Non-canonical food sources: bacterial metabolism of Maillard reaction products and its regulation
Curr Opin Microbiol. 2023 Oct 14;76:102393. doi: 10.1016/j.mib.2023.102393. Online ahead of print.ABSTRACTProteins are an important part of our regular diet. During food processing, their amino acid composition can be chemically altered by the reaction of free amino groups with sugars - a process termed glycation. The resulting Maillard reaction products (MRPs) have low bioavailability and thus predominantly end up in the colon where they encounter our gut microbiota. In the following review, we summarize bacterial strategies to efficiently metabolize these non-canonical amino acids. A particular focus will be on the compl...
Source: Current Opinion in Microbiology - October 16, 2023 Category: Microbiology Authors: J ürgen Lassak Erica F Aveta Patroklos Vougioukas Michael Hellwig Source Type: research

Non-canonical food sources: bacterial metabolism of Maillard reaction products and its regulation
Curr Opin Microbiol. 2023 Oct 14;76:102393. doi: 10.1016/j.mib.2023.102393. Online ahead of print.ABSTRACTProteins are an important part of our regular diet. During food processing, their amino acid composition can be chemically altered by the reaction of free amino groups with sugars - a process termed glycation. The resulting Maillard reaction products (MRPs) have low bioavailability and thus predominantly end up in the colon where they encounter our gut microbiota. In the following review, we summarize bacterial strategies to efficiently metabolize these non-canonical amino acids. A particular focus will be on the compl...
Source: Current Opinion in Microbiology - October 16, 2023 Category: Microbiology Authors: J ürgen Lassak Erica F Aveta Patroklos Vougioukas Michael Hellwig Source Type: research

Antibiotics from rare actinomycetes, beyond the genus Streptomyces
Curr Opin Microbiol. 2023 Oct 5;76:102385. doi: 10.1016/j.mib.2023.102385. Online ahead of print.ABSTRACTThroughout the golden age of antibiotic discovery, Streptomyces have been unsurpassed for their ability to produce bioactive metabolites. Yet, this success has been hampered by rediscovery. As we enter a new stage of biodiscovery, omics data and existing scientific repositories can enable informed choices on the biodiversity that may yield novel antibiotics. Here, we focus on the chemical potential of rare actinomycetes, defined as bacteria within the order Actinomycetales, but not belonging to the genus Streptomyces. T...
Source: Current Opinion in Microbiology - October 7, 2023 Category: Microbiology Authors: Jonathan Parra Ainsley Beaton Ryan F Seipke Barrie Wilkinson Matthew I Hutchings Katherine R Duncan Source Type: research

Antibiotics from rare actinomycetes, beyond the genus Streptomyces
Curr Opin Microbiol. 2023 Oct 5;76:102385. doi: 10.1016/j.mib.2023.102385. Online ahead of print.ABSTRACTThroughout the golden age of antibiotic discovery, Streptomyces have been unsurpassed for their ability to produce bioactive metabolites. Yet, this success has been hampered by rediscovery. As we enter a new stage of biodiscovery, omics data and existing scientific repositories can enable informed choices on the biodiversity that may yield novel antibiotics. Here, we focus on the chemical potential of rare actinomycetes, defined as bacteria within the order Actinomycetales, but not belonging to the genus Streptomyces. T...
Source: Current Opinion in Microbiology - October 7, 2023 Category: Microbiology Authors: Jonathan Parra Ainsley Beaton Ryan F Seipke Barrie Wilkinson Matthew I Hutchings Katherine R Duncan Source Type: research

Antibiotics from rare actinomycetes, beyond the genus Streptomyces
Curr Opin Microbiol. 2023 Oct 5;76:102385. doi: 10.1016/j.mib.2023.102385. Online ahead of print.ABSTRACTThroughout the golden age of antibiotic discovery, Streptomyces have been unsurpassed for their ability to produce bioactive metabolites. Yet, this success has been hampered by rediscovery. As we enter a new stage of biodiscovery, omics data and existing scientific repositories can enable informed choices on the biodiversity that may yield novel antibiotics. Here, we focus on the chemical potential of rare actinomycetes, defined as bacteria within the order Actinomycetales, but not belonging to the genus Streptomyces. T...
Source: Current Opinion in Microbiology - October 7, 2023 Category: Microbiology Authors: Jonathan Parra Ainsley Beaton Ryan F Seipke Barrie Wilkinson Matthew I Hutchings Katherine R Duncan Source Type: research

Antibiotics from rare actinomycetes, beyond the genus Streptomyces
Curr Opin Microbiol. 2023 Oct 5;76:102385. doi: 10.1016/j.mib.2023.102385. Online ahead of print.ABSTRACTThroughout the golden age of antibiotic discovery, Streptomyces have been unsurpassed for their ability to produce bioactive metabolites. Yet, this success has been hampered by rediscovery. As we enter a new stage of biodiscovery, omics data and existing scientific repositories can enable informed choices on the biodiversity that may yield novel antibiotics. Here, we focus on the chemical potential of rare actinomycetes, defined as bacteria within the order Actinomycetales, but not belonging to the genus Streptomyces. T...
Source: Current Opinion in Microbiology - October 7, 2023 Category: Microbiology Authors: Jonathan Parra Ainsley Beaton Ryan F Seipke Barrie Wilkinson Matthew I Hutchings Katherine R Duncan Source Type: research

Antibiotics from rare actinomycetes, beyond the genus Streptomyces
Curr Opin Microbiol. 2023 Oct 5;76:102385. doi: 10.1016/j.mib.2023.102385. Online ahead of print.ABSTRACTThroughout the golden age of antibiotic discovery, Streptomyces have been unsurpassed for their ability to produce bioactive metabolites. Yet, this success has been hampered by rediscovery. As we enter a new stage of biodiscovery, omics data and existing scientific repositories can enable informed choices on the biodiversity that may yield novel antibiotics. Here, we focus on the chemical potential of rare actinomycetes, defined as bacteria within the order Actinomycetales, but not belonging to the genus Streptomyces. T...
Source: Current Opinion in Microbiology - October 7, 2023 Category: Microbiology Authors: Jonathan Parra Ainsley Beaton Ryan F Seipke Barrie Wilkinson Matthew I Hutchings Katherine R Duncan Source Type: research

Antibiotics from rare actinomycetes, beyond the genus Streptomyces
Curr Opin Microbiol. 2023 Oct 5;76:102385. doi: 10.1016/j.mib.2023.102385. Online ahead of print.ABSTRACTThroughout the golden age of antibiotic discovery, Streptomyces have been unsurpassed for their ability to produce bioactive metabolites. Yet, this success has been hampered by rediscovery. As we enter a new stage of biodiscovery, omics data and existing scientific repositories can enable informed choices on the biodiversity that may yield novel antibiotics. Here, we focus on the chemical potential of rare actinomycetes, defined as bacteria within the order Actinomycetales, but not belonging to the genus Streptomyces. T...
Source: Current Opinion in Microbiology - October 7, 2023 Category: Microbiology Authors: Jonathan Parra Ainsley Beaton Ryan F Seipke Barrie Wilkinson Matthew I Hutchings Katherine R Duncan Source Type: research

Antibiotics from rare actinomycetes, beyond the genus Streptomyces
Curr Opin Microbiol. 2023 Oct 5;76:102385. doi: 10.1016/j.mib.2023.102385. Online ahead of print.ABSTRACTThroughout the golden age of antibiotic discovery, Streptomyces have been unsurpassed for their ability to produce bioactive metabolites. Yet, this success has been hampered by rediscovery. As we enter a new stage of biodiscovery, omics data and existing scientific repositories can enable informed choices on the biodiversity that may yield novel antibiotics. Here, we focus on the chemical potential of rare actinomycetes, defined as bacteria within the order Actinomycetales, but not belonging to the genus Streptomyces. T...
Source: Current Opinion in Microbiology - October 7, 2023 Category: Microbiology Authors: Jonathan Parra Ainsley Beaton Ryan F Seipke Barrie Wilkinson Matthew I Hutchings Katherine R Duncan Source Type: research

Antibiotics from rare actinomycetes, beyond the genus Streptomyces
Curr Opin Microbiol. 2023 Oct 5;76:102385. doi: 10.1016/j.mib.2023.102385. Online ahead of print.ABSTRACTThroughout the golden age of antibiotic discovery, Streptomyces have been unsurpassed for their ability to produce bioactive metabolites. Yet, this success has been hampered by rediscovery. As we enter a new stage of biodiscovery, omics data and existing scientific repositories can enable informed choices on the biodiversity that may yield novel antibiotics. Here, we focus on the chemical potential of rare actinomycetes, defined as bacteria within the order Actinomycetales, but not belonging to the genus Streptomyces. T...
Source: Current Opinion in Microbiology - October 7, 2023 Category: Microbiology Authors: Jonathan Parra Ainsley Beaton Ryan F Seipke Barrie Wilkinson Matthew I Hutchings Katherine R Duncan Source Type: research

Evolution and synthetic biology
Curr Opin Microbiol. 2023 Oct 4;76:102394. doi: 10.1016/j.mib.2023.102394. Online ahead of print.ABSTRACTEvolutionary observations have often served as an inspiration for biological design. Decoding of the central dogma of life at a molecular level and understanding of the cellular biochemistry have been elegantly used to engineer various synthetic biology applications, including building genetic circuits in vitro and in cells, building synthetic translational systems, and metabolic engineering in cells to biosynthesize and even bioproduce complex high-value molecules. Here, we review three broad areas of synthetic biology...
Source: Current Opinion in Microbiology - October 6, 2023 Category: Microbiology Authors: Marya Y Ornelas Jason E Cournoyer Stanley Bram Angad P Mehta Source Type: research

The power of the small: the underestimated role of small proteins in bacterial and archaeal physiology
Curr Opin Microbiol. 2023 Sep 28;76:102384. doi: 10.1016/j.mib.2023.102384. Online ahead of print.ABSTRACTSmall proteins encoded by small open-reading frames (sORFs) (≤70 aa) were overlooked for decades due to methodological reasons and are thus often missing in genome annotations. Novel detection methods such as ribosome profiling (Ribo-Seq) and mass spectrometry optimized for small proteins (peptidomics) have opened up a new field of interest and several catalogs of small proteins in bacteria and archaea have been recently reported. Many translated sORFs have been discovered in genomic locations previously thought to b...
Source: Current Opinion in Microbiology - September 30, 2023 Category: Microbiology Authors: Britta Jordan Katrin Weidenbach Ruth A Schmitz Source Type: research

The power of the small: the underestimated role of small proteins in bacterial and archaeal physiology
Curr Opin Microbiol. 2023 Sep 28;76:102384. doi: 10.1016/j.mib.2023.102384. Online ahead of print.ABSTRACTSmall proteins encoded by small open-reading frames (sORFs) (≤70 aa) were overlooked for decades due to methodological reasons and are thus often missing in genome annotations. Novel detection methods such as ribosome profiling (Ribo-Seq) and mass spectrometry optimized for small proteins (peptidomics) have opened up a new field of interest and several catalogs of small proteins in bacteria and archaea have been recently reported. Many translated sORFs have been discovered in genomic locations previously thought to b...
Source: Current Opinion in Microbiology - September 30, 2023 Category: Microbiology Authors: Britta Jordan Katrin Weidenbach Ruth A Schmitz Source Type: research

The power of the small: the underestimated role of small proteins in bacterial and archaeal physiology
Curr Opin Microbiol. 2023 Sep 28;76:102384. doi: 10.1016/j.mib.2023.102384. Online ahead of print.ABSTRACTSmall proteins encoded by small open-reading frames (sORFs) (≤70 aa) were overlooked for decades due to methodological reasons and are thus often missing in genome annotations. Novel detection methods such as ribosome profiling (Ribo-Seq) and mass spectrometry optimized for small proteins (peptidomics) have opened up a new field of interest and several catalogs of small proteins in bacteria and archaea have been recently reported. Many translated sORFs have been discovered in genomic locations previously thought to b...
Source: Current Opinion in Microbiology - September 30, 2023 Category: Microbiology Authors: Britta Jordan Katrin Weidenbach Ruth A Schmitz Source Type: research

The power of the small: the underestimated role of small proteins in bacterial and archaeal physiology
Curr Opin Microbiol. 2023 Sep 28;76:102384. doi: 10.1016/j.mib.2023.102384. Online ahead of print.ABSTRACTSmall proteins encoded by small open-reading frames (sORFs) (≤70 aa) were overlooked for decades due to methodological reasons and are thus often missing in genome annotations. Novel detection methods such as ribosome profiling (Ribo-Seq) and mass spectrometry optimized for small proteins (peptidomics) have opened up a new field of interest and several catalogs of small proteins in bacteria and archaea have been recently reported. Many translated sORFs have been discovered in genomic locations previously thought to b...
Source: Current Opinion in Microbiology - September 30, 2023 Category: Microbiology Authors: Britta Jordan Katrin Weidenbach Ruth A Schmitz Source Type: research