Percutaneous and Implanted Peripheral Nerve Stimulation for the Management of Pain: Current Evidence and Future Directions
This article provides an overview of commercially available devices, the evidence supporting their use, and novel treatments being considered for the future.Recent FindingsThere are four peripheral nerve stimulators commercially available in multiple countries around the world. The stimulation may be used temporarily, with percutaneous placement of leads, or indefinitely with permanent implantation of the leads. Two stimulation paradigms are described in the literature for treatment of pain —stimulation of motor (efferent) nerve fibers to create muscle contraction and stimulation of sensory (afferent) nerve fibers to cre...
Source: Current Physical Medicine and Rehabilitation Reports - January 12, 2020 Category: Rehabilitation Source Type: research

Muscular Dystrophy and Rehabilitation Interventions with Regenerative Treatment
AbstractPurpose of ReviewThis paper reviews the enhanced therapeutic effects of rehabilitation and regenerative medicine toward Duchenne muscular dystrophy.Recent FindingsDuchenne muscular dystrophy (DMD) is one of the most severe forms of muscle disorders. Muscle in DMD patients is extremely fragile and can be damaged even during normal daily activity. There is little in the way of treatment for the disease and no cure. Some investigators have been developing cell therapies for DMD by generating muscle stem cells from human-induced pluripotent stem (iPS) cells and other progenitor/stem cells. Although reports have shown d...
Source: Current Physical Medicine and Rehabilitation Reports - January 10, 2020 Category: Rehabilitation Source Type: research

Regenerative Rehabilitative Medicine for Joints and Muscles
AbstractPurpose of ReviewThe purpose of this paper was to review regenerative medicine treatments for joints and muscles.Recent FindingsThere is level 1 evidence supporting the use of platelet-rich plasma (PRP) injections for the treatment of osteoarthritis (OA). Few studies have investigated the efficacy and safety of bone marrow aspirate concentrate (BMAC), microfragmented fat (MF), and placental and amniotic product (PAP) injections for OA. Preliminary studies have not found a benefit of PRP injections for acute muscle injury. No studies have been performed evaluating the therapeutic effect of BMAC, MF, or PAP injection...
Source: Current Physical Medicine and Rehabilitation Reports - January 10, 2020 Category: Rehabilitation Source Type: research

Correction to: The Accuracy of SPECT/CT for Diagnosing Lumbar Zygapophyseal Joint Pain: a Systematic Review
The original version of this article unfortunately contained a mistake in the authorgroup section. Author Byron Schneider ’s family name was incorrectly presented as “Schnieder”. (Source: Current Physical Medicine and Rehabilitation Reports)
Source: Current Physical Medicine and Rehabilitation Reports - December 22, 2019 Category: Rehabilitation Source Type: research

Correction to: The Effectiveness and Safety of Percutaneous Platelet-Rich Plasma and Bone Marrow Aspirate Concentrate for the Treatment of Suspected Discogenic Low Back Pain: a Comprehensive Review
The original version of this article unfortunately contained a mistake in the authorgroup section. Author Byron Schneider ’s family name was incorrectly presented as “Schnieder”. (Source: Current Physical Medicine and Rehabilitation Reports)
Source: Current Physical Medicine and Rehabilitation Reports - December 19, 2019 Category: Rehabilitation Source Type: research

Systemic Effects of Steroids Following Epidural Steroid Injections
AbstractPurpose of ReviewSystemic absorption of corticosteroids occurs following epidural administration. Central steroid response, including sleeplessness, flushing, and non-positional headache, insomnia, hiccups, flushing, and increased radicular pain, represents some of the most common immediate or delayed adverse event related to epidural steroid injections (ESI).Recent FindingsThe systemic effects of corticosteroids themselves likely represent the most commonly encountered complications that result from ESI. These include hyperglycemia, hypothalamic-pituitary-adrenal axis suppression, decreased bone mineral density, a...
Source: Current Physical Medicine and Rehabilitation Reports - November 26, 2019 Category: Rehabilitation Source Type: research

Exercise Benefits in Patients Recovering from Traumatic Brain Injury
AbstractPurpose of ReviewThis paper aims to understand in what aspects exercise benefits traumatic brain injury patients. It examines the molecular basis of how exercise may facilitate cognitive recovery, discuss the clinical evidence of the benefits of exercise on cognition and mood impairments in patients, and identify potential barriers for patients recovering from traumatic brain injury from engaging in physical exercise.Recent FindingsThere are extensive reviews exploring the effect of exercise on patients recovering from traumatic brain injury. Exercise appears to have benefit in global cognition and mood. Exercise i...
Source: Current Physical Medicine and Rehabilitation Reports - November 26, 2019 Category: Rehabilitation Source Type: research

Cervical Ultrasound Utilization in Selective Cervical Nerve Root Injection for the Treatment of Cervical Radicular Pain: a Review
AbstractPurpose of ReviewThis paper aims to review the available literature addressing the safety, accuracy, and efficacy of ultrasound-guided injections for cervical radicular pain.Recent FindingsUltrasound-guided injections remain a “partially blind technique” due to the inability to visualize relevant structures and the distribution of injectate. There remains a need for adequately powered studies evaluating the safety, accuracy, and effectiveness of ultrasound-guided steroid injections in the cervical spine. Fluoroscopy r emains the best evidence-based image-guidance modality for injections into the cervical epidur...
Source: Current Physical Medicine and Rehabilitation Reports - November 14, 2019 Category: Rehabilitation Source Type: research

The Effectiveness and Safety of Percutaneous Platelet-Rich Plasma and Bone Marrow Aspirate Concentrate for the Treatment of Suspected Discogenic Low Back Pain: a Comprehensive Review
AbstractPurpose of ReviewComprehensively review the effectiveness and safety of percutaneous, fluoroscopically guided, intradiscal injection of platelet-rich plasma (PRP) and bone marrow aspirate concentrate (BMAC) for the treatment of suspected discogenic low back pain.Recent FindingsPublications in PubMed up to February 2019 were independently assessed. The literature search yielded three intradiscal PRP studies: one randomized controlled trial and two prospective cohort studies. Five intradiscal BMAC studies were identified. Four of the five prospective cohort studies were completed by the same primary author and result...
Source: Current Physical Medicine and Rehabilitation Reports - October 27, 2019 Category: Rehabilitation Source Type: research

Neurologic, Cognitive, and Behavioral Consequences of Opioid Overdose: a Review
AbstractPurpose of ReviewTo review the literature regarding neurologic, cognitive, and behavioral disorders resulting from non-fatal opioid overdose.Recent FindingsAlthough there is extensive literature regarding hypoxic-ischemic brain injury resulting from cardiac arrest, studies specifically examining opioid-induced brain injury are limited, derived mainly from patient case reports or animal models. Medical management of this population requires careful consideration of acute and long-term complications, as well as careful treatment planning in coordination with neurology, neuropsychology, psychiatry, and addiction medic...
Source: Current Physical Medicine and Rehabilitation Reports - October 20, 2019 Category: Rehabilitation Source Type: research

The Effectiveness and Safety of Genicular Nerve Radiofrequency Ablation for the Treatment of Recalcitrant Knee Pain Due to Osteoarthritis: a Comprehensive Literature Review
AbstractPurpose of ReviewReview the effectiveness and safety of current treatment protocols for fluoroscopically guided genicular nerve radiofrequency ablation (RFA) used for recalcitrant knee pain secondary to osteoarthritis (OA).Recent FindingsRandomized controlled trials and cohort studies of fluoroscopically guided RFA of the genicular nerves demonstrate variability in responder rates from 59% at 3  months to as high as 74% at 6 month follow-up. Studies that investigated the prognostic value of genicular nerve blocks to select patients for RFA demonstrate no difference in outcomes with current treatment protocols. Ot...
Source: Current Physical Medicine and Rehabilitation Reports - September 13, 2019 Category: Rehabilitation Source Type: research

Safe Injectate Choice, Visualization, and Delivery for Lumbar Transforaminal Epidural Steroid Injections: Evolving Literature and Considerations
This article summarizes the recent literature regarding considerations relevant to safe performance of TFESIs.Recent FindingsWe collated recent case report reporting of permanent neurologic injury after TFESI, which has been theorized to occur as a result of disrupted radiculomedullary arterial blood flow to the spinal cord. We also review how injectate selection, visualization methods, and delivery techniques may impact the safety considerations of these injections.SummaryWhile TFESIs are safe, there is continued need to optimize injectate selection, visualization methods, and delivery techniques to minimize the possibili...
Source: Current Physical Medicine and Rehabilitation Reports - September 6, 2019 Category: Rehabilitation Source Type: research

Neuroplasticity in Brain Injury: Maximizing Recovery
AbstractPurpose of ReviewThe ability to promote greater neuroplasticity through external influencers is an emerging field of study with potentially significant consequences on the treatment of neurologic injury. Several of these methods are reviewed in this paper.Recent FindingsThrough advances in neuroscience, a clearer understanding of the complexity of the brain ’s interconnectedness and its ability to adapt to the environment is leading to neurorehabilitation treatments that augment the brain’s capacity towards neuroplastic change.SummaryAn increased appreciation and recognition of neuroplasticity has led to novel ...
Source: Current Physical Medicine and Rehabilitation Reports - August 30, 2019 Category: Rehabilitation Source Type: research

Management of Traumatic Brain Injury: Special Considerations for Older Adults
AbstractPurpose of ReviewThis review focuses on the unique challenges facing older adults with traumatic brain injury (TBI) and provides considerations for appropriate medical treatment.Recent FindingsOlder adults are the fastest growing population to suffer TBI, typically due to falls. Despite less severe injuries based on the Glasgow Coma Scale, older adults more frequently have abnormal head CT findings, are more likely to be admitted to the hospital, and suffer higher mortality than younger adults. Older adults have higher degree of medical comorbidities that require careful management in the acute hospital and rehabil...
Source: Current Physical Medicine and Rehabilitation Reports - August 7, 2019 Category: Rehabilitation Source Type: research

Biological Sex/Gender and Biopsychosocial Determinants of Traumatic Brain Injury Recovery Trajectories
AbstractPurpose of ReviewThe goals of the report are to integrate recent and key foundational gender- and sex-related, post-traumatic brain injury (TBI) literature across several research domains, to highlight need for increased cross-field communication using an integrative biopsychosocial research model, and to provide recommendations for further research approaches and foci.Recent FindingsRecent findings of TBI studies addressing gender and/or biological sex provide evidence of women ’s unique risks for injury, significant differences in severity, type, and number of post-TBI symptoms reported by women vs. men, and co...
Source: Current Physical Medicine and Rehabilitation Reports - August 7, 2019 Category: Rehabilitation Source Type: research