Perirenal Infiltration of Signet Ring Cell Colon Carcinoma Shown by 68Ga-FAPI PET/CT
A soft tissue lesion surrounding the left kidney was detected in 18F-FDG PET/CT performed with suspicion of recurrence in a patient who was operated for descending colon cancer and showed mild FDG uptake. Intense fibroblast activation protein-specific inhibitor (FAPI) uptake in the perirenal soft tissue was observed in 68Ga-FAPI-04 PET/CT. Tru-cut biopsy of the left perirenal lesion revealed signet ring cell colon carcinoma metastasis. This case demonstrated that 68Ga-FAPI-04 PET/CT could be a promising radiopharmaceutical for the evaluation of signet ring cell colon carcinomas. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - June 14, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Pituitary Metastasis of Non–Small Cell Lung Cancer With High FDG Uptake on PET/CT Pituitary Metastasis of Non–Small Cell Lung Carcinoma
Pituitary metastasis is a rare event, and the pituitary gland is an uncommonly involved location in patients with intracranial metastases as it accounts for only approximately 2% of malignant metastases. Here, the authors present the 18F-FDG PET study of a very rare case of relapsed non–small cell lung cancer, locally and with 1 pituitary metastasis, in a 75-year-old White woman with asthenia and diabetes insipidus. 18F-FDG PET and cerebral MRI were performed to guide the therapeutic strategy due to an atypical pituitary high FDG avidity. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - June 14, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
18F-FDG PET/CT and 68Ga-DOTATATE PET/CT Findings in a Patient With Primary Renal Well-Differentiated Neuroendocrine Tumor
We presented a patient with primary renal WDNET who had undergone both 68Ga-DOTATATE PET/CT and 18F-FDG PET/CT for diagnosis and staging. This case illustrated that 68Ga-DOTATATE PET/CT scanning could play a role in the diagnosis, staging, and follow-up of primary renal WDNETs. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - June 14, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
18F-Labeled WBC PET/CT Scan in a Case of Recurrent Glioblastoma Multiforme, Presented as Pyrexia of Unknown Origin
We present a case of recurrent glioblastoma multiforme, who presented with PUO. 18F-FDG–labeled leukocyte PET/CT scan done for localization of infective focus demonstrated significant tracer accumulation at the periphery of the recurrent brain lesion. Subsequent excisional biopsy from the lesion was suggestive of noninfected recurrent glioblastoma multiforme. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - June 14, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Metastasis From Clear Cell Renal Cell Carcinoma Mimicking Well-Differentiated Pancreatic Neuroendocrine Tumor at 18F-FDG and 68Ga-DOTATOC PET/CT
We describe here the case of a 81-year-old man with a pancreatic lesion showing high 68Ga-DOTATOC uptake and mild 18F-FDG avidity, thus suggesting a well-differentiated pNET, which resulted at endoscopic ultrasound-guided fine-needle aspiration to be a clear cell renal cell carcinoma metastasis. In fact, the patient had right nephrectomy for clear cell renal cell carcinoma 27 years earlier. This case puts light on the role of PET/CT with 68Ga-DOTATOC in imaging RCC, a field which deserves to be further explored. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - June 14, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Role of Testicular Scintigraphy in the Assessment of Viability of Undescended Testis: Potential Pitfalls and Complementary Role of: 18: F FDG PET/CT
Doppler ultrasonography and testicular scintigraphy are sensitive techniques to detect the adequacy of blood flow to testicular tissue. Because Doppler ultrasonography is an operator-dependent imaging modality, it can result in equivocal findings. Testicular scintigraphy proves to be more accurate in such cases, but it may be inconclusive on occasion. The authors report the case of a young man with a left undescended testis where testicular scintigraphy was inconclusive for viability and 18F-FDG PET/CT provided important diagnostic information. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - June 14, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Distribution Pattern of the Monoamine Oxidase B Ligand, 18F-THK5351, in the Healthy Brain
Conclusions
This study presented the detailed distribution pattern of 18F-THK5351 in HCs and suggests that 18F-THK5351 uptake largely reflects MAO-B concentrations under normal conditions. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - June 14, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
PET Imaging of Estrogen Receptors for Gynecological Tumors
In the past few decades, PET with 18F-FDG has been used for the diagnosis of gynecological malignancies and is considered to be superior to conventional imaging methods in diagnostic accuracy for detecting metastatic lesions and local recurrence and in evaluating the treatment response. On the other hand, several gynecological tumors, such as endometrial cancer and leiomyoma, and breast cancer are estrogen-dependent, in which estrogen is essential for their development and progression. 18F-FES is an 18F-labeled compound of estradiol, the most bioactive type of estrogen, and 18F-FES PET has been well-established for diagnos...
Source: Clinical Nuclear Medicine - June 14, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
FDG PET/CT Features of Polysaccharide-Based Hemostatic Agent: Chronic Inflammatory Changes Can Mimic Metastatic Lesions
Conclusions
Despite the inconsistency of the literature, polysaccharide-based HAs can be demonstrated in human surgical specimens as amorphous basophilic materials even after a long time from the initial surgical procedure. These agents almost always cause chronic inflammatory changes. In addition, these agents may mimic “false-positive” findings on postoperative FDG PET/CT scans. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - June 14, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Melanin-Targeted PET Imaging With 18F-PFPN for Identifying Gastric Metastatic Melanoma
A 47-year-old man, who had a history of occipital skin dissection for melanoma, underwent 18F-FDG and 18F-PFPN (a specific tracer targeting melanin) PET due to increased stomach discomfort and melena. In 18F-FDG and 18F-PFPN images, strong uptakes were both found in the thickened gastric wall, which was suspected as metastatic melanoma to the stomach. This was further confirmed by pathological biopsy of gastric tissue. Our case illustrated that melanin-targeted PET imaging could provide an effective method for searching the metastases of melanoma. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - June 14, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Bone and Lymph Node Flare to Androgen Deprivation Therapy in Metastatic Hormone-Sensitive Prostate Cancer on 18F–Prostate-Specific Membrane Antigen PET/CT With Decreasing Prostate-Specific Antigen of 0.7 ng/mL
A 72-year-old man with prostate cancer was found to have prostate-specific membrane antigen (PSMA)–avid oligometastasis on initial staging with 18F-DCFPyL PET/CT. Meanwhile, his prostate-specific antigen was 10.0 ng/mL, and testosterone level was 381 ng/dL. Six weeks after initiation of treatment on androgen deprivation therapy plus abiraterone, his restaging 18F-DCFPyL PET/CT showed decreased PSMA uptake in primary prostate lesion, but increased uptake in bone and lymph node metastases, whereas his prostate-specific antigen decreased to 0.7 ng/mL, and testosterone level was (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - June 14, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Bone Scan With SPECT/CT Demonstrated C1 to C2 Involvement in Rheumatic Arthritis
An 80-year-old man was treated with rituximab for active rheumatoid arthritis until 2019, now controlled with Salazopyrin, prednisolone, methotrexate, and folic acid. However, laboratory data showed elevated C-reactive protein and erythrocyte sedimentation rate. Whole-body bone scan showed bony and joint destruction to the upper cervical vertebra (C spine), bilateral shoulders, wrists, finger joints, ankles, and left knee. SPECT/CT localized the upper C spine uptake to the C1/C2 joint and adjacent C1 and C2 with C1/C2 subluxation. C spine CT showed vertical atlantoaxial subluxation and bony erosions. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - June 14, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Duodenal Ulcer-Induced Gastric Outlet Obstruction Showing Pyloric Wall Thickening and Abnormal FDG Uptake Mimicking Malignancy
We describe a case of gastric outlet obstruction induced by duodenal ulcer showing irregular pyloric wall thickening with marked enhancement on contras-enhanced CT and increased FDG uptake of the pyloric wall on FDG PET/CT mimicking malignancy. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - June 14, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Increased Genioglossus Muscle FDG Activity Due to Using Pacifier
An 18-month-old girl with history of liver transplant underwent FDG PET/CT to evaluate posttransplant lymphoproliferative disorder. In addition to multistation hypermetabolic lymphadenopathy and abnormal activity in the liver, stomach, and small bowel, in keeping with known posttransplant lymphoproliferative disorder, the images also showed focal activity in the submental region. This submental activity persisted on 2 separate follow-up FDG PET/CT studies, even though other foci of abnormal activity resolved after chemotherapy. Records revealed that the patient was sucking on a pacifier prior to all 3 FDG PET/CT studies, a...
Source: Clinical Nuclear Medicine - June 14, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
68Ga-FAPI and 18F-FDG PET/CT Findings in a Patient With Pancreatic Tuberculosis Mimicking Malignant Tumor
We report the case of a 24-year-old man who presented with abdominal pain and jaundice. 18F-FDG and 68Ga-FAPI PET/CT showed increased radioactivity in the region of the pancreatic head, which suggested malignant tumor. However, postoperative pathological finding demonstrated the presence of tuberculosis. This case documents that the pancreatic tuberculosis may cause FAPI uptake, and nuclear medicine physician evaluating 68Ga-FAPI imaging should be aware of this potential pitfall. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - June 14, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
