Acquired cutis laxa associated with cutaneous mastocytosis.
This report describes a 26-year old woman who developed acquired cutis laxa and cutaneous mastocytosis leading to premature aging. She represents a unique co-occurrence of these two separate disease entities. To our knowledge, there has been only one published case report of acquired cutis laxa occurring in association with urticaria pigmentosa in a 4-year old girl. Our case would be a second case that exhibits the coexistence of these two disorders in an adult female. PMID: 26436968 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Hoang MV, Dang PV, Bui DV, Mejbel H, Mani DT, Smoller BR, Phung TL Tags: Dermatol Online J Source Type: research

Alopecia as the Presenting Symptom of Syphilis.
In this report, we present a case of a patient with essential syphilitic alopecia whose sole presenting symptom of syphilis was alopecia. Despite an initial negative rapid plasma reagin (RPR) test, he was ultimately found to have syphilis on scalp biopsy. His alopecia improved following treatment with benzathine penicillin. This presentation serves as a reminder to clinicians to be cognizant of alopecia as a presenting sign of syphilis. A review of the specificity and sensitivity of the typical tests used for the diagnosis is presented. PMID: 26436969 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Ornelas J, Agbai ON, Kiuru M, Sivamani RK Tags: Dermatol Online J Source Type: research

Elevated levels of antibodies against phosphatidylserine/prothrombin complex and/or cardiolipin associated with infection and recurrent purpura in a child: a forme fruste of antiphospholipid syndrome?
We report a case we describe as forme fruste antiphospholipid syndrome in which these criteria were not fulfilled. Purpura appeared repeatedly in a female infant starting from the age of 6 months and following episodes of upper respiratory infections and vaccinations. The levels of anti-cardiolipin IgG antibodies and anti-phosphatidylserine/prothrombin complex antibodies were elevated in accordance with these events. Histopathological evaluation revealed multiple small vessel thrombi in the dermis and adipose tissue. After 2 weeks of treatment with aspirin and heparin, the cutaneous symptoms subsided. Infection has long be...
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Kinoshita Y, Mayumi N, Inaba M, Igarashi T, Katagiri I, Kawana S Tags: Dermatol Online J Source Type: research

A case of hair re-pigmentation from a scalp melanoma.
We describe a 58-year-old woman who developed hair re-pigmentation on her vertex scalp as a marker of underlying melanoma. Histopathology revealed a nodular melanoma that was surrounding but not invading follicular epithelium. To our knowledge, there have only been 4 other previously published cases describing hair re-pigmentation in the setting of scalp melanoma. Focal hair re-pigmentation in adults should prompt a thorough evaluation for an underlying melanoma. PMID: 26436971 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Oza VS, Schulman JM, Mully TW, Ortiz S Tags: Dermatol Online J Source Type: research

Linear acral pseudolymphomatous angiokeratoma of children with associated nail dystrophy.
We describe a case of linearly-oriented infiltrative papules and nodules on the index finger of a young female with associated onychodystrophy. Histology demonstrated a heavy lymphocytic infiltrate with plasma cells and proliferation of blood vessels consistent with APACHE. Our case is unique given the linear array of cutaneous lesions and associated nail dystrophy. PMID: 26436972 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: McFaddin C, Greene J, Parekh P Tags: Dermatol Online J Source Type: research

"Cyrano nose" associated with hepatic hemangiomas successfully treated with propranolol.
We describe a patient who presented at two months of age with a "Cyrano nose" associated with multiple hepatic and cutaneous hemangiomas, which completely resolved after therapy with propranolol. Treatment was well tolerated and aesthetic result was excellent. PMID: 26436973 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Vergine G, Sorci M, Rosafio C, Bigucci B, Filippini B, Ancora G Tags: Dermatol Online J Source Type: research

Blue rubber bleb nevus syndrome: a rare multisystem affliction.
Abstract About 200 cases of blue rubber bleb nevus syndrome (BRBNS) have been reported in the literature. The disorder affects both sexes equally and the occurrence is mostly sporadic except for a few reports of cases with autosomal dominant inheritance pattern. Herein we report an 11-year-old girl with progressive BRBNS and onset at 5 years of age. PMID: 26436974 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Sangwan A, Kaur S, Jain VK, Dayal S Tags: Dermatol Online J Source Type: research

A case of acanthosis nigricans coexisting with mycosis fungoides.
We report a 67-year-old man that presented clinically with acanthosis nigricans, in which a subsequent diagnosis of mycosis fungoides was made. PMID: 26436975 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Cheng E, Roy DB, Magro CM Tags: Dermatol Online J Source Type: research

Síndrome de Graham-Little-Piccardi-Lassueur: variante disseminada de líquen plano folicular.
Síndrome de Graham-Little-Piccardi-Lassueur: variante disseminada de líquen plano folicular. Dermatol Online J. 2015;21(7) Authors: Kakizaki P, Donati A, Valente NY, Romiti R Abstract Graham-Little-Piccardi-Lassueur syndrome is a rare lichenoid dermatosis. It is characterized by the triad of scarring alopecia of the scalp, alopecia of the axilla and or groin, and keratotic follicular papules of the body. The present paper reports on two cases affecting young women. Histopathological findings suggest the disorder represents a generalized form of lichen planus follicularis. PMID: 2643...
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Kakizaki P, Donati A, Valente NY, Romiti R Tags: Dermatol Online J Source Type: research

Histiocytoid Sweet syndrome treated with azathioprine: a case report.
We report a 22-year-old woman with HSS, who, after minimal improvement with colchicine and dapsone, had significant improvement of her cutaneous eruption and systemic symptoms following empiric treatment with azathioprine. Since azathioprine has historically been known to cause SS, this case highlights a previously unreported treatment response for the histiocytoid variant. PMID: 26436977 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Miller J, Lee N, Sami N Tags: Dermatol Online J Source Type: research

A fibrous papule with abundant CD34-immunoreactive ganglion-like multinucleated giant cells: a case report and review of the literature.
Abstract Fibrous papules present clinically as benign, asymptomatic, dome-shaped, flesh colored papules on the face. Histologically, fibrous papules are characterized by fibrous stroma with fibroblasts and dilated blood vessels. Multiple variants of fibrous papules have been reported. Although scattered multinucleated cells in fibrous papules have been well described, we report a fibrous papule with abundant multinucleated ganglion-like giant cells that were immunoreactive with CD34. Recognition of such fibrous papule variants is important to avoid misdiagnosis as potentially more worrisome and/or aggressive melan...
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Schaberg KB, Chiou AS, Wang KC, Egbert BM Tags: Dermatol Online J Source Type: research

Jejunal adenocarcinoma with cutaneous metastasis.
We present a 60-year old man who developed a cutaneous metastasis of jejunal adenocarcinoma to his neck. This case highlights the clinicopathologic and immunophenotypic features of this uncommon cutaneous metastasis. PMID: 26436979 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Chung E, Syklawer E, Pulitzer MP, Marchetti MA, Querfeld C, Myskowski PL Tags: Dermatol Online J Source Type: research

Unilateral hyperkeratotic plaques along blaschko lines.
Abstract Epidermolytic ichthyosis (or epidermolytic hyperkeratosis) classically presents with erythroderma and increased fragility (blistering) at birth or soon thereafter. In later life, erythroderma and blistering improve gradually and the clinical picture is dominated by hyperkeratotic plaques in flexures and around joints. Linear epidermolytic hyperkeratosis is a unique, uncommon clinical variant and the absence of erythroderma and blistering are its hallmark. Linear lesions may be localized or generalized andunilateral or bilateral. Herein we report a 6-year-old girl with unilateral epidermolytic ichthyosis. ...
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Kumar P, Debbarman P, Rk S Tags: Dermatol Online J Source Type: research

Pitiríase rotunda: uma apresentação incomum.
Pitiríase rotunda: uma apresentação incomum. Dermatol Online J. 2015;21(7) Authors: Villa Verde RB, Viana Barbosa L, De Almeida Issa MC, Pantaleao L, Pavlikoff Issa L, Barbosa Luz F Abstract Pityriasis rotunda disorder of keratinization clinically described as persistent, large, sharply defined circular patches of ichthyosiform scaling with no inflammatory changes. Patients with pityriasis rotunda may be classified into one of two groups, which are based on ethnicity, number of lesions, family history, and association with systemic diseases. A 45-year-old woman presented with asym...
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Villa Verde RB, Viana Barbosa L, De Almeida Issa MC, Pantaleao L, Pavlikoff Issa L, Barbosa Luz F Tags: Dermatol Online J Source Type: research

Early diagnosis of subungual squamous cell carcinoma of the hallux.
We present a case of subungual SCC of the first toe without bone invasion. The tumor was diagnosed early, treated with conservative surgical excision, and showed no recurrence or metastasis after 2 years of follow-up. PMID: 26436982 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Kaksi SA, Ozdemir M, Balevi A, Cakir A, Tavh Y Tags: Dermatol Online J Source Type: research

Dermatology consultations in a tertiary care hospital: A retrospective study of 243 cases.
CONCLUSIONS: Our results revealed that common dermatoses account for a majority of dermatologic consultations. Modern ward teams continue to struggle with promptly recognizing and appropriately managing common skin conditions. Further training of ward physicians on common dermatologic conditions will improve recognition and treatment of skin conditions in hospitalized patients. PMID: 26437155 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Connolly DM, Silverstein DI Tags: Dermatol Online J Source Type: research

Zoledronic acid-associated symmetrical drug-related intertriginous and flexural exanthema (SDRIFE): report of baboon syndrome in a woman with recurrent metastatic breast cancer after receiving zoledronic acid.
CONCLUSIONS:   Non-contact allergenic drug-induced baboon syndrome has most commonly been associated with antibiotics such as beta-lactams and penicillins.  Zoledronic acid-associated baboon syndrome has not previously been observed in cancer patients.  Baboon syndrome (SDRIFE variant) was observed in a woman with recurrent metastatic breast cancer after her first exposure to zoledronic acid.  In summary, SDRIFE can occur in oncology patients receiving zoledronic acid and zoledronic acid should be added to the list of medications associated with the potential to cause non-contact allergenic drug-induced...
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Cohen PR Tags: Dermatol Online J Source Type: research

Subcorneal pustular dermatosis associated with Coccidioides immitis.
We present an adolescent male with primary pulmonary C.immitis infection manifesting with biopsy proven subcorneal pustular dermatosis. Serological studies revealed increasingly positive titers for coccidioidomycosis and symptoms resolved promptly following initiation of systemic antifungal therapy. Our unique case presentation illustrates subcorneal pustular dermatosis as a reactive eruption owing to primary pulmonary coccidioidomycosis. An association between the two conditions warrants further investigation. PMID: 26437157 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Iyengar S, Chambers CJ, Chang S, Fung MA, Sharon VR Tags: Dermatol Online J Source Type: research

Verruciform Genital-Associated (Vegas) Xanthoma: report of a patient with verruciform xanthoma of the scrotum and literature review.
CONCLUSION:   Verruciform xanthoma is a benign tumor commonly located within the oral cavity and characterized by the development of a small verrucous, papillomatous, polypoid, or sessile growth. Extraoral sites of verruciform xanthoma often include the penis, scrotum, or vulva; we introduce the term 'Vegas' (Verruciform Genital-Associated) xanthoma for these lesions. The lesions are often mistaken for viral warts or malignancies.  Although the mechanism of pathogenesis is unknown, verruciform xanthoma may have a multifactorial etiology involving inflammation, local immunosuppression, and/or metabolic dysfunction...
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Beutler BD, Cohen PR Tags: Dermatol Online J Source Type: research

Vesicular erythema migrans: an atypical and easily misdiagnosed form of Lyme disease.
Abstract Erythema migrans is the initial sign in the majority of patients infected with Borrelia, the genus of spirochetes that causes Lyme disease. Early identification and treatment decrease the risk of progression to later stages of disease. Although a "bull's eye" appearance owing to lesional clearing is considered classic for erythema migrans, this feature is surprisingly often lacking among patients in the United States. Furthermore, cutaneous Lyme disease can exhibit a wide range of morphologic variability in a minority of patients. Herein, we describe the case of a patient with Lyme disease in wh...
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Mazori DR, Orme CM, Mir A, Meehan SA, Neimann AL Tags: Dermatol Online J Source Type: research

Mycophenolate mofetil therapy for pediatric bullous pemphigoid.
We report a case of a toddler with recalcitrant BP who was successfully treated with mycophenolate mofetil (MMF). PMID: 26437160 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Seminario-Vidal L, Sami N, Miller J, Theos A Tags: Dermatol Online J Source Type: research

Pitted keratolysis: successful management with mupirocin 2% ointment monotherapy.
CONCLUSIONS: Several topical and oral treatments are available to successfully manage pitted keratolysis. Our patient confirms previous reports of pitted keratolysis resolving with mupirocin 2% ointment treatment. Monotherapy with mupirocin 2% ointment should be considered as a primary treatment alternative for pitted keratolysis. PMID: 26437161 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Greywal T, Cohen PR Tags: Dermatol Online J Source Type: research

A case report of primary cutaneous marginal zone lymphoma treated with intralesional steroids.
CONCLUSIONS AND RELEVANCE: This case reminds practitioners that intralesional corticosteroids can be effectively and safely used to treat localized PCMZL. Intralesional steroids are less invasive, cheaper, and easier to administer than the majority of other recommended therapies for PCMZL. Thus, although they are often overlooked, intralesional corticosteroids should be more often considered when developing a treatment plan for localized PCMZL. PMID: 26437162 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Kollipara R, Hans A, Hall J, Lisle A Tags: Dermatol Online J Source Type: research

Atypical propylthiouracil-induced ANCA-positive vasculitis: report of a case with unusual clinical and histopathologic findings.
We present an interesting case in which cytopenia and cutaneous vasculopathy occurred concomitantly in a critically ill patient.  The patient was initially treated for suspected infection until dermatologic and rheumatologic workup revealed ANCA-positivity and vasculopathy on histopathology, most consistent with an atypical presentation of ANCA-positive vasculitis.  Upon initiation of immunosuppressive therapy, the patient's condition rapidly improved emphasizing the importance of early recognition of this condition. PMID: 26437163 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Mull JL, Solus JF, Mutizwa MM, Chiang HC, Rosman IS, Musiek A Tags: Dermatol Online J Source Type: research

Leukemia cutis with lymphoglandular bodies: a clue to acute lymphoblastic leukemia cutis.
We report a 59-year-old woman with a history of B-cell acute lymphoblastic leukemia who relapsed with aleukemic lymphoblastic leukemia cutis. Lymphoglandular bodies were conspicuous on biopsy and may serve as a morphologic clue to lymphocytic differentiation while molecular and immunophenotypic studies are pending. The patient was successfully treated with local radiation therapy and oral ponatinib. PMID: 26437164 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Obiozor C, Ganguly S, Fraga GR Tags: Dermatol Online J Source Type: research

Primary care providers' perceptions of mobile store-and-forward teledermatology.
CONCLUSIONS: Our findings highlight that PCPs are highly satisfied with mobile app-based, store-and-forward teledermatology and that they believe teledermatology offers synergistic educational benefit. We hope these results will help guide the development of teledermatology programs to increase access to timely, cost-effective care. PMID: 26437165 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Barbieri JS, Nelson CA, Bream KD, Kovarik CL Tags: Dermatol Online J Source Type: research

A rare case of trigeminal trophic syndrome with an extensive scalp, forehead, and upper eyelid ulceration in a patient with undiagnosed Alzheimer disease.
CONCLUSIONS: Treatment options for trigeminal trophic syndrome are limited and disappointing especially in older patients with dementia. Family education and behavioral modification therapies may be well tolerated option in this population. PMID: 26437166 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Incel Uysal P, Artuz RF, Yalcin BA Tags: Dermatol Online J Source Type: research

A case report of crusted scabies in an adult patient with Down syndrome.
CONCLUSIONS AND RELEVANCE: Crusted scabies infection may occur in adult age individuals with Down syndrome regardless of immune status, leading us to encourage practitioners to consider this condition when presented with patients of this population. We also highlight the need for further exploration of disease prevalence in this patient population. PMID: 26437167 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Nagsuk P, Moore R, Lopez L Tags: Dermatol Online J Source Type: research

Successful treatment of palmoplantar pustulosis with isotretinoin.
CONCLUSIONS AND RELEVANCE: Acitretin represents an important treatment for PPP, but is limited by adverse effects and extended teratogenicity. Our experience supports the utility of isotretinoin as a potential therapeutic alternative, which may be particularly beneficial in patients who are poor candidates for or unable to tolerate acitretin therapy. PMID: 26437168 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Wilken R, Sharma A, Patel F, Maverakis E Tags: Dermatol Online J Source Type: research

Acne isolated within a Becker nevus of a 14 year-old girl.
We present a rare case of papular acne with in a BN of a 14 year-old girl. PMID: 26437169 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Juhl M, Pappo E, Bain M Tags: Dermatol Online J Source Type: research

Nicolau syndrome following intramuscular injection of oxytocin in pregnant women: report of two cases.
Abstract Nicolau syndrome, also known as embolia cutis medicamentosa, is a well known but very rare complication occuring after intramuscular drug injections and presenting with local intense pain. Immediately after injection the skin blanches and within minutes to hours an erythematous macule develops, which evolves into a livedoid violaceous patch with dendrites. This condition is initially hemorrhagic, then it ulcerates, and eventually heals with an atrophic scar. Many different drugs have been reported to cause Nicolau syndrome . To date there have been no reports of Nicolau syndrome caused by intramuscular ox...
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Seremet S, Turan E, Erdemir AT Tags: Dermatol Online J Source Type: research

Flagellate shiitake mushroom dermatitis.
Abstract An 84-year-old woman presented with 5 days of a pruritic skin eruption that formed arciform and linear patterns. She was diagnosed with flagellate shiitake mushroom dermatitis related to shiitake mushroom consumption the day prior symptom onset. PMID: 26437171 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Luber AJ, Ackerman LS Tags: Dermatol Online J Source Type: research

Isolation of Leclercia adecarboxylata from a patient with a subungual splinter.
We present a case of a polymicrobial infection including L. adecarboxylata in a healthy female patient with a subungual splinter, to increase awareness and aid in the diagnosis and treatment of cutaneous L. adecarboxylata infections. To our knowledge, this is the first reported case of trauma-related subungual L. adecarboxylata infection reported in the dermatology literature. PMID: 26437172 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Allawh R, Camp BJ Tags: Dermatol Online J Source Type: research

Generalized linear IgA dermatosis with palmar involvement.
We present three cases with prominent palmar involvement to alert the clinician of this potential physical exam finding and to consider LABD in the right context. PMID: 26437279 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Norris IN, Haeberle MT, Callen JP, Malone JC Tags: Dermatol Online J Source Type: research

Opioid associated intravenous and cutaneous microvascular drug abuse (skin-popping) masquerading as Degos disease (malignant atrophic papulosis) with multiorgan involvement.
CONCLUSION: Our patient's biopsy along with the rapid response to eculizumab indicates that this distinct thrombotic microangiopathy is another complement mediated thrombotic microangiopathy syndrome. Opioid thrombotic microangiopathy has a varied clinical presentation and can mimic other catastrophic microangiopathy syndromes, all of which have in common a responsiveness to complement inhibition. PMID: 26437280 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Magro CM, Toledo-Garcia A, Pala O, Momtahen S, Shapiro L Tags: Dermatol Online J Source Type: research

A 7-year-old with indurated skin and unilateral progressive joint immobility: A case of stiff skin syndrome.
We describe a case of a 7-year-old with stiff skin syndrome, and review the literature to discuss the clinical presentation, histological findings, and management of this condition. PMID: 26437281 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Ogunmakin K, Vangipuram R, Sturgeon A, Shimizu I Tags: Dermatol Online J Source Type: research

Sporotrichoid granuloma annulare-like dermatitis associated with systemic B-cell lymphoma.
CONCLUSIONS AND RELEVANCE: Atypical presentations of granuloma annulare including granuloma annulare-like dermatitis warrant evaluation for systemic malignancy in a subset of patients. PMID: 26437282 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Fisk WA, Millsop JW, Johnson MA, Konia TH, Fung MA, Sharon VR Tags: Dermatol Online J Source Type: research

Scleromyxedema secondary to hepatitis c virus and successfully treated with antiviral therapy.
We report a patient with scleromyxedema associated with hepatitis C virus, successfully treated with interferon and ribavirin therapy. PMID: 26437283 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Smith JA, Kalimullah FA, Erickson CP, Peng LS Tags: Dermatol Online J Source Type: research

Phacomatosis cesiomarmorata with hypospadias and phacomatosis cesioflammea with Sturge-Weber syndrome, Klippel-Trenaunay syndrome and aplasia of veins -- case reports with rare associations.
We report two such rare cases. The first is a 3-year-old boy exhibiting a rare association of cutis marmorata telangiectatica congenita with aberrant dermal melanocytosis along with hypospadias and melanosis oculi (traditionally classified as PPV type Vb or phacomatosis cesiomarmorata - Happle's classification). The other patient is a 5-year-old boy with Sturge-Weber syndrome, Klippel-Trenaunay syndrome, aplasia of iliac, femoral, and popliteal veins and congenital heart disease, associated with aberrant dermal melanocytosis and melanosis oculi (also classified as PPV type IIb or phacomatosis cesioflammea). These sporadic ...
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Kaur T, Sharma N, Sethi A, Kooner S, Banger H Tags: Dermatol Online J Source Type: research

Eruptive milia and comedones during treatment with dovitinib.
We report a case of eruptive facial milia and comedones in the setting of dovitinib treatment for metastatic gastrointestinal cancer. This case is unique as the clinical presentation was more rapid in onset and showed an absence of inflammatory lesions. Although the pathogenesis for skin manifestations is presently unknown, we present this case to increase awareness of potentially under-reported cutaneous side effects. PMID: 26437285 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Kimes K, Beasley K, Dalton SR Tags: Dermatol Online J Source Type: research

Trichophytum rubrum endonyx onychomycosis resistant to standard oral and topical therapies.
We present a 45 year-old man with an eight-year history of discoloration of the nail plate on his left hallux. He had been treated with two courses of oral terbinafine and topical 8% ciclopirox for presumed onychomycosis. On exam, his left great toenail contained a wide yellow-white longitudinal band involving a majority of the nail plate. No subungual debris, hyperkeratosis, or paronychial inflammation was present in the affected nail. Histopathology of the nail plate revealed numerous fungal elements arranged transversely and longitudinally, solely within the keratin layers of the nail plate; these were highlighted with ...
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Mulvaney PM, Telang GH, Jellinek N Tags: Dermatol Online J Source Type: research

Generalized lentiginosis in an 11 year old boy.
We report an 11-year-old boy who presented with multiple dark brown macules, varying in size, but less than 0.5 cm, with no abnormalities of other systemic organs. PMID: 26437287 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Gozali MV, Zhou BR, Luo D Tags: Dermatol Online J Source Type: research

Bullous pilomatricoma: a rarely reported variant of pilomatricoma.
We report and describe a rare variant called bullous pilomatricoma. PMID: 26437288 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: DiGiorgio CM, Kaskas NM, Matherne RJ, Shannon AB, Lee BD Tags: Dermatol Online J Source Type: research

Two sisters with Reed's syndrome: treatment with pregabalin.
Abstract Cutaneous leiomyomas, which originate in the arrector pili muscles of the skin are rarely seen benign cutaneous tumors. Sometimes familial cutaneous and uterine leiomyomatosis can occur together, an autosomal dominant genetic condition called Reed syndrome or familial leiomyomatosis cutis et uteri. This disorder can be accompanied by malignancies, particularly by renal carcinoma. In this paper, two sisters with Reed syndrome are presented in view of the rarity of the disorder and good response to pregabalin therapy. PMID: 26437289 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Yaldiz M, Metin M, Erdem MT, Dikicier BS, Kahyaoglu Z Tags: Dermatol Online J Source Type: research

Localized and linear lichen planopilaris over the face and scalp with associated alopecia - clinical and dermoscopy pattern.
Abstract A case of localized lichen planopilaris over the face, extending to the scalp is presented.This case highlights the different variations, which can occur in the presentation of localized lichen planus. The case was unique because of the extension of the lesions into the scalp. We also wanted to demonstrate the peculiar dermoscopic patterns of active lichen planopilaris when occurring over the face. PMID: 26437290 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Kaliyadan F, Ameer AA Tags: Dermatol Online J Source Type: research

What is the prognostic significance of acrometastases?
We report the cases of two patients with atypical lesions of the fingers in a context of cancer, in which biopsies confirmed a metastasis. Patients died rapidly before treatment was initiated. We discuss the characteristics of these atypical metastatic sites, associated with a generally poor prognosis. PMID: 26437291 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Baltazard T, Arnault JP, Dillied AS, Joly JP, Lok C Tags: Dermatol Online J Source Type: research

Immediate resolution of severe bullous chronic regional pain syndrome with onset of spinal paralysis.
We describe a patient with a rarely reported severe bullous CRPS variant on the left lower extremity, which resolved immediately upon developing spinal paralysis. PMID: 26437292 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Hu L, Watson AJ, Granter SR, Lipworth AD Tags: Dermatol Online J Source Type: research

Even well-controlled psoriasis patients have unmet treatment needs regardless of disease severity.
CONCLUSION: 16% of patients with psoriasis meet study definition for "well-controlled" disease. Less than 20% of these well- controlled patients with psoriasis are satisfied with their current level of control and clearance and would not consider trying new treatments, suggesting the majority of well-controlled patients, regardless of disease severity, still have unmet needs. Strongerpatient-physician communication may contribute to patient-based, comprehensive care in concordance with a health system that isheaded towards financial incentives for better patient satisfaction. PMID: 2...
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Vaidya TS, Anderson KL, Feldman SR Tags: Dermatol Online J Source Type: research

Additional evidence that rosacea pathogenesis may involve demodex: new information from the topical efficacy of ivermectin and praziquantel.
Abstract Additional evidence that Demodex folliculorum may contribute to the pathogenesis of papulopustular rosacea are new studies of two topical antiparasitic agents. Ivermectin and praziquantel have recently been shown to be effective in decreasing the severity of papulopustular rosacea. These two agents significantly differ in molecular structure, but yield similar antiparasitic mechanisms of action. Higher numbers of Demodex mites are found in the skin of patients with rosacea than in people with normal skin. If Demodex play a role in pathogenesis, then hypersensitivity to the mites, their flora, or their pro...
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Abokwidir M, Fleischer AB Tags: Dermatol Online J Source Type: research

Generalized pruritus in dysmetabolic hyperferritinemia treated by phlebotomy.
Abstract This paper describes a case of pruritus caused by dysmetabolic hyperferritinemia treated by multiple phlebotomies.A 63-year-old man was followed for generalized pruritus, which was resistant to the usual treatments. He presented with metabolic syndrome. Physical examination showed only excoriations and lichenification on the skin. The serum ferritin was high at 1043 ng/ml, with transferrin saturation at 67%. The other biological investigations and genetic tests for hemochromatosis were negative.In spite of the dietary measures, the ferritin level was still high (853ng/ml). Magnetic res...
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Brigant F, Hautefeuille V, Dadban A, Lok C, Nguyen-Khac E, Chaby G Tags: Dermatol Online J Source Type: research