Models of supportive care in oncology
Purpose of review
Supportive care services have evolved overtime to meet the growing supportive care need of patients with cancer and their families. In this review, we summarize existing definitions of supportive care, highlight empiric studies on supportive care delivery, and propose an integrated conceptual framework on supportive cancer care.
Recent findings
Supportive care aims at addressing the patients’ physical, emotional, social, spiritual, and informational needs throughout the disease trajectory. Interdisciplinary teams are needed to deliver multidimensional care. Oncology teams have an important ro...
Source: Current Opinion in Oncology - June 18, 2021 Category: Cancer & Oncology Tags: SUPPORTIVE CARE: Edited by Jean A. Klastersky Source Type: research
Editorial: Supportive care in cancer patients: quo vadis?
No abstract available (Source: Current Opinion in Oncology)
Source: Current Opinion in Oncology - June 18, 2021 Category: Cancer & Oncology Tags: SUPPORTIVE CARE: Edited by Jean A. Klastersky Source Type: research
Editorial introductions
No abstract available (Source: Current Opinion in Oncology)
Source: Current Opinion in Oncology - June 18, 2021 Category: Cancer & Oncology Tags: EDITORIAL INTRODUCTIONS Source Type: research
Highlighting recent treatment advances in metastatic prostate cancer: expanding the treatment arsenal
Purpose of review
Present highlights from recent research examining the treatment of advanced prostate cancer.
Recent findings
Although debate remains about the optimal sequencing of docetaxel and novel androgen directed therapies in addition to androgen deprivation therapy (ADT) in the treatment of men with new metastatic prostate cancer, the novel LHRH antagonist relugolix seems poised to become an appealing option in a choice of initial ADT. Novel radioisotopes, genomically selected therapies, and immune therapy combinations show progress in opening up new treatment options for men with castration-resistant p...
Source: Current Opinion in Oncology - April 15, 2021 Category: Cancer & Oncology Tags: GENITOURINARY SYSTEM: Edited by Arif Hussain Source Type: research
Emerging role of multiparametric magnetic resonance imaging in identifying clinically relevant localized prostate cancer
Purpose of review
To explore the recent advances and utility of multiparametric magnetic resonance imaging (mpMRI) in the diagnosis and risk-stratification of prostate cancer.
Recent findings
Low-risk, clinically insignificant prostate cancer has a decreased risk of morbidity or mortality. Meanwhile, patients with intermediate and high-risk prostate cancer may significantly benefit from interventions like radiation or surgery. To appropriately risk stratify these patients, MRI has emerged as the imaging modality in the last decade to assist in defining prostate cancer significance, location, and biologic aggress...
Source: Current Opinion in Oncology - April 15, 2021 Category: Cancer & Oncology Tags: GENITOURINARY SYSTEM: Edited by Arif Hussain Source Type: research
High-risk, recurrent and oligometastatic prostate cancer: recent developments on the role of radiation
Purpose of review
Although a standard of care in the treatment of organ-confined prostate cancer, use of radiation for treatment in the high-risk, metastatic and salvage settings is evolving rapidly.
Recent findings
Recent clinical trials have explored the role of increased treatment for high-risk disease with the addition of adjuvant chemotherapy and expanded the role of radiation in settings previously reserved for systemic therapy. Addition of adjuvant chemotherapy for high-risk prostate cancer is controversial and recent evidence is discussed that continues to refine the patient population for further evalua...
Source: Current Opinion in Oncology - April 15, 2021 Category: Cancer & Oncology Tags: GENITOURINARY SYSTEM: Edited by Arif Hussain Source Type: research
Understanding the tumor-immune microenvironment in prostate cancer
Purpose of review
This review aims to highlight recent advances in prostate cancer tumor-immune microenvironment research and summarize the state-of-the-art knowledge of immune checkpoint inhibitors in prostate cancer.
Recent findings
Immune checkpoint inhibitors are the cornerstone of modern immunotherapy which have shown encouraging results across a spectrum of cancers. However, only limited survival benefit has been seen in patients with prostate cancer. Prostate cancer progression and its response to immunotherapies are strongly influenced by the tumor-immune microenvironment, whose feature can be summarized...
Source: Current Opinion in Oncology - April 15, 2021 Category: Cancer & Oncology Tags: GENITOURINARY SYSTEM: Edited by Arif Hussain Source Type: research
The evolving treatment landscape of advanced urothelial carcinoma
Purpose of review
Bladder cancer is the 10th most common cancer in the world and the 6th most common cancer among men. In the past few years, several new agents have been approved for the treatment of urothelial tumors. In this paper, we review the evolving treatment landscape of advanced urothelial carcinoma (UC).
Recent findings
Since 2016, the Food and Drug Administration (FDA) has approved five immunotherapies targeting programmed cell death 1/programmed cell death 1 legend, an antinectin-4 antibody drug conjugate (ADC), and a fibroblast growth factor receptor (FGFR) inhibitor for the treatment of patients w...
Source: Current Opinion in Oncology - April 15, 2021 Category: Cancer & Oncology Tags: GENITOURINARY SYSTEM: Edited by Arif Hussain Source Type: research
A challenging frontier – the genomics and therapeutics of nonclear cell renal cell carcinoma
Purpose of review
As molecular profiling of renal cell carcinoma (RCC) continues to elucidate novel targets for nonclear cell histologies, understanding the landscape of these targets is of utmost importance. In this review, we highlight the genomic landscape of nonclear cell RCC and its implications for current and future systemic therapies.
Recent findings
Several genomic studies have described the mutational burden among nonclear cell histologies. These studies have highlighted the importance of MET in papillary RCC and led to several clinical trials evaluating the efficacy of MET inhibitors for papillary RCC...
Source: Current Opinion in Oncology - April 15, 2021 Category: Cancer & Oncology Tags: GENITOURINARY SYSTEM: Edited by Arif Hussain Source Type: research
Pearls and perils in the management of germ cell tumors
Purpose of review
Research and innovation over the past half century have rendered testicular cancer a highly curable malignancy. Challenges and uncertainty remain in several aspects related to the management and surveillance of patients with germ cell tumors (GCT). Long-term effects of treatment on survivors of testicular cancer remain as continued areas of interest. This review aims to highlight pearls and perils in the management of patients with GCT.
Recent findings
Uncertainty remain regarding complex aspects of first-line and salvage treatments of GCT, interpretation of tumor markers in cases of α-fetopro...
Source: Current Opinion in Oncology - April 15, 2021 Category: Cancer & Oncology Tags: GENITOURINARY SYSTEM: Edited by Arif Hussain Source Type: research
Sinonasal cancers treatments: state of the art
Purpose of review
The present review provides the reader with the state-of-the-art concepts of sinonasal oncology in view of the latest literature data.
Recent findings
Most recent publications in sinonasal oncology assessed treatment timing, centralization, surgical approach, margin status, orbit/neck management, salvage strategies, emerging surgical technologies, intensity-modulated radiation therapy (IMRT), volumetric modulated arc therapy (VMAT), particle radiotherapy, and neoadjuvant chemotherapy.
Summary
Indications to endoscopic surgery for sinonasal cancer have plateaued and are unlikely to furthe...
Source: Current Opinion in Oncology - April 15, 2021 Category: Cancer & Oncology Tags: HEAD AND NECK: Edited by Joël Guigay Source Type: research
Emerging systemic antitarget treatment for differentiated thyroid carcinoma
Purpose of review
We review the new systemic treatment strategies for differentiated thyroid carcinoma, as well as the acquaintance of its molecular biology.
Recent findings
Multiple kinase inhibitor drugs have become the standard therapy for thyroid cancer, albeit several adverse effects. In the last few years, new molecules have raised with an overall safety profile. Most of them, are considered targeted therapies directed toward driven-molecules alterations, such as neurotrophic tyrosine kinase receptor (NTRK) inhibitors for NTRK-fusion thyroid cancer and rearranged during transfection (RET) inhibitors for RE...
Source: Current Opinion in Oncology - April 15, 2021 Category: Cancer & Oncology Tags: HEAD AND NECK: Edited by Joël Guigay Source Type: research
Perspectives in pathomics in head and neck cancer
Purpose of review
Pathology is the cornerstone of cancer care. Pathomics, which represents the use of artificial intelligence in digital pathology, is an emerging and promising field that will revolutionize medical and surgical pathology in the coming years. This review provides an overview of pathomics, its current and future applications and its most relevant applications in Head and Neck cancer care.
Recent findings
The number of studies investigating the use of artificial intelligence in pathology is rapidly growing, especially as the utilization of deep learning has shown great potential with Whole Slide Im...
Source: Current Opinion in Oncology - April 15, 2021 Category: Cancer & Oncology Tags: HEAD AND NECK: Edited by Joël Guigay Source Type: research
The role of the tumor matrix environment in progression of head and neck cancer
Purpose of review
Head and neck squamous cell carcinoma (HNSCC) tissue is composed of multiple cell types embedded in an extracellular matrix (ECM) that actively participates in disease progression, spread and treatment response. In this review, we provide an update of our current knowledge about the ECM landscape of HNSCC, its functions, methods of analysis, and nonimmunological stromal targeting strategies that modify the tumor ECM to improve conventional and emerging therapies.
Recent findings
The tumor ECM differs significantly from that of normal tissue in abundance, composition, organization and mechanical...
Source: Current Opinion in Oncology - April 15, 2021 Category: Cancer & Oncology Tags: HEAD AND NECK: Edited by Joël Guigay Source Type: research
Systemic treatment of metastatic squamous cell carcinoma of the head and neck: proposal for management changes
Purpose of review
Worldwide, head and neck carcinomas account for 5% of all malignancies. Two-thirds of patients relapse after initial multimodal therapy. Until early 2010, the median overall survival (OS) of metastatic patients was about 10 months.
Recent findings
New drugs have been incorporated in patient management, thus enabling an increase in OS. Several first and second line protocols are now available but the lack of direct comparison makes the choice difficult between them.
Summary
This work aims to define the comprehensive medical management of patients with relapsing head and neck carcinoma. ...
Source: Current Opinion in Oncology - April 15, 2021 Category: Cancer & Oncology Tags: HEAD AND NECK: Edited by Joël Guigay Source Type: research
