Bone Uptake in Prostate Cancer Patients: Diagnostic Performances of PSMA-RADS v1.0, Clinical, Biological, and: 68: Ga-PSMA-11 PET Features to Predict Metastasis After Biochemical Recurrence
Conclusions
Most bone uptakes at PSMA PET/CT were benign lesions. PSMA-RADS, patients and tumor characteristics, and SUVmax could help identify PCa bone metastases. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 21, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Outcome of 177Lu-PSMA Radionuclide Treatment in Advanced Prostate Cancer and Its Association With Clinical Parameters: A Single-Center Experience
This study was set out to analyze the efficacy and safety of 177Lu-PSMA-617 (LuPSMA) treatment in metastatic castration-resistant prostate cancer (mCRPC) patients.
Patients and Methods
Progressive mCRPC patients who received at least 1 cycle of LuPSMA therapy were evaluated retrospectively. Demographic, clinic, and histopathological data were documented. Treatment efficacy was determined based on biochemical response criteria (Prostate Cancer Clinical Trial Working Group 3), and toxicity rates were defined based on CTCAE v4.03. The prognostic significance of laboratory/clinical data and 68Ga-PSMA PET/CT quantitative...
Source: Clinical Nuclear Medicine - July 21, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Severe Thrombocytopenia in Patients With Advanced Neuroendocrine Tumor Treated With Peptide Receptor Radioligand Therapy: Erratum
No abstract available (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 21, 2022 Category: Nuclear Medicine Tags: Erratum Source Type: research
Uncommon Metastases From Occult Breast Cancer Revealed by 18F-FDG and 68Ga-FAPI PET/CT
Metastases to gastrointestinal tract from breast cancer are very rare and can be diagnostically challenging. In this case, we reported 18F-FDG and 68Ga-FAPI PET/CT findings in a 54-year-old women with such uncommon metastases from breast cancer. Although the primary tumor of breast cancer remained radiologically occult, 68Ga-FAPI PET/CT showed a far better tumor-to-background ratio than 18F-FDG PET/CT for detecting the metastatic lesions, especially for detecting the retroperitoneal lymph node and rectal metastases. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 21, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
68Ga-FAPI-04 Versus 18F-FDG PET/CT in a Case With Intimal Sarcoma of the Pulmonary Artery
We describe 68Ga-FAPI-04 and 18F-FDG PET/CT findings in a case with intimal sarcoma of the pulmonary artery. The intrapulmonary artery tumor showed inhomogeneously increased FDG and FAPI uptake. Compared with FDG PET/CT, FAPI PET/CT more clearly delineated the tumor partially because of a very low background FAPI activity in the walls of the main pulmonary artery and right ventricle, which showed diffuse FDG uptake. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 21, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Unusual Illustration of Richter Transformation in Chronic Lymphocytic Leukemia on FDG PET/CT
A man with history of chronic lymphocytic leukemia (CLL) in remission had multiple rapidly growing lumps in recent 2 months. FDG PET/CT demonstrated disseminated FDG-avid nodal and extranodal lesions including those in unusual locations such as the nasopharynx, salivary glands, lungs, gastric wall, peritoneum, bones, and muscles. Subsequent biopsy of the right axillary mass showed absolute lymphocytosis with focus of large B-cell lymphoma. Flow cytometric immunophenotyping demonstrated κ-restricted CLL and B-cell lymphoma, consistent with Richter transformation of CLL. FDG PET/CT images of this case illustrated the most s...
Source: Clinical Nuclear Medicine - July 21, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Ectopic Gallbladder in the Left Upper Abdomen Shown on Hepatobiliary Scintigraphy
We reported an ectopically located gallbladder, which was located in the left upper abdomen on hepatobiliary scintigraphy in an 18-year-old woman. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 21, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
18F-SynVesT-1 PET in Focal Cortical Dysplasia Type II With Thickening Cortex
A case of 2-year-old girl with intractable seizures underwent 18F-FDG PET and MRI for seizure focus localization. MRI demonstrated cortical thickening and blurring of the gray-white matter interface in the right postcentral gyrus with focal hypometabolism in 18F-FDG PET. The patient subsequently was enrolled in clinical trial of 18F-SynVesT-1 PET study in epilepsy; a more restricted area of reduced 18F-SynVesT-1 uptake was noted in the thickened postcentral gyrus. The surgical limits of resection were defined based on ictal semiology, electroencephalography, and imagings. The patient is seizure-free after epilepsy surgery,...
Source: Clinical Nuclear Medicine - July 21, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Incidental Diagnosis of Right Renal Subcapsular Urinoma on an 18F-FDG PET/CT Scan Performed for Staging of Cervical Cancer
A 53-year-old woman with cervical cancer underwent FDG PET/CT staging, which demonstrated an avid cervical mass with right parametrial involvement and presence of bilateral lymph node metastases. The right ureter was encased, resulting in obstruction and renal pelvic dilatation. Avid right renal subcapsular lesions were also noted, which were hyperintense on T2-weighted imaging compatible to encapsulated fluid collections. These lesions were diagnosed as subcapsular urinoma due to transmitted back pressure caused by obstruction of the right ureter. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 21, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
FDG PET/CT in a Case With Primary Poorly Differentiated Urothelial-Type Adenocarcinoma of the Prostate
We describe FDG PET/CT findings in a case with primary poorly differentiated urothelial-type adenocarcinoma of the prostate with pelvic lymph node metastases. Both the prostate tumor and its metastatic lesions showed intense FDG uptake. The patient had normal serum prostate-specific antigen and elevated carcinoembryonic antigen levels, which may be helpful for the differential diagnosis. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 21, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
FDG PET/CT in Mixed Langerhans Cell Histiocytosis and Erdheim-Chester Disease
We report a 31-year-old woman with multisystem Langerhans cell histiocytosis (LCH). The recognition that pericardial disease was rare in LCH prompted review of the initial limited biopsies, which helped establish a second diagnosis of Erdheim-Chester disease. The increasing recognition of mixed histiocytoses requires searching for Erdheim-Chester disease when a patient is diagnosed with LCH and vice versa. FDG PET/CT can help establish the diagnosis or suggest mixed disease based on the organs involved. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 21, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Is Glucagon Administration Compatible With FDG PET/MRI?
Digestive peristalsis generates many artifacts that limit the abdominal and pelvic MRI interpretation. Apart from the hypoglycemia treatment in patients with diabetes, glucagon analog is also indicated for the digestive peristalsis reduction to reduce MRI artifacts. However, its use in PET/MRI is not described, given the risk of interaction with the metabolism of FDG. To assess the importance of this interaction on the FDG PET images, we report FDG PET/MRI images obtained with and without glucagon analog injection. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 21, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Extensive Biventricular Cardiac Sarcoidosis Detected on FDG PET/CT Using a 72-Hour Ketogenic Diet Preparation Protocol
A 49-year-old man had right bundle-branch block, with decreased left ventricle ejection fraction of 43%. Cardiac MRI demonstrated abnormal multifocal delayed gadolinium enhancement involving both ventricles. Cardiac sarcoidosis was further confirmed at cardiac biopsy. Dedicated FDG PET/CT with 72-hour ketogenic diet preparation to suppress physiological myocardial uptake of FDG was performed for disease evaluation. PET/CT revealed multifocal abnormal uptake in both ventricles concordant with cardiac MRI findings, in addition to hypermetabolic lymphadenopathy. Six months later, posttreatment PET/CT with the same 72-hour ket...
Source: Clinical Nuclear Medicine - July 21, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
68Ga-FAPI-04 Versus 18F-FDG PET/CT in a Case of Peutz-Jeghers Syndrome
We describe 68Ga-FAPI-04 and 18F-FDG PET/CT findings in a case of Peutz-Jeghers syndrome with primary duodenal clear cell sarcoma, peritoneal metastases, and multiple intestinal polyps varying in size. The duodenal tumor and its metastases showed increased FDG and FAPI uptake. The peritoneal metastases were delineated more clearly on FAPI PET/CT compared with FDG PET/CT. More interestingly, the intestinal polyps showed increased FDG uptake and no FAPI uptake. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 21, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
18F-FDG PET/CT Findings in a Patient With Primary Prostatic Synovial Sarcoma Combined With Adrenocortical Carcinoma
A 41-year-old man with 1-year history of hypertension was discovered to have a right adrenal mass on abdominal ultrasound. Contrast CT was performed to discriminate malignant from benign tumor, which revealed tumors of right adrenal gland and prostate. 18F-FDG PET/CT scan was performed for lesion characterization, and ruling out any distant metastasis. PET/CT scan showed high uptake in the right adrenal and prostatic lesions, which were surgically approved as adrenocortical carcinoma and primary prostatic synovial sarcoma. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 21, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
