Evaluation of the Hybrid Tracer Indocyanine Green–99mTc-Nanocolloid for Sentinel Node Biopsy in Bladder Cancer—A Prospective Pilot Study
Conclusion
Sentinel node biopsy in bladder cancer using the hybrid tracer ICG-99mTc-nanocolloid is feasible, and preoperative imaging is predictive for the ability to perform SN biopsy in 83% of the patients who displayed an SN. In patients with a successful preoperative SN mapping using lymphoscintigraphy and SPECT/CT, the intraoperative SN guidance and detection were effective, even outside the ePLND area. As such, this study underscores the critical role that preoperative imaging plays in challenging image-guided surgery applications. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - August 18, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
PET Imaging of Dementia: Update 2022
PET imaging plays an essential role in achieving earlier and more specific diagnoses of dementia syndromes, important for clinical prognostication and optimal medical management. This has become especially vital with the recent development of pathology-specific disease-modifying therapy for Alzheimer disease, which will continue to evolve and require methods to select appropriate treatment candidates. Techniques that began as research tools such as amyloid and tau PET have now entered clinical use, making nuclear medicine physicians and radiologists essential members of the care team. This review discusses recent changes i...
Source: Clinical Nuclear Medicine - August 18, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
The Detection Performance of 18F–Prostate-Specific Membrane Antigen-1007 PET/CT in Primary Prostate Cancer: A Systemic Review and Meta-analysis
Conclusions
In the current meta-analysis, we revealed the excellent performance of 18F-PSMA-1007 to detect localized prostatic tumor lesions and regional lymph node metastasis. Moreover, the uptake of localized tumors in primary prostate cancer was nearly liver uptake and may be considered a suspicious malignancy if it was equal to or greater than the liver uptake. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - August 18, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Imaging Aldosterone-Producing Adrenocortical Carcinoma With 68Ga-Pentixafor PET/CT
We report a case of primary aldosteronism due to adrenocortical carcinoma with intense 68Ga-pentixafor activity on PET/CT. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 21, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Confirmation of Ectopic Pancreatic Tissue: A Novel Use for: 18: F-Fluciclovine PET
This case features a 21-year-old woman with a history of ulcerative colitis who was incidentally found to have a para-jejunal mass when she presented with an ulcerative colitis flare. The mass was further characterized on MR enterography as most likely representing ectopic pancreatic tissue. Given the normal intense pancreatic uptake of 18F-fluciclovine, PET/CT was subsequently used to confirm that the mass represented ectopic pancreatic tissue. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 21, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
A Rare Pitfall in Bone Mineral Densitometry: Gaucher Disease
We report a rare case of type 3 Gaucher disease presenting with calcified mesenteric lymph nodes that interfere with bone mineral densitometric measurements. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 21, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
PET/CT Imaging of Hemorrhagic Pseudotumor Arising From Treated Plasmacytoma
Hemorrhagic pseudotumor occurs in approximately 1% to 2% of patients with hemophilia. This lesion is exceptionally rare in nonhemophiliac individuals. The authors present a case of treated right ischial plasmacytoma with a progressively enlarging expansile hemorrhagic pseudotumor, documented on 18F-FDG PET/CT and MRI and confirmed by histology. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 21, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Clinical Usefulness of 18F-FET PET in a Pediatric Patient With Suspected Demyelinating Disease
An 11-year-old boy who presented with headache and progressive right-sided weakness exhibited cortical swelling in the parafalcine area of both frontoparietal high convexity and splenium portion of corpus callosum on brain MRI. This suggested the possibility of encephalopathy, but required differential diagnosis from brain tumor. 18F-FET (O-(2-[18F]fluoroethyl)-l-tyrosine) PET/CT identified increased uptake along the parafalcine area of the frontoparietal lobes and the splenium portion of the corpus callosum. The relatively low target-to-background ratios were more indicative of inflammatory changes such as demyelinating d...
Source: Clinical Nuclear Medicine - July 21, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
18F-FDG Brain PET Findings in Narcolepsy Type 2
A 16-year-old adolescent boy with extensive travel throughout West Africa presented with a 6-year history of social withdrawal, anhedonia, and daytime sleepiness. The patient’s electroencephalography was normal. Initial MRI revealed small pituitary gland and left temporal developmental venous anomaly. Subsequently obtained 18F-FDG brain PET was notable for markedly severe hypometabolism in the brainstem. Further workup revealed a normal orexin, autoimmune encephalitis panel, and negative titers for Trypanosoma brucei and cruzi in the CSF. Outpatient sleep study showed mild obstructive sleep apnea, and multiple sleep late...
Source: Clinical Nuclear Medicine - July 21, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Peritoneal Tuberculosis Mimicking Peritoneal Carcinomatosis on 68Ga-FAPI-04 and 18F-FDG PET/CT
We report a case of tuberculosis peritonitis in a 26-year-old woman who presented with abdominal pain, fatigue, and weight loss for the last 4 months. Abdominal US and CT demonstrated intra-abdominal massive ascites, misty mesentery, and diffuse peritoneal thickening. In addition, 3 nodular lesions were detected in the right lung. 18F-FDG PET/CT showed hypermetabolism in lung nodules, mesenteric area, peritoneal thickening, and ascites. 68Ga-FAPI-04 (fibroblast activation protein–specific inhibitor) PET/CT imaging was also performed; high uptakes were detected in the same regions of 18F-FDG PET/CT. Tuberculosis diagnosis...
Source: Clinical Nuclear Medicine - July 21, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
18F-FES PET/CT for Characterization of Brain and Leptomeningeal Metastasis in Double Primary Cancer Patient
The clinical value of 16α-18F-fluoro-17 β-estradiol (18F-FES) PET in breast cancer has been widely investigated because it can visualize estrogen receptor–expressing lesions. This relatively new radiotracer adds clinical values by characterization of metastasis in double primary cancer. It also has advantage in finding small brain lesions, which has no background brain activity. Here, we present 18F-FES PET findings of brain and leptomeningeal metastases in a patient with breast and lung malignancy. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 21, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
68Ga-DOTATATE Uptake in Well-Differentiated Neuroendocrine Tumor of the External Auditory Canal
A 38-year-old woman presented with a 4-month history of left-sided otalgia and otorrhea. Otoscopy revealed a mass in the left external auditory canal causing obliteration. A biopsy was taken, and the diagnosis was consistent with a well-differentiated neuroendocrine tumor. The patient was referred to our department for staging with 68Ga-DOTATATE PET/CT. Increased radiopharmaceutical uptake was observed in the primary tumor and metastatic lymph nodes. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 21, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
A Peculiar 18F-FDG Spinal Uptake Helps Diagnosis and Effective Treatment of Polymyalgia Rheumatica: “The Corset Sign”
Polymyalgia rheumatica is the most common inflammatory rheumatic disease in elderly people, usually develops in patients older than 50 years, more frequently in females. An emerging imaging tool in the diagnostic workup of this condition is whole-body PET/CT, which allows an overall assessment of the articular and extra-articular structures involved. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 21, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Dual-Phase 18F-FP-CIT PET in 2 Different Clinical Phenotypes of Sporadic Creutzfeldt-Jakob Disease
We describe MRI and dual-phase 18F-FP-CIT PET findings in 2 cases of sporadic CJD presenting different clinical phenotypes (Heidenhain variant and corticobasal syndrome). Our case series suggest that dual-phase FP-CIT-PET findings may improve the diagnosis of CJD by combining the perfusion patterns in early phase with the dopamine transporter density in delayed phase. Familiarity with these dual-phase FP-CIT PET findings is helpful for early correct diagnosis of CJD. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 21, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Functional Alterations Due to COVID-19 Lung Lesions—Lessons From a Multicenter V/Q Scan-Based Registry
Conclusions
In COVID-19 patients assessed with V/Q SPECT/CT, a large proportion demonstrated parenchymal lung lesions on CT, responsible for ventilation and perfusion injury. COVID-19–related pulmonary lesions were, in order of frequency and functional impairment, consolidations, CP, and ground-glass opacity, with typically a reverse mismatched or matched pattern. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - July 21, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
