Function of autophagy genes in innate immune defense against mucosal pathogens
Curr Opin Microbiol. 2024 Mar 29;79:102456. doi: 10.1016/j.mib.2024.102456. Online ahead of print.ABSTRACTMucosal immunity is posed to constantly interact with commensal microbes and invading pathogens. As a fundamental cell biological pathway affecting immune response, autophagy regulates the interaction between mucosal immunity and microbes through multiple mechanisms, including direct elimination of microbes, control of inflammation, antigen presentation and lymphocyte homeostasis, and secretion of immune mediators. Some of these physiologically important functions do not involve canonical degradative autophagy but rely...
Source: Current Opinion in Microbiology - March 30, 2024 Category: Microbiology Authors: Xiaoyan Cui Ya-Ting Wang Source Type: research
Host determinants and responses underlying SARS-CoV-2 liver tropism
Curr Opin Microbiol. 2024 Mar 23;79:102455. doi: 10.1016/j.mib.2024.102455. Online ahead of print.ABSTRACTHepatic sequelae are frequently reported in coronavirus disease 2019 cases and are correlated with increased disease severity. Therefore, a detailed exploration of host factors contributing to hepatic impairment and ultimately infection outcomes in patients is essential for improved clinical management. The causes of hepatic injury are not limited to drug-mediated toxicity or aberrant host inflammatory responses. Indeed, multiple studies report the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2...
Source: Current Opinion in Microbiology - March 24, 2024 Category: Microbiology Authors: Natalie Heinen Mara Kl öhn Saskia Westhoven Richard Jp Brown Stephanie Pfaender Source Type: research
Host determinants and responses underlying SARS-CoV-2 liver tropism
Curr Opin Microbiol. 2024 Mar 23;79:102455. doi: 10.1016/j.mib.2024.102455. Online ahead of print.ABSTRACTHepatic sequelae are frequently reported in coronavirus disease 2019 cases and are correlated with increased disease severity. Therefore, a detailed exploration of host factors contributing to hepatic impairment and ultimately infection outcomes in patients is essential for improved clinical management. The causes of hepatic injury are not limited to drug-mediated toxicity or aberrant host inflammatory responses. Indeed, multiple studies report the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2...
Source: Current Opinion in Microbiology - March 24, 2024 Category: Microbiology Authors: Natalie Heinen Mara Kl öhn Saskia Westhoven Richard Jp Brown Stephanie Pfaender Source Type: research
Host determinants and responses underlying SARS-CoV-2 liver tropism
Curr Opin Microbiol. 2024 Mar 23;79:102455. doi: 10.1016/j.mib.2024.102455. Online ahead of print.ABSTRACTHepatic sequelae are frequently reported in coronavirus disease 2019 cases and are correlated with increased disease severity. Therefore, a detailed exploration of host factors contributing to hepatic impairment and ultimately infection outcomes in patients is essential for improved clinical management. The causes of hepatic injury are not limited to drug-mediated toxicity or aberrant host inflammatory responses. Indeed, multiple studies report the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2...
Source: Current Opinion in Microbiology - March 24, 2024 Category: Microbiology Authors: Natalie Heinen Mara Kl öhn Saskia Westhoven Richard Jp Brown Stephanie Pfaender Source Type: research
Host determinants and responses underlying SARS-CoV-2 liver tropism
Curr Opin Microbiol. 2024 Mar 23;79:102455. doi: 10.1016/j.mib.2024.102455. Online ahead of print.ABSTRACTHepatic sequelae are frequently reported in coronavirus disease 2019 cases and are correlated with increased disease severity. Therefore, a detailed exploration of host factors contributing to hepatic impairment and ultimately infection outcomes in patients is essential for improved clinical management. The causes of hepatic injury are not limited to drug-mediated toxicity or aberrant host inflammatory responses. Indeed, multiple studies report the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2...
Source: Current Opinion in Microbiology - March 24, 2024 Category: Microbiology Authors: Natalie Heinen Mara Kl öhn Saskia Westhoven Richard Jp Brown Stephanie Pfaender Source Type: research
Host determinants and responses underlying SARS-CoV-2 liver tropism
Curr Opin Microbiol. 2024 Mar 23;79:102455. doi: 10.1016/j.mib.2024.102455. Online ahead of print.ABSTRACTHepatic sequelae are frequently reported in coronavirus disease 2019 cases and are correlated with increased disease severity. Therefore, a detailed exploration of host factors contributing to hepatic impairment and ultimately infection outcomes in patients is essential for improved clinical management. The causes of hepatic injury are not limited to drug-mediated toxicity or aberrant host inflammatory responses. Indeed, multiple studies report the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2...
Source: Current Opinion in Microbiology - March 24, 2024 Category: Microbiology Authors: Natalie Heinen Mara Kl öhn Saskia Westhoven Richard Jp Brown Stephanie Pfaender Source Type: research
The expanding universe of contractile injection systems in bacteria
Curr Opin Microbiol. 2024 Mar 22;79:102465. doi: 10.1016/j.mib.2024.102465. Online ahead of print.ABSTRACTContractile injection systems (CISs) are phage tail-like machineries found in a wide range of bacteria. They are often deployed by bacteria to translocate effectors into the extracellular space or into target cells. CISs are classified into intracellular type VI secretion systems (T6SSs) and extracellular CIS (eCISs). eCISs are assembled in cytoplasm and released into the extracellular milieu upon cell lysis, while T6SSs are the secretion systems widespread among Gram-negative bacteria and actively translocate effector...
Source: Current Opinion in Microbiology - March 23, 2024 Category: Microbiology Authors: Lin Lin Source Type: research
The expanding universe of contractile injection systems in bacteria
Curr Opin Microbiol. 2024 Mar 22;79:102465. doi: 10.1016/j.mib.2024.102465. Online ahead of print.ABSTRACTContractile injection systems (CISs) are phage tail-like machineries found in a wide range of bacteria. They are often deployed by bacteria to translocate effectors into the extracellular space or into target cells. CISs are classified into intracellular type VI secretion systems (T6SSs) and extracellular CIS (eCISs). eCISs are assembled in cytoplasm and released into the extracellular milieu upon cell lysis, while T6SSs are the secretion systems widespread among Gram-negative bacteria and actively translocate effector...
Source: Current Opinion in Microbiology - March 23, 2024 Category: Microbiology Authors: Lin Lin Source Type: research
Upping the ante: enhanced expression of interferon-antagonizing ORF6 and ORF9b proteins by SARS-CoV-2 variants of concern
Curr Opin Microbiol. 2024 Mar 21;79:102454. doi: 10.1016/j.mib.2024.102454. Online ahead of print.ABSTRACTSARS-CoV-2 exhibits a remarkable capability to subvert the host antiviral innate immune system. This adeptness is orchestrated by viral proteins, which initially attempt to obstruct the activation of the antiviral immune program and then act as a fail-safe mechanism to mitigate the downstream effects of the activated immune response. This dual strategy leads to delayed expression and enfeebled action of type-I and -III interferons at the infection site, enabling the virus to replicate extensively in the lungs and subse...
Source: Current Opinion in Microbiology - March 22, 2024 Category: Microbiology Authors: Allen Caobi Mohsan Saeed Source Type: research
Ecology and evolution of algal-fungal symbioses
Curr Opin Microbiol. 2024 Mar 9;79:102452. doi: 10.1016/j.mib.2024.102452. Online ahead of print.ABSTRACTEcological interactions and symbiosis between algae and fungi are ancient, widespread, and diverse with many independent origins. The heterotrophic constraint on fungal nutrition drives fungal interactions with autotrophic organisms, including algae. While ancestors of modern fungi may have evolved as parasites of algae, there remains a latent ability in algae to detect and respond to fungi through a range of symbioses that are witnessed today in the astounding diversity of lichens, associations with corticoid and polyp...
Source: Current Opinion in Microbiology - March 10, 2024 Category: Microbiology Authors: Gregory Bonito Source Type: research
Ecology and evolution of algal-fungal symbioses
Curr Opin Microbiol. 2024 Mar 9;79:102452. doi: 10.1016/j.mib.2024.102452. Online ahead of print.ABSTRACTEcological interactions and symbiosis between algae and fungi are ancient, widespread, and diverse with many independent origins. The heterotrophic constraint on fungal nutrition drives fungal interactions with autotrophic organisms, including algae. While ancestors of modern fungi may have evolved as parasites of algae, there remains a latent ability in algae to detect and respond to fungi through a range of symbioses that are witnessed today in the astounding diversity of lichens, associations with corticoid and polyp...
Source: Current Opinion in Microbiology - March 10, 2024 Category: Microbiology Authors: Gregory Bonito Source Type: research
Ecology and evolution of algal-fungal symbioses
Curr Opin Microbiol. 2024 Mar 9;79:102452. doi: 10.1016/j.mib.2024.102452. Online ahead of print.ABSTRACTEcological interactions and symbiosis between algae and fungi are ancient, widespread, and diverse with many independent origins. The heterotrophic constraint on fungal nutrition drives fungal interactions with autotrophic organisms, including algae. While ancestors of modern fungi may have evolved as parasites of algae, there remains a latent ability in algae to detect and respond to fungi through a range of symbioses that are witnessed today in the astounding diversity of lichens, associations with corticoid and polyp...
Source: Current Opinion in Microbiology - March 10, 2024 Category: Microbiology Authors: Gregory Bonito Source Type: research
Ecology and evolution of algal-fungal symbioses
Curr Opin Microbiol. 2024 Mar 9;79:102452. doi: 10.1016/j.mib.2024.102452. Online ahead of print.ABSTRACTEcological interactions and symbiosis between algae and fungi are ancient, widespread, and diverse with many independent origins. The heterotrophic constraint on fungal nutrition drives fungal interactions with autotrophic organisms, including algae. While ancestors of modern fungi may have evolved as parasites of algae, there remains a latent ability in algae to detect and respond to fungi through a range of symbioses that are witnessed today in the astounding diversity of lichens, associations with corticoid and polyp...
Source: Current Opinion in Microbiology - March 10, 2024 Category: Microbiology Authors: Gregory Bonito Source Type: research
Ecology and evolution of algal-fungal symbioses
Curr Opin Microbiol. 2024 Mar 9;79:102452. doi: 10.1016/j.mib.2024.102452. Online ahead of print.ABSTRACTEcological interactions and symbiosis between algae and fungi are ancient, widespread, and diverse with many independent origins. The heterotrophic constraint on fungal nutrition drives fungal interactions with autotrophic organisms, including algae. While ancestors of modern fungi may have evolved as parasites of algae, there remains a latent ability in algae to detect and respond to fungi through a range of symbioses that are witnessed today in the astounding diversity of lichens, associations with corticoid and polyp...
Source: Current Opinion in Microbiology - March 10, 2024 Category: Microbiology Authors: Gregory Bonito Source Type: research
Ecology and evolution of algal-fungal symbioses
Curr Opin Microbiol. 2024 Mar 9;79:102452. doi: 10.1016/j.mib.2024.102452. Online ahead of print.ABSTRACTEcological interactions and symbiosis between algae and fungi are ancient, widespread, and diverse with many independent origins. The heterotrophic constraint on fungal nutrition drives fungal interactions with autotrophic organisms, including algae. While ancestors of modern fungi may have evolved as parasites of algae, there remains a latent ability in algae to detect and respond to fungi through a range of symbioses that are witnessed today in the astounding diversity of lichens, associations with corticoid and polyp...
Source: Current Opinion in Microbiology - March 10, 2024 Category: Microbiology Authors: Gregory Bonito Source Type: research
