The ribosome as a small-molecule sensor
Curr Opin Microbiol. 2023 Dec 29;77:102418. doi: 10.1016/j.mib.2023.102418. Online ahead of print.ABSTRACTSensing small molecules is crucial for microorganisms to adapt their genetic programs to changes in their environment. Arrest peptides encoded by short regulatory open reading frames program the ribosomes that translate them to undergo translational arrest in response to specific metabolites. Ribosome stalling in turn controls the expression of downstream genes on the same messenger RNA by translational or transcriptional means. In this review, we present our current understanding of the mechanisms by which ribosomes t...
Source: Current Opinion in Microbiology - December 30, 2023 Category: Microbiology Authors: Arunima Bhattacharya Thibaud T Renault Cristobal Axel Innis Source Type: research
Contributions of diverse models of the female reproductive tract to the study of Chlamydia trachomatis-host interactions
Curr Opin Microbiol. 2023 Dec 15;77:102416. doi: 10.1016/j.mib.2023.102416. Online ahead of print.ABSTRACTChlamydia trachomatis is a common cause of sexually transmitted infections in humans with devastating sequelae. Understanding of disease on all scales, from molecular details to the immunology underlying pathology, is essential for identifying new ways of preventing and treating chlamydia. Infection models of various complexity are essential to understand all aspects of chlamydia pathogenesis. Cell culture systems allow for research into molecular details of infection, including characterization of the unique biphasic ...
Source: Current Opinion in Microbiology - December 16, 2023 Category: Microbiology Authors: Forrest C Walker Isabelle Derr é Source Type: research
Contributions of diverse models of the female reproductive tract to the study of Chlamydia trachomatis-host interactions
Curr Opin Microbiol. 2023 Dec 15;77:102416. doi: 10.1016/j.mib.2023.102416. Online ahead of print.ABSTRACTChlamydia trachomatis is a common cause of sexually transmitted infections in humans with devastating sequelae. Understanding of disease on all scales, from molecular details to the immunology underlying pathology, is essential for identifying new ways of preventing and treating chlamydia. Infection models of various complexity are essential to understand all aspects of chlamydia pathogenesis. Cell culture systems allow for research into molecular details of infection, including characterization of the unique biphasic ...
Source: Current Opinion in Microbiology - December 16, 2023 Category: Microbiology Authors: Forrest C Walker Isabelle Derr é Source Type: research
Contributions of diverse models of the female reproductive tract to the study of Chlamydia trachomatis-host interactions
Curr Opin Microbiol. 2023 Dec 15;77:102416. doi: 10.1016/j.mib.2023.102416. Online ahead of print.ABSTRACTChlamydia trachomatis is a common cause of sexually transmitted infections in humans with devastating sequelae. Understanding of disease on all scales, from molecular details to the immunology underlying pathology, is essential for identifying new ways of preventing and treating chlamydia. Infection models of various complexity are essential to understand all aspects of chlamydia pathogenesis. Cell culture systems allow for research into molecular details of infection, including characterization of the unique biphasic ...
Source: Current Opinion in Microbiology - December 16, 2023 Category: Microbiology Authors: Forrest C Walker Isabelle Derr é Source Type: research
Contributions of diverse models of the female reproductive tract to the study of Chlamydia trachomatis-host interactions
Curr Opin Microbiol. 2023 Dec 15;77:102416. doi: 10.1016/j.mib.2023.102416. Online ahead of print.ABSTRACTChlamydia trachomatis is a common cause of sexually transmitted infections in humans with devastating sequelae. Understanding of disease on all scales, from molecular details to the immunology underlying pathology, is essential for identifying new ways of preventing and treating chlamydia. Infection models of various complexity are essential to understand all aspects of chlamydia pathogenesis. Cell culture systems allow for research into molecular details of infection, including characterization of the unique biphasic ...
Source: Current Opinion in Microbiology - December 16, 2023 Category: Microbiology Authors: Forrest C Walker Isabelle Derr é Source Type: research
Contributions of diverse models of the female reproductive tract to the study of Chlamydia trachomatis-host interactions
Curr Opin Microbiol. 2023 Dec 15;77:102416. doi: 10.1016/j.mib.2023.102416. Online ahead of print.ABSTRACTChlamydia trachomatis is a common cause of sexually transmitted infections in humans with devastating sequelae. Understanding of disease on all scales, from molecular details to the immunology underlying pathology, is essential for identifying new ways of preventing and treating chlamydia. Infection models of various complexity are essential to understand all aspects of chlamydia pathogenesis. Cell culture systems allow for research into molecular details of infection, including characterization of the unique biphasic ...
Source: Current Opinion in Microbiology - December 16, 2023 Category: Microbiology Authors: Forrest C Walker Isabelle Derr é Source Type: research
Contributions of diverse models of the female reproductive tract to the study of Chlamydia trachomatis-host interactions
Curr Opin Microbiol. 2023 Dec 15;77:102416. doi: 10.1016/j.mib.2023.102416. Online ahead of print.ABSTRACTChlamydia trachomatis is a common cause of sexually transmitted infections in humans with devastating sequelae. Understanding of disease on all scales, from molecular details to the immunology underlying pathology, is essential for identifying new ways of preventing and treating chlamydia. Infection models of various complexity are essential to understand all aspects of chlamydia pathogenesis. Cell culture systems allow for research into molecular details of infection, including characterization of the unique biphasic ...
Source: Current Opinion in Microbiology - December 16, 2023 Category: Microbiology Authors: Forrest C Walker Isabelle Derr é Source Type: research
Contributions of diverse models of the female reproductive tract to the study of Chlamydia trachomatis-host interactions
Curr Opin Microbiol. 2023 Dec 15;77:102416. doi: 10.1016/j.mib.2023.102416. Online ahead of print.ABSTRACTChlamydia trachomatis is a common cause of sexually transmitted infections in humans with devastating sequelae. Understanding of disease on all scales, from molecular details to the immunology underlying pathology, is essential for identifying new ways of preventing and treating chlamydia. Infection models of various complexity are essential to understand all aspects of chlamydia pathogenesis. Cell culture systems allow for research into molecular details of infection, including characterization of the unique biphasic ...
Source: Current Opinion in Microbiology - December 16, 2023 Category: Microbiology Authors: Forrest C Walker Isabelle Derr é Source Type: research
Contributions of diverse models of the female reproductive tract to the study of Chlamydia trachomatis-host interactions
Curr Opin Microbiol. 2023 Dec 15;77:102416. doi: 10.1016/j.mib.2023.102416. Online ahead of print.ABSTRACTChlamydia trachomatis is a common cause of sexually transmitted infections in humans with devastating sequelae. Understanding of disease on all scales, from molecular details to the immunology underlying pathology, is essential for identifying new ways of preventing and treating chlamydia. Infection models of various complexity are essential to understand all aspects of chlamydia pathogenesis. Cell culture systems allow for research into molecular details of infection, including characterization of the unique biphasic ...
Source: Current Opinion in Microbiology - December 16, 2023 Category: Microbiology Authors: Forrest C Walker Isabelle Derr é Source Type: research
Contributions of diverse models of the female reproductive tract to the study of Chlamydia trachomatis-host interactions
Curr Opin Microbiol. 2023 Dec 15;77:102416. doi: 10.1016/j.mib.2023.102416. Online ahead of print.ABSTRACTChlamydia trachomatis is a common cause of sexually transmitted infections in humans with devastating sequelae. Understanding of disease on all scales, from molecular details to the immunology underlying pathology, is essential for identifying new ways of preventing and treating chlamydia. Infection models of various complexity are essential to understand all aspects of chlamydia pathogenesis. Cell culture systems allow for research into molecular details of infection, including characterization of the unique biphasic ...
Source: Current Opinion in Microbiology - December 16, 2023 Category: Microbiology Authors: Forrest C Walker Isabelle Derr é Source Type: research
Contributions of diverse models of the female reproductive tract to the study of Chlamydia trachomatis-host interactions
Curr Opin Microbiol. 2023 Dec 15;77:102416. doi: 10.1016/j.mib.2023.102416. Online ahead of print.ABSTRACTChlamydia trachomatis is a common cause of sexually transmitted infections in humans with devastating sequelae. Understanding of disease on all scales, from molecular details to the immunology underlying pathology, is essential for identifying new ways of preventing and treating chlamydia. Infection models of various complexity are essential to understand all aspects of chlamydia pathogenesis. Cell culture systems allow for research into molecular details of infection, including characterization of the unique biphasic ...
Source: Current Opinion in Microbiology - December 16, 2023 Category: Microbiology Authors: Forrest C Walker Isabelle Derr é Source Type: research
Contributions of diverse models of the female reproductive tract to the study of Chlamydia trachomatis-host interactions
Curr Opin Microbiol. 2023 Dec 15;77:102416. doi: 10.1016/j.mib.2023.102416. Online ahead of print.ABSTRACTChlamydia trachomatis is a common cause of sexually transmitted infections in humans with devastating sequelae. Understanding of disease on all scales, from molecular details to the immunology underlying pathology, is essential for identifying new ways of preventing and treating chlamydia. Infection models of various complexity are essential to understand all aspects of chlamydia pathogenesis. Cell culture systems allow for research into molecular details of infection, including characterization of the unique biphasic ...
Source: Current Opinion in Microbiology - December 16, 2023 Category: Microbiology Authors: Forrest C Walker Isabelle Derr é Source Type: research
Contributions of diverse models of the female reproductive tract to the study of Chlamydia trachomatis-host interactions
Curr Opin Microbiol. 2023 Dec 15;77:102416. doi: 10.1016/j.mib.2023.102416. Online ahead of print.ABSTRACTChlamydia trachomatis is a common cause of sexually transmitted infections in humans with devastating sequelae. Understanding of disease on all scales, from molecular details to the immunology underlying pathology, is essential for identifying new ways of preventing and treating chlamydia. Infection models of various complexity are essential to understand all aspects of chlamydia pathogenesis. Cell culture systems allow for research into molecular details of infection, including characterization of the unique biphasic ...
Source: Current Opinion in Microbiology - December 16, 2023 Category: Microbiology Authors: Forrest C Walker Isabelle Derr é Source Type: research
Artificial selection of microbial communities: what have we learnt and how can we improve?
Curr Opin Microbiol. 2023 Dec 12;77:102400. doi: 10.1016/j.mib.2023.102400. Online ahead of print.ABSTRACTMicrobial communities are capable of performing diverse functions with important bioindustrial and medical applications. One approach to improving a community function is to breed new communities by artificially selecting for those displaying high community function ('community selection'). Importantly, community selection can improve the function of interest without needing to understand how the function arises, just like in classical artificial selection of individuals. However, experimental studies of community sele...
Source: Current Opinion in Microbiology - December 13, 2023 Category: Microbiology Authors: Joshua L Thomas Jamila Rowland-Chandler Wenying Shou Source Type: research
Artificial selection of microbial communities: what have we learnt and how can we improve?
Curr Opin Microbiol. 2023 Dec 12;77:102400. doi: 10.1016/j.mib.2023.102400. Online ahead of print.ABSTRACTMicrobial communities are capable of performing diverse functions with important bioindustrial and medical applications. One approach to improving a community function is to breed new communities by artificially selecting for those displaying high community function ('community selection'). Importantly, community selection can improve the function of interest without needing to understand how the function arises, just like in classical artificial selection of individuals. However, experimental studies of community sele...
Source: Current Opinion in Microbiology - December 13, 2023 Category: Microbiology Authors: Joshua L Thomas Jamila Rowland-Chandler Wenying Shou Source Type: research
