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Circadian Rhythms and Sleep Disorders Associated to Major Depressive Disorder: Pathophysiology and Therapeutic Opportunities
CNS Neurol Disord Drug Targets. 2023 Oct 25. doi: 10.2174/0118715273254093231020052002. Online ahead of print.ABSTRACTMajor depressive disorder (MDD) is a complex mood disorder. While much progress has been made in understanding the pathophysiology of MDD, no single mechanism can explain all facets of this disorder. Several studies show that disturbances in biological rhythms can lead to the development of MDD. Indeed, insomnia or hypersomnia are symptoms included in the MDD diagnostic criteria. Clinical studies and meta-analyses showed a strong relationship between MDD and sleep disorders. Sleep disorder and MDD are assoc...
Source: CNS and Neurological Disorders Drug Targets - October 27, 2023 Category: Drugs & Pharmacology Authors: Luana M Manosso Luciano A Duarte Nicoly S Martinello Gisiane B Mathia Gislaine Z R éus Source Type: research

Artificial Intelligence in The Management of Neurodegenerative Disorders
CNS Neurol Disord Drug Targets. 2023 Oct 11. doi: 10.2174/0118715273266095231009092603. Online ahead of print.ABSTRACTNeurodegenerative disorders are characterized by a gradual but irreversible loss of neurological function. The ability to detect and treat these conditions successfully is crucial for ensuring the best possible quality of life for people who suffer from them. The development of effective new methods for managing and treating neurodegenerative illnesses has been made possible by recent developments in computer technology. In this overview, we take a look at the prospects for applying computational approaches...
Source: CNS and Neurological Disorders Drug Targets - October 20, 2023 Category: Drugs & Pharmacology Authors: Sanchit Dhankar Somdutt Mujwar Nitika Garg Samrat Chauhan Prerna Sharma Satish Kumar Sharma Mohammad Amjad Kamal Dr Nidhi Rani Suresh Kumar Monika Saini Source Type: research

Phosphodiesterase 2 and Its Isoform a as Therapeutic Targets in the Central Nervous System Disorders
CNS Neurol Disord Drug Targets. 2023 Sep 25. doi: 10.2174/1871527323666230811093126. Online ahead of print.ABSTRACTCyclic adenosine monophosphates (cAMP) and cyclic guanosine monophosphate (cGMP) are two essential second messengers, which are hydrolyzed by phosphodiesterase's (PDEs), such as PDE-2. Pharmacological inhibition of PDE-2 (PDE2A) in the central nervous system improves cAMP and cGMP signaling, which controls downstream proteins related to neuropsychiatric, neurodegenerative, and neurodevelopmental disorders. Considering that there are no specific treatments for these disorders, PDE-2 inhibitors' development has ...
Source: CNS and Neurological Disorders Drug Targets - October 19, 2023 Category: Drugs & Pharmacology Authors: Sanjay K Metkar Yuqing Yan Yue Lu Jianming Lu Xiongwei Zhu Fu Du Ying Xu Source Type: research

The Landscape of Randomized Clinical Trial Meta-analyses on Statins for Aneurysmal Subarachnoid Hemorrhage: A Scoping Review
CONCLUSION: The limitations reported by several meta-analyses, included low patient numbers or disproportionate representation of patients from certain RCTs, differences in drug treatment, patient diagnostic criteria and outcome evaluation between RCTs, as well as poor data quality or lack of RCTs data. Knowledge of the reported limitations may aid the design of future clinical trials and/or their meta-analyses.PMID:37855296 | DOI:10.2174/0118715273270503230928100141 (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - October 19, 2023 Category: Drugs & Pharmacology Authors: Panagiotis Skouras Theodosis Kalamatianos Mariam Markouli Angelos Karagiannis Lampis C Stavrinou Source Type: research

Memory Reflections of the Microbiota-Gut and Oligodendrocyte Axis
CNS Neurol Disord Drug Targets. 2023 Oct 5. doi: 10.2174/0118715273256132230921103333. Online ahead of print.ABSTRACTMemory is the persisting consequence of cognitive activities instigated by and engrossed on exterior information from the environment and commenced by an intensive on internal mental representations. Establishing a gut-brain axis (GBA) in health and disease has recently brought the gut, the main portal of communication with the external environment, to the forefront of this interaction. Dietary stimuli have long been linked to brain development, behavioral responses, and memory reflections. Vagus nerve, immu...
Source: CNS and Neurological Disorders Drug Targets - October 19, 2023 Category: Drugs & Pharmacology Authors: Suman Kumar Ray Sukhes Mukherjee Source Type: research

Length of Survival, Outcome, and Potential Predictors in Poor-Grade Aneurysmal Subarachnoid Hemorrhage Patients Treated with Microsurgical Clipping
CONCLUSION: Management of poor-grade aSAH patients has been dramatically changed. Microsurgical clipping provides promising results in carefully selected younger patients.PMID:37855362 | DOI:10.2174/0118715273258678231011060312 (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - October 19, 2023 Category: Drugs & Pharmacology Authors: Xanthoula Lambrianou Christos Tzerefos Christina Arvaniti Anastasia Tasiou Kostas N Fountas Source Type: research