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Improving liver transplant outcomes with transplant-omics and network biology
Curr Opin Organ Transplant. 2023 Sep 13. doi: 10.1097/MOT.0000000000001100. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Molecular omics data is increasingly ubiquitous throughout medicine. In organ transplantation, recent large-scale research efforts are generating the 'transplant-ome' - the entire set of molecular omics data, including the genome, transcriptome, proteome, and metabolome. Importantly, early studies in anesthesiology have demonstrated how perioperative interventions alter molecular profiles in various patient populations. The next step for anesthesiologists and intensivists will be to tailor perioperat...
Source: Current Opinion in Organ Transplantation - September 14, 2023 Category: Transplant Surgery Authors: Joseph Scarpa Source Type: research

How to measure human leukocyte antigen-specific B cells
Curr Opin Organ Transplant. 2023 Oct 1;28(5):345-354. doi: 10.1097/MOT.0000000000001097. Epub 2023 Aug 18.ABSTRACTPURPOSE OF REVIEW: The implementation of highly sensitive immune assays measuring anti-human leukocyte antigen (HLA) antibodies has modified alloimmune risk stratification and diagnosis of rejection. Nonetheless, anti-HLA antibodies represent the downstream effector mechanism of the B-cell response. Better characterizing the cellular components of the humoral immune response (including memory B cells (mBCs) and long-lived plasma cells) could help to further stratify the alloimmune risk stratification and enable...
Source: Current Opinion in Organ Transplantation - September 7, 2023 Category: Transplant Surgery Authors: Delphine Kervella Alba Torija Jose M Z úñiga Oriol Bestard Source Type: research

Management of the sensitized heart transplant candidate
Curr Opin Organ Transplant. 2023 Oct 1;28(5):362-369. doi: 10.1097/MOT.0000000000001096. Epub 2023 Aug 9.ABSTRACTPURPOSE OF REVIEW: For sensitized heart transplant candidates who have antibodies to human leukocyte antigens (HLA), finding a suitable donor can be challenging and can lead to adverse waitlist outcomes. In recent years, the number of sensitized patients awaiting heart transplantation has increased likely due to the use of durable and mechanical circulatory support as well as increasing number of candidates with underlying congenital heart disease.RECENT FINDINGS: Advances in the assessment of HLA antibodies all...
Source: Current Opinion in Organ Transplantation - September 7, 2023 Category: Transplant Surgery Authors: Michelle M Kittleson Source Type: research

Acute complication posttransplant: primary allograft dysfunction
Curr Opin Organ Transplant. 2023 Oct 1;28(5):376-383. doi: 10.1097/MOT.0000000000001091. Epub 2023 Aug 9.ABSTRACTPURPOSE OF REVIEW: Heart transplant is the gold standard treatment for patients with end-stage heart failure, improving both quality of life and survival. Despite advances in donor and recipient management, primary graft dysfunction (PGD) remains the most common cause of morbidity and mortality in the early posttransplant period. This review summarizes recent discoveries in the underlying pathophysiology, risk prediction and management of PGD.RECENT FINDINGS: The incidence of PGD appears to be rising and it is n...
Source: Current Opinion in Organ Transplantation - September 7, 2023 Category: Transplant Surgery Authors: Darshan H Brahmbhatt David Blitzer Filio Billia Hannah Copeland Source Type: research

Living liver donor pain management
Curr Opin Organ Transplant. 2023 Sep 8. doi: 10.1097/MOT.0000000000001099. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Optimal pain control in living liver donors undergoing hepatectomy is strongly recommended considering their unique status as healthy individuals willingly undergoing surgery for the benefit of the recipient. This review aims to examine and evaluate different strategies aimed at ensuring effective postoperative pain management in living liver donors.RECENT FINDINGS: Enhanced recovery after surgery (ERAS) protocols have proven effective in optimizing patient outcomes, including in living liver donor he...
Source: Current Opinion in Organ Transplantation - September 7, 2023 Category: Transplant Surgery Authors: Ryung A Kang Justin Sangwook Ko Source Type: research