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Transplantation for colorectal liver metastasis
Curr Opin Organ Transplant. 2023 Nov 24. doi: 10.1097/MOT.0000000000001126. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Liver transplantation has emerged as a possible treatment for selected patients with nonresectable colorectal liver metastasis, but controversy still exists regarding optimal selection criteria and acceptable outcomes.RECENT FINDINGS: Univariate analysis in the largest cohorts confirms that metachronous disease, Oslo score = 0-1, metabolic tumor volume (MTV) less than 70 cm3, and tumor burden score less than 9 are positive predictive factors for good overall survival outcomes. Some recent trials migh...
Source: Current Opinion in Organ Transplantation - November 23, 2023 Category: Transplant Surgery Authors: P ål-Dag Line Svein Dueland Source Type: research

Cardiac evaluation of the liver transplant candidate
Curr Opin Organ Transplant. 2023 Nov 24. doi: 10.1097/MOT.0000000000001122. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: This review aims to summarize recent changes in the cardiac evaluation of adult liver transplant candidates. Over the last several years, there have been significant advances in the use of coronary computed tomography angiography (CCTA) with and without fractional flow reserve (FFR) and increasingly widespread availability of coronary calcium scoring for risk stratification for obstructive coronary artery disease. This has led to novel strategies for risk stratification in cirrhotic patients being co...
Source: Current Opinion in Organ Transplantation - November 23, 2023 Category: Transplant Surgery Authors: Stephen Possick Vandana Khungar Ranjit Deshpande Source Type: research

Controlling infections in hospitalized pretransplant candidates
Curr Opin Organ Transplant. 2023 Nov 15. doi: 10.1097/MOT.0000000000001120. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Infections in hospitalized patients awaiting solid organ transplantation can pose complicated diagnostic and therapeutic challenges. Goals of management include stabilizing the patient, treating or controlling infections, and decreasing the risk of reactivation of infection after transplant.RECENT FINDINGS: Groups such as The Organ Procurement and Transplantation Network, American Society of Transplantation Infectious Diseases Community of Practice and the European Society of Clinical Microbiology an...
Source: Current Opinion in Organ Transplantation - November 22, 2023 Category: Transplant Surgery Authors: Marian G Lacy Evgenii Filippov Saman Nematollahi Source Type: research

Regulatory dendritic cell therapy in organ transplantation
Curr Opin Organ Transplant. 2023 Nov 23. doi: 10.1097/MOT.0000000000001127. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Regulatory dendritic cells (DCregs; also 'tolerogenic DCs'), innate immune cells that regulate the alloimmune response, are a novel cellular therapy for organ transplantation. Preliminary results from early-phase clinical trials in live donor kidney and liver transplantation are promising. This follows many years of research elucidating mechanisms of action and utility of DCregs. Herein, we review early-phase clinical trial observations and recent advances in the production, modification, and future-...
Source: Current Opinion in Organ Transplantation - November 22, 2023 Category: Transplant Surgery Authors: Yannis Hadjiyannis Angus W Thomson Source Type: research

Optimizing cardiac status in the preliver transplant candidate
Curr Opin Organ Transplant. 2023 Nov 14. doi: 10.1097/MOT.0000000000001119. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Liver transplant is a widely accepted therapy for end-stage liver disease. With advances in our understanding of transplant, candidates are increasingly older with more cardiac comorbidities. Cardiovascular disease also represents a leading cause of morbidity and mortality posttransplant.RECENT FINDINGS: Preoperative cardiac risk stratification and treatment may improve short-term and long-term outcomes after liver transplant. Importantly, the appropriate frequency of surveillance has not been define...
Source: Current Opinion in Organ Transplantation - November 22, 2023 Category: Transplant Surgery Authors: Maxine W Stachel Eugene C DePasquale Source Type: research

Enhanced recovery after surgery for liver transplantation: a review of recent literature
Curr Opin Organ Transplant. 2023 Nov 9. doi: 10.1097/MOT.0000000000001117. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: This review was created to highlight important articles from the past year related to the evolving field of enhanced recovery after surgery (ERAS) in liver transplantation that are relevant to the transplant anesthesiologist.RECENT FINDINGS: The International Liver Transplantation Society (ILTS) recently completed a landmark project, the ERAS4OLT.org project, which culminated in 80 recommendations for ERAS in liver transplantation. These recommendations encompass management for deceased donor recipien...
Source: Current Opinion in Organ Transplantation - November 8, 2023 Category: Transplant Surgery Authors: Cara E Crouch Erin Stewart Adrian Hendrickse Source Type: research