Liver transplantation for intrahepatic cholangiocarcinoma: who, when and how
Curr Opin Organ Transplant. 2024 Jan 24. doi: 10.1097/MOT.0000000000001136. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Using transplant oncology principles, selected patients with intrahepatic cholangiocarcinoma (iCCA) may achieve long-term survival after liver transplantation. Strategies for identifying and managing these patients are discussed in this review.RECENT FINDINGS: Unlike initial reports, several modern series have reported positive outcomes after liver transplantation for iCCA. The main challenges are in identifying the appropriate candidates and graft scarcity. Tumor burden and response to neoadjuvant therapies have been successfully used to identify favorable biology in unresectable cases. New molecular biomarkers will probably predict this response in the future. Also, new technologies and better strategies have been used to increase graft availability for these patients without affecting the liver waitlist.SUMMARY: Liver transplantation for the management of patients with unresectable iCCA is currently a reality under strict research protocols. Who is a candidate for transplantation, when to use neoadjuvant and locoregional therapies, and how to increase graft availability are the main topics of this review.PMID:38258823 | DOI:10.1097/MOT.0000000000001136
Source: Current Opinion in Organ Transplantation - Category: Transplant Surgery Authors: Pablo Achurra Eduardo Fernandes Grainne O'Kane Robert Grant Mark Cattral Gonzalo Sapisochin Source Type: research
More News: Bile Duct Cancer | Biology | Cancer & Oncology | Cholangiocarcinoma | Grants | Liver | Liver Transplant | Molecular Biology | Neoadjuvant Therapy | Transplant Surgery | Transplants | Urology & Nephrology