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Recent advances in cytomegalovirus infection management in solid organ transplant recipients
Curr Opin Organ Transplant. 2024 Jan 31. doi: 10.1097/MOT.0000000000001139. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Human cytomegalovirus (CMV) continues to be the most important infectious complication following solid organ transplantation (SOT).RECENT FINDINGS: Universal prophylaxis and preemptive therapy are the most adopted strategies for prevention of CMV disease globally. Prophylaxis with valganciclovir is the most widely used approach to CMV prevention, however leukopenia and late onset CMV disease after discontinuation of prophylaxis requires new strategies to prevent this complication. The use of assays d...
Source: Current Opinion in Organ Transplantation - January 30, 2024 Category: Transplant Surgery Authors: Paolo Antonio Grossi Maddalena Peghin Source Type: research

Liver transplantation for intrahepatic cholangiocarcinoma: who, when and how
Curr Opin Organ Transplant. 2024 Jan 24. doi: 10.1097/MOT.0000000000001136. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Using transplant oncology principles, selected patients with intrahepatic cholangiocarcinoma (iCCA) may achieve long-term survival after liver transplantation. Strategies for identifying and managing these patients are discussed in this review.RECENT FINDINGS: Unlike initial reports, several modern series have reported positive outcomes after liver transplantation for iCCA. The main challenges are in identifying the appropriate candidates and graft scarcity. Tumor burden and response to neoadjuvant t...
Source: Current Opinion in Organ Transplantation - January 23, 2024 Category: Transplant Surgery Authors: Pablo Achurra Eduardo Fernandes Grainne O'Kane Robert Grant Mark Cattral Gonzalo Sapisochin Source Type: research

Urine CXCL10 as a biomarker in kidney transplantation
Curr Opin Organ Transplant. 2024 Jan 22. doi: 10.1097/MOT.0000000000001135. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Urine CXCL10 is a promising biomarker for posttransplant renal allograft monitoring but is currently not widely used for clinical management.RECENT FINDINGS: Large retrospective studies and data from a prospective randomized trial as well as a prospective cohort study demonstrate that low urine CXCL10 levels are associated with a low risk of rejection and can exclude BK polyomavirus replication with high certainty. Urine CXCL10 can either be used as part of a multiparameter based risk assessment tool...
Source: Current Opinion in Organ Transplantation - January 18, 2024 Category: Transplant Surgery Authors: Patricia Hirt-Minkowski Stefan Schaub Source Type: research

Bacterial infections in solid organ transplant recipients
Curr Opin Organ Transplant. 2024 Jan 12. doi: 10.1097/MOT.0000000000001134. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Bacteria are the leading cause of infections in solid organ transplant (SOT) recipients, significantly impacting patient outcome. Recently detailed and comprehensive epidemiological data have been published.RECENT FINDING: This literature review aims to provide an overview of bacterial infections affecting different types of SOT recipients, emphasizing underlying risk factors and pathophysiological mechanisms.SUMMARY: Lung transplantation connects two microbiotas: one derived from the donor's lower r...
Source: Current Opinion in Organ Transplantation - January 11, 2024 Category: Transplant Surgery Authors: Johan Courjon Dionysios Neofytos Christian van Delden Source Type: research

Immunotherapy for transplantation of hepatocellular carcinoma: the next frontier in adjunctive therapy
Curr Opin Organ Transplant. 2023 Dec 27. doi: 10.1097/MOT.0000000000001133. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: The increasing success of liver transplantation in hepatocellular carcinoma (HCC) drives an ever-evolving search for innovative strategies to broaden eligible patients' pools. Recent advances in immuno-oncology have turned the spotlight on immune checkpoint inhibitors (ICIs). This review offers an updated overview of ICIs in liver transplantation for HCC, exploring neoadjuvant and adjuvant approaches and addressing unanswered questions on safety, patients' selection, and response predictors.RECENT FI...
Source: Current Opinion in Organ Transplantation - January 2, 2024 Category: Transplant Surgery Authors: Parissa Tabrizian Marcus Zeitlhoefler Ahmed Talaat Hassan Rebecca Marino Source Type: research

Current Opinion in Organ Transplantation welcomes a new Editor-in-Chief
Curr Opin Organ Transplant. 2024 Feb 1;29(1):1-2. doi: 10.1097/MOT.0000000000001132. Epub 2024 Jan 4.NO ABSTRACTPMID:38164938 | DOI:10.1097/MOT.0000000000001132 (Source: Current Opinion in Organ Transplantation)
Source: Current Opinion in Organ Transplantation - January 2, 2024 Category: Transplant Surgery Authors: Sarah J Booth Source Type: research