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Neuroprotection of Sex Bias: A Protective Response to Traumatic Brain Injury in the Females
CNS Neurol Disord Drug Targets. 2023 Aug 17. doi: 10.2174/1871527323666230817102125. Online ahead of print.ABSTRACTTraumatic brain injury (TBI) is a major healthcare problem and a common cause of mortality and morbidity. Clinical and preclinical research suggests sex-related differences in short- and long-term outcomes following TBI; however, males have been the main focus of TBI research. Females show a protective response against TBI. Female animals in preclinical studies and women in clinical trials have shown comparatively better outcomes against mild, moderate, or severe TBI. This reflects a favorable protective natur...
Source: CNS and Neurological Disorders Drug Targets - August 18, 2023 Category: Drugs & Pharmacology Authors: Mohammad I Yatoo Ghaith A Bahader Shafayat A Beigh Adil M Khan Antonisamy William James Maleha R Asmi Zahoor A Shah Source Type: research

Mycotoxins and Amyotrophic Lateral Sclerosis: food exposure, nutritional implications and dietary solutions
In conclusion, after suggesting some possible solutions to mitigate mycotoxin exposure risk, we affirm that future collaborations between scientists and policymakers are important to develop sustainable interventions and promote health through dietary diversity.PMID:37592793 | DOI:10.2174/1871527323666230817145434 (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - August 18, 2023 Category: Drugs & Pharmacology Authors: Umberto Manera Enrico Matteoni Antonio Canosa Stefano Callegaro Federico Casale Daniela Marchis Rosario Vasta Cristina Moglia Adriano Chi ò Andrea Calvo Source Type: research

The number of antiseizure medications taken and not the lipid profile was associated with seizure control in adult patients with epilepsy
CNS Neurol Disord Drug Targets. 2023 Aug 16. doi: 10.2174/1871527323666230816090102. Online ahead of print.ABSTRACTPrevious studies show changes in lipid metabolism in epilepsy. The aim of this study was to investigate the association between lipid profile and clinical variables in adult patients with epilepsy (APE). Seventy-two APE participated in this pilot study at an outpatient neurology service. The lipid profile (total cholesterol, low-density lipoprotein (LDL) cholesterol, very-low-density lipoproteins (VLDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglycerides), age at disease onset, disease du...
Source: CNS and Neurological Disorders Drug Targets - August 17, 2023 Category: Drugs & Pharmacology Authors: Vania Aparecida Leandro-Merhi Gl ória Maria de Almeida Souza Tedrus Giovanna Gigolotti Jacober de Moraes Michele Novaes Ravelli Source Type: research

Unraveling the Role of Neuroligin3 in Autism Spectrum Disorders: Pathophysiological Insights and Targeted Therapies
CNS Neurol Disord Drug Targets. 2023 Jul 27. doi: 10.2174/1871527323666230727102244. Online ahead of print.ABSTRACTAutism Spectrum Disorder is a neurodevelopmental disorder characterized by impaired social and communication skills, repetitive behaviors, and/or restricted interests with a prevalence of as high as 1% of children. Autism spectrum has strongly associated with genetic factors and exhibits wide clinical and heterogeneous genetic architecture. Most genes associated with Autism are involved in neuronal and synaptic development. The neuroligin3, the sex-linked gene on the X chromosome, was the first gene to be asso...
Source: CNS and Neurological Disorders Drug Targets - July 27, 2023 Category: Drugs & Pharmacology Authors: Fatima Azzahrae El Yacoubi Mohamed Oukabli Azeddine Ibrahimi Hassan Kisra Mounia Bensaid Source Type: research