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Editorial: New innovations in therapeutic targets for gastrointestinal toxicity: exploring targets beyond the intestine
No abstract available (Source: Current Opinion in Supportive and Palliative Care)
Source: Current Opinion in Supportive and Palliative Care - May 5, 2020 Category: Palliative Care Tags: GASTROINTESTINAL SYMPTOMS: Edited by Nicole Blijlevens and Andrea M. Stringer Source Type: research

Opioid analgesia: recent developments
Purpose of review Opioids are potent drugs for the treatment of severe pain, but they are burdened by detrimental side-effects, such as respiratory depression, addiction, sedation and constipation. Their clinical application is undisputed in acute (e.g. perioperative) and cancer pain, but their use in chronic nonmalignant pain has met increasing scrutiny and has contributed to the opioid crisis. Thus, novel analgesics with reduced side-effects are badly needed. Recent findings Current research topics include enkephalinase inhibitors, allosteric and multivalent ligands, biased opioid receptor signaling and selective ac...
Source: Current Opinion in Supportive and Palliative Care - May 5, 2020 Category: Palliative Care Tags: PAIN: NON-MALIGNANT DISEASES: Edited by Anthony H. Dickenson and Kirsty Bannister Source Type: research

Potential therapeutic treatments of cancer-induced bone pain
Purpose of review The treatment of cancer-induced bone pain (CIBP) has been proven ineffective and relies heavily on opioids, the target of highly visible criticism for their negative side effects. Alternative therapeutic agents are needed and the last few years have brought promising results, detailed in this review. Recent findings Cysteine/glutamate antiporter system, xc−, cannabinoids, kappa opioids, and a ceramide axis have all been shown to have potential as novel therapeutic targets without the negative effects of opioids. Summary Review of the most recent and promising studies involving CIBP, specifically...
Source: Current Opinion in Supportive and Palliative Care - May 5, 2020 Category: Palliative Care Tags: PAIN: NON-MALIGNANT DISEASES: Edited by Anthony H. Dickenson and Kirsty Bannister Source Type: research

Managing childhood cancer pain into survivorship: recognition and emerging principles
Purpose of review Continual refinement and further stratification of childhood cancer treatment has led to increased survivorship with recognized improvements in many long-term health outcomes. Despite this progress, persisting pain prevalence in childhood cancer survivors is increasing and emerging as a significant long-term health concern. Recent findings Currently, there is no guidance on how to approach and manage persisting pain in survivors of childhood cancer. Summary Clinicians should work with children and young people to optimize the management of pain and other symptoms on treatment. Focusing on an early...
Source: Current Opinion in Supportive and Palliative Care - May 5, 2020 Category: Palliative Care Tags: PAIN: CANCER: Edited by Anthony H. Dickenson and Paul Farquhar-Smith Source Type: research

Breakthrough cancer pain in 2020
Purpose of review An overview on breakthrough cancer pain (BTCP), including inherent limitations of the terminology, assessment, clinical presentation, and treatment options. Recent findings The estimated prevalence of BTCP is dependent on the defined cutoffs for controlled background pain and the magnitude of the pain flare. In addition, pain flares outside the definition of BTCP are prevalent. In the 11th Revision of the International Classification of Diseases, the temporal characteristics of cancer pain are described as continuous background pain and intermittent episodic pain. BTCP should be assessed by validated...
Source: Current Opinion in Supportive and Palliative Care - May 5, 2020 Category: Palliative Care Tags: PAIN: CANCER: Edited by Anthony H. Dickenson and Paul Farquhar-Smith Source Type: research

Cannabis and cannabinoids in cancer pain management
Purpose of review An increasing number of patients are turning to cannabis and cannabinoids for management of their palliative and nonpalliative cancer pain and other cancer-related symptoms. Canadians have a legal framework for access to medical cannabis, which provides a unique perspective in a setting lacking robust clinical evidence. This review seeks to delineate the role of cannabis and cannabinoids in cancer pain management and offers insight into the Canadian practice. Recent findings A cohort study using nabiximols on advanced cancer pain in patients already optimized on opioids, over 3 weeks, demonstrated im...
Source: Current Opinion in Supportive and Palliative Care - May 5, 2020 Category: Palliative Care Tags: PAIN: CANCER: Edited by Anthony H. Dickenson and Paul Farquhar-Smith Source Type: research

Editorial introductions
No abstract available (Source: Current Opinion in Supportive and Palliative Care)
Source: Current Opinion in Supportive and Palliative Care - May 5, 2020 Category: Palliative Care Tags: EDITORIAL INTRODUCTIONS Source Type: research

Online interventions for sexual health in cancer
Purpose of review Recent advances in digital healthcare, combined with the increasing appreciation for the need for sexual health programming in cancer, has established a zeitgeist for further development of digital health interventions for sexual health in cancer. Developers of digital health interventions should consider two equally important factors: efficacy of the intervention, and participant engagement. This review describes the status of digital health interventions in sexual health within the oncology setting. Recent findings Sexual dysfunction and related psychological distress affecting patients and their p...
Source: Current Opinion in Supportive and Palliative Care - January 30, 2020 Category: Palliative Care Tags: COMMUNICATION IN CANCER: ITS IMPACT ON THE EXPERIENCE OF CANCER CARE: Edited by Elie Isenberg-Grzeda and Janet Ellis Source Type: research

Online interventions to address body image distress in cancer
Purpose of review Body image is a critical psychosocial issue for patients with cancer, because of the profound effects the disease and its treatment can have on appearance and bodily functioning. Adverse psychological effects of body image changes associated with cancer include debilitating levels of anxiety, social avoidance, depression, problems with intimacy and impaired sexuality, and feelings of shame/inadequacy. The construct of body image is increasingly recognized as complex and multifaceted from an embodied lens, creating more meaningful and efficacious interventions. Although there is some evidence now for in-...
Source: Current Opinion in Supportive and Palliative Care - January 30, 2020 Category: Palliative Care Tags: COMMUNICATION IN CANCER: ITS IMPACT ON THE EXPERIENCE OF CANCER CARE: Edited by Elie Isenberg-Grzeda and Janet Ellis Source Type: research

Online couple interventions in cancer
Purpose of review Cancer diagnosis and treatment can have long-lasting psychological and physical consequences that affect both patients and their intimate partners. Improved understanding of extant dyadic interventions in the context of cancer, and how access to these may be enhanced through web-based technologies, introduce new directions for how cancer-related psychological distress for couples may be ameliorated. Recent findings Couples are negatively impacted by cancer, both individually, and as a dyad. Bolstering techniques to support effective communication about common cancer-related concerns and support for a...
Source: Current Opinion in Supportive and Palliative Care - January 30, 2020 Category: Palliative Care Tags: COMMUNICATION IN CANCER: ITS IMPACT ON THE EXPERIENCE OF CANCER CARE: Edited by Elie Isenberg-Grzeda and Janet Ellis Source Type: research

Online interventions geared toward increasing resilience and reducing distress in family caregivers
Purpose of review Family caregivers of patients with cancer often spend a great deal of effort on physically and emotionally demanding work while taking care of patients. However, the majority of caregivers are not properly equipped for their role as caregivers, which may lead to increased distress in both caregivers and patients. Herein, we reviewed the recent literature (last 3 years) examining online interventions that seek to support caregiver resilience and decrease distress. Recent findings Our search identified interventions involving three main themes: informational support, positive activities, and social sup...
Source: Current Opinion in Supportive and Palliative Care - January 30, 2020 Category: Palliative Care Tags: COMMUNICATION IN CANCER: ITS IMPACT ON THE EXPERIENCE OF CANCER CARE: Edited by Elie Isenberg-Grzeda and Janet Ellis Source Type: research

Digital interventions for adolescent and young adult cancer survivors
Purpose of review AYA patients with cancer have a unique set of psychosocial and support needs to compared with their younger and older counterparts. Digital health interventions overcome many of the barriers to AYA participation in behavioral health interventions. Due to the rapid shifts in digital health, it is important to continually assess the state of the field. Recent findings There has been a sharp increase in the number of digital health interventions published in the literature. Interventions are using a variety of modalities and targeting many health behaviors and psychosocial outcomes. Most studies are foc...
Source: Current Opinion in Supportive and Palliative Care - January 30, 2020 Category: Palliative Care Tags: COMMUNICATION IN CANCER: ITS IMPACT ON THE EXPERIENCE OF CANCER CARE: Edited by Elie Isenberg-Grzeda and Janet Ellis Source Type: research

Online psychosocial interventions for posttreatment cancer survivors: an international evidence review and update
Purpose of review The present review describes recent research on online psychosocial interventions for posttreatment cancer survivors from January 2018 to June 2019. Recent findings Twenty-three studies were included in the review (the majority included were feasibility studies and only five randomized controlled trials had large samples). Websites were the most common platforms for intervention delivery (9/23) and cognitive behavioral therapy was the most frequently used therapeutic approach (11/23). Three interventions based on this framework and delivered via websites or combined website-telehealth platforms showe...
Source: Current Opinion in Supportive and Palliative Care - January 30, 2020 Category: Palliative Care Tags: COMMUNICATION IN CANCER: ITS IMPACT ON THE EXPERIENCE OF CANCER CARE: Edited by Elie Isenberg-Grzeda and Janet Ellis Source Type: research

Online interventions aimed at reducing psychological distress in cancer patients: evidence update and suggestions for future directions
Purpose of review A great proportion of people affected by cancer experience psychological distress. To reduce pressure on limited health-management resources available, evidence-based eHealth or online interventions can fill an important gap by making psychosocial care more easily accessible. However, evidence of their effectiveness is mixed. This present review provides an update on the effectiveness of online interventions in reducing psychological distress in patients with cancer by including studies published from January 2018 to September 2019. Recent findings Thirty-three publications describing online interven...
Source: Current Opinion in Supportive and Palliative Care - January 30, 2020 Category: Palliative Care Tags: COMMUNICATION IN CANCER: ITS IMPACT ON THE EXPERIENCE OF CANCER CARE: Edited by Elie Isenberg-Grzeda and Janet Ellis Source Type: research

Editorial: Communication in cancer: its impact on the experience of cancer care
No abstract available (Source: Current Opinion in Supportive and Palliative Care)
Source: Current Opinion in Supportive and Palliative Care - January 30, 2020 Category: Palliative Care Tags: COMMUNICATION IN CANCER: ITS IMPACT ON THE EXPERIENCE OF CANCER CARE: Edited by Elie Isenberg-Grzeda and Janet Ellis Source Type: research