A large hyperplastic nodule on the abdomen.
Abstract A 65-year-old man presented with a slowly enlarging, hyperplastic cutaneous nodule on the abdomen that developed over a period of 20 years. Based on the clinical manifestation and typical histopathology, the patient received a diagnosis of giant basal cell carcinoma. PMID: 25612134 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - January 28, 2015 Category: Dermatology Authors: Zhang Y, Li Z, Xiao S, Feng Y Tags: Dermatol Online J Source Type: research

Sweet syndrome with panniculitis, arthralgia, episcleritis, and neurologic involvement precipitated by antibiotics.
CONCLUSION: This case illustrates Sweet syndrome related to nitrofurantoin and/or ciprofloxacin. This is the second report of Sweet syndrome related to these antibiotics and the first associated with ocular, joint, and neurologic involvement. PMID: 25525996 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Kwok T, Mahmood MN, Salopek TG Tags: Dermatol Online J Source Type: research

Primary malignant melanoma of the ovary arising in a cystic teratoma; case report and review of the literature.
We report a case of primary malignant melanoma of the ovary arising in a cystic teratoma. We demonstrate junctional activity of melanocytes showing malignant transformation with both radial and vertical growth phases, a feature diagnostic for primary malignant melanoma but not always demonstrated in such cases. We compiled and reviewed twelve cases that are also able to demonstrate junctional activity. PMID: 25525997 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Lee J, Magpayo J, Panchari C, Peng SK Tags: Dermatol Online J Source Type: research

A novel association of an uncommon pigmentation pattern: coexistence of cutis tricolor with intracranial teratoma and holoprosencephaly.
Abstract Cutis tricolor was first described in a 17-year-old male patient by Happle et al. as a rare coexistence of circumscribed hyperpigmentation and hypopigmentation close to each other on a background of normally pigmented skin. Cutis tricolor has been reported as an isolated cutaneous finding or in various associations. To the best of our knowledge, cutis tricolor in association with teratoma and holoprosencephaly has not been reported in the literature. Herein, we report a male patient who presented with a teratoma and a combination of whorl-like hypopigmentation together with hyperpigmented patches adjacent...
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Tekin B, Yucelten AD, Bayri Y Tags: Dermatol Online J Source Type: research

Treatment of pagetoid reticulosis with intensity modulated radiation therapy.
Abstract Pagetoid reticulosis, also known as Woringer-Kolopp disease, is a rare variant of cutaneous T-cell lymphoma usually presenting as an isolated patch or plaque on the extremities. Immunohistochemical staining of T-cell markers can be variable, but as the name implies the epidermotropic lymphocytes consistently display a "pagetoid" appearance. The following case demonstrates clearance of this condition with intensity modulated radiation therapy, whereas most cases are managed with electron beam therapy if radiation therapy is implemented. PMID: 25525999 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Mount C, Ferraro D, Gru A, Bradbury M, Cornelius L, Gay H Tags: Dermatol Online J Source Type: research

Cutaneous involvement in multiple myeloma: a case report with an unusual location.
We report herein a patient with MM, subtype IgA kappa, with unusual clinical presentation including the lower lip. PMID: 25526000 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Youssef M, Letaief A, Elhani I, Soua Y, Moussa A, Belhadjali H, Amri M, Zili J Tags: Dermatol Online J Source Type: research

Systemic allergic contact dermatitis associated with allergy to intraoral metals.
Abstract Contact (allergic) dermatitis is a skin disorder related to natural exposure to various allergens. Systemic contact dermatitis (SCD) describes a cutaneous eruption in response to systemic exposure to an allergen. The exact pathologic mechanism remains uncertain. Herein we describe a 36-year-old woman with symmetric systemic allergic contact dermatitis, unresponsive to conventional treatment, associated with dental alloy-contact hypersensitivity. We did skin patch testing and the blood lymphocyte transformation test (LTT) from the dental allergen series to assess contact allergy to restorative dental mater...
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Pigatto PD, Brambilla L, Ferrucci S, Zerboni R, Somalvico F, Guzzi G Tags: Dermatol Online J Source Type: research

Mid-dermal elastolysis: report of a case and literature review.
We report the case of a young woman who presented with this disorder after an inflammatory process during pregnancy and we review the main characteristics of this rare entity. PMID: 25526002 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Barrado-Solis N, Rodrigo-Nicolas B, Moles-Poveda P, Millan-Parrilla F, Ferrando-Marco J, Miquel-Miquel J Tags: Dermatol Online J Source Type: research

Drug-associated skin lesions in a patient with myelofibrosis receiving ruxolitinib.
We report a drug eruption associated with ruxolitinib. PMID: 25526003 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Fournier JB, Cummings F, Cannella J, Breen C, Zhou L, Iwamoto S Tags: Dermatol Online J Source Type: research

Crusted scabies of the scalp in a patient with systemic lupus erythematosus.
CONCLUSIONS: Our case highlights the atypical presentation of crusted scabies with primary scalp involvement and need for vigilance in recognizing and appropriately treating this condition to prevent the consequences of longstanding infection. Combination treatment with ivermectin and permethrin is appropriate management for this condition. PMID: 25526004 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Yee BE, Carlos CA, Hata T Tags: Dermatol Online J Source Type: research

Hailey-Hailey disease exacerbated by multiple pregnancies: case report and review of the literature.
We report a case of a woman with recurrent flare-ups of Hailey-Hailey disease with repeated pregnancies and remission of her disease during non-pregnancy periods. To our knowledge, this is the first reported case of Hailey-Hailey disease exacerbated by pregnancy. PMID: 25526005 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Mauzo SH, Sulit DJ Tags: Dermatol Online J Source Type: research

Hair-thread tourniquet syndrome: a case report and review of treatment.
We present a case of HTTS and discuss the demographics and etiology, and review the most current treatment methods. PMID: 25526006 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Au S, Landers JT Tags: Dermatol Online J Source Type: research

Congenital eccrine nevus on the neck.
Abstract Eccrine nevus (EN) is a very rare hamartoma of the skin and with varying clinical manifestations. Histologically, these neoplasms present as a proliferation of normally structured eccrine sweat glands in the dermis. There have been no more than 20 cases previously have been reported in the English literature. Herein we report a 25-year-old man with eccrine nevus on the neck. To our best knowledge, this is the first case that the lesion affecting the neck. PMID: 25526007 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Zhang Y, Feng Y, Xiao S Tags: Dermatol Online J Source Type: research

Rosacea in skin of color: not a rare diagnosis.
CONCLUSIONS: Patients of color rarely receive a diagnosis of rosacea, even when they have symptoms suggesting it. Rosacea has not become more commonly diagnosed in skin of color in recent years. PMID: 25526008 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Al-Dabagh A, Davis SA, McMichael AJ, Feldman SR Tags: Dermatol Online J Source Type: research

Bullous hemorrhagic dermatosis distant from the site of heparin injection.
We present a 59-year-old woman who developed heparin-related bullous hemorrhagic dermatosis, at sites distant from the injections, one month after starting treatment with enoxaparin. PMID: 25526009 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Concha-Garzon M, Sotomayor-Lopez E, Solano-Lopez G, Fraga J, De Argila D Tags: Dermatol Online J Source Type: research

Cetuximab-induced Crusted Pustular Eruption with Patchy Alopecia.
Abstract A 52-year-old man with recurrent metastatic rectal carcinoma being treated with cetuximab presented to the emergency department with a diffuse papulopustular eruption on the face, scalp, chest, and groin, accompanied by patchy alopecia of the scalp and facial hair. PMID: 25526010 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Fischer R, Blackmon J, Rajpara A Tags: Dermatol Online J Source Type: research

Scabies of the nail unit.
We present a man with a history of crusted scabies that resolved with treatment, but later the patient reported a chronic problem with crumbly, thickened nails, which were found to be harboring scabies mites. PMID: 25526011 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Oh S, Vandergriff T Tags: Dermatol Online J Source Type: research

A case of cutaneous larva migrans presenting in a pregnant patient.
We present a case of CLM in a 31-year-old pregnant woman. The treatment of CLM relies on antihelminthic agents, such as thiabendazole, albendazole, and ivermectin. This case was interesting in that the standard treatment options previously mentioned were contraindicated owing to the patient's pregnancy. Cryotherapy with liquid nitrogen resulted in complete resolution of her lesion and symptoms. PMID: 25526012 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Kudrewicz K, Crittenden KN, Himes A Tags: Dermatol Online J Source Type: research

Successful long-term thalidomide therapy for discoid lupus erythematosus-lichen planus overlap syndrome.
Abstract Although thalidomide is a U.S. Food and Drug Admistration (FDA) approved medication for erythema nodosum leprosum and multiple myeloma, it has many off-label uses, including for discoid lupus erythematosus (DLE), Behçet's disease, apththous ulcers in HIV patients, and prurigo nodularis. Herein, we present a patient with an overlap of discoid lupus erythematosus and lichen planus who was successfully treated with thalidomide for over 19 years without significant side effects. We propose that some of the most common side effects, including peripheral neuropathy, numbness, parasthesias, sedation, and ...
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Zhang L, Au S, Aronson IK Tags: Dermatol Online J Source Type: research

Primary cutaneous follicle-center lymphoma.
We present a 64-year-old man with a three-year history of pruritic, pink papules and nodules of the face who was found to have a clonal lymphoproliferative B-cell disease that was characterized by a clonal IGH rearrangement. Although morphologic features present in the biopsy specimen were consistent with a reactive process, additional clinicopathologic correlation (anatomic presentation of lesions on the face, the absence of t(14:18) translocation, and bcl-2 and MUM1 expression) reinforced suspicion of a cutaneous B-cell lymphoma. Systemic work-up with CT/PET and a bone marrow biopsy ultimately excluded systemic disease a...
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Ahearn IM, Hu SW, Meehan SA, Latkowski JA Tags: Dermatol Online J Source Type: research

Indeterminate cell histiocytosis that presented clinically as benign cephalic histiocytosis.
We describe a 12-month-old boy with a four-month history of asymptomatic, small, pink-tan papules on his face. Histopathologic evaluation showed a superficial, dermal infiltrate of histiocytes that was positive for S100, CD1a, CD68, and Factor XIIIa. To our knowledge, this represents the first report of the clinical presentation of benign cephalic histiocytosis with immunohistochemical findings of ICH. We review the classification of histiocytic disorders and the clinical and immunohistochemical features of both ICH and benign cephalic histiocytosis. PMID: 25526330 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Haimovic A, Chernoff K, Hale CS, Meehan SA, Schaffer JV Tags: Dermatol Online J Source Type: research

New world cutaneous leishmaniasis.
Abstract A 24-year-old Bangladeshi man presented with a 12-week history of a pruritic papule on his left elbow that had enlarged and ulcerated. He was without any constitutional or systemic symptoms. He reported a history of extensive travel in the two years prior to presentation that included Bangladesh, South and Central America, and Mexico. Histopathologic features were consistent with leishmaniasis. Speciation by the Centers for Disease Control showed L. brasiliensis. PMID: 25526331 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Trufant JW, Lewin JM, Hale CS, Meehan SA, Pomeranz MK Tags: Dermatol Online J Source Type: research

Plate-like osteoma cutis.
Abstract Osteoma cutis is the aberrant development of bone within the skin. The bone formation may be de novo (primary) or result from an injury to the skin (secondary). Here we present a healthy 53-year-old man with no known abnormalities in calcium or phosphate metabolism with plate-like osteoma cutis of the scalp. Plate- or plaque-like osteoma cutis was initially described as a congenital condition but has now been reported several times in the literature as an idiopathic process that occurs in adults. Treatment options are limited and are only required if the lesion is bothersome to the patient. PMID: 255...
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Orme CM, Hale CS, Meehan SA, Long W Tags: Dermatol Online J Source Type: research

Exogenous ochronosis.
We present a case of exogenous ochronosis in a 53-year-old woman with skin type IV, who used a topical hydroquinone preparation of an unknown concentration for several years. Traditionally, exogenous ochronosis was thought to occur exclusively in patients with darker skin types who use high concentrations of hydroquinone cream. Reports now document cases in patients of all skin types and in patients even using low concentrations of hydroquinone cream for short periods of time. Although the incidence of exogenous ochronosis in the United States is unclear, it may be more common than many clinicians believe. It is important ...
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Nagler A, Hale CS, Meehan SA, Leger M Tags: Dermatol Online J Source Type: research

White fibrous papulosis of the neck.
We present a 76-year old woman with a five-year history of asymptomatic, white papules that were grouped on the lateral and posterior aspects of the neck, inferior axillae, and central mid-back. The histopathologic findings showed thickened collagen bundles. A diagnosis of white fibrous papulosis of the neck was made, which is believed to be a manifestation of intrinsic aging. There are no treatments for white fibrous papulosis of the neck. One hypothesized approach is the application of a topical anti-oxidant to reduce free-radical induced aging. PMID: 25526334 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Schaffer PR, Tran K, Kaplan J, Patel R, Kamino H, Ramachandran S, Franks AG Tags: Dermatol Online J Source Type: research

Netherton syndrome with ichthyosis linearis circumflexa and trichorrhexis invaginatum.
Abstract Netherton syndrome is a rare, autosomal recessive disorder that is characterized by congenital ichthyosis, trichorrhexis invaginata, and atopic diathesis. Ichthyosis presents at birth with erythroderma and subsequently evolves into ichthyosis linearis circumflexa; hair shaft abnormalities tend to present later. The disorder is caused by loss-of-function mutations in the SPINK5 (serine protease inhibitor Kazal-type 5) gene that encodes LEKTI (lympho-epithelial Kazal-type related inhibitor), which is a protease inhibitor that counteracts epidermal proteases involved in desquamation. Use of topical medicatio...
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Ng E, Hale CS, Meehan SA, Cohen DE Tags: Dermatol Online J Source Type: research

Cranial fasciitis.
Abstract A 26-year-old man presented with an 18-month history of a subcutaneous mass on his forehead that occurred shortly after being struck by a blunt object. Histopathologic examination showed a proliferation of bland spindle cells and a collagenous stroma that was consistent with cranial fasciitis. Cranial fasciitis, which is a variant of nodular fasciitis, is a benign fibroblastic neoplasm that overlies the skull and often is associated with trauma. Although its rapid onset may give the clinical impression of a malignant condition, cranial fasciitis typically is cured by simple excision without further sequel...
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Ginsberg B, Ng E, Hu SW, Meehan SA Tags: Dermatol Online J Source Type: research

Nevus lipomatosus superficialis.
We describe a 15-year-old boy with a three-year history of the classic type of nevus lipomatosus superficialis, which presented as linear arrays of soft, cerebriform papulonodules and plaques in the right inguinal fold. Investigation for chromosomal aberrations and dysregulation of Wnt signaling may provide insights into the pathogenesis of this hamartoma. Treatment is usually with surgical excision although successful use of other modalities has been described. PMID: 25526337 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Kim RH, Stevenson ML, Hale CS, Meehan SA, Chernoff K, Schaffer JV Tags: Dermatol Online J Source Type: research

Candida parapsilosis of the nail-bed without onychomycosis.
We present a unique case of C. parapsilosis infection of the nail bed without infection of the nail plate and with twenty-nail melanonychia. PMID: 25526338 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Rieder E, Hu SW, Meehan SA, Adigun C Tags: Dermatol Online J Source Type: research

Vegetative pyoderma gangrenosum.
We present a case of multiple vegetative pyoderma gangrenosum lesions arising in prior surgical sites in a patient found to have IgA monoclonal gammopathy and abnormal urinary protein electrophoresis. PMID: 25526339 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Kim RH, Lewin J, Hale CS, Meehan SA, Stein J, Ramachandran S Tags: Dermatol Online J Source Type: research

Nail lichen planus in a patient with alopecia totalis.
Abstract A 67-year-old man with a three-year history of non-scarring alopecia that progressed to alopecia totalis despite intralesional glucocorticoid injections is presented. He developed 20-nail dystrophy that was recalcitrant to antifungal and anti-inflammatory treatments. Biopsy of the nail matrix showed histopathologic features of lichen planus. Alopecia totalis and isolated lichen planus of the nails are uncommon subtypes of common dermatologic disorders. Rarely reported concurrently, we provide a review of the literature of their association, which is most likely attributed to their autoimmune pathogeneses....
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Ginsberg BA, Yost JM, Lewin J, Hale CS, Meehan SA, Carucci JA, Ramachandran S Tags: Dermatol Online J Source Type: research

Palmoplantar lichen planus.
We present a case of PPLP that improved with methotrexate after failing treatment with acitretin. PMID: 25526341 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Rieder E, Hale CS, Meehan SA, Leger M Tags: Dermatol Online J Source Type: research

Dermatitis herpetiformis.
Abstract Dermatitis herpetiformis (DH) is an autoimmune bullous disease, which represents the cutaneous manifestation of gluten sensitivity, in the setting of celiac disease. Although classical DH is characterized clinically by grouped, vesicles on an erythematous base, primary lesions often are absent owing to the intense, associated pruritus. Instead, many cases present only with erythematous erosions with numerous overlying excoriations. As in celiac disease, the core pathogenic mechanisms of DH are likely mediated by immunoglobulin A class autoantibodies against one of several transglutaminase enzymes. As the ...
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Yost JM, Hale CS, Meehan SA, McLellan BN Tags: Dermatol Online J Source Type: research

Pemphigus foliaceus.
Abstract A 55-year-old woman presented after a four-year history of impetiginized eczema that was distributed over her face, scalp, chest, and back and a recent diagnosis of breast cancer. A skin biopsy specimen for direct immunofluorescence demonstrated intercellular IgG4. Anti-desmoglein 1 and 3 antibodies were present. Indirect immunofluorescence testing was positive on monkey but not rat esophagus. These findings were consistent with a diagnosis of pemphigus foliaceus in association with a malignant condition. After many years of the use of topical glucocorticoids and oral antibiotics, the patient's disease wa...
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Orne CM, Hale CS, Meehan SA, Leger M Tags: Dermatol Online J Source Type: research

Collision tumor of eccrine poroma, seborrheic keratosis, and a viral wart.
Abstract A 68-year-old woman presented for evaluation of a large, red-brown plaque on her left buttock with irregular borders and prominent overlying verrucous changes. The plaque had been present since childhood but over a three-year period had been enlarging with increasing nodularity and easy bleeding with trauma. Histopathologic examination demonstrated an enlarged papillated and polypoid heterogeneous lesion. In part of the specimen, there are bulbous aggregates of small squamous cells with foci of eccrine ductal differentiation. There are other areas with horn pseudocysts, hypergranulosis, and compact orthok...
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Bloom BS, Kamino H, Hale CS, Pomeranz MK Tags: Dermatol Online J Source Type: research

Adiposis dolorosa.
We report a 46-year-old woman with a nine-year history of obesity; chronic diffuse pain in the adipose tissue of her medial upper arms, lower trunk, and thighs; multiple biopsy-proven lipomas and angiolipomas; and a lipomatous pseudomass of the breast. Her systemic symptoms included generalized weakness, fatigue, memory impairment, and arthralgias. Although some of the lesions were tender, most were only appreciated with palpation. Her clinical history and histopathologic data suggested adiposis dolorosa (Dercum's disease). Owing to the chronic pain, an interdisciplinary approach with the use of analgesics and doxycycline ...
Source: Dermatol Online J - December 24, 2014 Category: Dermatology Authors: Schaffer PR, Hale CS, Meehan SA, Shupack JL, Ramachandran S Tags: Dermatol Online J Source Type: research

[A case of lichenoid sarcoidosis with characteristic clinical and histopathological findings].
We report a patient with a one month history of an eruption of skin colored papules. Some were grouped in a symmetrical distribution on the trunk, inner arms, and lumbar region. Pathologic examination revealed an infiltrate in the papillary dermis showing a band of noncaseating granulomas along with disruption of the basal lamina and lichenoid changes. The clinicopathological correlation confirmed the diagnosis of lichenoid sarcoidosis. We consider our case interesting owing to the clinical presentation and the lichenoid distribution of granulomas. PMID: 24746311 [PubMed - indexed for MEDLINE] (Source: Dermatol Online J)
Source: Dermatol Online J - December 19, 2014 Category: Dermatology Authors: Sanchez-Lopez J, Porriño-Bustamante ML, Aneiros-Fernández J, Naranjo-Sintes R, Fernández-Pugnaire MA Tags: Dermatol Online J Source Type: research

[Malignant acanthosis nigricans: report of a case].
Abstract The authors present a case of a 44-year-old patient with a disseminated dermatosis diagnosed as acanthosis nigricans. The patient was a smoker and investigation of the cause of her skin lesions resulted in discovery of an asymptomatic metastatic carcinoma in the laryngopharanx, probably of pulmonary origin. PMID: 24746313 [PubMed - indexed for MEDLINE] (Source: Dermatol Online J)
Source: Dermatol Online J - December 19, 2014 Category: Dermatology Authors: Lazzarini R, Simone K, Queiroz G, Courral I, Magliari ME, Feder CK, Lellis R Tags: Dermatol Online J Source Type: research

Detailed protocol for administration of intralesional IL-2 for the treatment of Stage IIIc and IV M1a metastatic melanoma based on current NCCN guidelines.
Abstract Melanoma claims approximately 9,000 lives in the United States annually [1]. Patients who present with satellite, in-transit, or distant cutaneous metastases have limited treatment options and the prognosis for patients with metastatic disease remains poor. Surgical excision remains the most common treatment modality for cutaneous metastases, but may not address concurrent subclinical in-transit metastases. Other palliative treatment options include Bacillus Calmette-Guérin (BCG) and isolated limb perfusion (ILP). Although intravenous IL-2 has been used for treatment of metastatic melanoma since 19...
Source: Dermatol Online J - November 25, 2014 Category: Dermatology Authors: Patel F, Wilken R, Burrall B, Martinez S, Wells V, King B, Maverakis E Tags: Dermatol Online J Source Type: research

A case of Griscelli syndrome.
We report the case of a 10-year-old child of consanguineous parents. He presented with abdominal pain and fever and was noted to have silvery hair, eyelashes, and eyebrows. Bone marrow studies indicated hemophagocytosis, whilst microscopic examination of the hair showed irregular agglomerations of pigment in hair shafts. The prognosis, treatment, and genetic counseling needs differ considerably among the various forms of Griscelli Syndrome. PMID: 25419745 [PubMed - as supplied by publisher] (Source: Dermatol Online J)
Source: Dermatol Online J - November 25, 2014 Category: Dermatology Authors: Kerketta JA, Lodh M, Mandal K Tags: Dermatol Online J Source Type: research

Necrolytic acral erythema masquerading as cellulitis.
Abstract Necrolytic acral erythema (NAE) is a rare cutaneous sign of hepatitis C virus infection and has recently been linked to zinc deficiency. It presents as well-demarcated erythematous plaques in a sandal-like distribution on the dorsal feet with psoriasiform epidermal hyperplasia on histology. Our patient reported a 9-month history of progressive bilateral lower extremity erythema, swelling, erosions, and nail dystrophy that failed to improve despite multiple courses of antibiotics for presumed lower extremity cellulitis. Serum studies revealed zinc deficiency. This case supports the association of NAE with ...
Source: Dermatol Online J - November 25, 2014 Category: Dermatology Authors: Iyengar S, Chang S, Ho B, Fung M, Konia TH, Prakash N, Sharon VR Tags: Dermatol Online J Source Type: research

Deep dermatofibrosarcoma protuberans in a ninety-year old-woman.
Abstract A 92-year-old woman was referred for the assesment of an asymptomatic subcutaneous tumor that developed after an accidental fall. The mass clinically and radiologically simulated a subcutaneous hematoma. Finally, the histological study was consistent with subcutaneous dermatofibrosarcoma protuberans. PMID: 25419747 [PubMed - as supplied by publisher] (Source: Dermatol Online J)
Source: Dermatol Online J - November 25, 2014 Category: Dermatology Authors: Gracia-Cazana T, Pastushenko I, Concellon M, Grasa M Tags: Dermatol Online J Source Type: research

Hydroxychloroquine-induced fatal toxic epidermal necrolysis complicated by angioinvasive rhizopus.
Abstract The majority of toxic epidermal necrolysis (TEN) cases are provoked by "high risk" medications (e.g. allopurinol, aromatic anticonvulsants, nevirapine, oxicam non-steroidal anti-inflammatory agents, and sulfonamides). TEN usually occurs 1 to 8 weeks after initial administration of the offending agent, but re-administration can evoke TEN within hours to days [1]. Hydroxychloroquine has rarely been associated with TEN, with one case proving fatal [2-4]. Herein, we report a case of hydroxychloroquine-induced fatal TEN complicated by angioinvasive Rhizopus. To our knowledge, this is the first case r...
Source: Dermatol Online J - November 25, 2014 Category: Dermatology Authors: Cameron MC, Word AP, Dominguez A Tags: Dermatol Online J Source Type: research

Unusual CD8 positive lymphomatoid papulosis in childhood.
We report a 15-year-old girl with CD8+ T-cells, an unusual phenotype in this disease. The clinical and pathological differential diagnoses are discussed. PMID: 25419749 [PubMed - as supplied by publisher] (Source: Dermatol Online J)
Source: Dermatol Online J - November 25, 2014 Category: Dermatology Authors: Mateo S, Vazquez Osorio I, Jose Seoane M, Manuel Suarez-Penaranda J, Vazquez Veiga H Tags: Dermatol Online J Source Type: research

Unusual case of frontal mucocele presenting with forehead ulcer.
We report an 80-year-old woman presenting with a forehead skin ulcer and painless subcutaneous forehead induration. Histopathologic examination revealed mucin deposition and inflammation. Computerized tomography (CT) and magnetic resonance imaging (MRI) scans showed a mass originating from the frontal sinus with frontal bony defect and frontocutaneous fistula. Surgical excision of the mass confirmed the mucocele diagnosis. In this article, we present a case of frontocutaneous fistula and skin ulcer, which is an unexpected complication of frontal mucocele. We propose that in the case of a localized non-healing ulcerated for...
Source: Dermatol Online J - November 25, 2014 Category: Dermatology Authors: Altintas Kaksi S, Kaski M, Balevi A, Ozdemir M, Cakir A Tags: Dermatol Online J Source Type: research

A case report of primary cutaneous histoplasmosis requiring deep tissue sampling for diagnosis.
Abstract Importance: This is a case of primary cutaneous histoplasmosis, without any systemic involvement, that occurred without a history of trauma. Due to its rarity and varied clinical presentation, there is much difficulty in diagnosis of this disease entitiy, especially in differentiating it from pyoderma gangreosum. This patient required deep tissue sampling and a DNA probe for Histoplasma to establish a time-sensitive diagnosis as multiple superficial biopsies are nondiagnositic. PMID: 25419751 [PubMed - as supplied by publisher] (Source: Dermatol Online J)
Source: Dermatol Online J - November 25, 2014 Category: Dermatology Authors: Kollipara R, Hans A, Hall J, Watson K Tags: Dermatol Online J Source Type: research

An eschar and violaceous nodules as the presenting signs of lymphomatoid granulomatosis.
We report a 31-year-old male with LYG who presented with cutaneous symptoms. The skin biopsy was devoid of B-cells and non-reactive for EBV. We present this case to emphasize the role of dermatologists in the diagnosis of LYG and to caution clinicians that cutaneous lesions may lack diagnostic evidence of EBV infection. PMID: 25419752 [PubMed - as supplied by publisher] (Source: Dermatol Online J)
Source: Dermatol Online J - November 25, 2014 Category: Dermatology Authors: Fischer R, Shaath T, Meade C, Fraga GR, Rajpara A Tags: Dermatol Online J Source Type: research

Aggressive meningioma presents as innocuous forehead lesion: a case report.
Abstract Cutaneous meningiomas are very rare neoplasms. In this case report we document a type III (anaplastic meningioma) presenting as a subcutaneous forehead mass. Anaplastic meningiomas arise from the neuraxis. They are biologically aggressive neoplasms that extend into the dermis or subcutaneous tissue via direct extension through the bone. PMID: 25419753 [PubMed - as supplied by publisher] (Source: Dermatol Online J)
Source: Dermatol Online J - November 25, 2014 Category: Dermatology Authors: Joselow A, Raugi G, Knezevich SR Tags: Dermatol Online J Source Type: research

Eccrine poromatosis in a patient with acute myeloid leukemia following chemotherapy.
We report a case of eccrine poromatosis occuring on the palms and soles occuring after chemotherapy in a patient with a history of acute myeloid leukemia. PMID: 25419754 [PubMed - as supplied by publisher] (Source: Dermatol Online J)
Source: Dermatol Online J - November 25, 2014 Category: Dermatology Authors: Garshick M, DeFilippis EM, Harp J, Gaan J Tags: Dermatol Online J Source Type: research

Erythema ab igne: evolving technology, evolving presentation.
We present a case of a 49-year-old woman with erythema ab igne on her posterior thighs owing to 2-4 hours per day of seat heater use in her car. Erythema ab igne is caused by prolonged exposure to a heat source. It used to be caused mainly by wood stoves used to heat homes. Erythema ab igne is now more often related to other heat sources, including heating pads, laptop computers, and car seat heaters, as in our case. As technology changes, so does the presentation of skin conditions that are related to technology. PMID: 25419755 [PubMed - as supplied by publisher] (Source: Dermatol Online J)
Source: Dermatol Online J - November 25, 2014 Category: Dermatology Authors: Kesty K, Feldman SR Tags: Dermatol Online J Source Type: research