FDG PET/CT in Isolated Nasal Cavity Metastasis From Squamous Cell Lung Cancer
We present FDG PET/CT findings in a case with isolated nasal cavity metastasis from squamous cell lung cancer. The nasal cavity tumor invaded the nasal septum and hard palate and showed intense inhomogeneous activity, mimicking a primary malignancy. Knowledge of the atypical manifestations of metastatic lung cancer will be helpful for correct diagnosis. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - November 15, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
A Single Gallbladder Fold Creates a Unique Visual and Temporal Pattern of Radiotracer Accumulation on Hepatobiliary Scintigraphy
We describe the case of 76-year-old man with a gallbladder fold mimicking duplication of the gallbladder or an associated choledochal cyst on scintigraphy. Correlative imaging with CT and ultrasound helped elucidate the true anatomy. This case demonstrates the type of difficult scintigraphic patterns that can arise with variant anatomy and the necessary role of cross-sectional, anatomic imaging in unraveling such situations. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - November 15, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
68Ga-DOTA-FAPI-04 PET/CT Imaging in a Case of Radioactive Iodine–Induced Chronic Parotitis
68Ga-DOTA-FAPI-04 is a promising PET agent for tumor imaging. However, inflammatory lesions can also show increased FAPI uptake. Herein, we reported a 52-year-old woman who underwent total thyroidectomy for thyroid papillary carcinoma 1 year ago and underwent adjuvant radioiodine therapy 1 month later. After 131I therapy, she began to develop pain and swelling in bilateral cheeks, which developed into oral dryness. The patient was diagnosed with radioactive iodine–induced parotitis. 68Ga-DOTA-FAPI-04 PET/CT showed the density of bilateral parotid glands increased, and the volume decreased with intense tracer uptake. 99mT...
Source: Clinical Nuclear Medicine - November 15, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
68Ga-FAPI and 18F-FDG PET/CT Images of a Patient With Rosai-Dorfman Disease With Liver Involvement
We report a case of Rosai-Dorfman disease with liver and bone marrow involvement. In this case, 18F-FDG PET/CT revealed FDG avidity in multiple lymph nodes, liver, and bone marrow. 68Ga-FAPI PET/CT showed higher uptake of 68Ga-FAPI than that of 18F-FDG in the same lesions. The findings of 68Ga-FAPI PET/CT in this patient highlighted the potential value of 68Ga-FAPI for staging in Rosai-Dorfman disease. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - November 15, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
18F-FDG and 18F-Fluciclovine Uptake in Poorly Differentiated Lung Adenocarcinoma in the Setting of Biochemically Recurrent Prostatic Adenocarcinoma
A 64-year-old man with a history of Gleason 7 (3 + 4) pT2cN0 prostatic adenocarcinoma status post prostatectomy underwent a fluciclovine PET/CT that showed a tracer-avid right upper lobe spiculated solitary pulmonary nodule. Follow-up FDG PET/CT showed a hypermetabolic right upper lobe spiculated solitary pulmonary nodule. Fine-needle aspiration was consistent with primary lung adenocarcinoma. Subsequently, right upper lobectomy was performed, and poorly differentiated lung adenocarcinoma was confirmed. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - November 15, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
18F-Flutemetamol PET/CT for Transthyretin Amyloid Cardiomyopathy: Timing Matters
We report 18F-flutemetamol PET/CT finding in an 88-year-old man with cognitive impairment and transthyretin amyloid cardiomyopathy. Early phase PET/CT images showed significantly increased myocardial uptake, but there was no myocardial uptake in delayed phase PET/CT images. A dual-time-point amyloid PET/CT imaging may be helpful to diagnose and differentiate subtypes of amyloid cardiomyopathy in patients with suspected cardiac amyloidosis. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - November 15, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Cerebellar Metastasis From Thyroid Carcinoma With Prominent 123I Uptake But Less Impressive MRI Findings in a Pediatric Patient
We report a case of classic variant–papillary thyroid carcinoma with right cerebellar metastasis in a 7-year-old girl on a 123I SPECT/CT study. A brain MRI on the same day shows a tiny millimetric enhancing nodule in the right cerebellum with no perceivable perilesional edema, confirming the 123I scan findings. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - November 15, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Hypermetabolic Esophagitis Dessicans Superficialis Mimicking Esophageal Cancer on FDG PET/CT
An 83-year-old man with history of multiple myeloma obtained an FDG PET/CT for surveillance. Although there was no evidence of metabolically active myeloma, an incidental highly FDG-avid focus was noted at the gastroesophageal junction. Findings were interpreted as malignancy. The patient underwent esophagogastroduodenoscopy, which showed nonerythematous desquamation of the distal esophagus consistent with esophagitis dessicans superficialis (EDS) without any evidence of malignancy. There is paucity of literature regarding EDS and its image findings. This case illustrates an instance of focal mass-like uptake on FDG PET/CT...
Source: Clinical Nuclear Medicine - November 15, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Combination of Astrogliosis and Phosphorylated Tau for the Preclinical Diagnosis of Alzheimer Disease Using 3-Dimensional Stereotactic Surface Projection Images With 18F-THK5351
We examined the utility of 18F-THK5351 in preclinical AD using 3-dimensional stereotactic surface projection images optimized for its pathological accumulation by comparison with a normal dataset. By using this 18F-THK5351 3-dimensional stereotactic surface projection procedure, which can evaluate phosphorylated tau and neuroinflammation, we could diagnose preclinical AD effectively. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - November 15, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Reverse Liver Spleen Uptake on [68Ga]Ga-PSMA-11 PET/CT
An 80-year-old man underwent [68Ga]Ga-PSMA-11 PET/CT for staging of high-risk prostate cancer. Homogeneously increased liver uptake, more than 3-fold the splenic uptake, was seen. There was no hepatic lesion evident on CT. A higher liver to splenic uptake is more typical of some 18F-labeled PSMA PET/CT but unusual in 68Ga-labeled PSMA PET/CT scan. Further evaluation revealed a history of impaired renal function, bilateral renal atrophy, relatively decreased renal uptake of [68Ga]Ga-PSMA-11, and prominent bowel activity. We concluded that impaired renal function and subsequent poor excretion resulted in increased hepatic ex...
Source: Clinical Nuclear Medicine - November 15, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Potential Pitfall of Fluciclovine PET/CT in Castrate-Resistant Prostate Cancer With Adrenal Metastasis
An 83-year-old man with castrate-resistant prostate cancer underwent an 18F-fluciclovine PET/CT scan, which was negative for local disease recurrence or locoregional lymphadenopathy, but there were multiple fluciclovine-avid bone metastases. In addition, mildly avid bilateral adrenal nodules were thought to be benign. However, on follow-up PET/CT 10 months later, while on additional therapy with enzalutamide, the bilateral nodules became mass lesions with interval decreased fluciclovine avidity. Adrenal metastases were suspected given their rapid growth, with subsequent CT-guided biopsy revealing metastatic prostate cancer...
Source: Clinical Nuclear Medicine - November 15, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
AL-Type Amyloidosis Involving Stomach and Lungs in 99mTc-DPD Bone Scan
We present 99mTc-DPD bone scan images of AL-type amyloidosis involving stomach and lung. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - November 15, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
The Manifestation of a Patient With Myelofibrosis in 68Ga-DOTA-FAPI-04 PET/CT Mimicking “Super Bone Imaging”
We report a 50-year-old woman who was diagnosed with primary myelofibrosis. 18F-FDG PET/CT showed mild uptake in diffuse sclerotic lesions in the bone matrix, whereas 68Ga-DOTA-FAPI-04 showed intense uptake at the whole skeleton. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - November 15, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Quantitative Assessment of Bone Marrow Activity Using 18F-FLT PET in Aplastic Anemia and Myelodysplastic Syndromes
Purpose
Peripheral cytopenias are typical of blood test abnormalities associated with a variety of conditions, including aplastic anemia (AA) and myelodysplastic syndromes (MDSs). We prospectively investigated the feasibility of quantitative analysis of whole-body bone marrow activity using PET with 3′-deoxy-3′-18F-fluorothymidine (18F-FLT) in AA and MDS.
Patients and Methods
Sixty-eight patients with cytopenia underwent 18F-FLT PET/MRI scan, with simultaneous bone marrow aspiration and biopsy for hematopoiesis evaluation. SUVs were measured in the vertebrae (Th3, 6, and 9 and L3), bilateral iliac crests, an...
Source: Clinical Nuclear Medicine - November 15, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Diverse Patterns and Clinical Significance of 11C-Methionine PET in Dysembryoplastic Neuroepithelial Tumors
Conclusions
MET-PET uptake correlates well with the clinical behavior of DNETs at the time of PET examination. Moreover, High MET-PET uptake is closely related to seizure recurrence if tumors are not entirely resected. Efforts to achieve gross total resection should be made for DNETs with high MET-PET uptake. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - November 15, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
