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Advances in desensitization for human leukocyte antigen incompatible kidney transplantation
Curr Opin Organ Transplant. 2023 Dec 14. doi: 10.1097/MOT.0000000000001131. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Human leukocyte antigen (HLA) sensitization is a major barrier to kidney transplantation induced by exposure to alloantigens through pregnancy, blood product exposure and previous transplantations. Desensitization strategies are undertaken to improve the chances of finding compatible organ offers. Standard approaches to desensitization include the use of plasmapheresis/low dose intravenous immunoglobulin (IVIG) or high dose IVIG plus anti-CD20. However, current methods to reduce HLA antibodies are no...
Source: Current Opinion in Organ Transplantation - December 13, 2023 Category: Transplant Surgery Authors: Ashley Vo Noriko Ammerman Stanley C Jordan Source Type: research

Ethical issues in solid organ transplantation: transfusion-free transplantation in Jehovah's witness patients
Curr Opin Organ Transplant. 2023 Dec 7. doi: 10.1097/MOT.0000000000001128. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Jehovah's Witnesses do not accept transfusion of major allogeneic blood fractions. Successful solid organ transplantation is challenging for Jehovah's Witnesses when anemia, coagulation disturbances, and difficult technical aspects co-exist, and key blood bank resources cannot be utilized. Organ availability for transplantation is limited and demand exceeds supply for all organ types. Historically, the likelihood of poor outcomes in Jehovah's Witnesses patients placed ethical limitations on transplant...
Source: Current Opinion in Organ Transplantation - December 6, 2023 Category: Transplant Surgery Authors: Rick Selby Taylor Selby-Medical Michael Richman Source Type: research

Molecular profiling in the management of hepatocellular carcinoma
Curr Opin Organ Transplant. 2023 Dec 4. doi: 10.1097/MOT.0000000000001124. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: The purpose of this review is to both summarize the current knowledge of hepatocellular carcinoma molecular biology and to suggest a framework in which to prospectively translate this knowledge into patient care. This is timely as recent guidelines recommend increased use of these technologies to advance personalized liver cancer care.RECENT FINDINGS: The main themes covered here address germline and somatic genetic alterations recently discovered in hepatocellular carcinoma, largely owing to next gen...
Source: Current Opinion in Organ Transplantation - December 1, 2023 Category: Transplant Surgery Authors: Nadine Soliman Ashish Saharia Maen Abdelrahim Ashton A Connor Source Type: research