Renal histology and MRI findings in a 
37-year-old Japanese patient with autosomal recessive polycystic kidney disease
.
In conclusion, the renal features of adult-onset ARPKD may differ from those of infantile disease.
. PMID: 28933340 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - September 21, 2017 Category: Urology & Nephrology Authors: Ito Y, Sekine A, Takada D, Yabuuchi J, Kogure Y, Ueno T, Sumida K, Yamanouchi M, Hayami N, Suwabe T, Hoshino J, Sawa N, Takaichi K, Kinowaki K, Fujii T, Ohashi K, Kikuchi H, Mandai S, Chiga M, Mori T, Sohara E, Uchida S, Ubara Y Tags: Clin Nephrol Source Type: research

C4d-expressing glomerulopathy and proteinuria post transplantation of a 
too-big-for-size mismatched kidney allograft: An unusual case with good outcome
.
Abstract A 5-year-old severely growth-retarded child with tubulointerstitial, oliguric end-stage renal disease received an adult-size kidney transplant. Three years post grafting under standard triple immunosuppression (mycophenolate mofetil, tacrolimus, and prednisone) de novo nephrotic range proteinuria without the nephrotic syndrome developed. Graft function was normal (serum creatinine: 0.2 - 0.3 mg/dL), there were no donor-specific HLA antibodies (DSA), and the urine sediment was inactive. Two biopsies collected 3 and 4 years post-transplantation showed severe glomerular capillary wall remodeling an...
Source: Clinical Nephrology - September 21, 2017 Category: Urology & Nephrology Authors: Gougeon F, Mikhailov AV, Gibson K, Kozlowski T, Singh HK, Nickeleit V Tags: Clin Nephrol Source Type: research

Variability in hemoglobin levels in hemodialysis patients in the current era: a retrospective cohort study.
CONCLUSIONS: In 2012 vs. 2004, hemoglobin levels decreased, the range of levels narrowed, and variability decreased modestly; transfusions increased. The highest risk of mortality and MACE appeared to occur in patients with persistently low, rather than highly variable, hemoglobin levels. PMID: 28899480 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - September 7, 2017 Category: Urology & Nephrology Authors: Gilbertson DT, Hu Y, Peng Y, Maroni BJ, Wetmore JB Tags: Clin Nephrol Source Type: research

Unusual association of ADPKD and bullous emphysema: a case report and literature review.
PMID: 28862130 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - September 1, 2017 Category: Urology & Nephrology Authors: Kelkar AH, Crabb JE, Pflederer BR Tags: Clin Nephrol Source Type: research

Successful therapy with mycophenolic acid in  a membranous glomerulonephritis due to Kimura disease
.
Successful therapy with mycophenolic acid in a membranous glomerulonephritis due to Kimura disease
. Clin Nephrol. 2017 Aug 30;: Authors: Gaillard J, Rotman S, Girardet C, Spertini F Abstract Kimura disease (KD) is a rare inflammatory soft tissue disorder of unknown origin most frequent in Asians, the prevalence of which is growing in Western countries. Painless papules and/or nodules with a predilection for the head and the neck region, lymphadenopathies, parotid gland involvement, eosinophilia, and raised IgE levels are parts of its presentation. Renal involvement with various forms of g...
Source: Clinical Nephrology - August 30, 2017 Category: Urology & Nephrology Authors: Gaillard J, Rotman S, Girardet C, Spertini F Tags: Clin Nephrol Source Type: research

Comparison of hemodialysis with medium 
cut-off dialyzer and on-line hemodiafiltration on the removal of small and middle-sized molecules
.
CONCLUSION: The use of MCO (Theranova) dialyzer in HD produces similar removal of urea, creatinine, β2-microglobulin and myoglobin as does ol-HDF, with good tolerance profile and without modification of nutritional status.
. PMID: 28853700 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - August 30, 2017 Category: Urology & Nephrology Authors: Belmouaz M, Diolez J, Bauwens M, Duthe F, Ecotiere L, Desport E, Bridoux F Tags: Clin Nephrol Source Type: research

The prevalence and risk factors of abnormal circadian blood pressure in patients with IgA nephropathy 
.
CONCLUSION: Abnormal circadian BP rhythm was common in IgAN patients and occurred in the early stages of chronic kidney disease. Low eGFR, high serum uric acid, and small vessel hyalinosis increased risk of abnormal BP rhythm in IgAN patients.
. PMID: 28853701 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - August 30, 2017 Category: Urology & Nephrology Authors: Zhou S, Fu J, Liu M, Yang S, Zhou Q, Yu X, Yang Q Tags: Clin Nephrol Source Type: research

Familial antiglomerular basement membrane disease in zero human leukocyte antigen mismatch siblings 
.
We present a case of a 65-year-old woman with rapidly-progressive glomerulonephritis and pulmonary involvement, consistent with Goodpasture's syndrome. Two of her 15 siblings also had a history of anti-GBM disease during adolescence and both received a kidney transplant. Our patient and her siblings were smokers and had also had exposure to kerosene, a low-viscosity hydrocarbon. HLA testing was performed and showed identical HLA typing (0 of 6 HLA mismatch) as one of her brothers with anti-GBM disease. Interestingly, they both had HLA-DR15. Despite severe acute kidney injury requiring hemodialysis, the patient responded we...
Source: Clinical Nephrology - August 30, 2017 Category: Urology & Nephrology Authors: Angioi A, Cheungpasitporn W, Sethi S, Vriese A, Lepori N, Schwab T, Fervenza F Tags: Clin Nephrol Source Type: research

Potential pitfalls in estimating renal injury by KDIGO, overcome by measuring creatinine clearance in acute kidney injury 
.
Potential pitfalls in estimating renal injury by KDIGO, overcome by measuring creatinine clearance in acute kidney injury
. Clin Nephrol. 2017 Aug 30;: Authors: Mellas J Abstract Acute kidney injury (AKI) is a common and serious condition frequently encountered in hospitalized patients. The severity of kidney injury is defined by the KDIGO criteria which attempt to establish the degree of renal impairment. These criteria do not measure actual creatinine clearance (K) but rather represents static measures of a dynamic process in AKI and are fraught with potential for false positives and negatives res...
Source: Clinical Nephrology - August 30, 2017 Category: Urology & Nephrology Authors: Mellas J Tags: Clin Nephrol Source Type: research

Comparison of hypoalbuminemia-corrected serum calcium using bcp albumin assay to ionized calcium and impact on prescribing in hemodialysis patients 
.
CONCLUSION: When BCP assay is used, conventional correction equations should not be utilized in hemodialysis patients; uncorrected serum calcium has a better predictive value.
. PMID: 28853704 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - August 30, 2017 Category: Urology & Nephrology Authors: Pan WC, Lau W, Mattman A, Kiaii M, Jung B Tags: Clin Nephrol Source Type: research

Urinary creatinine excretion in AKI - just another look.
PMID: 28853705 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - August 30, 2017 Category: Urology & Nephrology Authors: Keller F Tags: Clin Nephrol Source Type: research

Healthcare outcomes in undocumented immigrants undergoing two emergency dialysis approaches 
.
We report the impact of this administrative change on the biochemical parameters, utilization, and adverse outcomes in an undocumented patient cohort. METHODS: This retrospective case series examines 19 undocumented ESRD patients during a 6-month transition divided into three 2-month periods (P1, P2, P3). In P1, patients received emergent dialysis based on interdialytic interval and clinical judgment. In P2 (early transition) and P3 (equilibrium), patients were dialyzed according to strict numerical criteria coupled with clinical judgment. RESULTS: Emergent criteria-based dialysis (P2 and P3) was associated with ...
Source: Clinical Nephrology - August 17, 2017 Category: Urology & Nephrology Authors: Sher SJ, Moorthi RN, Aftab W, Moe SM, Weaver CS, Messina FC, Martinez-Hoover NM, Anderson MD, Eadon MT Tags: Clin Nephrol Source Type: research

Hemodialysis treatment engenders anxiety and emotional distress 
.
Hemodialysis treatment engenders anxiety and emotional distress
. Clin Nephrol. 2017 Aug 17;: Authors: Kopple JD, Shapiro BB, Feroze U, Kim JC, Zhang M, Li Y, Martin DJ Abstract AIMS: Anxiety is common in maintenance hemodialysis (MHD) patients. The extent to which anxiety is engendered by the dialysis treatment itself is not known. We investigated whether anxiety occurs with individual hemodialysis treatments and examined factors associated with these symptoms. MATERIALS AND METHODS: This was a cross-sectional study examining 246 MHD patients. Anxiety and other emotional distresses associated ...
Source: Clinical Nephrology - August 17, 2017 Category: Urology & Nephrology Authors: Kopple JD, Shapiro BB, Feroze U, Kim JC, Zhang M, Li Y, Martin DJ Tags: Clin Nephrol Source Type: research

The spectrum of biopsy-proven secondary glomerular diseases: A cross-sectional study in China 
.
The spectrum of biopsy-proven secondary glomerular diseases: A cross-sectional study in China
. Clin Nephrol. 2017 Aug 10;: Authors: Wang P, Tang L, Yao J, Su H, Liu Y, Kong X, Li W, Cui M, Sun Q, Zhen J, Xu D Abstract AIMS: The distribution of the spectrum of chronic kidney disease (CKD) has been found to vary with time. Limited information is available regarding the changing spectrum of secondary glomerular diseases (SGDs). To further investigate changes in the spectrum of SGDs, we performed a cross-sectional study. METHODS: From June 2010 to May 2015, 5,935 patients from 37 hospitals in Shan...
Source: Clinical Nephrology - August 10, 2017 Category: Urology & Nephrology Authors: Wang P, Tang L, Yao J, Su H, Liu Y, Kong X, Li W, Cui M, Sun Q, Zhen J, Xu D Tags: Clin Nephrol Source Type: research

Interstitial complement C3 activation and macrophage infiltration in patients with hypertensive nephropathy 
.
CONCLUSION: In human HN, inflammation involving complement C3 activation and macrophage infiltration as well as interactions between them, may play important roles in the pathogenesis and progression of interstitial fibrosis and kidney damage.
. PMID: 28793954 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - August 10, 2017 Category: Urology & Nephrology Authors: Cui J, Wan J, You D, Zou Z, Chen Y, Li Z, Lian Q Tags: Clin Nephrol Source Type: research

Optimization of therapeutic drug monitoring of vancomycin in patients with chronic hemodialysis 
.
CONCLUSION: The vancomycin dosing algorithm using limited concentration monitoring for hemodialysis patients achieved drug concentrations comparable to those found with more frequent monitoring and resulted in significant cost savings.
. PMID: 28793955 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - August 10, 2017 Category: Urology & Nephrology Authors: Mahmoud LB, Chaabouni Y, Ghozzi H, Feriani H, Hakim A, Kharrat M, Marrakchi C, Sahnoun Z, Jmaa MB, Zeghal K, Hachicha J Tags: Clin Nephrol Source Type: research

A case of severe nephrotoxicity associated with long-term dietary supplement use.
We report a 65-year-old male who had very heavy daily intake of dietary supplements for 3 years. He presented with acute kidney injury and nephrotic-range proteinuria. The renal biopsy showed acute tubular necrosis with vacuolization, acute interstitial nephritis, and secondary membranous nephropathy, consistent with an non-steroidal anti-inflammatory drug (NSAID)-like nephropathy. This was postulated to be related to the cyclooxygenase (COX) inhibitors (anthocyanins) in cherry extract that was a significant part of the patient's dietary supplement use. His proteinuria completely resolved and serum creatinine stabiliz...
Source: Clinical Nephrology - August 2, 2017 Category: Urology & Nephrology Authors: Koraishy FM, Moeckel GW, Geller DS Tags: Clin Nephrol Source Type: research

MODY3, renal cysts, and Dandy-Walker variants with a microdeletion spanning the HNF1A gene.
Abstract Heterozygous hepatocyte nuclear factor-1-α gene (HNF1A) mutations are the most common cause of maturity-onset diabetes of the young (MODY), but they rarely involve extrahepatic manifestations. Renal cysts and diabetes syndrome can be caused by HNF1B mutations. No association between MODY3 and Dandy-Walker variants (DWV) has been reported. HNF1A mutations might be responsible for renal malformations. In a Japanese girl with glycosuria, developmental delay, mental retardation, renal cysts, and DWV, the HNF1B gene had no mutations. Array comparative genomic hybridization analysis identified a de-novo i...
Source: Clinical Nephrology - August 2, 2017 Category: Urology & Nephrology Authors: Matsukura H, Nagamori M, Miya K, Yorifuji T Tags: Clin Nephrol Source Type: research

Evaluation of the safety and immunogenicity of subcutaneous HX575 epoetin alfa in the treatment of anemia associated with chronic kidney disease in predialysis and dialysis patients 
.
CONCLUSIONS: SC HX575 was effective for correcting and maintaining correction of anemia, and the mean weekly dose remained stable over time.
. PMID: 28766493 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - August 2, 2017 Category: Urology & Nephrology Authors: Casadevall N, Dobronravov V, Eckardt KU, Ertürk S, Martynyuk L, Schmitt S, Schaffar G, Rudy A, Krendyukov A, Ode M Tags: Clin Nephrol Source Type: research

Resting energy expenditure: a valuable predictor for KT/Vurea in peritoneal dialysis patients 
.
CONCLUSION: REE may be a helpful indicator for choosing a suitable dialysis modality for patients with end-stage renal disease (ESRD) and for improving the prognosis after PD.
. PMID: 28766494 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - August 2, 2017 Category: Urology & Nephrology Authors: Xu T, Xie J, Wang W, Ren H, Chen N Tags: Clin Nephrol Source Type: research

Pulmonary embolism with endovascular thrombolysis for thrombosed hemodialysis arteriovenous access 
.
CONCLUSION: There is a clinically significant risk of symptomatic PE after arteriovenous access thrombolysis for access thrombosis in HD patients.
. PMID: 28766495 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - August 2, 2017 Category: Urology & Nephrology Authors: Rajaram YS, Le T, Ross-Smith M, Owen A, Chuen J, Mount PF Tags: Clin Nephrol Source Type: research

Differences in characteristics and outcomes between community- and hospital-acquired acute kidney injury: A systematic review and meta-analysis 
.
Differences in characteristics and outcomes between community- and hospital-acquired acute kidney injury: A systematic review and meta-analysis
. Clin Nephrol. 2017 Jul 24;: Authors: Inokuchi R, Hara Y, Yasuda H, Itami N, Terada Y, Doi K Abstract INTRODUCTION: No comprehensive review has examined the difference between community-acquired (CA) and hospital-acquired (HA) acute kidney injury (AKI) in terms of patient characteristics, in-hospital mortality, and hospital stay length. MATERIALS AND METHODS: We conducted a systematic review and meta-analysis of observational studies, using MEDLINE, EM...
Source: Clinical Nephrology - July 24, 2017 Category: Urology & Nephrology Authors: Inokuchi R, Hara Y, Yasuda H, Itami N, Terada Y, Doi K Tags: Clin Nephrol Source Type: research

Pretreatment with paricalcitol attenuates level and expression of matrix metalloproteinases in a rat model of renal ischemia-reperfusion injury 
.
CONCLUSION: Paricalcitol may attenuate renal tubular injury caused by IRI by decreasing both level and expression of MMPs. Further studies are required to investigate the interplay between activated vitamin D and MMPs in AKI.
. PMID: 28737133 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - July 24, 2017 Category: Urology & Nephrology Authors: Ersan S, Celik A, Tanrisev M, Kose I, Cavdar Z, Unlu M, Kocak A, Ural C, Yilmaz B, Kose T Tags: Clin Nephrol Source Type: research

Nephrotic syndrome in primary myelofibrosis with renal extramedullary hematopoiesis and glomerulopathy in the JAK inhibitor era.
We present a nephrotic syndrome in PMF-related glomerulopathy, associated with EMH, without renal failure, in a patient under treatment for 2 years with JAK2 inhibitor ruxolitinib. Despite treatment, the patient died 7 months after renal biopsy. Nephrologists still know very little about this topic and there is no homogeneous data about incidence, pathogenesis, and optimal treatment of this poor prognostic PMF-associated nephrotic syndrome. We focus on data in the literature in the hope of stimulating hematologists, nephrologists, pathologists to future studies about the natural history of renal involvement, usef...
Source: Clinical Nephrology - July 24, 2017 Category: Urology & Nephrology Authors: Sordo RD, Brugnano R, Covarelli C, Fiorucci G, Falzetti F, Barbatelli G, Nunzi E, Sidoni A Tags: Clin Nephrol Source Type: research

Survey among nephrologists in Germany: current practice and management of pregnant women on dialysis 
.
CONCLUSIONS: Our survey demonstrates that the practice of nephrologists in treating pregnant women on dialysis differs significantly. These findings highlight the need for European guidelines to standardize the care of pregnant dialysis patients.
. PMID: 28699884 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - July 12, 2017 Category: Urology & Nephrology Authors: Duffner J, Schulte-Kemna L, Reister B, Ludwig U, Keller F, Erp RV, Schröppel B Tags: Clin Nephrol Source Type: research

Does Helicobacter pylori infection play a role in iron deficiency anemia in hemodialysis patients?
Abstract BACKGROUND: Among the disorders that may affect patients with end-stage renal disease (ESRD), anemia is the most responsive to treatment; any reversible cause should be identified, and the most common reversible cause is iron deficiency. We investigated the relationship between Helicobacter pylori infection and iron deficiency anemia in a hemodialysis population. MATERIALS AND METHODS: This cross-sectional study included 90 adult patients with ESRD on maintenance hemodialysis. Iron deficiency anemia (IDA) was determined by hemoglobin, serum iron, ferritin, and transferrin saturation (TSAT) values. H....
Source: Clinical Nephrology - July 12, 2017 Category: Urology & Nephrology Authors: El-Said H, Attallah AB, Ali-Eldin ZA Tags: Clin Nephrol Source Type: research

Interleukin-1 inhibition, chronic kidney disease-mineral and bone disorder, and physical function 
.
CONCLUSIONS: In conclusion, 12 weeks of IL-1 inhibition did not improve markers of CKD-MBD or physical function.
. PMID: 28699886 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - July 12, 2017 Category: Urology & Nephrology Authors: Nowak KL, Hung A, Ikizler TA, Farmer-Bailey H, Salas-Cruz N, Sarkar S, Hoofnagle A, You Z, Chonchol M Tags: Clin Nephrol Source Type: research

Upward trend of dapsone-induced methemoglobinemia in renal transplant community 
.
Upward trend of dapsone-induced methemoglobinemia in renal transplant community
. Clin Nephrol. 2017 Jul 12;: Authors: Salim SA, Nair LR, Palabindala V, Craici I Abstract Dapsone, a sulfone antibiotic, is used for prophylaxis of Pneumocystis jirovecii pneumonia in patients with documented sulfa allergy. Acquired methemoglobinemia caused by dapsone is not uncommon in patients with normal glucose-6-phosphate dehydrogenase (G6PD) levels. Discrepancy between oxygen saturation measured by pulse oximetry and arterial oxygen saturation (SpO2) readings, a phenomenon known as "saturation gap," is n...
Source: Clinical Nephrology - July 12, 2017 Category: Urology & Nephrology Authors: Salim SA, Nair LR, Palabindala V, Craici I Tags: Clin Nephrol Source Type: research

Predicting augmented renal clearance using estimated glomerular filtration rate in critically-ill children 
.
Predicting augmented renal clearance using estimated glomerular filtration rate in critically-ill children
. Clin Nephrol. 2017 Jul 12;: Authors: Lee B, Kim J, Park JD, Kang HM, Cho YS, Kim KS Abstract AIMS: Measured glomerular filtration rate (mGFR) is often used to identify augmented renal clearance (ARC). However, in the clinical setting, estimated GFR (eGFR) is obtained more quickly and inexpensively. We aimed to determine whether eGFR can identify ARC by evaluating the correlation between the eGFR and vancomycin trough level (VTL). MATERIALS AND METHODS: We retrospectively reviewed the rec...
Source: Clinical Nephrology - July 12, 2017 Category: Urology & Nephrology Authors: Lee B, Kim J, Park JD, Kang HM, Cho YS, Kim KS Tags: Clin Nephrol Source Type: research

Successful launch of an ABO-incompatible kidney transplantation program to overcome the shortage of compatible living donors: experience at a single center 
.
CONCLUSIONS: In this study, graft renal function and survival after ABOi KT were excellent, and the incidence of acute rejection was similar to that of ABOc KT. However, efforts are needed to reduce hemorrhagic and infectious complications after ABOi KT. ABOi KT can be a good strategy to overcome ABO antibody barriers and relieve donor shortage.
. PMID: 28679466 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - July 6, 2017 Category: Urology & Nephrology Authors: Song SH, Lee J, Kim BS, Kim S, Lee JG, Jeong HJ, Kim YS, Kim MS, Kim HO, Kim SI, Huh KH Tags: Clin Nephrol Source Type: research

A 12-week dose-escalating study of etelcalcetide (ONO-5163/AMG 416), 
a novel intravenous calcimimetic, for secondary hyperparathyroidism in 
Japanese hemodialysis patients
.
CONCLUSIONS: Dose-escalated triweekly etelcalcetide was effective for SHPT in Japanese hemodialysis patients and was satisfactorily tolerated.
. PMID: 28671062 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - July 3, 2017 Category: Urology & Nephrology Authors: Yokoyama K, Fukagawa M, Shigematsu T, Akiba T, Fujii A, Odani M, Akizawa T Tags: Clin Nephrol Source Type: research

Acute kidney injury in critically-ill adult patients with seasonal influenza infection.
CONCLUSIONS: Influenza-related critical illness is rare but can cause AKI in a large proportion of affected patients. In this setting, requirement for renal replacement therapy could be associated with increased mortality risk.
. PMID: 28669380 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - July 2, 2017 Category: Urology & Nephrology Authors: Dovč A, Premru V, Pečavar B, Ponikvar R Tags: Clin Nephrol Source Type: research

Rituximab for the treatment of membranous nephropathy: a single-center experience.
CONCLUSION: The remission rate after rituximab treatment in our cohort of patients with idiopathic membranous nephropathy was lower than in other studies. The reason for this is possibly the application of a single dose of rituximab in the majority of patients, which might have been insufficient in patients with higher proteinuria.
. PMID: 28664837 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - June 30, 2017 Category: Urology & Nephrology Authors: Rigler AA, Jerman A, Orsag A, Kojc N, Kovač D, Škoberne A, Borštnar Š, Večerić Haler Ž, Avguštin N, Kveder R, Ferluga D, Vizjak A, Lindič J Tags: Clin Nephrol Source Type: research

Treatment of antibody-mediated rejection of kidney grafts with bortezomib and/or rituximab compared to standard regimen: experience of Slovene National Center.
CONCLUSIONS: Bortezomib or rituximab, added to standard treatment, did not significantly improve kidney graft survival and was also not associated with significant side effects, except cytopenia in some cases. Treatment of acute ABMR resulted in better graft survival than chronic ABMR.
. PMID: 28664838 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - June 30, 2017 Category: Urology & Nephrology Authors: Oblak T, Lindič J, Gubenšek J, Kveder R, Aleš Rigler A, Škoberne A, Večerić Haler Ž, Borštnar Š, Avguštin N, Ponikvar R, Mlinšek G, Ferluga D, Kojc N, Godnov U, Kovač D Tags: Clin Nephrol Source Type: research

Effects of paricalcitol on biomarkers of inflammation and fibrosis in kidney transplant recipients: results of a randomized controlled trial.
In this study, we evaluated the effect of paricalcitol on renin-angiotensin system (RAS) activity as well as interleukin (IL)-6 and transforming growth factor (TGF)-β plasma concentrations as biomarkers of inflammation and fibrosis. METHODS: This placebo-controlled, double-blind trial enrolled a national cohort of kidney transplant recipients with urinary protein-to-creatinine ratio (UPCR) ≥ 20 mg/mmol despite optimization of the RAS blockade. Patients were randomly assigned to receive 24 weeks of treatment with 2 µg/day paricalcitol or placebo. The primary endpoint was the percent ch...
Source: Clinical Nephrology - June 30, 2017 Category: Urology & Nephrology Authors: Oblak M, Mlinšek G, Kandus A, Buturović-Ponikvar J, Arnol M Tags: Clin Nephrol Source Type: research

Anticoagulation assessment methods in plasma exchange with regional citrate anticoagulation: evaluation of post-filter and filtered plasma ionized calcium.
CONCLUSIONS: A modest agreement between filtered plasma and postfilter iCa values could be acceptable if only a confirmation of anticoagulant effect is required. Measuring filtered plasma instead of postfilter iCa would reduce blood loss with sampling, which could be important in some settings.
. PMID: 28664840 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - June 30, 2017 Category: Urology & Nephrology Authors: Antonič M, Gubenšek J, Buturović-Ponikvar J, Ponikvar R Tags: Clin Nephrol Source Type: research

Mixed isopropanol-methanol intoxication following ingestion of alcohol-based hand rub  solution
.
We describe a case of combined methanol and isopropanol intoxication by ingestion of alcohol-based hand rub solution. Metabolic acidosis was absent in our patient, presumably because formic acid production is blocked by isopropanol, which inhibits alcohol dehydrogenase. Our case highlights the importance of considering methanol intoxication in patients who ingested alcohol-based hand rub solution, even when there is no metabolic acidosis, and timely removal of the toxic alcohols by dialysis in these patients would prevent permanent retinal damage.
. PMID: 28655383 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - June 28, 2017 Category: Urology & Nephrology Authors: Chan G, Chan J, Szeto CC, Chow KM Tags: Clin Nephrol Source Type: research

Altered basophil function in patients with chronic kidney disease on hemodialysis 
.
CONCLUSION: Together, these data demonstrate that basophil functions related to adhesion and degranulation are altered in CKD patients on hemodialysis, which indicates a potential role for the basophil in the pathogenesis of complications related to infections.
. PMID: 28655384 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - June 28, 2017 Category: Urology & Nephrology Authors: Aljadi Z, Nopp A, Winqvist O, Russom A, Hylander B, Jacobson S, Lundahl J Tags: Clin Nephrol Source Type: research

No impact of surviving sepsis campaign care bundles in reducing sepsis-associated acute kidney injury 
.
CONCLUSION: In a cohort of septic patients, none of the SSC care tasks significantly decreased SA-AKI incidence within the first week after onset of sepsis.
. PMID: 28655385 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - June 28, 2017 Category: Urology & Nephrology Authors: Pérez-Fernández X, Sabater-Riera J, Ballus-Noguera J, Cárdenas-Campos P, Moreno-González G, Alonso-Juste V, Corral-Velez V, Gutierrez-Arámbula D, Gumucio-Sanguino V, Betbesé-Roig A, Liu KD Tags: Clin Nephrol Source Type: research

Rhabdomyolysis and interferon- β: case report and short review.
CONCLUSIONS: The most probable cause of rhabdomyolysis in our patient could have been the combination of interferon effect, which down-regulates P450 expression, with inhibition of the P450 activity by furanocoumarin derivatives from pomelo juice. Therefore, patients treated with drugs that have a possible interaction with inhibitors of cytochrome P450 should be warned against pomelo ingestion.
. PMID: 28655386 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - June 28, 2017 Category: Urology & Nephrology Authors: Jerman A, Kovač D, Večerić-Haler Ž, Hočevar A, Ota A, Banović S, Lindič J Tags: Clin Nephrol Source Type: research

Hemodialysis treatment of cardiorenal syndrome.
CONCLUSIONS: Chronic renal replacement therapy with hemodialysis and strict uremic, electrolyte, and volume control may be more beneficial for patients with advanced heart failure with preserved or reduced LVEF than ultrafiltration alone. We have observed better survival of terminal cardiorenal patients treated with hemodialysis than in the general NYHA IV population, with lower hospital readmission rate and less hospitalized days for heart failure.
. PMID: 28655387 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - June 28, 2017 Category: Urology & Nephrology Authors: Leskovar B, Furlan T, Poznič S, Potisek M, Adamlje A Tags: Clin Nephrol Source Type: research

Ultrasound-guided percutaneous endovascular treatment of arteriovenous fistula/graft.
CONCLUSIONS: Ultrasound-guided endovascular treatment of arteriovenous fistula or graft is a feasible and safe method of reestablishing or maintaining a functional vascular access.
. PMID: 28655388 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - June 28, 2017 Category: Urology & Nephrology Authors: Leskovar B, Furlan T, Poznič S, Potisek M, Adamlje A, Ključevšek T Tags: Clin Nephrol Source Type: research

Role of dry lean body mass for estimation of glomerular filtration rate in kidney transplant recipients.
CONCLUSION: The estimating GFR equations are neither accurate nor precise in renal transplant recipients. Dry lean body mass is an important parameter that could potentially improve the GFR estimation in this population.
. PMID: 28655389 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - June 28, 2017 Category: Urology & Nephrology Authors: Borštnar Š, Lindič J, Škoberne A, Ležaič L, Sočan A, Kandus A, Kovač D Tags: Clin Nephrol Source Type: research

Acute granulomatous interstitial nephritis and acute rejection in a kidney transplant recipient after zoledronic acid therapy - a case report and review of the literature.
CONCLUSION: To our knowledge, this is the first case of AGIN related to bisphosphonate zoledronate in a kidney transplant patient with consequent acute cellular rejection. In using intravenous zoledronate infusion in a kidney transplant recipient, we should be aware that it could potentially induce acute granulomatous tubulointerstitial nephritis and acute rejection.
. PMID: 28655390 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - June 28, 2017 Category: Urology & Nephrology Authors: Avguštin N, Kovač D, Kojc N, Mlinšek G, Lindič J Tags: Clin Nephrol Source Type: research

Prevalence and risk factors for nonvertebral bone fractures in kidney transplant recipients - a single-center retrospective analysis.
CONCLUSION: Fracture rate in our transplant patient population was comparable to that reported in the literature. Except for a higher level of serum total alkaline phosphatase in the fracture group, we found no other early laboratory risk factors for bone fractures. BMD at the femoral region 1 - 10 years after kidney transplantation but not BMD at the time of transplantation was a risk factor for nonvertebral fractures. Osteopenia and osteoporosis in the post-transplant period were found to be a fracture risk factor.
. PMID: 28655391 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - June 28, 2017 Category: Urology & Nephrology Authors: Jerman A, Lindič J, Škoberne A, Borštnar Š, Bergoč MM, Godnov U, Kovač D Tags: Clin Nephrol Source Type: research

Outcome of polyomavirus nephropathy in renal transplant patients: a single-center experience.
CONCLUSION: PVN-associated interstitial inflammation and tubulitis cannot be differentiated morphologically from T-cell-mediated tubulointerstitial rejection. Significant interstitial inflammation and tubulitis in PVN under low-dose immunosuppression might represent immune reconstitution injury, which is reduced after successful BKV clearance from the serum and kidney. Concomitant rejection in PVN patients on low immunosuppression might be efficiently treated with transient pulse immunosuppressive therapy.
. PMID: 28655392 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - June 28, 2017 Category: Urology & Nephrology Authors: Kojc N, Rigler AA, Mlinšek G, Kovač D, Ferluga D, Arnol M Tags: Clin Nephrol Source Type: research

The role of single nucleotide polymorphisms of CYP3A and ABCB1 on tacrolimus predose concentration in kidney transplant recipients.
CONCLUSIONS: Due to high inter- and intrapatient tacrolimus variability, a patient-tailored approach to define the optimal maintenance tacrolimus C0 for each individual patient is needed. Our model will rely on individual pharmacogenomic and clinical data to cover different patient-specific risk factors for adverse outcomes.
. PMID: 28655393 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - June 28, 2017 Category: Urology & Nephrology Authors: Mlinšek G, Dolžan V, Goričar K, Buturović-Ponikvar J, Arnol M Tags: Clin Nephrol Source Type: research

Bone mineral disturbances in patients with chronic kidney disease stage 5 not yet on dialysis.
CONCLUSIONS: Our data show that 76% of our patients with CKD stage 5 not yet on dialysis achieved adequate control of secondary hyperparathyroidism. Marked reduction of intact PTH levels in a significant proportion of our patients prompt us to assess the administration of excessive amounts of calcium and/or vitamin D supplements to prevent over-suppression of PTH, which can induce adynamic bone disease.
. PMID: 28619127 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - June 16, 2017 Category: Urology & Nephrology Authors: Pernat AM, Zrimšek M Tags: Clin Nephrol Source Type: research

Bioimpedance-based rather than weight-based ultrafiltration prescription for children on  maintenance hemodialysis
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Bioimpedance-based rather than weight-based ultrafiltration prescription for children on maintenance hemodialysis
. Clin Nephrol. 2017 Jun 16;: Authors: Ardissino G, Belingheri M, Perrone M, Tel F, Consonni D, Testa S Abstract The determination of dry weight (DW) in young children on hemodialysis (HD) remains challenging. Bioimpedance analysis (BIA) is a potentially helpful means of estimating the need for ultrafiltration and monitoring body fluids in patients on renal replacement therapy, but its role has not yet been clearly defined. The aim of this paper is to share our experience of prescri...
Source: Clinical Nephrology - June 16, 2017 Category: Urology & Nephrology Authors: Ardissino G, Belingheri M, Perrone M, Tel F, Consonni D, Testa S Tags: Clin Nephrol Source Type: research

Tubular urinary indexes reliably distinguish between primary tubulointerstitial and primary glomerular diseases in patients referred for kidney biopsy.
CONCLUSIONS: Prior to kidney biopsy, tubular urinary indexes may present a valuable tool in distinguishing patients with TID from patients with GLOM.
. PMID: 28601117 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - June 9, 2017 Category: Urology & Nephrology Authors: Škoberne A, Borštnar Š, Avguštin N, Kovač D, Rigler AA, Večerić-Haler Ž, Pajek J, Krsnik M, Kojc N, Ferluga D, Lindič J Tags: Clin Nephrol Source Type: research