CNS and Neurological Disorders Drug Targets This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Flow diversion for the management of posterior circulation's intracranial aneurysms
CNS Neurol Disord Drug Targets. 2023 Jun 26. doi: 10.2174/1871527322666230626110934. Online ahead of print.ABSTRACTThe endovascular treatment of posterior circulation aneurysms, although challenging, has been well-established due to various factors that limit the surgical approach in most cases. Flow diversion has also been utilized in the treatment of such aneurysms, although its effectiveness and safety still require evaluation. Numerous studies have examined the outcomes and complication rates in patients treated with FD, resulting in varying findings. This review aimed to summarize the most recent literature concerning...
Source: CNS and Neurological Disorders Drug Targets - June 27, 2023 Category: Drugs & Pharmacology Authors: Antonis Adamou Kirill Alektoroff Maria Politi Maria Alexandrou Christian Roth Panagiotis Papanagiotou Source Type: research

Role of Alpha-7-Nicotinic Acetylcholine Receptor in Alzheimer's Disease
CNS Neurol Disord Drug Targets. 2023 Jun 27. doi: 10.2174/1871527322666230627123426. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a neurodegenerative disorder affecting millions worldwide. One of the leading hypotheses for the underlying cause of AD is a reduction in nicotinic receptor levels in the brain. Among the nicotinic receptors, the alpha-7-nicotinic acetylcholine receptor (α7nAChR) has received particular attention due to its involvement in cognitive function.α7nAChR is a ligand-gated ion channel that is primarily found in the hippocampus and prefrontal cortex, areas of the brain responsible for lea...
Source: CNS and Neurological Disorders Drug Targets - June 27, 2023 Category: Drugs & Pharmacology Authors: Sushma Singh Neetu Agrawal Ahsas Goyal Source Type: research

Evolutionary unmasking Resuscitative therapeutics potential of centhaquin citrate in hypovolemic shock
CNS Neurol Disord Drug Targets. 2023 Jun 23. doi: 10.2174/1871527322666230623113013. Online ahead of print.ABSTRACTHypovolemic shock (HS), a clinical condition of insufficient blood perfusion and oxygenation in body tissues, is associated with immense morbidity and mortality. Treatment approaches include fluid replacement and surgical repair of reversible causes of hemorrhage; however, they cause irreversible blood perfusion loss, systemic inflammation, multiple organ failure, and death. Centhaquin citrate (CC) is an innovative centrally acting cardiovascular active agent that is initially intended as an antihypertensive d...
Source: CNS and Neurological Disorders Drug Targets - June 26, 2023 Category: Drugs & Pharmacology Authors: Ravinder Singh Varinder Singh Pratima Kumari Namita Aggarwal Muskaan Oberoi Heena Khan Thakur Gurjeet Singh Source Type: research

Casein kinase 2 affects epilepsy by regulating ion channels: a potential mechanism
CNS Neurol Disord Drug Targets. 2023 Jun 22. doi: 10.2174/1871527322666230622124618. Online ahead of print.ABSTRACTEpilepsy, characterized by recurrent seizures and abnormal brain discharges, is the third most common chronic disorder of the Central Nervous System (CNS). Although significant progress has been made in the research on antiepileptic drugs (AEDs), approximately one-third of patients with epilepsy are refractory to these drugs. Thus, research on the pathogenesis of epilepsy is ongoing to find more effective treatments. Many pathological mechanisms are involved in epilepsy, including neuronal apoptosis, mossy fib...
Source: CNS and Neurological Disorders Drug Targets - June 23, 2023 Category: Drugs & Pharmacology Authors: Yan Liu Di Xia Lianmei Zhong Ling Chen Linming Zhang Mingda Ai Rong Mei Ruijing Pang Source Type: research

Navigated Transcranial Magnetic Stimulation (nTMS) based Preoperative Planning for Brain Tumor Treatment
This study reviews several studies on TMS and its subtypes in treating cancer and surgical planning. nTMS gives wider and improved dimensions of preoperative planning of the motor-eloquent areas in brain tumor patients. nTMS also predicts postoperative neurological deficits, which might be helpful in counseling patients. nTMS have the potential for finding possible abnormalities in the motor cortex areas.PMID:37340739 | DOI:10.2174/1871527322666230619103429 (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - June 21, 2023 Category: Drugs & Pharmacology Authors: Hammad Riaz Mohammad Uzair Muhammad Arshad Ali Hamza Nedal Bukhari Faisal Azam Shahid Bashir Source Type: research

Prevention of Parkinson's disease: from risk factors to early interventions
CNS Neurol Disord Drug Targets. 2023 Jun 16. doi: 10.2174/1871527322666230616092054. Online ahead of print.ABSTRACTParkinson's disease (PD) is a debilitating neurological disorder characterized by progressively worsening motor dysfunction. Currently, available therapies merely alleviate symptoms, and there are no cures. Consequently, some researchers have now shifted their attention to identifying the modifiable risk factors of PD, with the intention of possibly implementing early interventions to prevent the development of PD. Four primary risk factors for PD are discussed including environmental factors (pesticides and h...
Source: CNS and Neurological Disorders Drug Targets - June 16, 2023 Category: Drugs & Pharmacology Authors: Ming Guan Ng Brendan Jun Lam Chan Rhun Yian Koh Khuen Yen Ng Soi Moi Chye Source Type: research

Lifestyle modulators of neuroplasticity in Parkinson's disease: evidence in human neuroimaging studies
CNS Neurol Disord Drug Targets. 2023 Jun 16. doi: 10.2174/1871527322666230616121213. Online ahead of print.ABSTRACTParkinson's disease is a neurodegenerative disease characterized by both motor and non-motor symptoms. A progressive neuronal loss and the consequent clinical impairment lead to deleterious effects on daily living and quality of life. Despite effective symptomatic therapeutic approaches, no disease-modifying therapies are currently available. Emerging evidence suggests that adopting a healthy lifestyle can improve the quality of life of Parkinson's disease patients. In addition, modulating lifestyle factors ca...
Source: CNS and Neurological Disorders Drug Targets - June 16, 2023 Category: Drugs & Pharmacology Authors: Silvia Paola Caminiti Silvia Gallo Federico Menegon Andrea Naldi Cristoforo Comi Giacomo Tondo Source Type: research