation, potential risk factors, complications, and treatment options to guide clinicians. The mean age at presentation was 48 years. Of the 29 cases, 17 (59%) were asymptomatic. Male patients presented at a younger age and were more likely to present with complications compared to females who presented at an older age with asymptomatic lesions (P=0.006). Features of patients described included dementia, hirsutism, a deep or narrow umbilicus, multiple nevi, obesity, a...
Source: Dermatol Online J - September 15, 2019 Category: Dermatology Authors: Soriano LF, Pathmarajah P, Rajpopat S, Sahota A Tags: Dermatol Online J Source Type: research

What patients see online: assessing the online identities of Pennsylvania dermatologists.
CONCLUSION: Dermatologists should be better aware of their digital presence and the strategies to better control their online identity. PMID: 31738838 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - September 15, 2019 Category: Dermatology Authors: Karanfilian KM, De Guzman E, Kim C, Madill E, Ayyaswami V, Kamath P, Agarwal N, Koch E, Prabhu AV Tags: Dermatol Online J Source Type: research

Interactive teaching and repeat exposure maximize medical student satisfaction but do not promote long-term retention of dermatologic knowledge.
CONCLUSIONS: Medical students are able to maintain long-term retention of dermatologic knowledge irrespective of in-class teaching method. Repeat exposure to material is important but self-review of dermatology alone is sufficient for long-term retention. Dermatology course directors should incorporate interactive teaching into medical school curricula to increase learner satisfaction. PMID: 31738839 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - September 15, 2019 Category: Dermatology Authors: Watchmaker J, Gonzales EC, Larson AR Tags: Dermatol Online J Source Type: research

Primary cutaneous Epstein-Barr virus-positive diffuse large B-cell lymphoma (DLBCL) in a patient taking fingolimod.
Abstract A 55-year-old man with relapsing-remitting multiple sclerosis on fingolimod presented to the dermatology clinic with skin lesions on the left temple and cheek. Histopathology showed a diffuse infiltrate of enlarged, atypical lymphocytes throughout the dermis with an overlying grenz zone and a subpopulation of scattered smaller lymphocytes and plasma cells. Epstein-Barr virus-encoded RNA in situ hybridization stain was positive. Based on the morphologic and immunophenotypic findings, a diagnosis of EBV-positive diffuse large B-cell lymphoma was made. This case aims to raise awareness for the dermatologist ...
Source: Dermatol Online J - September 15, 2019 Category: Dermatology Authors: Wills A, Fan G, Kim E, Okada CY, White KP, Hopkins RS Tags: Dermatol Online J Source Type: research

Nutritional deficiency dermatitis related to branched-chain amino acid restriction in a child with maple syrup urine disease.
We present a one-year-old girl with maple syrup urine disease with dermatitis secondary to the restriction of amino acids as part of the treatment. We present the clinical evolution and histopathological correlation. PMID: 31738841 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - September 15, 2019 Category: Dermatology Authors: Campuzano-García AE, Castanedo-Cázares JP Tags: Dermatol Online J Source Type: research

Vulvar Majocchi granuloma and kerion formation in an immunocompetent female.
We report a rare case of vulvar Majocchi granuloma and kerion formation secondary to Trichophyton in an immunocompetent woman. The patient responded well to oral terbinafine and a short course of oral corticosteroids with a slow taper. Resolution of deep dermatophytosis requires prompt pathogen identification and treatment to avoid scarring and hair loss. Herein, we aim to increase clinical awareness and early recognition of this atypical presentation of a Majocchi granuloma with kerion formation. PMID: 31738842 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - September 15, 2019 Category: Dermatology Authors: Labadie JG, Guggina LM Tags: Dermatol Online J Source Type: research

Two cases of atypical periorificial dermatitis caused by Candida parapsilosis in patients volunteering in dog shelters.
Abstract Candida is a genus of yeasts that can be a part of normal human skin flora, but may cause disease when the skin barrier is compromised. C. albicans is the most common pathogenic species of this genus, but in recent years infection with other species, such as C. parapsilosis has been growing. C. parapsilosis is a species of Candida that has been found in the skin of humans and other mammals, including dogs. In this brief report, the authors describe two cases of atypical periorifical infection with C. parapsilosis in patients who both volunteered in dog shelters. Owing to the atypical presentation of the f...
Source: Dermatol Online J - September 15, 2019 Category: Dermatology Authors: Pettit C, Diaz S, Kaffenberger B Tags: Dermatol Online J Source Type: research

Tufted angioma presenting with subclinical coagulopathy.
We present an asymptomatic 10-month-old boy who presented with an erythematous patch of the right upper extremity and subsequently was diagnosed by biopsy with tufted angioma. Baseline laboratory workup of our patient revealed mildly decreased fibrinogen and elevated D-dimer levels without thrombocytopenia or elevated partial thromboplastin time. This suggests that asymptomatic patients with tufted angioma may present with coagulopathy in the absence of Kasabach-Merritt phenomenon. This also highlights the importance of obtaining baseline laboratory workup in patients presenting with tufted angioma. PMID: 31738844 [Pu...
Source: Dermatol Online J - September 15, 2019 Category: Dermatology Authors: Cohen S, Anderson KL, Sangueza OP, Taylor SL Tags: Dermatol Online J Source Type: research

Digital ulcerative lichenoid dermatitis in a patient receiving anti-PD-1 therapy.
This report adds an undescribed reaction to the increasing diversity of cutaneous irAE associated with anti-PD-1 therapy. PMID: 31738845 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - September 15, 2019 Category: Dermatology Authors: Martínez-Doménech Á, García-Legaz Martínez M, Magdaleno-Tapial J, Valenzuela-Oñate C, Pérez-Pastor G, Pérez-Ferriols A Tags: Dermatol Online J Source Type: research

Pigmented fungiform papillae of the tongue: a clinical and histologic description.
Abstract A 28-year-old man with a history of mycosis fungoides presented for evaluation of multiple dark-brown macules and hyperpigmented dome-shaped papules on the distal tongue. A shave biopsy of the tongue revealed melanin pigment in the basal keratinocytes and melanophages in the lamina propria, consistent with pigmented fungiform papillae of the tongue. Relevant clinical and histologic features of this diagnosis are reviewed. PMID: 31738846 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - September 15, 2019 Category: Dermatology Authors: Chamseddin B, Vandergriff T Tags: Dermatol Online J Source Type: research

Classic features of primary systemic amyloidosis (AL amyloidosis) leading to diagnosis of plasma cell myeloma.
Abstract The diagnosis of primary systemic amyloidosis, also known as AL (amyloid light-chain) amyloidosis, is often delayed owing to its nonspecific manifestations as well as its rarity. A 64-year-old woman presented with an eight-month history of significant weight loss, anemia, fatigue, and progressive painful cutaneous lesions on her hands, lips, back, perianal, and vulvar area that were originally treated unsuccessfully with antimalarials and systemic corticosteroids. Histopathological examination revealed an amorphous dermis with pale pink material that demonstrated positive birefringence with Congo red stai...
Source: Dermatol Online J - September 15, 2019 Category: Dermatology Authors: Tan KW, Zhu B, Behrens E, Tarbox MB Tags: Dermatol Online J Source Type: research

Systemic contact dermatitis related to alcoholic beverage consumption.
Abstract Systemic contact dermatitis is a rash secondary to systemic exposure to allergens after sensitization. Numerous agents are implicated including Balsam of Peru, a plant-derived compound often used for flavoring and fragrance. Alcoholic beverages can contain many possible allergens, including cinnamon, vanilla, citrus peels, and Balsam of Peru. Herein, we describe two patients presenting with recurrent, diffuse, erythematous, and pruritic cutaneous eruptions suspicious for contact dermatitis. Based on clinical history, exam, and formal and at-home patch testing results, we believe the most likely etiology w...
Source: Dermatol Online J - September 15, 2019 Category: Dermatology Authors: Ramachandran V, Cline A, Feldman SR Tags: Dermatol Online J Source Type: research

Successful treatment of hidradenitis suppurativa in the setting of Crohn disease with combination adalimumab and ustekinumab.
Abstract Herein we report the combination of adalimumab and ustekinumab to successfully treat a 39-year-old woman who presented for evaluation of hidradenitis suppurativa in the setting of Crohn disease of both the small and large intestine. The patient reported previous control of her hidradenitis when she was using adalimumab for her Crohn disease. She had recently been started on ustekinumab for Crohn disease and had flaring of her hidradenitis. The patient re-started on adalimumab weekly and ustekinumab every 8 weeks. After one month, the patient reported clear improvement in her hidradenitis and Crohn disease...
Source: Dermatol Online J - September 15, 2019 Category: Dermatology Authors: Cline A, Pichardo RO Tags: Dermatol Online J Source Type: research

Contact dermatitis: one for the books.
We present a case of a well-demarcated, erythematous, scaly plaque on a finger caused from reading with an e-book device. Although metal from mobile devices can cause ACD, mobile device cases may cause irritation or contain additives that can also cause contact dermatitis. Similar presentations of contact dermatitis may become more common as technology use increases. PMID: 31738850 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - September 15, 2019 Category: Dermatology Authors: Su JJ, Haidari W, Hoffman MB, Feldman SR Tags: Dermatol Online J Source Type: research

Artifacts and landmarks: pearls and pitfalls for in vivo reflectance confocal microscopy of the skin using the tissue-coupled device.
Abstract Reflectance confocal microscopy (RCM) is a non-invasive imaging tool for cellular-level examination of skin lesions, typically from the epidermis to the superficial dermis. Clinical studies show RCM imaging is highly sensitive and specific in the diagnosis of skin diseases. RCM is disseminating from academic tertiary care centers with early adopter "experts" into diverse clinical settings, with image acquisition performed by technicians and image interpretation by physicians. In the hands of trained users, RCM serves an aid to accurately diagnose and monitor skin tumors and inflammatory processe...
Source: Dermatol Online J - August 15, 2019 Category: Dermatology Authors: Gill M, Alessi-Fox C, Kose K Tags: Dermatol Online J Source Type: research

Fall risk assessment and injury prevention in the Mohs surgery clinic: a review of the literature and recommendations for improving patient safety.
CONCLUSION: Identifying fall risk factors can improve patient safety and reduce falls in the dermatologic surgery clinic. PMID: 31553857 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - August 15, 2019 Category: Dermatology Authors: Lopez AT, Fisher J, Samie FH Tags: Dermatol Online J Source Type: research

A review of topical corticosteroid sprays for the treatment of inflammatory dermatoses.
Abstract BACKGROUND: Topical corticosteroids are available in many vehicles. However, patients' preference for vehicles are variable and could be tailored to maximize patient adherence. Spray vehicles may offer, convenience, and strong efficacy. METHODS: A literature review was conducted using keywords: clobetasol, desoximetasone, betamethasone, triamcinolone, corticosteroid, topical, spray, vehicles, treatment, and clinical trial. RESULTS: For moderate-to-severe plaque psoriasis, 87% of subjects achieved an Overall Disease Severity (ODS) Score ≤2 at week two and 78% achieved an ODS ≤1 after four w...
Source: Dermatol Online J - August 15, 2019 Category: Dermatology Authors: Habet KA, Kolli SS, Pona A, Feldman SR Tags: Dermatol Online J Source Type: research

The prevalence of atopic dermatitis in adults: systematic review on population studies.
Abstract Atopic dermatitis (AD) is a common multifactorial skin disease occurring primarily in young children. AD has increased in prevalence over the past decades, but little knowledge exists on the prevalence of AD in adults. Herein, published estimates of the point-prevalence and one-year prevalence of AD in adults are reviewed in the context of various study characteristics such as the age and gender distribution of the populations, sampling methods, study design, and geographical area of origin. In total, 14 different population studies reporting the prevalence of AD in adults in 17 countries were identified....
Source: Dermatol Online J - August 15, 2019 Category: Dermatology Authors: Mathiesen SM, Thomsen SF Tags: Dermatol Online J Source Type: research

What are the ethical and legal considerations when your patient refuses the standard of care?
Abstract In medical practice, physicians are sometimes faced with patients who reject the gold-standard treatment for a condition. In this hypothetical clinical scenario, we present the case of a patient who refuses Mohs micrographic surgery for management of infiltrative basal cell carcinoma and instead requests off-label therapy with imiquimod. We discuss the treating dermatologist's options in response to this patient's request and the ethical considerations surrounding the case. We conclude that the physician has the right to refuse to provide treatment that deviates from standard clinical practice but that th...
Source: Dermatol Online J - August 15, 2019 Category: Dermatology Authors: Braun TL, Patel V, Dao H, Rosen T Tags: Dermatol Online J Source Type: research

A strategic evidence-based framework for international medical graduates (IMGs) applying to dermatology residence in the United States: a literature review.
Abstract Dermatology is one of the least diverse medical fields, partly owing to the low number of international medical graduates that apply and match to dermatology residency programs in the United States each year. Our objective was to determine and outline the factors that can increase competitiveness of international applicants interested in applying to dermatology residency in the U.S. Higher match rates for IMGs were associated with several applicant-dependent characteristics, including higher USMLE scores, higher research participation and numbers of publications, strong recommendation letters, and dermato...
Source: Dermatol Online J - August 15, 2019 Category: Dermatology Authors: Ramos-Rodriguez AJ, Timerman D, Kyriacou MI, Martin RF Tags: Dermatol Online J Source Type: research

Discrete cutaneous lesions in a critically ill patient treated only for AIDS and miliary tuberculosis: a case report of disseminated histoplasmosis.
Abstract Histoplasmosis is a systemic mycosis caused by the dimorphic fungus Histoplasma capsulatum, with disseminated histoplasmosis (HD) being one of its clinical forms. As a consequence of the HIV-AIDS pandemic, HD has become prevalent not only in regions that are recognized as endemic but also in areas not considered endemic, such as Europe and Asia. Its clinical manifestations are varied and mimic several infectious diseases, mainly tuberculosis. In endemic areas, it is the first manifestation of AIDS in 50 to 70% of patients. The diagnosis of histoplasmosis is difficult and HD can lead to death if not diagno...
Source: Dermatol Online J - August 15, 2019 Category: Dermatology Authors: Oliveira RD, Alencar RRFR, Antonio BVR, Leal PC, Franco EDS, Santos LMD Tags: Dermatol Online J Source Type: research

Cutaneous collagenous vasculopathy: papular form.
We present a patient with histopathologic features of cutaneous collagenous vasculopathy and scattered erythematous papules on the trunk with a striking dermatoscopic finding. We propose the term of 'cutaneous papular collagenous vasculopathy' as a new clinical manifestation of this disease. PMID: 31553863 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - August 15, 2019 Category: Dermatology Authors: Conde-Ferreirós A, Roncero-Riesco M, Cañueto J, Román-Curto C, Santos-Briz Á Tags: Dermatol Online J Source Type: research

A neonatal pustule:Langerhans cell histiocytosis.
We present a case of single lesion self-limited LCH in a full-term male infant with interesting morphology. Physical examination revealed a painless, 6 millimeter, well-demarcated, papule encircled by erythema with central hemorrhage. An infectious workup was negative and a punch biopsy was obtained, which showed a dermal infiltrate of histiocytes consistent with a diagnosis of LCH. The lesion healed without intervention within three weeks. Our case highlights the need for dermatologists to consider LCH in the differential diagnosis for lesions of varying morphology in children, as proper identification is necessary to mon...
Source: Dermatol Online J - August 15, 2019 Category: Dermatology Authors: McKenzie S, Vecerek N, Kang Y, Knowles B, Hogeling M Tags: Dermatol Online J Source Type: research

Eosinophilic fasciitis presenting as a unilateral, solitary plaque.
Abstract Eosinophilic fasciitis is a rare connective tissue disorder characterized by inflammation of the fascia that leads to painful, indurated skin. Because of its variable clinical presentation and overlap with conditions, such as morphea, the diagnosis of eosinophilic fasciitis can be challenging and relies on clinical presentation, histopathologic and laboratory analysis, and response to therapy. Herein, we present an unusual, solitary, isolated plaque with pathologic features and response to therapy most consistent with eosinophilic fasciitis. PMID: 31553865 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - August 15, 2019 Category: Dermatology Authors: Alexanian C, Cheng M, Kiuru M, Wang JZ, Le ST, Tartar DM Tags: Dermatol Online J Source Type: research

Treatment-resistant ulcerative necrobiosis lipoidica in a diabetic patient responsive to ustekinumab.
We present a case of a 29-year-old female with uncontrolled diabetes and treatment-resistant necrobiosis lipoidica which was responsive to ustekinumab. PMID: 31553866 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - August 15, 2019 Category: Dermatology Authors: Pourang A, Sivamani RK Tags: Dermatol Online J Source Type: research

Low-dose naltrexone: a novel adjunctive treatment in symptomatic alopecias?
Abstract Naltrexone is a competitive antagonist of μ, κ and γ opioid receptors, used for treatment of alcoholism and opioid addiction. Low-dose naltrexone (LDN) is defined as daily doses ranging from 1mg to 5mg. This is purported to have a paradoxical effect that leads to an increase in endogenous opioids, including beta-endorphins, which have anti-inflammatory properties. Theses mechanisms may also justify their possible role in the treatment of inflammatory conditions. The aim of this article is to discuss the use of LDN as an adjuvant therapeutic option in symptomatic alopecias presenting with tr...
Source: Dermatol Online J - August 15, 2019 Category: Dermatology Authors: Tortelly VD, De Mattos T, Fernandes LSA, Nunes BEM, Melo DF Tags: Dermatol Online J Source Type: research

Horizontal animation deformity as unusual complication of neurotoxin modulation of the gummy smile.
Abstract Injections of botulinum toxin type A represent the most common nonsurgical cosmetic treatment worldwide. The authors report a case of dynamic horizontal wrinkling in the upper lip that appeared after botulinum toxin type A injections to treat gummy smile associated with nasal alar base reduction, in a 28-year-old woman. The anatomic features and pathogenic mechanism underlying this unusual complication are analyzed and discussed. PMID: 31553868 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - August 15, 2019 Category: Dermatology Authors: Chen G, Oranges CM, Giordano S, Huang R, Wang W Tags: Dermatol Online J Source Type: research

Resolution of folliculitis decalvans with medical honey.
In this report, we posit the potential utility of medical grade honey as a safe and cost-effective adjuvant therapy in the treatment of folliculitis decalvans. We describe a patient with painful, boggy scalp pustules who achieved clearance of his scalp lesions with the addition of Manuka honey. To our knowledge, this report is the first to demonstrate the clinical use of honey in the management of folliculitis decalvans and may lend support to the role of Staphylococcus in the pathogenesis of this disease. PMID: 31553869 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - August 15, 2019 Category: Dermatology Authors: Yeh JE, Hartman RI, Xu J, Hoang M, Yasuda MR Tags: Dermatol Online J Source Type: research

Advertisement for Assistant/Associate/Full ClinX/HSCP (4 Positions) UC Davis School of Medicine, Department of Dermatology.
Abstract The University of California, Davis, School of Medicine, Department of Dermatology, is recruiting for four academic dermatologists in the Clinical X series or Health Sciences Clinical Professor (HSCP) series at the Assistant/Associate/Full Professor level based on experience and qualifications. These positions are for general medical dermatologists. The appointments may be made up to 100%.   Basic Qualifications: Candidates must possess an MD or MD/PhD, can be board eligible, but must be board-certified in dermatology at the time of starting employment and must be eligible for medical licensure in th...
Source: Dermatol Online J - August 15, 2019 Category: Dermatology Authors: Department Of Dermatology UDSOM Tags: Dermatol Online J Source Type: research

A review of next generation sequencing technologies used in the evaluation of the skin microbiome: what a time to be alive.
Abstract The role of the microbiome in healthy and disease states of the human body is progressively being found to extend beyond the gastrointestinal tract and into other organ systems such as the skin. Researching the microbiome thus has become paramount to understanding additional physiological and pathophysiological mechanisms that may be at play between microbes and their hosts. Cell cultures have traditionally been used to study the microbiome, but in our current day and age, advanced metagenomic techniques - such as 16S rRNA amplicon sequencing and whole metagenomic shotgun sequencing - are better able to c...
Source: Dermatol Online J - July 15, 2019 Category: Dermatology Authors: Sandhu SS, Pourang A, Sivamani RK Tags: Dermatol Online J Source Type: research

Melanoma screening using patient self-assessed risk and total body photography.
Abstract The current standard of care for high-risk melanoma patients is a two-step process using Total Body Photography (TBP) followed by dermoscopy and is limited to a select group of patients. Methods: A cross-sectional study of patient characteristics and self-reported melanoma risk factors associated with TBP usage and pathology-confirmed outcomes was conducted on a sample of 4,692 patients in a single practitioner private dermatology setting. Results: TBP patients were significantly more likely to be male, partnered, tobacco users, highly educated, and have increased self-reported risk factors (such as fair ...
Source: Dermatol Online J - July 15, 2019 Category: Dermatology Authors: Drugge ED, Okundaye OI, Sarac RM, Drugge RJ Tags: Dermatol Online J Source Type: research

DNA-based detection for onychomycosis correlates better to histopathology than does fungal culture.
We describe a real-time PCR assay for 15 different fungi that are associated with onychomycosis. Of 425 clinical samples suspected of onychomycosis analyzed by fungal culture and PCR, 219 samples were positive for both (52% agreement). Of the 206 discordant samples, 95% were resolved in favor of PCR by DNA sequencing. On a larger data set of 2,452 samples, positivity rates for histopathology, PCR, and culture were 85%, 73%, and 54% respectively. Further, 48% of PCR positive and 51% of histopathology positive samples were negative by culture. PCR outperformed culture compared to histopathology for sensitivity (80% versus 49...
Source: Dermatol Online J - July 15, 2019 Category: Dermatology Authors: Gustafson E, Bakotic W, Bennett L, Page L, McCarthy L Tags: Dermatol Online J Source Type: research

Quantification of ultraviolet (UV) radiation in the shade and in direct sunlight.
Abstract Ultraviolet (UV) radiation is associated with negative health effects, including sun damage and skin cancer. The purpose of this study is to compare the protective effects of the shade provided by a sun umbrella versus that provided by a tree. Sun sensors that register the level and dose of UV radiation were placed in the shade and in direct sunlight. Measurements were recorded every half hour between the hours of 12:30 p.m. and 3:00 p.m. in Sacramento, California. The results suggest that the level of UV radiation in the shade is not zero. The sensors located in tree shade indicated that over 5% of UV ra...
Source: Dermatol Online J - July 15, 2019 Category: Dermatology Authors: Saric-Bosanac SS, Clark AK, Nguyen V, Pan A, Chang FY, Li CS, Sivamani RK Tags: Dermatol Online J Source Type: research

Granulomatous slack skin: case report with electron microscopic features.
Abstract Granulomatous slack skin (GSS) is a rare subtype of mycosis fungoides. It usually presents as slowly evolving, erythematous, slack plaques that usually involve folds of lax skin. Herein, we report a case of GSS and we show electron microscopy examination. Atypical T cells with convoluted and cerebriform nuclei, lymphophagocytosis, and elastophagocytosis are key features of GSS under electron microscopy. PMID: 31450274 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - July 15, 2019 Category: Dermatology Authors: Wang B, Zheng J, Wang HW Tags: Dermatol Online J Source Type: research

Epidermotropic CXCR3 positive marginal zone lymphoma: a distinctive clinical histopathological entity potentially originating in the skin; it does not always indicate splenic marginal zone lymphoma.
We present an 89-year-old man with epidermotropic B cell lymphoma, who presented with a pityriasis rosea-like skin rash. An initial diagnosis of diffuse large cell B cell lymphoma was made based on the extent of dermal-based large cell infiltration. However, after recognizing the epidermotropic component and the distinctive clinical presentation, a diagnosis of epidermotropic B cell lymphoma was rendered. There was minimal bone marrow involvement based only on flow cytometric analysis, but there was no apparent bone marrow or splenic involvement on routine light microscopic assessment. Remission was = achieved with single ...
Source: Dermatol Online J - July 15, 2019 Category: Dermatology Authors: Magro CM, Momtahen S, Coleman M, Grossman ME Tags: Dermatol Online J Source Type: research

An unusual spiculated presentation of follicular porokeratosis.
We present the case of a 26-year-old man with chronic diffuse follicular spicules associated with alopecia. Clinical findings were suggestive of trichodysplasia spinulosa, but multiple biopsies showed findings consistent with follicular porokeratosis. Diffusely spiculated presentation as present in our patient has not been previously reported in the literature. It is important to recognize the necessity of histopathologic confirmation in a diagnostically challenging condition such as follicular porokeratosis. PMID: 31450276 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - July 15, 2019 Category: Dermatology Authors: Young PM, Leavens J, Gaspard S, Kim G, Armstrong AW Tags: Dermatol Online J Source Type: research

Two siblings affected by Netherton/Com èl syndrome. Diagnostic pathology and description of a new SPINK5 variant.
We describe two siblings affected by Netherton/Comèl syndrome who were referred to our Center for Genodermatosis. A diagnostic pathway and the description of a new SPINK5 variant has been determined for these two patients. A novel genetic mutation has been found. PMID: 31450277 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - July 15, 2019 Category: Dermatology Authors: Schepis C, Siragusa M, Centofanti A, Vinci M, Calì F Tags: Dermatol Online J Source Type: research

Juvenile hyaline fibromatosis: an unusual clinical presentation.
We report a localized form of juvenile hyaline fibromatosis, a rare disease with several cases reported in the worldwide literature. A 23-year-old man presented with multiple tumors, joint contractures, and osteolytic bone lesions, but without gingival hyperplasia in one year of follow-up. Although, the onset of this condition is commonly in early childhood with progression, his unusual clinical presentation began at eight years of age with late progression in adolescence. PMID: 31450278 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - July 15, 2019 Category: Dermatology Authors: Lyra ALCO, Razo LM, Estrella RR, Pantaleão L Tags: Dermatol Online J Source Type: research

Cutaneous manifestations of angioimmunoblastic T-cell lymphoma.
Abstract Angioimmunoblastic T-cell lymphoma (AITL) is a rare form of non-Hodgkin lymphoma often accompanied by autoimmune and paraneoplastic phenomena. Up to 50% of patients with AITL present with skin manifestations. This case series highlights two cases of AITL presenting with unusual cutaneous findings: one with a medium-vessel vasculitis and another with a chronic urticarial eruption. Clinicians should consider AITL in the differential diagnosis of vasculitis or urticaria refractory to standard treatment. PMID: 31450279 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - July 15, 2019 Category: Dermatology Authors: Hoskins S, Moriarty N, White K, Kalus A, Shustov A, Shinohara MM Tags: Dermatol Online J Source Type: research

Onset of frontal fibrosing alopecia during inhibition of Th1/17 Pathways with ustekinumab.
We present a 62-year-old woman who developed persistent FFA while on ustekinumab for treatment of preexisting psoriasis. This case presents evidence against Th1 and Th17 pathways as essential to pathogenesis in FFA. This case also suggests that IL-12 and IL-23 inhibition is ineffective for this form of scarring alopecia. PMID: 31450280 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - July 15, 2019 Category: Dermatology Authors: King AD, Lam L, Goh C Tags: Dermatol Online J Source Type: research

Tiger-like mycosis fungoides: an unusual clinical presentation of a rare variant of mycosis fungoides.
We describe a 72-year-old man, who presented with a two-year history of an unusual eruption, which started on the abdomen, around the waistline, and gradually spread to involve his back, trunk, and buttocks. Clinically, the skin eruption presented as tiger-like stripes. The diagnosis was confirmed after histopathologic examination. The patient was treated with NB-UVB phototherapy with marked improvement. PMID: 31450281 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - July 15, 2019 Category: Dermatology Authors: Ahmad A, Semkova K, Stefanato CM, Calonje EJ, Choczaj-Kukula A, Palamaras I Tags: Dermatol Online J Source Type: research

Interstitial granulomatous drug reaction related to hydrochlorothiazide.
We present a case of interstitial granulomatous drug reaction related to hydrochlorothiazide and our approach to management of this condition. The diagnosis was confirmed with a skin biopsy and a rechallenge of hydrochlorothiazide, which exacerbated the patient's symptoms. The patient improved significantly with rigorous photoprotection, combination dapsone-alitretinoin therapy, and discontinuation of hydrochlorothiazide. PMID: 31450282 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - July 15, 2019 Category: Dermatology Authors: Grose E, Ramien M Tags: Dermatol Online J Source Type: research

Twenty-year-old woman presenting with typical Kawasaki disease.
We describe adult-onset Kawasaki disease (KD) and review clinical manifestations and treatment guidelines. Our patient is a 20-year-old female who initially presented to an outside hospital for fever, cervical lymphadenopathy, malaise, exudative tonsillitis, and skin eruption. She received antibiotics for suspected exudative pharyngitis, but experienced continued fevers and presented to the UCLA emergency room one week later. She had diffuse petechial macules coalescing into reticulated patches, fingertip peeling, conjunctival injection, oral erosions, and tongue swelling. Despite her age, given her constellation of sympto...
Source: Dermatol Online J - July 15, 2019 Category: Dermatology Authors: Vecerek N, Dupuy EO, Kang Y, Sarantopoulos GP, Worswick S, Knowles BC Tags: Dermatol Online J Source Type: research

Undifferentiated pleomorphic sarcoma presenting as an exophytic pedunculated tumor on the left scapula.
We report a man with an undifferentiated pleomorphic sarcoma presenting as an exophytic pedunculated tumor of the left scapula. Histopathology analysis revealed spindle-shaped cells with great pleomorphism and numerous mitoses. Immunohistochemistry showed diffuse expression of vimentin. Wide local excision was performed after an oncology consultation. After two-years of follow-up, the patient has shown no evidence of recurrence or metastases. PMID: 31450284 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - July 15, 2019 Category: Dermatology Authors: Cerejeira A, Gomes N, Costa-Silva M, Moreira E, Azevedo F Tags: Dermatol Online J Source Type: research

The impacts of oral health symptoms, hygiene, and diet on the development and severity of psoriasis.
In this study, we utilize a specially designed questionnaire administered to 265 patients at The Ohio State University's dermatology clinics to explore the relationship between psoriasis and a combination of factors that included dietary habits, oral health, and oral hygiene practices. Age, family history of psoriasis, previous diagnosis of strep throat or rheumatoid arthritis, and oral pain or discomfort experienced within the last 12 months were all found to be significant predictors of psoriasis. Additionally, higher body mass index scores, poor gum health, and speech difficulties related to dental problems were all cor...
Source: Dermatol Online J - July 15, 2019 Category: Dermatology Authors: Macklis P, Adams KM, Li D, Krispinsky A, Bechtel M, Trinidad J, Kaffenberger J, Kumar P, Kaffenberger BH Tags: Dermatol Online J Source Type: research

Cutaneous and systemic IgG4-related disease: a review for dermatologists.
Abstract Immunoglobulin G4-related disease (IgG4-RD) is a chronic inflammatory condition characterized by IgG4+ plasma cell infiltration of the skin and other organs. Cutaneous forms of the disease may be under recognized owing to poorly defined diagnostic criteria and relatively recent recognition in the literature. The aim of this review is to describe the clinical, histological, and serological presentations of cutaneous IgG4-RD, and to provide an overview of its systemic manifestations for dermatologists. Cases of cutaneous IgG4-RD identified in the literature review were compared to control cases. Clinically,...
Source: Dermatol Online J - June 15, 2019 Category: Dermatology Authors: Shenoy A, Mohandas N, Gottlieb A Tags: Dermatol Online J Source Type: research

Cutaneous manifestations of genodermatoses and primary immunodeficiency.
Abstract Immunodeficiency is most commonly related to inherited syndromes, infections, chemotherapy, or aging. As the population of individuals with immunodeficiency continues to grow, physicians are confronted with the task of diagnosing dermatologic disease in this population. Cutaneous involvement in immunodeficiency disorders serves as a useful tool that aids diagnosis and provides prognostic value. Given that cutaneous manifestations often herald an underlying immunodeficiency disorder, understanding the complexities of these diseases is important for appropriate clinical management. Although certain diseases...
Source: Dermatol Online J - June 15, 2019 Category: Dermatology Authors: Lewis DJ, Wu JH, Boyd M, Duvic M, Feldman SR Tags: Dermatol Online J Source Type: research

Malacoplakia of the skin: overview of a rare clinical entity.
Abstract BACKGROUND: Malacoplakia is a rare acquired, infection-related granulomatous disorder, that may affect many systems, but typically occurs in the urinary tract. Cutaneous involvement is less prevalent, and most commonly presents with a perianal or genital region localization. Cutaneous malacoplakia is believed to be caused by an acquired bactericidal defect of macrophages in the setting of chronic infections and immunocompromised states. A diagnosis of cutaneous malacoplakia should be considered when encountering non-specific granulomatous lesions that are refractory to treatment. Histologic findings are m...
Source: Dermatol Online J - June 15, 2019 Category: Dermatology Authors: Kyriakou G, Gialeli E, Vryzaki E, Koumoundourou D, Glentis A, Georgiou S Tags: Dermatol Online J Source Type: research