Advances in Quantitative Tissue Characterization in Myocarditis

AbstractPurpose of ReviewMyocarditis is a heterogeneous disease with variable histologic and clinical presentation. Cardiovascular magnetic resonance (CMR) imaging recently emerged as the imaging modality of choice in myocarditis. This review summarizes recent findings and future directions in this field.Recent FindingsAdvanced quantitative T1 mapping and T2 mapping methods have the technical advantage to detect diffuse myocardial injury in myocarditis, which was not adequately addressed by standard, semiquantitative CMR techniques so far. Recent studies demonstrated that the technical advantages of T1 and T2 mapping techniques improve the diagnostic accuracy and assessment of disease activity in myocarditis compared to standard CMR techniques using the Lake Louise Criteria for a CMR-based diagnosis of myocarditis.SummaryQuantitative tissue characterization by T1 and T2 mapping techniques will further enhance the value of CMR in myocarditis.
Source: Current Cardiovascular Imaging Reports - Category: Radiology Source Type: research

Related Links:

Modern Pathology, Published online: 18 September 2019; doi:10.1038/s41379-019-0363-0Immune checkpoint inhibitor associated myocarditis occurs in both high-grade and low-grade forms
Source: Modern Pathology - Category: Pathology Authors: Source Type: research
Publication date: 5 January 2020Source: Journal of Molecular Structure, Volume 1199Author(s): Dong-Song Bai, Li-Ying Bai, Ming Zhao, Qing-Shan ZhangAbstractThis work presents the synthesis and characterization of a dicyanamide-bridged coordination polymer [Co(L)2(dca)]n (1) by using the bidentate NO donor Schiff base ligand (2-methoxy-6-((methylimino)methyl)phenol. Furthermore, the nanoparticles of complex 1 (denoted as nano 1) was prepared by a green grinding approach, which has good water dispersibility. The CVB3 infection mice model was built successfully, followed by nano 1 given for treatment. RT-PCR was used to detec...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Condition:   Myocarditis Intervention:   Sponsor:   Medical University of Warsaw Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 10 September 2019Source: Journal of Cardiology CasesAuthor(s): Shogo Yamaguchi, Akinori Sawamura, Masato Nakaguro, Yoshie Shimoyama, Ryota Morimoto, Hiroo Kato, Yoshihito Arao, Hideo Oishi, Tomoaki Haga, Tasuku Kuwayama, Tsuyoshi Yokoi, Hiroaki Hiraiwa, Toru Kondo, Takahiro Okumura, Toyoaki MuroharaAbstractA 51-year-old male, previously diagnosed with central diabetes insipidus due to lymphocytic hypophysitis, presented with fever and dyspnea for 1 week. On arrival, he exhibited hypotension (85/60 mmHg) and sinus tachycardia (110 bpm). His electrocardiogram revealed mild ST elev...
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
TpNOCA: Troponin-positive nonobstructive coronary arteries Apparent myocardial infarction in the absence of obstructive coronary artery disease MINOCA: Myocardial Infarction With Nonobstructive Coronary Arteries Term reserved for only those who have evidence of ischemia related myocardial necrosis MINOCA included only coronary disorders like coronary dissection, plaque disruption, coronary spasm, microvascular dysfunction, coronary thrombus and embolism (recanalized). TpNOCA includes in addition to MINOCA, myocardial disorders like myocarditis, takotsubo cardiomyopathy and other cardiomyopathies as well as non cardia...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Cardiology Source Type: blogs
Conclusion From the experimental findings, it was concluded that clozapine could depress the eNOS regulation and thereby perhaps initiates cardiovascular complications through subsequent vascular events [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Drug Research - Category: Drugs & Pharmacology Authors: Tags: Short Communication Source Type: research
We present a case of extensively metastatic oral mucosal melanoma that responded successfully to combined immune checkpoint blockade with ipilimumab and nivolumab but developed multiple immune-related adverse events, including myocarditis, a rare event associated with immunotherapy of elderly melanoma patients. Though the acute myocarditis was managed successfully, the patient succumbed to sudden cardiac death. This case highlights the fact, that autoimmune carditis must be considered when working up the sudden onset of shortness of breath in patients on immune checkpoint blockade. After controlling the acute myocarditis w...
Source: Journal of Immunotherapy - Category: Allergy & Immunology Tags: Clincal Studies Source Type: research
This study aimed to compare the efficacy and safety of ulinastatin combined with creatine phosphate sodium and ribavirin combined with creatine phosphate sodium in the treatment of pediatric viral myocarditis. PATIENTS AND METHODS: 155 children with viral myocarditis in the Xuzhou Children's Hospital, were retrospectively analyzed. 80 of them received ulinastatin combined with creatine phosphate sodium, and were regarded as observation group; other 75 patients received ribavirin combined with creatine phosphate sodium and were regarded as the control group. The therapeutic efficacy of the two groups was observed, the i...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
In conclusion, IL-10-producing B cells downregulate the proportion of Th1 and Th17 cells to alleviate inflammatory damage in the myocardium during VMC before the induction or the early phase of disease.SignificanceThese findings suggest that IL-10-producing B cells may be a new therapeutic target for modulating the immune response in VMC.
Source: Life Sciences - Category: Biology Source Type: research
This study demonstrates that formalin treatment increases the stability and immunogenicity of CVB1-VLP vaccine and may offer a universal tool for the stabilization of VLPs in the production of more efficient vaccines.
Source: Antiviral Therapy - Category: Virology Source Type: research
More News: Cardiology | Cardiovascular | Heart | Myocarditis | Radiology | Study