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Challenges with the current United Network for Organ Sharing heart allocation system
Curr Opin Organ Transplant. 2023 Aug 15. doi: 10.1097/MOT.0000000000001092. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: The revised United States heart organ allocation system was launched in October 2018. In this review, we summarize this United Network for Organ Sharing (UNOS) policy and describe intended and unintended consequences.RECENT FINDINGS: Although early studies published after the change suggested postheart transplant survival declined at 6 months and 1 year, recent publications with longer follow-up time have confirmed comparable posttransplant survival in adjusted models and several patient cohorts. Mor...
Source: Current Opinion in Organ Transplantation - August 18, 2023 Category: Transplant Surgery Authors: Timothy A Gong Shelley A Hall Source Type: research

Role of complement in humoral immunity
Curr Opin Organ Transplant. 2023 Aug 15. doi: 10.1097/MOT.0000000000001095. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Antibody-mediated rejection (AMR) after solid organ transplantation remains an unsolved problem and leads to poor early and late patient outcomes. The complement system is a well recognized pathogenic mediator of AMR. Herein, we review the known molecular mechanisms of disease and results from ongoing clinical testing of complement inhibitors after solid organ transplant.RECENT FINDINGS: Activation and regulation of the complement cascade is critical not only for the terminal effector function of don...
Source: Current Opinion in Organ Transplantation - August 15, 2023 Category: Transplant Surgery Authors: Manuel Alfredo Podest à Nicholas Chun Source Type: research

Dual organ transplantation: when heart alone is not enough
Curr Opin Organ Transplant. 2023 Aug 15. doi: 10.1097/MOT.0000000000001093. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: The number of dual organ transplantations (DOT) are steadily increasing over the past few years. This is both a reflection of increasing complexity and advanced disease process in the patients and greater transplant center experience with performing dual organ transplants. Due to lack of standardization of the process, there remains significant center-based variability in patient selection, perioperative and long-term management of these patients.RECENT FINDINGS: Overall posttransplant outcomes for D...
Source: Current Opinion in Organ Transplantation - August 15, 2023 Category: Transplant Surgery Authors: Abdulelah Nuqali Lavanya Bellumkonda Source Type: research