Advances in Quantitative Tissue Characterization in Myocarditis
AbstractPurpose of ReviewMyocarditis is a heterogeneous disease with variable histologic and clinical presentation. Cardiovascular magnetic resonance (CMR) imaging recently emerged as the imaging modality of choice in myocarditis. This review summarizes recent findings and future directions in this field.Recent FindingsAdvanced quantitative T1 mapping and T2 mapping methods have the technical advantage to detect diffuse myocardial injury in myocarditis, which was not adequately addressed by standard, semiquantitative CMR techniques so far. Recent studies demonstrated that the technical advantages of T1 and T2 mapping techn...
Source: Current Cardiovascular Imaging Reports - February 5, 2017 Category: Radiology Source Type: research

Molecular Imaging of Atherosclerosis: a Clinical Focus
AbstractPurpose of ReviewMolecular imaging of cardiovascular disease is a powerful clinical and experimental approach that can inform our understanding of atherosclerosis biology. Complementing cross-sectional imaging techniques that provide detailed anatomical information, molecular imaging can further detect important biological changes occurring within atheroma and refine the prediction of vascular complications.Recent FindingsMolecular imaging of atherosclerosis can illuminate underlying pathophysiology and serve as a surrogate endpoint in clinical trials of new drugs.SummaryThis review showcases promising molecular ap...
Source: Current Cardiovascular Imaging Reports - February 3, 2017 Category: Radiology Source Type: research

Imaging Options in Cardiac Amyloidosis: Differentiating AL from ATTR
AbstractPurpose of ReviewCardiac amyloidosis (CA) results from the myocardial deposition of abnormally folded endogenous proteins leading to significant morbidity and mortality. Accurate and timely non-invasive diagnosis of cardiac amyloidosis and the correct identification of amyloid type are critical for choosing appropriate therapy. Disease type is defined by the precursor protein and most typically involves light chain (AL) or transthyretin (ATTR). Traditionally, cardiac amyloidosis has been suspected on the basis of characteristic echocardiographic features and confirmed with endomyocardial biopsy. Recent advances in ...
Source: Current Cardiovascular Imaging Reports - January 31, 2017 Category: Radiology Source Type: research

Chagas ’ Disease: Update on Current Diagnosis
AbstractPurpose of ReviewChagas ’ disease has become an emerging health problem due to increased migration. In the present review, we have summarized the usefulness of non-invasive imaging tools for the diagnosis of cardiac involvement in Chagas’ disease, with emphasis on modern technologies. M-mode, bidimensional (2-D), and t hree-dimensional (3-D) echocardiographies may allow the evaluation of left ventricular (LV) regional and global contractile function, right ventricle (RV) impairment, evidence of aneurysms and thrombi, and assessment of diastolic function in any stage of the disease.Recent FindingsNew modalities ...
Source: Current Cardiovascular Imaging Reports - November 3, 2016 Category: Radiology Source Type: research

Controversies in the Use of Fractional Flow Reserve Form Computed Tomography (FFR CT ) vs. Coronary Angiography
AbstractPurpose of ReviewInvasive coronary angiography (ICA) is the gold standard for the anatomical assessment of coronary artery disease. In addition, it provides assessment to coronary physiology and myocardial blood flow through fractional flow reserve (FFR). Furthermore, invasive FFR provides a clear road map that helps in the management of suspected coronary artery disease patients especially if an  intermediate coronary lesion is considered. Despite all these developments, this invasive technique carries its own risk. Non-invasive coronary assessment using coronary computed tomography angiography (CCTA) is now an ...
Source: Current Cardiovascular Imaging Reports - November 3, 2016 Category: Radiology Source Type: research

Role of Intravascular Ultrasound in the Detection of Cardiovascular Disease in Diabetes and Metabolic Syndrome in Latin America
AbstractPurpose of ReviewIntravascular ultrasound (IVUS) is an essential tool in the cardiac cath lab, providing tomographic slices series of intra-luminal and vascular wall images with high quality and spatial resolution, that complement angiographic luminal information. It has been successfully used in research for the understanding of atherosclerotic process, and it was the first clinical method that delineated diverse patterns of atherosclerosis. IVUS also contributed to the advancement in the knowledge of restenosis after percutaneous coronary interventions (PCI).Recent FindingsRoutine clinical of IVUS is hindered in ...
Source: Current Cardiovascular Imaging Reports - November 1, 2016 Category: Radiology Source Type: research

The Potential Role of Combined Highly Sensitive Troponin and Coronary Computed Tomography Angiography in the Evaluation of Patients with Suspected Acute Coronary Syndrome in the Emergency Department
AbstractThe evaluation and triage of patients presenting to the emergency department (ED) with suspected acute coronary syndrome (ACS) remains to be challenging despite available guidelines and clinical evidence. The current guidelines in the USA recommend clinical risk assessment based on cardiovascular risk factors followed by serial electrocardiograms and conventional cardiac troponin measurements, which are supplemented by advanced non-invasive cardiac testing in the majority of patients. This approach is safe, but leads to a lengthy work-up and high cost of care. There is clinical need for diagnostic strategies that w...
Source: Current Cardiovascular Imaging Reports - October 25, 2016 Category: Radiology Source Type: research

Cardiovascular PET/MRI: Initial Clinical Experience
AbstractPurpose of ReviewThe study aims to give a review of the current state of cardiovascular hybrid PET/MRI and to outline its evolution in near future.Recent FindingsProof of feasibility of cardiovascular hybrid PET/MRI has been provided for different cardiovascular pathologies using [18F]-fluorodeoxyglucose (FDG) as tracer; hybrid FDG PET/MRI allows in acute myocardial infarction the visualization of the area-at-risk of infarction, and initial studies show the prognostic value of PET/MRI concerning functional recovery in acute myocardial infarction. FDG PET/MRI enables the detection of inflammation in viral myocarditi...
Source: Current Cardiovascular Imaging Reports - October 13, 2016 Category: Radiology Source Type: research

Modern Assessment of Diastolic Function
AbstractPurpose of ReviewThe goal of this review is to outline the new guidelines released by the ASE/EACVI that seek to simplify the assessment of diastolic function and evaluate the use and potential application of new and emerging technologies.Recent FindingsThe latest guidelines have decreased the number of parameters needed to evaluate diastolic function to 3. The parameters necessary include peak tricuspid regurgitation (TR) velocity, average E/e ′, and indexed left atrial volume (LAVi). At least 2 out of 3 must be positive to determine diastolic dysfunction. There are certain disease states that limit the applicat...
Source: Current Cardiovascular Imaging Reports - October 13, 2016 Category: Radiology Source Type: research

Current and Future Applications of Coronary CT Angiography with and Without FFR in the Emergency Room
AbstractPurpose of ReviewMultiple clinical trials have established the value of Coronary CT angiography (CCTA) for the evaluation of patients presenting to the ED with chest pain and a low to intermediate risk for acute coronary syndrome (ACS). CCTA can be used to evaluate these patients rapidly, effectively, and with relatively low cost and radiation dose.Recent FindingsNew research continues to accumulate, and despite much evidence to support its use in the ED setting, at least one recently published study has presented potentially contradictory results. Additionally, newer techniques that enhance the utility of CCTA, su...
Source: Current Cardiovascular Imaging Reports - October 13, 2016 Category: Radiology Source Type: research

Molecular Imaging of Angiogenesis in Cardiac Regeneration
This article reviews recent literature on noninvasive in vivo molecular imaging of angiogenesis after MI as an integral part of cardiac regeneration. (Source: Current Cardiovascular Imaging Reports)
Source: Current Cardiovascular Imaging Reports - September 9, 2016 Category: Radiology Source Type: research

Speckle Tracking Echocardiographic Imaging in Metabolic Cardiomyopathies
AbstractPurpose of ReviewThe aging population in western nations has experienced an increase in the prevalence of heart failure alongside the increasing rates of obesity, metabolic syndrome, and type 2 diabetes mellitus. Clinical studies have established a strong link between these metabolic derangements and the risk of heart failure.Recent FindingsEchocardiography is an essential tool in supporting the diagnosis of heart failure and establishing its phenotype. Advanced echocardiographic methods based on speckle tracking echocardiography provide unique insights into myocardial mechanics and underlie the novel approach to p...
Source: Current Cardiovascular Imaging Reports - September 4, 2016 Category: Radiology Source Type: research

Noninvasive Cardiac Imaging in Obesity: Challenges and Opportunities
(Source: Current Cardiovascular Imaging Reports)
Source: Current Cardiovascular Imaging Reports - July 22, 2016 Category: Radiology Source Type: research

Therapeutic Uses of Contrast Microbubbles
Abstract Purpose of Review The potential for non-invasive targeted delivery of therapeutic agents and targeted thrombus dissolution using diagnostic ultrasound (DUS) and intravenous microbubbles or droplets is an emerging technology that will change diagnostic ultrasound systems into therapeutic devices. Recent Findings Targeted ultrasound destruction of microbubbles which carry either DNA or inhibitor RNA sequences have been utilized to both promote microvascular regenerati...
Source: Current Cardiovascular Imaging Reports - July 4, 2016 Category: Radiology Source Type: research

Enhanced IVUS: Advances Allowing Higher Resolution and Integrated Devices
Abstract Purpose of Review Intravascular ultrasound (IVUS) has been in use for nearly 30 years and has greatly assisted in the evaluation and advancement of coronary interventional devices and strategy. With increasing interest in vulnerable plaque, new imaging tools and/or improved IVUS resolution is required. This chapter will describe these enhancements. Recent Findings Optical coherence tomography (OCT) has become catheter based and allows improved definition of vulnera...
Source: Current Cardiovascular Imaging Reports - July 4, 2016 Category: Radiology Source Type: research