Stenotrophomonas maltophilia: An Urgent Threat with Increasing Antibiotic Resistance
Curr Microbiol. 2023 Nov 13;81(1):6. doi: 10.1007/s00284-023-03524-5.ABSTRACTStenotrophomonas maltophilia is a Gram-negative opportunistic pathogen that can cause many infections, such as chronic pulmonary infections in patients with cystic fibrosis and infections in immunocompromised patients with hematology-oncology diseases. Because of its remarkable and increasing antimicrobial resistance, the treatment of S. maltophilia infections is quite challenging. Meanwhile, the prevalence of S. maltophilia infections is increasing in recent decades. S. maltophilia is usually considered to be of low virulence but has numerous vir...
Source: Current Microbiology - November 13, 2023 Category: Microbiology Authors: Jiaying Liu Yanghui Xiang Ying Zhang Source Type: research
Bio Prospecting of Endophytes and PGPRs in Artemisinin Production for the Socio-economic Advancement
Curr Microbiol. 2023 Nov 10;81(1):4. doi: 10.1007/s00284-023-03516-5.ABSTRACTThe growing demand for Artemisia annua plants in healthcare, food, and pharmaceutical industries has led to increased cultivation efforts to extract a vital compound, Artemisinin. The efficacy of Artemisinin as a potent drug against malaria disease is well established but its limited natural abundance. However, the common practice of using chemical fertilizers for maximum yield has adverse effects on plant growth, development, and the quality of phytochemicals. To address these issues, the review discusses the alternative approach of harnessing be...
Source: Current Microbiology - November 10, 2023 Category: Microbiology Authors: Adi Nath Abhijeet Sharma Shailendra Kumar Singh Shanthy Sundaram Source Type: research
Insights into the Biological Properties of Ligands and Identity of Operator Site for LanK Protein Involved in Landomycin Production
Curr Microbiol. 2023 Nov 10;81(1):5. doi: 10.1007/s00284-023-03528-1.ABSTRACTLanK is a TetR type regulatory protein that coordinates the late steps of the biosynthesis of the landomycin family of antitumor angucyclic polyketides and their export from the cells of Streptomyces cyanogenus S136. We recently described the structure of LanK and showed that it is the carbohydrate portion of the landomycins that is responsible for abrogating the repressing effect of LanK on landomycin production and export. The effect has been established in a series of in vitro tests using synthetic analogs of the landomycin carbohydrate chains....
Source: Current Microbiology - November 10, 2023 Category: Microbiology Authors: Maksym Deneka Iryna Ostash Subbarao Yalamanchili Clay S Bennett Bohdan Ostash Source Type: research
Bio Prospecting of Endophytes and PGPRs in Artemisinin Production for the Socio-economic Advancement
Curr Microbiol. 2023 Nov 10;81(1):4. doi: 10.1007/s00284-023-03516-5.ABSTRACTThe growing demand for Artemisia annua plants in healthcare, food, and pharmaceutical industries has led to increased cultivation efforts to extract a vital compound, Artemisinin. The efficacy of Artemisinin as a potent drug against malaria disease is well established but its limited natural abundance. However, the common practice of using chemical fertilizers for maximum yield has adverse effects on plant growth, development, and the quality of phytochemicals. To address these issues, the review discusses the alternative approach of harnessing be...
Source: Current Microbiology - November 10, 2023 Category: Microbiology Authors: Adi Nath Abhijeet Sharma Shailendra Kumar Singh Shanthy Sundaram Source Type: research
Insights into the Biological Properties of Ligands and Identity of Operator Site for LanK Protein Involved in Landomycin Production
Curr Microbiol. 2023 Nov 10;81(1):5. doi: 10.1007/s00284-023-03528-1.ABSTRACTLanK is a TetR type regulatory protein that coordinates the late steps of the biosynthesis of the landomycin family of antitumor angucyclic polyketides and their export from the cells of Streptomyces cyanogenus S136. We recently described the structure of LanK and showed that it is the carbohydrate portion of the landomycins that is responsible for abrogating the repressing effect of LanK on landomycin production and export. The effect has been established in a series of in vitro tests using synthetic analogs of the landomycin carbohydrate chains....
Source: Current Microbiology - November 10, 2023 Category: Microbiology Authors: Maksym Deneka Iryna Ostash Subbarao Yalamanchili Clay S Bennett Bohdan Ostash Source Type: research
