Beyond resistance: antifungal heteroresistance and antifungal tolerance in fungal pathogens
Curr Opin Microbiol. 2024 Feb 23;78:102439. doi: 10.1016/j.mib.2024.102439. Online ahead of print.ABSTRACTFungal infections are increasing globally, causing alarmingly high mortality and economic burden. In addition to antifungal resistance, other more subtle drug responses appear to increase the likelihood of treatment failures. These responses include heteroresistance and tolerance, terms that are more well-defined for antibacterial drugs, but are also evident in pathogenic fungi. Here, we compare these antifungal responses with similarly named antibacterial responses, and we review recent advances in how we understand t...
Source: Current Opinion in Microbiology - February 24, 2024 Category: Microbiology Authors: Feng Yang Judith Berman Source Type: research
Beyond resistance: antifungal heteroresistance and antifungal tolerance in fungal pathogens
Curr Opin Microbiol. 2024 Feb 23;78:102439. doi: 10.1016/j.mib.2024.102439. Online ahead of print.ABSTRACTFungal infections are increasing globally, causing alarmingly high mortality and economic burden. In addition to antifungal resistance, other more subtle drug responses appear to increase the likelihood of treatment failures. These responses include heteroresistance and tolerance, terms that are more well-defined for antibacterial drugs, but are also evident in pathogenic fungi. Here, we compare these antifungal responses with similarly named antibacterial responses, and we review recent advances in how we understand t...
Source: Current Opinion in Microbiology - February 24, 2024 Category: Microbiology Authors: Feng Yang Judith Berman Source Type: research
Beyond resistance: antifungal heteroresistance and antifungal tolerance in fungal pathogens
Curr Opin Microbiol. 2024 Feb 23;78:102439. doi: 10.1016/j.mib.2024.102439. Online ahead of print.ABSTRACTFungal infections are increasing globally, causing alarmingly high mortality and economic burden. In addition to antifungal resistance, other more subtle drug responses appear to increase the likelihood of treatment failures. These responses include heteroresistance and tolerance, terms that are more well-defined for antibacterial drugs, but are also evident in pathogenic fungi. Here, we compare these antifungal responses with similarly named antibacterial responses, and we review recent advances in how we understand t...
Source: Current Opinion in Microbiology - February 24, 2024 Category: Microbiology Authors: Feng Yang Judith Berman Source Type: research
Beyond resistance: antifungal heteroresistance and antifungal tolerance in fungal pathogens
Curr Opin Microbiol. 2024 Feb 23;78:102439. doi: 10.1016/j.mib.2024.102439. Online ahead of print.ABSTRACTFungal infections are increasing globally, causing alarmingly high mortality and economic burden. In addition to antifungal resistance, other more subtle drug responses appear to increase the likelihood of treatment failures. These responses include heteroresistance and tolerance, terms that are more well-defined for antibacterial drugs, but are also evident in pathogenic fungi. Here, we compare these antifungal responses with similarly named antibacterial responses, and we review recent advances in how we understand t...
Source: Current Opinion in Microbiology - February 24, 2024 Category: Microbiology Authors: Feng Yang Judith Berman Source Type: research
Cardiac damage and tropism of severe acute respiratory syndrome coronavirus 2
Curr Opin Microbiol. 2024 Feb 22;78:102437. doi: 10.1016/j.mib.2024.102437. Online ahead of print.ABSTRACTUntil now, the World Health Organization registered over 771 million cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection worldwide, of which 6.97 million resulted in death. Virus-related cardiovascular events and pre-existing heart problems have been identified as major contributing factors to global infection-related morbidity and mortality, emphasizing the necessity for risk assessment and future prevention. In this review, we highlight cardiac manifestations that might arise from an infec...
Source: Current Opinion in Microbiology - February 23, 2024 Category: Microbiology Authors: Melina Tangos Muhammad Jarkas Ibrahim Akin Ibrahim El-Battrawy Nazha Hamdani Source Type: research
Cardiac damage and tropism of severe acute respiratory syndrome coronavirus 2
Curr Opin Microbiol. 2024 Feb 22;78:102437. doi: 10.1016/j.mib.2024.102437. Online ahead of print.ABSTRACTUntil now, the World Health Organization registered over 771 million cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection worldwide, of which 6.97 million resulted in death. Virus-related cardiovascular events and pre-existing heart problems have been identified as major contributing factors to global infection-related morbidity and mortality, emphasizing the necessity for risk assessment and future prevention. In this review, we highlight cardiac manifestations that might arise from an infec...
Source: Current Opinion in Microbiology - February 23, 2024 Category: Microbiology Authors: Melina Tangos Muhammad Jarkas Ibrahim Akin Ibrahim El-Battrawy Nazha Hamdani Source Type: research
Coevolution of a generalist pathogen with many hosts: the case of the amphibian chytrid Batrachochytrium dendrobatidis
Curr Opin Microbiol. 2024 Feb 21;78:102435. doi: 10.1016/j.mib.2024.102435. Online ahead of print.ABSTRACTGeneralist pathogens maintain infectivity in numerous hosts; how this broad ecological niche impacts host-pathogen coevolution remains to be widely explored. Batrachochytrium dendrobatidis (Bd) is a highly generalist pathogenic fungus that has caused devastating declines in hundreds of amphibian species worldwide. This review examines amphibian chytridiomycosis host-pathogen interactions and available evidence for coevolution between Bd and its numerous hosts. We summarize recent evidence showing that Bd genotypes vary...
Source: Current Opinion in Microbiology - February 22, 2024 Category: Microbiology Authors: Tamilie Carvalho Anat M Belasen L Felipe Toledo Timothy Y James Source Type: research
Coevolution of a generalist pathogen with many hosts: the case of the amphibian chytrid Batrachochytrium dendrobatidis
Curr Opin Microbiol. 2024 Feb 21;78:102435. doi: 10.1016/j.mib.2024.102435. Online ahead of print.ABSTRACTGeneralist pathogens maintain infectivity in numerous hosts; how this broad ecological niche impacts host-pathogen coevolution remains to be widely explored. Batrachochytrium dendrobatidis (Bd) is a highly generalist pathogenic fungus that has caused devastating declines in hundreds of amphibian species worldwide. This review examines amphibian chytridiomycosis host-pathogen interactions and available evidence for coevolution between Bd and its numerous hosts. We summarize recent evidence showing that Bd genotypes vary...
Source: Current Opinion in Microbiology - February 22, 2024 Category: Microbiology Authors: Tamilie Carvalho Anat M Belasen L Felipe Toledo Timothy Y James Source Type: research
Editorial overview: A critical crossroad in microbiome research: Where do we go?
Curr Opin Microbiol. 2024 Feb 19;78:102438. doi: 10.1016/j.mib.2024.102438. Online ahead of print.NO ABSTRACTPMID:38377654 | DOI:10.1016/j.mib.2024.102438 (Source: Current Opinion in Microbiology)
Source: Current Opinion in Microbiology - February 20, 2024 Category: Microbiology Authors: Maria Carmen Collado Christopher J Stewart Source Type: research
Editorial overview: A critical crossroad in microbiome research: Where do we go?
Curr Opin Microbiol. 2024 Feb 19;78:102438. doi: 10.1016/j.mib.2024.102438. Online ahead of print.NO ABSTRACTPMID:38377654 | DOI:10.1016/j.mib.2024.102438 (Source: Current Opinion in Microbiology)
Source: Current Opinion in Microbiology - February 20, 2024 Category: Microbiology Authors: Maria Carmen Collado Christopher J Stewart Source Type: research
Multi-layered genome defences in bacteria
Curr Opin Microbiol. 2024 Feb 17;78:102436. doi: 10.1016/j.mib.2024.102436. Online ahead of print.ABSTRACTBacteria have evolved a variety of defence mechanisms to protect against mobile genetic elements, including restriction-modification systems and CRISPR-Cas. In recent years, dozens of previously unknown defence systems (DSs) have been discovered. Notably, diverse DSs often coexist within the same genome, and some co-occur at frequencies significantly higher than would be expected by chance, implying potential synergistic interactions. Recent studies have provided evidence of defence mechanisms that enhance or complemen...
Source: Current Opinion in Microbiology - February 18, 2024 Category: Microbiology Authors: Aleksei Agapov Kate S Baker Paritosh Bedekar Rama P Bhatia Tim R Blower Michael A Brockhurst Cooper Brown Charlotte E Chong Joanne L Fothergill Shirley Graham James Pj Hall Alice Maestri Stuart McQuarrie Anna Olina Stefano Pagliara Mario Recker Anna Richm Source Type: research
Multi-layered genome defences in bacteria
Curr Opin Microbiol. 2024 Feb 17;78:102436. doi: 10.1016/j.mib.2024.102436. Online ahead of print.ABSTRACTBacteria have evolved a variety of defence mechanisms to protect against mobile genetic elements, including restriction-modification systems and CRISPR-Cas. In recent years, dozens of previously unknown defence systems (DSs) have been discovered. Notably, diverse DSs often coexist within the same genome, and some co-occur at frequencies significantly higher than would be expected by chance, implying potential synergistic interactions. Recent studies have provided evidence of defence mechanisms that enhance or complemen...
Source: Current Opinion in Microbiology - February 18, 2024 Category: Microbiology Authors: Aleksei Agapov Kate S Baker Paritosh Bedekar Rama P Bhatia Tim R Blower Michael A Brockhurst Cooper Brown Charlotte E Chong Joanne L Fothergill Shirley Graham James Pj Hall Alice Maestri Stuart McQuarrie Anna Olina Stefano Pagliara Mario Recker Anna Richm Source Type: research
Multi-layered genome defences in bacteria
Curr Opin Microbiol. 2024 Feb 17;78:102436. doi: 10.1016/j.mib.2024.102436. Online ahead of print.ABSTRACTBacteria have evolved a variety of defence mechanisms to protect against mobile genetic elements, including restriction-modification systems and CRISPR-Cas. In recent years, dozens of previously unknown defence systems (DSs) have been discovered. Notably, diverse DSs often coexist within the same genome, and some co-occur at frequencies significantly higher than would be expected by chance, implying potential synergistic interactions. Recent studies have provided evidence of defence mechanisms that enhance or complemen...
Source: Current Opinion in Microbiology - February 18, 2024 Category: Microbiology Authors: Aleksei Agapov Kate S Baker Paritosh Bedekar Rama P Bhatia Tim R Blower Michael A Brockhurst Cooper Brown Charlotte E Chong Joanne L Fothergill Shirley Graham James Pj Hall Alice Maestri Stuart McQuarrie Anna Olina Stefano Pagliara Mario Recker Anna Richm Source Type: research
Phage susceptibility determinants of the opportunistic pathogen Staphylococcus epidermidis
Curr Opin Microbiol. 2024 Feb 15;78:102434. doi: 10.1016/j.mib.2024.102434. Online ahead of print.ABSTRACTStaphylococcus epidermidis is a common member of the human skin and nose microbiomes and a frequent cause of invasive infections. Transducing phages accomplish the horizontal transfer of resistance and virulence genes by mispackaging of mobile-genetic elements, contributing to severe, therapy-refractory S. epidermidis infections. Lytic phages on the other hand can be interesting candidates for new anti-S. epidermidis phage therapies. Despite the importance of phages, we are only beginning to unravel S. epidermidis phag...
Source: Current Opinion in Microbiology - February 16, 2024 Category: Microbiology Authors: Christian Beck Janes Krusche Ahmed M A Elsherbini Xin Du Andreas Peschel Source Type: research
Phage susceptibility determinants of the opportunistic pathogen Staphylococcus epidermidis
Curr Opin Microbiol. 2024 Feb 15;78:102434. doi: 10.1016/j.mib.2024.102434. Online ahead of print.ABSTRACTStaphylococcus epidermidis is a common member of the human skin and nose microbiomes and a frequent cause of invasive infections. Transducing phages accomplish the horizontal transfer of resistance and virulence genes by mispackaging of mobile-genetic elements, contributing to severe, therapy-refractory S. epidermidis infections. Lytic phages on the other hand can be interesting candidates for new anti-S. epidermidis phage therapies. Despite the importance of phages, we are only beginning to unravel S. epidermidis phag...
Source: Current Opinion in Microbiology - February 16, 2024 Category: Microbiology Authors: Christian Beck Janes Krusche Ahmed M A Elsherbini Xin Du Andreas Peschel Source Type: research
