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Prevention of Parkinson's disease: from risk factors to early interventions
CNS Neurol Disord Drug Targets. 2023 Jun 16. doi: 10.2174/1871527322666230616092054. Online ahead of print.ABSTRACTParkinson's disease (PD) is a debilitating neurological disorder characterized by progressively worsening motor dysfunction. Currently, available therapies merely alleviate symptoms, and there are no cures. Consequently, some researchers have now shifted their attention to identifying the modifiable risk factors of PD, with the intention of possibly implementing early interventions to prevent the development of PD. Four primary risk factors for PD are discussed including environmental factors (pesticides and h...
Source: CNS and Neurological Disorders Drug Targets - June 16, 2023 Category: Drugs & Pharmacology Authors: Ming Guan Ng Brendan Jun Lam Chan Rhun Yian Koh Khuen Yen Ng Soi Moi Chye Source Type: research

Lifestyle modulators of neuroplasticity in Parkinson's disease: evidence in human neuroimaging studies
CNS Neurol Disord Drug Targets. 2023 Jun 16. doi: 10.2174/1871527322666230616121213. Online ahead of print.ABSTRACTParkinson's disease is a neurodegenerative disease characterized by both motor and non-motor symptoms. A progressive neuronal loss and the consequent clinical impairment lead to deleterious effects on daily living and quality of life. Despite effective symptomatic therapeutic approaches, no disease-modifying therapies are currently available. Emerging evidence suggests that adopting a healthy lifestyle can improve the quality of life of Parkinson's disease patients. In addition, modulating lifestyle factors ca...
Source: CNS and Neurological Disorders Drug Targets - June 16, 2023 Category: Drugs & Pharmacology Authors: Silvia Paola Caminiti Silvia Gallo Federico Menegon Andrea Naldi Cristoforo Comi Giacomo Tondo Source Type: research

Oxidative Stress and Dopaminergic Metabolism: A Major PD Pathogenic Mechanism and Basis of Potential Antioxidant Therapies
CNS Neurol Disord Drug Targets. 2023 Jun 9. doi: 10.2174/1871527322666230609141519. Online ahead of print.ABSTRACTReactive oxygen species (ROS)-induced oxidative stress triggers the vicious cycle leading to the degeneration of dopaminergic neurons in the nigra pars compacta. ROS produced during the metabolism of dopamine is immediately neutralized by the endogenous antioxidant defense system (EADS) under physiological conditions. Aging decreases the vigilance of EADS and makes the dopaminergic neurons more vulnerable to oxidative stress. As a result, ROS left over by EADS oxidize the dopamine-derived catechols and produces...
Source: CNS and Neurological Disorders Drug Targets - June 12, 2023 Category: Drugs & Pharmacology Authors: Aamir Rasool Robina Manzoor Ullah Kaleem Imdad Kaleem Shahid Bashir Anum Farrukh Sahir Khattak Asad Haq Ramsha Afzal Source Type: research

The peripheral profile of the chitinase 3-like-1 in benign multiple sclerosis - a single centre's experience
CONCLUSIONS: Our findings suggest that there are no differences in serum CHI3L1 levels between BMS patients and HC. However, serum CHI3L1 levels are sensitive to clinical inflammatory activity and may be associated with relapses in BMS patients.PMID:37303176 | DOI:10.2174/1871527322666230609164534 (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - June 12, 2023 Category: Drugs & Pharmacology Authors: Laura Barcutean Adina Hutanu Sebastian Andone Smaranda Maier Rodica Balasa Source Type: research

Microarray-based analysis of differential gene expression profile in rotenone-induced Parkinson's disease zebrafish model
CONCLUSION: The mechanisms of T cell receptor signaling, microgliosis regulation, cellular response to IL-1, and apoptotic signaling pathways have potentially contributed to PD development in rotenone-treated zebrafish.PMID:37291778 | DOI:10.2174/1871527322666230608122552 (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - June 9, 2023 Category: Drugs & Pharmacology Authors: Yong Hui Nies Mohamad Fairuz Yahaya Wei Ling Lim Seong Lin Teoh Source Type: research