Cell cycle-regulated ApiAP2s and parasite development: the Toxoplasma paradigm
Curr Opin Microbiol. 2023 Oct 26;76:102383. doi: 10.1016/j.mib.2023.102383. Online ahead of print.ABSTRACTThe cell division cycle of T. gondii is driven by cyclically expressed ApiAP2 transcription factors (AP2s) that promote gene sets (regulons) associated with specific biological functions. AP2s drive other AP2s, thereby propelling the progressive gene expression waves defining the lytic cycle. AP2s can act as dimers by themselves, in combination with other AP2s (constitutive or cyclical) or in complexes with epigenetic factors. Exit from the cell cycle into either the extracellular state or differentiation into bradyzoi...
Source: Current Opinion in Microbiology - October 28, 2023 Category: Microbiology Authors: Kourosh Zarringhalam Sida Ye Jingjing Lou Yasaman Rezvani Marc-Jan Gubbels Source Type: research
Innovative and potential treatments for fungal central nervous system infections
Curr Opin Microbiol. 2023 Oct 25;76:102397. doi: 10.1016/j.mib.2023.102397. Online ahead of print.ABSTRACTFungal infections of the central nervous system (FI-CNS) are a problematic and important medical challenge considering that those most affected are immunocompromised. Individuals with systemic cryptococcosis (67-84%), candidiasis (3-64%), blastomycosis (40%), coccidioidomycosis (25%), histoplasmosis (5-20%), mucormycosis (12%), and aspergillosis (4-6%) are highly susceptible to develop CNS involvement, which often results in high mortality (15-100%) depending on the mycosis and the affected immunosuppressed population....
Source: Current Opinion in Microbiology - October 28, 2023 Category: Microbiology Authors: Marta Reguera-Gomez Michael R Dores Luis R Martinez Source Type: research
Cell cycle-regulated ApiAP2s and parasite development: the Toxoplasma paradigm
Curr Opin Microbiol. 2023 Oct 26;76:102383. doi: 10.1016/j.mib.2023.102383. Online ahead of print.ABSTRACTThe cell division cycle of T. gondii is driven by cyclically expressed ApiAP2 transcription factors (AP2s) that promote gene sets (regulons) associated with specific biological functions. AP2s drive other AP2s, thereby propelling the progressive gene expression waves defining the lytic cycle. AP2s can act as dimers by themselves, in combination with other AP2s (constitutive or cyclical) or in complexes with epigenetic factors. Exit from the cell cycle into either the extracellular state or differentiation into bradyzoi...
Source: Current Opinion in Microbiology - October 28, 2023 Category: Microbiology Authors: Kourosh Zarringhalam Sida Ye Jingjing Lou Yasaman Rezvani Marc-Jan Gubbels Source Type: research
Innovative and potential treatments for fungal central nervous system infections
Curr Opin Microbiol. 2023 Oct 25;76:102397. doi: 10.1016/j.mib.2023.102397. Online ahead of print.ABSTRACTFungal infections of the central nervous system (FI-CNS) are a problematic and important medical challenge considering that those most affected are immunocompromised. Individuals with systemic cryptococcosis (67-84%), candidiasis (3-64%), blastomycosis (40%), coccidioidomycosis (25%), histoplasmosis (5-20%), mucormycosis (12%), and aspergillosis (4-6%) are highly susceptible to develop CNS involvement, which often results in high mortality (15-100%) depending on the mycosis and the affected immunosuppressed population....
Source: Current Opinion in Microbiology - October 28, 2023 Category: Microbiology Authors: Marta Reguera-Gomez Michael R Dores Luis R Martinez Source Type: research
Cell cycle-regulated ApiAP2s and parasite development: the Toxoplasma paradigm
Curr Opin Microbiol. 2023 Oct 26;76:102383. doi: 10.1016/j.mib.2023.102383. Online ahead of print.ABSTRACTThe cell division cycle of T. gondii is driven by cyclically expressed ApiAP2 transcription factors (AP2s) that promote gene sets (regulons) associated with specific biological functions. AP2s drive other AP2s, thereby propelling the progressive gene expression waves defining the lytic cycle. AP2s can act as dimers by themselves, in combination with other AP2s (constitutive or cyclical) or in complexes with epigenetic factors. Exit from the cell cycle into either the extracellular state or differentiation into bradyzoi...
Source: Current Opinion in Microbiology - October 28, 2023 Category: Microbiology Authors: Kourosh Zarringhalam Sida Ye Jingjing Lou Yasaman Rezvani Marc-Jan Gubbels Source Type: research
The multifaceted roles of Myb domain-containing proteins in apicomplexan parasites
Curr Opin Microbiol. 2023 Oct 20;76:102395. doi: 10.1016/j.mib.2023.102395. Online ahead of print.ABSTRACTApicomplexan parasites are a large and diverse clade of protists responsible for significant diseases of humans and animals. Central to the ability of these parasites to colonize their host and evade immune responses is an expanded repertoire of gene-expression programs that requires the coordinated action of complex transcriptional networks. DNA-binding proteins and chromatin regulators are essential orchestrators of apicomplexan gene expression that often act in concert. Although apicomplexan genomes encode various f...
Source: Current Opinion in Microbiology - October 22, 2023 Category: Microbiology Authors: Dominic Schwarz Sebastian Lourido Source Type: research
Crosstalk between (p)ppGpp and other nucleotide second messengers
Curr Opin Microbiol. 2023 Oct 20;76:102398. doi: 10.1016/j.mib.2023.102398. Online ahead of print.ABSTRACTIn response to environmental cues, bacteria produce intracellular nucleotide messengers to regulate a wide variety of cellular processes and physiology. Studies on individual nucleotide messengers, such as (p)ppGpp or cyclic (di)nucleotides, have established their respective regulatory themes. As research on nucleotide signaling networks expands, recent studies have begun to uncover various crosstalk mechanisms between (p)ppGpp and other nucleotide messengers, including signal conversion, allosteric regulation, and tar...
Source: Current Opinion in Microbiology - October 22, 2023 Category: Microbiology Authors: Danny K Fung Aude E Trinquier Jue D Wang Source Type: research
The multifaceted roles of Myb domain-containing proteins in apicomplexan parasites
Curr Opin Microbiol. 2023 Oct 20;76:102395. doi: 10.1016/j.mib.2023.102395. Online ahead of print.ABSTRACTApicomplexan parasites are a large and diverse clade of protists responsible for significant diseases of humans and animals. Central to the ability of these parasites to colonize their host and evade immune responses is an expanded repertoire of gene-expression programs that requires the coordinated action of complex transcriptional networks. DNA-binding proteins and chromatin regulators are essential orchestrators of apicomplexan gene expression that often act in concert. Although apicomplexan genomes encode various f...
Source: Current Opinion in Microbiology - October 22, 2023 Category: Microbiology Authors: Dominic Schwarz Sebastian Lourido Source Type: research
Crosstalk between (p)ppGpp and other nucleotide second messengers
Curr Opin Microbiol. 2023 Oct 20;76:102398. doi: 10.1016/j.mib.2023.102398. Online ahead of print.ABSTRACTIn response to environmental cues, bacteria produce intracellular nucleotide messengers to regulate a wide variety of cellular processes and physiology. Studies on individual nucleotide messengers, such as (p)ppGpp or cyclic (di)nucleotides, have established their respective regulatory themes. As research on nucleotide signaling networks expands, recent studies have begun to uncover various crosstalk mechanisms between (p)ppGpp and other nucleotide messengers, including signal conversion, allosteric regulation, and tar...
Source: Current Opinion in Microbiology - October 22, 2023 Category: Microbiology Authors: Danny K Fung Aude E Trinquier Jue D Wang Source Type: research
The multifaceted roles of Myb domain-containing proteins in apicomplexan parasites
Curr Opin Microbiol. 2023 Oct 20;76:102395. doi: 10.1016/j.mib.2023.102395. Online ahead of print.ABSTRACTApicomplexan parasites are a large and diverse clade of protists responsible for significant diseases of humans and animals. Central to the ability of these parasites to colonize their host and evade immune responses is an expanded repertoire of gene-expression programs that requires the coordinated action of complex transcriptional networks. DNA-binding proteins and chromatin regulators are essential orchestrators of apicomplexan gene expression that often act in concert. Although apicomplexan genomes encode various f...
Source: Current Opinion in Microbiology - October 22, 2023 Category: Microbiology Authors: Dominic Schwarz Sebastian Lourido Source Type: research
Crosstalk between (p)ppGpp and other nucleotide second messengers
Curr Opin Microbiol. 2023 Oct 20;76:102398. doi: 10.1016/j.mib.2023.102398. Online ahead of print.ABSTRACTIn response to environmental cues, bacteria produce intracellular nucleotide messengers to regulate a wide variety of cellular processes and physiology. Studies on individual nucleotide messengers, such as (p)ppGpp or cyclic (di)nucleotides, have established their respective regulatory themes. As research on nucleotide signaling networks expands, recent studies have begun to uncover various crosstalk mechanisms between (p)ppGpp and other nucleotide messengers, including signal conversion, allosteric regulation, and tar...
Source: Current Opinion in Microbiology - October 22, 2023 Category: Microbiology Authors: Danny K Fung Aude E Trinquier Jue D Wang Source Type: research
The multifaceted roles of Myb domain-containing proteins in apicomplexan parasites
Curr Opin Microbiol. 2023 Oct 20;76:102395. doi: 10.1016/j.mib.2023.102395. Online ahead of print.ABSTRACTApicomplexan parasites are a large and diverse clade of protists responsible for significant diseases of humans and animals. Central to the ability of these parasites to colonize their host and evade immune responses is an expanded repertoire of gene-expression programs that requires the coordinated action of complex transcriptional networks. DNA-binding proteins and chromatin regulators are essential orchestrators of apicomplexan gene expression that often act in concert. Although apicomplexan genomes encode various f...
Source: Current Opinion in Microbiology - October 22, 2023 Category: Microbiology Authors: Dominic Schwarz Sebastian Lourido Source Type: research
Crosstalk between (p)ppGpp and other nucleotide second messengers
Curr Opin Microbiol. 2023 Oct 20;76:102398. doi: 10.1016/j.mib.2023.102398. Online ahead of print.ABSTRACTIn response to environmental cues, bacteria produce intracellular nucleotide messengers to regulate a wide variety of cellular processes and physiology. Studies on individual nucleotide messengers, such as (p)ppGpp or cyclic (di)nucleotides, have established their respective regulatory themes. As research on nucleotide signaling networks expands, recent studies have begun to uncover various crosstalk mechanisms between (p)ppGpp and other nucleotide messengers, including signal conversion, allosteric regulation, and tar...
Source: Current Opinion in Microbiology - October 22, 2023 Category: Microbiology Authors: Danny K Fung Aude E Trinquier Jue D Wang Source Type: research
The multifaceted roles of Myb domain-containing proteins in apicomplexan parasites
Curr Opin Microbiol. 2023 Oct 20;76:102395. doi: 10.1016/j.mib.2023.102395. Online ahead of print.ABSTRACTApicomplexan parasites are a large and diverse clade of protists responsible for significant diseases of humans and animals. Central to the ability of these parasites to colonize their host and evade immune responses is an expanded repertoire of gene-expression programs that requires the coordinated action of complex transcriptional networks. DNA-binding proteins and chromatin regulators are essential orchestrators of apicomplexan gene expression that often act in concert. Although apicomplexan genomes encode various f...
Source: Current Opinion in Microbiology - October 22, 2023 Category: Microbiology Authors: Dominic Schwarz Sebastian Lourido Source Type: research
Crosstalk between (p)ppGpp and other nucleotide second messengers
Curr Opin Microbiol. 2023 Oct 20;76:102398. doi: 10.1016/j.mib.2023.102398. Online ahead of print.ABSTRACTIn response to environmental cues, bacteria produce intracellular nucleotide messengers to regulate a wide variety of cellular processes and physiology. Studies on individual nucleotide messengers, such as (p)ppGpp or cyclic (di)nucleotides, have established their respective regulatory themes. As research on nucleotide signaling networks expands, recent studies have begun to uncover various crosstalk mechanisms between (p)ppGpp and other nucleotide messengers, including signal conversion, allosteric regulation, and tar...
Source: Current Opinion in Microbiology - October 22, 2023 Category: Microbiology Authors: Danny K Fung Aude E Trinquier Jue D Wang Source Type: research
