Current Opinion in Supportive and Palliative Care Current Opinion in Supportive and Palliative Care RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Bladder preservation in urothelial carcinoma: current trends and future directions
This article explores the bladder sparing alternatives to radical cystectomy and urinary diversion to assist Urologists, Medical Oncologists, and Palliative Care providers in their informed decision making with patients. Recent findings Bladder sparing strategies such as partial cystectomy and trimodality therapy offer long-term cancer outcomes comparable to radical cystectomy in carefully selected patients. Moreover, the toxicity profile in patients, having improved over time, is acceptable, including a low risk of salvage cystectomy. Summary Bladder preservation therapy offers an alternative to radical cyst...
Source: Current Opinion in Supportive and Palliative Care - November 17, 2021 Category: Palliative Care Tags: RENAL AND UROLOGICAL PROBLEMS: Edited by Fred Saad and Andrea Kokorovic Source Type: research

The emerging treatment landscape of advanced urothelial carcinoma
Purpose of review Urothelial carcinoma (UC) is one of the most common malignancies in the Western world. Historically, patients with advanced disease have had a poor prognosis and progress within months of completing upfront platinum-based chemotherapy. In the last two years, the treatment landscape for metastatic UC (mUC) has significantly shifted with the emergence of contemporary immunotherapy and targeted agents. The purpose of this review is to highlight the current and emerging systemic treatment options for mUC of the bladder. Recent findings PD-1/PD-L1 immune checkpoint inhibitors (ICIs) have demonstrate...
Source: Current Opinion in Supportive and Palliative Care - November 17, 2021 Category: Palliative Care Tags: RENAL AND UROLOGICAL PROBLEMS: Edited by Fred Saad and Andrea Kokorovic Source Type: research

Genetics in prostate cancer: implications for clinical practice
Purpose of review Recent advances in our understanding of prostate cancer genetics have transformed the field. However, challenges in implementation and clinical application remain. The aim of this review is to discuss recent noteworthy publications in prostate cancer germline testing, genetically informed treatment, and polygenetic risk. Recent findings The recent U.S. Food and Drug Administration approval of two poly adenosine diphosphate-ribose inhibitors (olaparib and rucaparib) for the treatment of men with metastatic castration-resistant prostate cancer with mutations in DNA damage repair genes and updates...
Source: Current Opinion in Supportive and Palliative Care - November 17, 2021 Category: Palliative Care Tags: RENAL AND UROLOGICAL PROBLEMS: Edited by Fred Saad and Andrea Kokorovic Source Type: research

Editorial: Patient selection in urologic oncology - one size does not fit all
No abstract available (Source: Current Opinion in Supportive and Palliative Care)
Source: Current Opinion in Supportive and Palliative Care - November 17, 2021 Category: Palliative Care Tags: RENAL AND UROLOGICAL PROBLEMS: Edited by Fred Saad and Andrea Kokorovic Source Type: research

l-Menthol – a new treatment for breathlessness?
Purpose of review In patients with advanced chronic obstructive pulmonary disease (COPD), it is challenging to treat breathlessness. In addition, novel palliative interventions are required for multiple perspectives of breathlessness that may still be present after disease-specific therapies. This review provides an overview of the mechanisms and effects of l-menthol on breathlessness by covering the latest relevant papers. Recent findings A literature review identified one randomized controlled trial assessing the effect of l-menthol on relieving breathlessness in patients with COPD. It has been reported that t...
Source: Current Opinion in Supportive and Palliative Care - November 17, 2021 Category: Palliative Care Tags: RESPIRATORY PROBLEMS: Edited by Magnus Ekström and Morag Farquhar Source Type: research

A scoping review of unmet needs of caregivers of patients with pulmonary fibrosis
Purpose of review Pulmonary fibrosis is an incurable lung disease that leads to significant morbidity. In many patients, pulmonary fibrosis is progressive causing debilitating dyspnea that impairs patients’ ability to perform everyday tasks and maintain independence. Informal caregivers provide invaluable support for patients with pulmonary fibrosis; however, support for the caregiver is inadequate. The purpose of this scoping review is to identify unmet needs for caregivers of pulmonary fibrosis patients. Recent findings During the past 18 months, there has been an increase in studies about the impact of pu...
Source: Current Opinion in Supportive and Palliative Care - November 17, 2021 Category: Palliative Care Tags: RESPIRATORY PROBLEMS: Edited by Magnus Ekström and Morag Farquhar Source Type: research

Underlying conditions contributing to breathlessness in the population
Purpose of review Assessment of underlying conditions that contribute to breathlessness is fundamental for symptom management. This review aims to summarize the knowledge from the past two years on the most common underlying conditions among individuals with breathlessness in the general population and to identify research gaps. Recent findings Nine studies from the last two years were included in the review; two studies systematically assessed underlying conditions among breathless individuals in the general population. The modified Medical Research Council (mMRC) scale was used in eight of nine studies. Respir...
Source: Current Opinion in Supportive and Palliative Care - November 17, 2021 Category: Palliative Care Tags: RESPIRATORY PROBLEMS: Edited by Magnus Ekström and Morag Farquhar Source Type: research

Non-invasive ventilation support for people with amyotrophic lateral sclerosis: multidisciplinary team management
Purpose of review To summarise recent developments in the use of noninvasive ventilation (NIV) for people with amyotrophic lateral sclerosis (pwALS), with a specific focus on how multidisciplinary teams (MDT) can support best practice. Recent findings We included 13 papers, 12 with observational designs and one qualitative interview design. The review is structured using four content domains: prognosis, the effectiveness of NIV, NIV tolerance, and MDT structure and delivery. Findings suggest a modest survival benefit of NIV for pwALS. Further evidence is needed to consider the appropriate time of initiation in t...
Source: Current Opinion in Supportive and Palliative Care - November 17, 2021 Category: Palliative Care Tags: RESPIRATORY PROBLEMS: Edited by Magnus Ekström and Morag Farquhar Source Type: research

Nasal high flow oxygen therapy during acute admissions or periods of worsening symptoms
Purpose of review Nasal high flow therapy (NHF) is increasingly used in acute care settings. In this review, we consider recent advances in the utilization of NHF in chronic obstructive pulmonary disease (COPD), terminal cancer and symptom management. Considerations around NHF use during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic are also discussed. Recent findings NHF enables humidification and high flows to be provided together with titrated, supplemental oxygen therapy. Compared to conventional oxygen therapy, NHF improves respiratory physiology by reducing workload, enhancing m...
Source: Current Opinion in Supportive and Palliative Care - November 17, 2021 Category: Palliative Care Tags: RESPIRATORY PROBLEMS: Edited by Magnus Ekström and Morag Farquhar Source Type: research

Palliative care in COVID-19
Purpose of review The purpose of this paper is (1) to provide insight in the palliative care needs of patients with COVID-19; (2) to highlight the challenges of COVID-19 for palliative care; and (3) to highlight developments in COVID-19 palliative care. Recent findings Patients with serious COVID-19 have palliative care needs in all domains: physical, psychological, social and spiritual. COVID-19 palliative care is confronted with many challenges, including: the uncertain prognosis, resource limitations, challenges regarding advance care planning, lack of guidance, limited multidisciplinary collaboration, need f...
Source: Current Opinion in Supportive and Palliative Care - November 17, 2021 Category: Palliative Care Tags: RESPIRATORY PROBLEMS: Edited by Magnus Ekström and Morag Farquhar Source Type: research

Editorial: Breathing problems in focus
No abstract available (Source: Current Opinion in Supportive and Palliative Care)
Source: Current Opinion in Supportive and Palliative Care - November 17, 2021 Category: Palliative Care Tags: RESPIRATORY PROBLEMS: Edited by Magnus Ekström and Morag Farquhar Source Type: research

Editorial introductions
No abstract available (Source: Current Opinion in Supportive and Palliative Care)
Source: Current Opinion in Supportive and Palliative Care - November 17, 2021 Category: Palliative Care Tags: EDITORIAL INTRODUCTIONS Source Type: research

NO, way to go: critical amino acids to replenish nitric oxide production in treating mucositis
Purpose of review There is still an unmet need for preventive and treatment strategies for chemotherapy-induced and radiotherapy-induced mucositis and its associated systemic inflammatory response (SIR) in cancer patients. Because of citrulline depletion due to cytotoxic therapy, nitric oxide (NO) production can be reduced, limiting its effect in many physiological processes. Restoring NO production could relieve mucositis severity by supporting host damage control mechanisms. Amino acids glutamine, arginine and citrulline are involved in NO production. This review including recent literature of preclinical and clinica...
Source: Current Opinion in Supportive and Palliative Care - August 6, 2021 Category: Palliative Care Tags: GASTROINTESTINAL SYMPTOMS: Edited by Nicole Marie Anna Blijlevens and Andrea M. Stringer Source Type: research

Role of dietary fiber in safeguarding intestinal health after pelvic radiotherapy
Purpose of review Damage to healthy bowel tissue during pelvic radiotherapy can produce devastating and life-long changes in bowel function. The surging interest in microbiota and its importance for our wellbeing has generated a bulk of research highlighting how the food we consume impacts bowel health and disease. Dietary fiber is known to promote bowel health, yet there is a limited number of studies on dietary fiber in connection to pelvic radiotherapy. Here, we review some of the literature on the subject and present the most recent publications in the field. Recent findings Advice given concerning dietary f...
Source: Current Opinion in Supportive and Palliative Care - August 6, 2021 Category: Palliative Care Tags: GASTROINTESTINAL SYMPTOMS: Edited by Nicole Marie Anna Blijlevens and Andrea M. Stringer Source Type: research

Cancer care disparities in the LGBT community
Purpose of review A review of the recent literature (2019–2021) around the current disparities in care for LGBT individuals with cancer. Recent findings Recent studies highlight that there continue to be multiple barriers to LGBT individuals with cancer receiving equity of care. These include healthcare professionals (HCPs) lack of knowledge of LGBT-specific issues and an under appreciation of the importance of sexuality and gender in order to provide holistic, person-centred care. Suggestions are made of how embedding training, updating guidelines, and improving communication skills could help to address this...
Source: Current Opinion in Supportive and Palliative Care - August 6, 2021 Category: Palliative Care Tags: SOCIO-CULTURAL-ECONOMIC DETERMINANTS OF ACCESS TO QUALITY CANCER CARE: Edited by Elie Isenberg-Grzeda and Janet Ellis Source Type: research