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Therapeutic Potential of Myricetin in the Treatment of Neurological, Neuropsychiatric, and Neurodegenerative Disorders
CNS Neurol Disord Drug Targets. 2023 Jul 18. doi: 10.2174/1871527322666230718105358. Online ahead of print.ABSTRACTMyricetin (MC), 3,5,7,3',4',5'-hexahydroxyflavone, chemically belongs to a flavonoid category known to confer antioxidant, antimicrobial, antidiabetic, and neuroprotective effects. MC is known to suppress the generation of Reactive Oxygen Species (ROS), lipid peroxidation (MDA), and inflammatory markers. It has been reported to improve insulin function in the human brain and periphery. Besides this, it modulates several neurochemicals including glutamate, GABA, serotonin, etc. MC has been shown to reduce the e...
Source: CNS and Neurological Disorders Drug Targets - July 18, 2023 Category: Drugs & Pharmacology Authors: Neeraj Kumar Sethiya Neha Ghiloria Akanksha Srivastav Dheeraj Bisht Sushil Kumar Chaudhary Vaibhav Walia Md Sabir Alam Source Type: research

Flow diversion for the management of posterior circulation's intracranial aneurysms
CNS Neurol Disord Drug Targets. 2023 Jun 26. doi: 10.2174/1871527322666230626110934. Online ahead of print.ABSTRACTThe endovascular treatment of posterior circulation aneurysms, although challenging, has been well-established due to various factors that limit the surgical approach in most cases. Flow diversion has also been utilized in the treatment of such aneurysms, although its effectiveness and safety still require evaluation. Numerous studies have examined the outcomes and complication rates in patients treated with FD, resulting in varying findings. This review aimed to summarize the most recent literature concerning...
Source: CNS and Neurological Disorders Drug Targets - June 27, 2023 Category: Drugs & Pharmacology Authors: Antonis Adamou Kirill Alektoroff Maria Politi Maria Alexandrou Christian Roth Panagiotis Papanagiotou Source Type: research

Role of Alpha-7-Nicotinic Acetylcholine Receptor in Alzheimer's Disease
CNS Neurol Disord Drug Targets. 2023 Jun 27. doi: 10.2174/1871527322666230627123426. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a neurodegenerative disorder affecting millions worldwide. One of the leading hypotheses for the underlying cause of AD is a reduction in nicotinic receptor levels in the brain. Among the nicotinic receptors, the alpha-7-nicotinic acetylcholine receptor (α7nAChR) has received particular attention due to its involvement in cognitive function.α7nAChR is a ligand-gated ion channel that is primarily found in the hippocampus and prefrontal cortex, areas of the brain responsible for lea...
Source: CNS and Neurological Disorders Drug Targets - June 27, 2023 Category: Drugs & Pharmacology Authors: Sushma Singh Neetu Agrawal Ahsas Goyal Source Type: research

Flow diversion for the management of posterior circulation's intracranial aneurysms
CNS Neurol Disord Drug Targets. 2023 Jun 26. doi: 10.2174/1871527322666230626110934. Online ahead of print.ABSTRACTThe endovascular treatment of posterior circulation aneurysms, although challenging, has been well-established due to various factors that limit the surgical approach in most cases. Flow diversion has also been utilized in the treatment of such aneurysms, although its effectiveness and safety still require evaluation. Numerous studies have examined the outcomes and complication rates in patients treated with FD, resulting in varying findings. This review aimed to summarize the most recent literature concerning...
Source: CNS and Neurological Disorders Drug Targets - June 27, 2023 Category: Drugs & Pharmacology Authors: Antonis Adamou Kirill Alektoroff Maria Politi Maria Alexandrou Christian Roth Panagiotis Papanagiotou Source Type: research

Role of Alpha-7-Nicotinic Acetylcholine Receptor in Alzheimer's Disease
CNS Neurol Disord Drug Targets. 2023 Jun 27. doi: 10.2174/1871527322666230627123426. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a neurodegenerative disorder affecting millions worldwide. One of the leading hypotheses for the underlying cause of AD is a reduction in nicotinic receptor levels in the brain. Among the nicotinic receptors, the alpha-7-nicotinic acetylcholine receptor (α7nAChR) has received particular attention due to its involvement in cognitive function.α7nAChR is a ligand-gated ion channel that is primarily found in the hippocampus and prefrontal cortex, areas of the brain responsible for lea...
Source: CNS and Neurological Disorders Drug Targets - June 27, 2023 Category: Drugs & Pharmacology Authors: Sushma Singh Neetu Agrawal Ahsas Goyal Source Type: research

Flow diversion for the management of posterior circulation's intracranial aneurysms
CNS Neurol Disord Drug Targets. 2023 Jun 26. doi: 10.2174/1871527322666230626110934. Online ahead of print.ABSTRACTThe endovascular treatment of posterior circulation aneurysms, although challenging, has been well-established due to various factors that limit the surgical approach in most cases. Flow diversion has also been utilized in the treatment of such aneurysms, although its effectiveness and safety still require evaluation. Numerous studies have examined the outcomes and complication rates in patients treated with FD, resulting in varying findings. This review aimed to summarize the most recent literature concerning...
Source: CNS and Neurological Disorders Drug Targets - June 27, 2023 Category: Drugs & Pharmacology Authors: Antonis Adamou Kirill Alektoroff Maria Politi Maria Alexandrou Christian Roth Panagiotis Papanagiotou Source Type: research

Role of Alpha-7-Nicotinic Acetylcholine Receptor in Alzheimer's Disease
CNS Neurol Disord Drug Targets. 2023 Jun 27. doi: 10.2174/1871527322666230627123426. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a neurodegenerative disorder affecting millions worldwide. One of the leading hypotheses for the underlying cause of AD is a reduction in nicotinic receptor levels in the brain. Among the nicotinic receptors, the alpha-7-nicotinic acetylcholine receptor (α7nAChR) has received particular attention due to its involvement in cognitive function.α7nAChR is a ligand-gated ion channel that is primarily found in the hippocampus and prefrontal cortex, areas of the brain responsible for lea...
Source: CNS and Neurological Disorders Drug Targets - June 27, 2023 Category: Drugs & Pharmacology Authors: Sushma Singh Neetu Agrawal Ahsas Goyal Source Type: research

Flow diversion for the management of posterior circulation's intracranial aneurysms
CNS Neurol Disord Drug Targets. 2023 Jun 26. doi: 10.2174/1871527322666230626110934. Online ahead of print.ABSTRACTThe endovascular treatment of posterior circulation aneurysms, although challenging, has been well-established due to various factors that limit the surgical approach in most cases. Flow diversion has also been utilized in the treatment of such aneurysms, although its effectiveness and safety still require evaluation. Numerous studies have examined the outcomes and complication rates in patients treated with FD, resulting in varying findings. This review aimed to summarize the most recent literature concerning...
Source: CNS and Neurological Disorders Drug Targets - June 27, 2023 Category: Drugs & Pharmacology Authors: Antonis Adamou Kirill Alektoroff Maria Politi Maria Alexandrou Christian Roth Panagiotis Papanagiotou Source Type: research

Role of Alpha-7-Nicotinic Acetylcholine Receptor in Alzheimer's Disease
CNS Neurol Disord Drug Targets. 2023 Jun 27. doi: 10.2174/1871527322666230627123426. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a neurodegenerative disorder affecting millions worldwide. One of the leading hypotheses for the underlying cause of AD is a reduction in nicotinic receptor levels in the brain. Among the nicotinic receptors, the alpha-7-nicotinic acetylcholine receptor (α7nAChR) has received particular attention due to its involvement in cognitive function.α7nAChR is a ligand-gated ion channel that is primarily found in the hippocampus and prefrontal cortex, areas of the brain responsible for lea...
Source: CNS and Neurological Disorders Drug Targets - June 27, 2023 Category: Drugs & Pharmacology Authors: Sushma Singh Neetu Agrawal Ahsas Goyal Source Type: research

Flow diversion for the management of posterior circulation's intracranial aneurysms
CNS Neurol Disord Drug Targets. 2023 Jun 26. doi: 10.2174/1871527322666230626110934. Online ahead of print.ABSTRACTThe endovascular treatment of posterior circulation aneurysms, although challenging, has been well-established due to various factors that limit the surgical approach in most cases. Flow diversion has also been utilized in the treatment of such aneurysms, although its effectiveness and safety still require evaluation. Numerous studies have examined the outcomes and complication rates in patients treated with FD, resulting in varying findings. This review aimed to summarize the most recent literature concerning...
Source: CNS and Neurological Disorders Drug Targets - June 27, 2023 Category: Drugs & Pharmacology Authors: Antonis Adamou Kirill Alektoroff Maria Politi Maria Alexandrou Christian Roth Panagiotis Papanagiotou Source Type: research

Role of Alpha-7-Nicotinic Acetylcholine Receptor in Alzheimer's Disease
CNS Neurol Disord Drug Targets. 2023 Jun 27. doi: 10.2174/1871527322666230627123426. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a neurodegenerative disorder affecting millions worldwide. One of the leading hypotheses for the underlying cause of AD is a reduction in nicotinic receptor levels in the brain. Among the nicotinic receptors, the alpha-7-nicotinic acetylcholine receptor (α7nAChR) has received particular attention due to its involvement in cognitive function.α7nAChR is a ligand-gated ion channel that is primarily found in the hippocampus and prefrontal cortex, areas of the brain responsible for lea...
Source: CNS and Neurological Disorders Drug Targets - June 27, 2023 Category: Drugs & Pharmacology Authors: Sushma Singh Neetu Agrawal Ahsas Goyal Source Type: research

Flow diversion for the management of posterior circulation's intracranial aneurysms
CNS Neurol Disord Drug Targets. 2023 Jun 26. doi: 10.2174/1871527322666230626110934. Online ahead of print.ABSTRACTThe endovascular treatment of posterior circulation aneurysms, although challenging, has been well-established due to various factors that limit the surgical approach in most cases. Flow diversion has also been utilized in the treatment of such aneurysms, although its effectiveness and safety still require evaluation. Numerous studies have examined the outcomes and complication rates in patients treated with FD, resulting in varying findings. This review aimed to summarize the most recent literature concerning...
Source: CNS and Neurological Disorders Drug Targets - June 27, 2023 Category: Drugs & Pharmacology Authors: Antonis Adamou Kirill Alektoroff Maria Politi Maria Alexandrou Christian Roth Panagiotis Papanagiotou Source Type: research

Role of Alpha-7-Nicotinic Acetylcholine Receptor in Alzheimer's Disease
CNS Neurol Disord Drug Targets. 2023 Jun 27. doi: 10.2174/1871527322666230627123426. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a neurodegenerative disorder affecting millions worldwide. One of the leading hypotheses for the underlying cause of AD is a reduction in nicotinic receptor levels in the brain. Among the nicotinic receptors, the alpha-7-nicotinic acetylcholine receptor (α7nAChR) has received particular attention due to its involvement in cognitive function.α7nAChR is a ligand-gated ion channel that is primarily found in the hippocampus and prefrontal cortex, areas of the brain responsible for lea...
Source: CNS and Neurological Disorders Drug Targets - June 27, 2023 Category: Drugs & Pharmacology Authors: Sushma Singh Neetu Agrawal Ahsas Goyal Source Type: research

Flow diversion for the management of posterior circulation's intracranial aneurysms
CNS Neurol Disord Drug Targets. 2023 Jun 26. doi: 10.2174/1871527322666230626110934. Online ahead of print.ABSTRACTThe endovascular treatment of posterior circulation aneurysms, although challenging, has been well-established due to various factors that limit the surgical approach in most cases. Flow diversion has also been utilized in the treatment of such aneurysms, although its effectiveness and safety still require evaluation. Numerous studies have examined the outcomes and complication rates in patients treated with FD, resulting in varying findings. This review aimed to summarize the most recent literature concerning...
Source: CNS and Neurological Disorders Drug Targets - June 27, 2023 Category: Drugs & Pharmacology Authors: Antonis Adamou Kirill Alektoroff Maria Politi Maria Alexandrou Christian Roth Panagiotis Papanagiotou Source Type: research

Role of Alpha-7-Nicotinic Acetylcholine Receptor in Alzheimer's Disease
CNS Neurol Disord Drug Targets. 2023 Jun 27. doi: 10.2174/1871527322666230627123426. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a neurodegenerative disorder affecting millions worldwide. One of the leading hypotheses for the underlying cause of AD is a reduction in nicotinic receptor levels in the brain. Among the nicotinic receptors, the alpha-7-nicotinic acetylcholine receptor (α7nAChR) has received particular attention due to its involvement in cognitive function.α7nAChR is a ligand-gated ion channel that is primarily found in the hippocampus and prefrontal cortex, areas of the brain responsible for lea...
Source: CNS and Neurological Disorders Drug Targets - June 27, 2023 Category: Drugs & Pharmacology Authors: Sushma Singh Neetu Agrawal Ahsas Goyal Source Type: research