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Dual organ transplantation: when heart alone is not enough
Curr Opin Organ Transplant. 2023 Aug 15. doi: 10.1097/MOT.0000000000001093. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: The number of dual organ transplantations (DOT) are steadily increasing over the past few years. This is both a reflection of increasing complexity and advanced disease process in the patients and greater transplant center experience with performing dual organ transplants. Due to lack of standardization of the process, there remains significant center-based variability in patient selection, perioperative and long-term management of these patients.RECENT FINDINGS: Overall posttransplant outcomes for D...
Source: Current Opinion in Organ Transplantation - August 15, 2023 Category: Transplant Surgery Authors: Abdulelah Nuqali Lavanya Bellumkonda Source Type: research

Role of complement in humoral immunity
Curr Opin Organ Transplant. 2023 Aug 15. doi: 10.1097/MOT.0000000000001095. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Antibody-mediated rejection (AMR) after solid organ transplantation remains an unsolved problem and leads to poor early and late patient outcomes. The complement system is a well recognized pathogenic mediator of AMR. Herein, we review the known molecular mechanisms of disease and results from ongoing clinical testing of complement inhibitors after solid organ transplant.RECENT FINDINGS: Activation and regulation of the complement cascade is critical not only for the terminal effector function of don...
Source: Current Opinion in Organ Transplantation - August 15, 2023 Category: Transplant Surgery Authors: Manuel Alfredo Podest à Nicholas Chun Source Type: research

Donor-derived infections in solid organ transplant recipients
Curr Opin Organ Transplant. 2023 Aug 9. doi: 10.1097/MOT.0000000000001094. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: The potential for transmission of donor-derived infections (DDIs) is impossible to eliminate, but a thoughtful and systematic approach to donor evaluation can mitigate the risk. Prevention is a key issue and clinicians must maintain a high index of suspicion and remain vigilant in staying up to date on emerging infections. COVID-19 and Monkeypox have represented a new challenge for infectious disease screening and recommendations have been evolving, as knowledge in the field has grown. Additional cons...
Source: Current Opinion in Organ Transplantation - August 9, 2023 Category: Transplant Surgery Authors: Maddalena Peghin Paolo Antonio Grossi Source Type: research

Histologic and molecular features of antibody-mediated rejection
Curr Opin Organ Transplant. 2023 Jul 31. doi: 10.1097/MOT.0000000000001088. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: This review aims to summarize the highlights from recent research that involved pathological and molecular analysis of kidney allografts.RECENT FINDINGS: As the research on antibody-mediated rejection (AMR) continues to evolve, studies are focused on identification through transcript studies of pathogenetic pathways involved in the development of AMR as well as refinement of diagnostic methods either by correlating Banff pathologic lesions with clinical and molecular data or by machine learning. Of n...
Source: Current Opinion in Organ Transplantation - August 1, 2023 Category: Transplant Surgery Authors: Ivy A Rosales Rex Neal Smith Robert B Colvin Source Type: research