A case of filgrastim-induced neutrophilic dermatosis of the dorsal hands in a patient with Felty Syndrome
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662999.ABSTRACTNeutrophilic dermatosis of the dorsal hands (NDDH) is a variant of Sweet syndrome that presents with erythematous bullae, papules/plaques, or pustules on the dorsal hands. It is most commonly associated with hematologic and solid organ malignancies, though cases of NDDH associated with inflammatory bowel disease, rheumatologic disorders, and medication exposure have also been described in the literature. Felty syndrome is a rare complication of long-standing rheumatoid arthritis characterized by neuropathy, splenomegaly, and neutropenia. Granulocyte colo...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Tejas P Joshi Yelena Dokic Gordana Verstovsek Theodore Rosen Source Type: research
Recurrence of non-sexually acquired acute genital ulceration following COVID-19 vaccination
We report a case of non-sexually acquired acute genital ulceration that initially presented in 2008 as Lipschutz labial ulcers associated with acute Epstein-Barr virus infection, with recurrence twelve years later following administration of the second dose of the Pfizer-BioNTech COVID-19 vaccine. This case report and exhaustive literature review challenges widely accepted views regarding the typical age range of patients affected by non-sexually acquired acute genital ulceration, the sexual history of affected populations, the pathophysiology of lesion occurrence, and possibility of lesion recurrence.PMID:38478671 | DOI:1...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Christy L Waterman Iris K Aronson Source Type: research
Cutaneous erythematous lupus with acneiform presentation
We present a 57-year-old woman with cutaneous lupus erythematosus (CLE), initially treated as acne. She noted blemishes, including nodules and facial swelling for nine months associated with discrete itching of the ears. Examination showed multiple malar nodules, comedones, pustules, atrophic scars, and hyperpigmentation. A biopsy was performed and revealed atrophic epidermis, discrete hyperkeratosis, vacuolar degeneration of basal layer, basal membrane zone with upper dermal lymphohistiocytic inflammatory infiltrate and deep perivascular and peri-adenexal lymphocytes, vascular ectasia, and mucin deposits. The acneiform pr...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Gabriela C Caputo Carolina Sh Bartos Carla Pagliari Paulo R Criado Source Type: research
Symptomatic perineural and intraneural invasion of the trigeminal nerve and subsequent abducens Nerve palsy by cutaneous squamous cell carcinoma
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329663002.ABSTRACTA 74-year-old woman who presented initially with trigeminal neuralgia of the left forehead and scalp was later found to have a poorly differentiated squamous cell carcinoma (SCC) with large-nerve perineural and intraneural invasion of the left supraorbital nerve. Negative histopathologic margins were achieved in three stages of permanent fixed tissue en face processing and the final defect was repaired with a large rotation flap. Approximately one month after repair, the patient presented with new-onset diplopia and was found to have a complete left cran...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Frank T Winsett Andrew M Armenta Kristyna L Gleghorn Brandon P Goodwin Brent C Kelly Richard F Wagner Source Type: research
Is orofacial granulomatosis a distinct clinical disorder?
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329663003.ABSTRACTOrofacial granulomatosis is a rare disorder that is heterogeneously defined in the published literature. Herein, we describe a patient with orofacial granulomatosis with clinical and histologic evidence, discuss differential diagnoses, and offer clinical pearls for diagnosing and assessing this disorder. Our case provides support that orofacial granulomatosis is a distinct disorder as opposed to a sequela of other systemic granulomatous diseases. This information will aid dermatologists in decision making and diagnosing the disorder.PMID:38478674 | DOI:1...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Tiaranesha K Jackson Yacine N Sow Christopher Wachuku Tatiana M Barrera Katherine Omueti-Ayoade Emily Chu Susan C Taylor Nicholas Mollanazar Source Type: research
A widespread blistering eruption: diffuse cutaneous mastocytosis
We report a 5-month-old male who presented with a 3-week history of cutaneous bullae and pruritus. On examination, he had erythema of the cheeks bilaterally and diffuse slightly hyperpigmented, indurated skin on his trunk and abdomen. There were tense vesicles, bullae, and erosions linearly arranged on his trunk and extremities. Both the laboratory and imaging workup were normal. Subsequently, a punch biopsy of a vesicle on the abdomen was obtained and findings confirmed a diagnosis of diffuse cutaneous mastocytosis. An EpiPen(r) was prescribed due to the slightly increased anaphylaxis risk compared to other forms of masto...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Adaora Ewulu Michael A Cardis Melody C Carter Kaiane A Habeshian Source Type: research
Painful subcutaneous nodules in an alcoholic: a case of pancreatic panniculitis
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329663005.ABSTRACTPancreatic panniculitis is an uncommon manifestation of pancreatic disease, affecting approximately 2-3% of patients with acute or chronic pancreatitis [1]. Its accurate diagnosis is crucial for effective treatment as skin manifestations usually precede systemic symptoms of pancreatitis. The diagnosis of pancreatic panniculitis requires identifying and confirming pancreatic disease in addition to the typical histopathological findings of lobular panniculitis without vasculitis. Herein, we present a patient with pancreatic panniculitis, underlying acute p...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Marianne Cortes Brittany P Smirnov Source Type: research
Actinic comedonal plaque sine elastosis: a rare presentation or a hitherto unexplored variant of comedonal plaque in skin of color?
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329663006.NO ABSTRACTPMID:38478677 | DOI:10.5070/D329663006 (Source: Dermatol Online J)
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Alexis Hilts Kisalay Ghosh Biswanath Behera Robert Brodell Shyam Bhanushankar Verma Source Type: research
Provider language proficiency information on dermatology residency program web sites
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329663007.NO ABSTRACTPMID:38478678 | DOI:10.5070/D329663007 (Source: Dermatol Online J)
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Eric Olsen Mari Paz Castanedo-Tardan Source Type: research
Spontaneous, long-lasting re-pigmentation of grey hair: an association with psychoemotional stress relief
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329663008.NO ABSTRACTPMID:38478679 | DOI:10.5070/D329663008 (Source: Dermatol Online J)
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Alec Sevilla Martin Picard Elijah J Horesh Ali Rajabi-Estarabadi Ralf Paus Source Type: research
Anti-laminin 332 antibodies in graft-versus-host disease-associated bullous pemphigoid after allogeneic peripheral blood stem cell transplantation
We report a 48-year-old woman with bullous pemphigoid (BP) with antibodies against the B3 subunit of laminin 332 after the development of graft-versus-host disease (GVHD). She was diagnosed with recurrent acute lymphoblastic leukemia at 40 years of age and underwent two rounds of allogeneic peripheral blood stem cell transplantations (PBST). Two and a half years after the second PBST, multiple tense blisters appeared on her face, hands, and lower legs. The diagnosis of BP was based on hematoxylin eosin and immunofluorescence staining and immunoblotting analyses. A combination regimen of topical corticosteroids (clobetasol ...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Yasutoshi Hida Riho Kageji Hirofumi Bekku Norito Ishii Source Type: research
Secondary syphilis presenting as leukocytoclastic vasculitis in a 61-year-old man
We report a case of secondary syphilis presenting with an acute, rapidly progressive purpuric eruption mimicking leukocytoclastic vasculitis. A 61-year-old man presented with a 6-day history of nonpruritic rash on his chest and lower extremities associated with fatigue, sore throat, and night sweats. Examination revealed purpuric papules, extending from the dorsal feet to the hips; mucosal surfaces were not involved. A diagnosis of cutaneous small-vessel vasculitis was favored with possible triggers of IgA vasculitis. Initial work-up showed acute kidney injury and microscopic hematuria. Renal biopsy showed IgA nephropathy ...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Nada Mohamed Nicole N Dacy Lisa M Lopez Lindsay M Bicknell Source Type: research
Two congenital cases of pigmented epithelioid melanocytoma with unique clinical and genetic features
We report two unique cases of congenital PEM with PRKCA fusion transcripts: a multifocal PEM with an aggressive incompletely resectable scalp tumor and a solitary palmar PEM with newly reported ITGB5-PRKCA fusion. Through these case reports and a summary of previously reported cases, we outline the spectrum of disease of PEM and highlight the key clinical and histopathologic features associated with PEM with PRKCA fusion transcripts. We also discuss the treatment options and suggest that surgical excision without further adjuvant systemic treatment is reasonable first-line therapy given the favorable prognosis.PMID:3847863...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Hiba Zaaroura Benoit Cyrenne Gino R Somers Karen Wy Wong Kristen M Davidge Evan J Propst Abhaya V Kulkarni Winnie Lo Anita Villani Irene Lara-Corrales Rebecca Levy Source Type: research
Generalized perforating granuloma annulare associated with latent tuberculosis successfully treated with isoniazid: case report and review
We report a 66-year-old woman who presented with a 7-month history of mostly asymptomatic generalized infiltrated, flesh-colored to red-brown umbilicated or crusted papules. Histopathological findings were compatible with perforating granuloma annulare. Diagnostic workup revealed latent tuberculosis. To the best of our knowledge, this is the second published case of GPGA associated with latent tuberculosis and the first one that was successfully treated by isoniazid monotherapy. From our case we can speculate and support the theory that GPGA is a phenotypic granulomatous response to multiple etiologies and/or antigenic sti...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Igor Kapetanovic Martina Bosic Branislav Lekic Dubravka Zivanovic Source Type: research
Exacerbation of Darier disease with lithium therapy
Dermatol Online J. 2023 Oct 15;29(5). doi: 10.5070/D329562405.ABSTRACTDarier disease is an autosomal dominant blistering disorder linked to mutation of the endoplasmic reticulum calcium pump, SERCA2, which compromises keratinocyte adhesion and differentiation. Beyond the typical keratotic and eroded skin lesions, patients with Darier disease often present with psychiatric co-morbidities. Herein, we present a biopsy-confirmed case of Darier disease in a patient with bipolar disorder, whose cutaneous disease dramatically worsened upon initiation of lithium therapy. In consultation with the patient's psychiatrist, lithium was...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Shant Tamazian Cory L Simpson Source Type: research
